Onion (Allium cepa) extract prevents cadmium induced renal dysfunction

Indian Journal of Nephrology

Volumn 19, Issue 4, 2009, Pages 140-144

  Ige, S F ^a   Salawu, E O ^a   Olaleye, S B ^a   Adeeyo, O A ^a   Badmus, J ^a   Adeleke, A A ^a  

^a LADOKE AKINTOLA UNIVERSITY OF TECHNOLOGY   (Nigeria)

Author keywords

Allium cepa; Cadmium; Heavy metals; Reactive oxygen species; Renal clearance

Indexed keywords

CADMIUM; CREATININE; ONION EXTRACT; SUPEROXIDE DISMUTASE; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEAVY METAL POISONING; KIDNEY CLEARANCE; KIDNEY DISEASE; KIDNEY FUNCTION; MALE; NEPHROTOXICITY; NONHUMAN; ONION; PROTEIN BLOOD LEVEL; RAT; URINE