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Volumn 33, Issue 3, 2013, Pages 202-208

Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats

Author keywords

Allium cepa; Antioxidants; Cardiotoxicity; Doxorubicin; Rat; TUNEL

Indexed keywords

CREATINE KINASE; CREATINE KINASE MB; DOXORUBICIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; ONION EXTRACT; SUPEROXIDE DISMUTASE; TROPONIN I;

EID: 84873059182     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1738     Document Type: Article
Times cited : (43)

References (50)
  • 2
    • 79953693870 scopus 로고    scopus 로고
    • Protective effect of bilberry (Vaccinium myrtillus) against doxorubicin-induced oxidative cardiotoxicity in rats
    • Ashour OM, Elberry AA, Alahdal A, Al Mohamadi AM, Nagy AA, Abdel-Naim AB. 2011. Protective effect of bilberry (Vaccinium myrtillus) against doxorubicin-induced oxidative cardiotoxicity in rats. Med. Sci. Monit. 17(4): 110-115.
    • (2011) Med. Sci. Monit. , vol.17 , Issue.4 , pp. 110-115
    • Ashour, O.M.1    Elberry, A.A.2    Alahdal, A.3    Al Mohamadi, A.M.4    Nagy, A.A.5    Abdel-Naim, A.B.6
  • 3
    • 73649194769 scopus 로고
    • Improved method for the determination of blood glutathione
    • Beutler E, Duron O, Kelly M. 1963. Improved method for the determination of blood glutathione. J. Lab. Clin. Med. 61: 882-888.
    • (1963) J. Lab. Clin. Med. , vol.61 , pp. 882-888
    • Beutler, E.1    Duron, O.2    Kelly, M.3
  • 4
    • 0028989273 scopus 로고
    • Diagnostic efficiency of troponin T measurements in rats with experimental myocardial cell damage
    • Bleuel H, Deschl U, Bertsch T, Bolz G, Rebel W. 1995. Diagnostic efficiency of troponin T measurements in rats with experimental myocardial cell damage. Exp. Toxicol. Pathol. 47: 121-127.
    • (1995) Exp. Toxicol. Pathol. , vol.47 , pp. 121-127
    • Bleuel, H.1    Deschl, U.2    Bertsch, T.3    Bolz, G.4    Rebel, W.5
  • 6
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation
    • Buage JA, Aust SD. 1978. Microsomal lipid peroxidation. Meth. Enzymol. 12: 302-310.
    • (1978) Meth. Enzymol. , vol.12 , pp. 302-310
    • Buage, J.A.1    Aust, S.D.2
  • 7
    • 0037102148 scopus 로고    scopus 로고
    • Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio
    • Childs AC, Phaneuf SL, Dirks AJ, Phillips T, Leeuwenburgh C. 2002. Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio. Cancer Res. 62: 4592-4598.
    • (2002) Cancer Res. , vol.62 , pp. 4592-4598
    • Childs, A.C.1    Phaneuf, S.L.2    Dirks, A.J.3    Phillips, T.4    Leeuwenburgh, C.5
  • 8
    • 0015493966 scopus 로고
    • Doxorubicin in disseminated osteosarcoma
    • Cores EP, Holland JF, Wang JJ, Sinks, LF. 1972. Doxorubicin in disseminated osteosarcoma. JAMA 221: 1132-1138.
    • (1972) JAMA , vol.221 , pp. 1132-1138
    • Cores, E.P.1    Holland, J.F.2    Wang, J.J.3    Sinks, L.F.4
  • 9
    • 33646030654 scopus 로고    scopus 로고
    • The superoxide dismutase inhibitor diethyldithiocarbamate has antagonistic effects on apoptosis by triggering both cytochrome c release and caspase inhibition
    • Dumay A, Rincheval V, Trotot P, Mignotte B, Vayssiere JL. 2006. The superoxide dismutase inhibitor diethyldithiocarbamate has antagonistic effects on apoptosis by triggering both cytochrome c release and caspase inhibition. Free Radic. Biol. Med. 40: 1377-1390.
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 1377-1390
    • Dumay, A.1    Rincheval, V.2    Trotot, P.3    Mignotte, B.4    Vayssiere, J.L.5
  • 10
    • 77951647379 scopus 로고    scopus 로고
    • Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats
    • Elberry AA, Abdel-Naim AB, Abdel-Sattar EA. 2010: Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats. Food Chem. Toxicol. 48(5): 1178-1184.
    • (2010) Food Chem. Toxicol. , vol.48 , Issue.5 , pp. 1178-1184
    • Elberry, A.A.1    Abdel-Naim, A.B.2    Abdel-Sattar, E.A.3
  • 11
    • 0347722762 scopus 로고    scopus 로고
    • Protective effects of erdosteine against doxorubicin-induced cardiomyopathy in rats
    • Fadillioglu E, Erdoǧan H, Söǧüt S, Kuku I. 2003. Protective effects of erdosteine against doxorubicin-induced cardiomyopathy in rats. J. Appl. Toxicol. 23(1): 71-74.
    • (2003) J. Appl. Toxicol. , vol.23 , Issue.1 , pp. 71-74
    • Fadillioglu, E.1    Erdoǧan, H.2    Söǧüt, S.3    Kuku, I.4
  • 14
    • 0033938716 scopus 로고    scopus 로고
    • Antioxidant effect of onion oil (Allium cepa. Linn) on the damages induced by nicotine in rats as compared to aipha-tocopherol
    • Helen A, Krishnakumar K, Vijayammal PL, Augusti KT. 2000. Antioxidant effect of onion oil (Allium cepa. Linn) on the damages induced by nicotine in rats as compared to aipha-tocopherol. Toxicol. Lett. 116: 61-68.
    • (2000) Toxicol. Lett. , vol.116 , pp. 61-68
    • Helen, A.1    Krishnakumar, K.2    Vijayammal, P.L.3    Augusti, K.T.4
  • 15
    • 0027504187 scopus 로고
    • Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
    • Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. 1993. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342: 1007-1011.
    • (1993) Lancet , vol.342 , pp. 1007-1011
    • Hertog, M.G.1    Feskens, E.J.2    Hollman, P.C.3    Katan, M.B.4    Kromhout, D.5
  • 17
  • 18
    • 0034625535 scopus 로고    scopus 로고
    • Apoptosis and heart failure: A critical review of the literature
    • Kang PM, Izumo S. 2000. Apoptosis and heart failure: A critical review of the literature. Circus. Res. 86: 1107-1120.
    • (2000) Circus. Res. , vol.86 , pp. 1107-1120
    • Kang, P.M.1    Izumo, S.2
  • 19
    • 0023205079 scopus 로고
    • Garlic (Allium sativum) and onion (Allium cepa): a review of their relationship to cardiovascular disease
    • Kendler BS. 1987: Garlic (Allium sativum) and onion (Allium cepa): a review of their relationship to cardiovascular disease. Prev. Med. 16: 670-685.
    • (1987) Prev. Med. , vol.16 , pp. 670-685
    • Kendler, B.S.1
  • 21
    • 0023819810 scopus 로고
    • G2 block induced by DNA crosslinking agents and its possible consequences
    • Konopa J. 1988. G2 block induced by DNA crosslinking agents and its possible consequences. Biochem. Pharmacol. 37: 2303-2309.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 2303-2309
    • Konopa, J.1
  • 22
    • 0017067418 scopus 로고
    • Glutathione peroxidase activity in selenium deficient rat liver
    • Lawrence RA, Burk RF. 1976. Glutathione peroxidase activity in selenium deficient rat liver. Biochem. Biophys. Res. Commun. 71: 952-958.
    • (1976) Biochem. Biophys. Res. Commun. , vol.71 , pp. 952-958
    • Lawrence, R.A.1    Burk, R.F.2
  • 23
    • 0015849162 scopus 로고
    • A clinicopathologic analysis of adriamycin cardiotoxicity
    • Lefrak EA, Pitha J, Rosenheim S, Gottlieb JA. 1973. A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 32: 302-314.
    • (1973) Cancer , vol.32 , pp. 302-314
    • Lefrak, E.A.1    Pitha, J.2    Rosenheim, S.3    Gottlieb, J.A.4
  • 24
    • 0032504097 scopus 로고    scopus 로고
    • Melatonin: a pineal hormone with antioxidant property protects against adriamycin cardiomyopathy in rats
    • Morishima I, Matsui H, Mukawa H, Hayashi K, Toki Y, Okumura K. 1999. Melatonin: a pineal hormone with antioxidant property protects against adriamycin cardiomyopathy in rats. Life Sci. 63(7): 511-521.
    • (1999) Life Sci. , vol.63 , Issue.7 , pp. 511-521
    • Morishima, I.1    Matsui, H.2    Mukawa, H.3    Hayashi, K.4    Toki, Y.5    Okumura, K.6
  • 25
    • 2642586567 scopus 로고    scopus 로고
    • Protection against acute adriamycin-induced cardiotoxicity by garlic: role of endogenous antioxidants and inhibition of TNF-α expression
    • Mukherjee S, Banerjee SK, Maulik M, Dinda AK, Maulik KS. 2003. Protection against acute adriamycin-induced cardiotoxicity by garlic: role of endogenous antioxidants and inhibition of TNF-α expression. BMC Pharmacol. 3(16): 1-9.
    • (2003) BMC Pharmacol. , vol.3 , Issue.16 , pp. 1-9
    • Mukherjee, S.1    Banerjee, S.K.2    Maulik, M.3    Dinda, A.K.4    Maulik, K.S.5
  • 26
    • 0022559530 scopus 로고
    • Erythrocyte superoxide dismutase activity and other parameters of copper status in rats ingesting lead acetate
    • Mylorie AA, Collins H, Umbles C, Kyle J. 1986. Erythrocyte superoxide dismutase activity and other parameters of copper status in rats ingesting lead acetate. Toxicol. Appl. Pharmacol. 82: 512-520.
    • (1986) Toxicol. Appl. Pharmacol. , vol.82 , pp. 512-520
    • Mylorie, A.A.1    Collins, H.2    Umbles, C.3    Kyle, J.4
  • 27
    • 34548403111 scopus 로고    scopus 로고
    • Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin
    • Neilan TG, Blake SL, Ichinose F, Raher MJ, Buys ES, Jassal DS. 2007. Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin. Circulation 116: 506-514.
    • (2007) Circulation , vol.116 , pp. 506-514
    • Neilan, T.G.1    Blake, S.L.2    Ichinose, F.3    Raher, M.J.4    Buys, E.S.5    Jassal, D.S.6
  • 28
    • 69749114647 scopus 로고    scopus 로고
    • Antibacterial activity of Allium cepa (Onions) and Zingiber officinale (Ginger) on Staphylococcus aureus and Pseudomonas aeruginosa isolated from high vaginal swab
    • Nelson CA, Reginald AO, Okoro N, Janet K. 2007. Antibacterial activity of Allium cepa (Onions) and Zingiber officinale (Ginger) on Staphylococcus aureus and Pseudomonas aeruginosa isolated from high vaginal swab. Trop. Med. Int. Health 3(2): 1-5.
    • (2007) Trop. Med. Int. Health , vol.3 , Issue.2 , pp. 1-5
    • Nelson, C.A.1    Reginald, A.O.2    Okoro, N.3    Janet, K.4
  • 29
    • 0037409586 scopus 로고    scopus 로고
    • Comparison of antioxidant activities of onion and garlic and extracts by inhibition of lipid peroxidation and radical scavenging activity
    • Nuutila AM, Puuponen-Pimia R, Aarni M, Oksman-Caldentey K. 2003. Comparison of antioxidant activities of onion and garlic and extracts by inhibition of lipid peroxidation and radical scavenging activity. Food Chem. 81: 485-493.
    • (2003) Food Chem. , vol.81 , pp. 485-493
    • Nuutila, A.M.1    Puuponen-Pimia, R.2    Aarni, M.3    Oksman-Caldentey, K.4
  • 31
    • 0025051505 scopus 로고
    • Doxorubicin cardiotoxicity analysis of prevailing hypotheses
    • Olson RD, Mushlin PS. 1990. Doxorubicin cardiotoxicity analysis of prevailing hypotheses. FASEB J. 4: 3076-3086.
    • (1990) FASEB J. , vol.4 , pp. 3076-3086
    • Olson, R.D.1    Mushlin, P.S.2
  • 32
    • 67650863482 scopus 로고    scopus 로고
    • Methanolic extract of onion (Allium cepa) attenuates ischemia/hypoxia-induced apoptosis in cardiomyocytes via antioxidant effect
    • Park S, Kim MY, Lee DH, Lee SH, Baik EJ, Moon CH, Park SW, Ko EY, Oh SR, Jung YS. 2009. Methanolic extract of onion (Allium cepa) attenuates ischemia/hypoxia-induced apoptosis in cardiomyocytes via antioxidant effect. Eur. J. Nutr. 48(4): 235-242.
    • (2009) Eur. J. Nutr. , vol.48 , Issue.4 , pp. 235-242
    • Park, S.1    Kim, M.Y.2    Lee, D.H.3    Lee, S.H.4    Baik, E.J.5    Moon, C.H.6    Park, S.W.7    Ko, E.Y.8    Oh, S.R.9    Jung, Y.S.10
  • 33
    • 0023804947 scopus 로고
    • Diagnostic value of serum creatine kinase and lactate dehydrogenase isoenzyme determinations for monitoring early cardiac damage in rats
    • Preus M, Bhargava AS, Khater AE, Gunzel P. 1988. Diagnostic value of serum creatine kinase and lactate dehydrogenase isoenzyme determinations for monitoring early cardiac damage in rats. Toxicol. Lett. 42: 225.
    • (1988) Toxicol. Lett. , vol.42 , pp. 225
    • Preus, M.1    Bhargava, A.S.2    Khater, A.E.3    Gunzel, P.4
  • 34
    • 42049089504 scopus 로고    scopus 로고
    • Protection of multiple antioxidants Chinese herbal medicine on the oxidative stress induced by adriamycin chemotherapy
    • Qin XJ, He W, Hai CX, Liang X, Liu R. 2008. Protection of multiple antioxidants Chinese herbal medicine on the oxidative stress induced by adriamycin chemotherapy. J. Appl. Toxicol. 28(3): 271-282.
    • (2008) J. Appl. Toxicol. , vol.28 , Issue.3 , pp. 271-282
    • Qin, X.J.1    He, W.2    Hai, C.X.3    Liang, X.4    Liu, R.5
  • 35
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw S, Nihal M, Ahmad N. 2008. Dose translation from animal to human studies revisited. FASEB J. 22: 659-661.
    • (2008) FASEB J. , vol.22 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 36
    • 0034957066 scopus 로고    scopus 로고
    • The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats
    • Saad SY, Najjar TA, Al-Rikabi AC. 2001. The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats. Pharmacol. Res. 43: 211-218.
    • (2001) Pharmacol. Res. , vol.43 , pp. 211-218
    • Saad, S.Y.1    Najjar, T.A.2    Al-Rikabi, A.C.3
  • 37
    • 0033014821 scopus 로고    scopus 로고
    • Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane
    • Sawyer DB, Fukazawa R, Arstall MA, Kelly RA. 1999. Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane. Circus. Res. 84: 257-265.
    • (1999) Circus. Res. , vol.84 , pp. 257-265
    • Sawyer, D.B.1    Fukazawa, R.2    Arstall, M.A.3    Kelly, R.A.4
  • 40
    • 1542316326 scopus 로고    scopus 로고
    • Antimutagenic, antioxidant and free radical scavenging activity of ethyl acetate extracts from white, yellow and red onions
    • Shon MY, Choi SD, Kahng GG, Nam SH, Sung NJ. 2004. Antimutagenic, antioxidant and free radical scavenging activity of ethyl acetate extracts from white, yellow and red onions. Food Chem. Toxicol. 42: 659-666.
    • (2004) Food Chem. Toxicol. , vol.42 , pp. 659-666
    • Shon, M.Y.1    Choi, S.D.2    Kahng, G.G.3    Nam, S.H.4    Sung, N.J.5
  • 41
    • 0023264732 scopus 로고
    • Subcellular effects of adriamycin in the heart: a concise review
    • Singal PK, Deally CMR, Weinberg LE. 1987. Subcellular effects of adriamycin in the heart: a concise review. J. Mol. Cell. Cardiol. 19: 817-828.
    • (1987) J. Mol. Cell. Cardiol. , vol.19 , pp. 817-828
    • Singal, P.K.1    Deally, C.M.R.2    Weinberg, L.E.3
  • 42
    • 0027237540 scopus 로고
    • Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells
    • Skladanowski A, Konopa J. 1993. Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells. Biochem. Pharmacol. 46: 375-382.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 375-382
    • Skladanowski, A.1    Konopa, J.2
  • 44
    • 84873055328 scopus 로고    scopus 로고
    • The Patent Website. n.d. Use of an Onion Extract For Making a Composition to Control Weight Gain. Available from: [June 16].
    • The Patent Website. n.d. Use of an Onion Extract For Making a Composition to Control Weight Gain. Available from: http://patents.com/us-20110142971.html [June 16, 2011].
    • (2011)
  • 45
    • 0032103818 scopus 로고    scopus 로고
    • Free radical involvement in doxorubucin-induced electrophysiological alterations in rat papillary muscle fibres
    • Venditti P, Balestrieri M, De Leo T, Di Meo S. 1998. Free radical involvement in doxorubucin-induced electrophysiological alterations in rat papillary muscle fibres. Cardiovasc. Res. 38: 695-702.
    • (1998) Cardiovasc. Res. , vol.38 , pp. 695-702
    • Venditti, P.1    Balestrieri, M.2    De Leo, T.3    Di Meo, S.4
  • 47
    • 6044274062 scopus 로고    scopus 로고
    • Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management
    • Yeh ET, Tong AT, Lenihan DJ, Yusuf SW, Swafford J, Champion C. 2004. Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation 109: 3122-3131.
    • (2004) Circulation , vol.109 , pp. 3122-3131
    • Yeh, E.T.1    Tong, A.T.2    Lenihan, D.J.3    Yusuf, S.W.4    Swafford, J.5    Champion, C.6
  • 48
    • 0031556535 scopus 로고    scopus 로고
    • Reactive oxygen species-induced DNA damage and its modification: a chemical investigation
    • Yu TW, Anderson D. 1997. Reactive oxygen species-induced DNA damage and its modification: a chemical investigation. Mutat. Res. 379: 201-210.
    • (1997) Mutat. Res. , vol.379 , pp. 201-210
    • Yu, T.W.1    Anderson, D.2
  • 49
    • 0016763976 scopus 로고
    • Toxicologic screening of daunorubicin (NSC-82151), adriamycin (NSC-123127), and their derivatives in rats
    • Zbinden G, Brändle E. 1975. Toxicologic screening of daunorubicin (NSC-82151), adriamycin (NSC-123127), and their derivatives in rats. Cancer Chemother. Rep. 59(4): 707-715.
    • (1975) Cancer Chemother. Rep. , vol.59 , Issue.4 , pp. 707-715
    • Zbinden, G.1    Brändle, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.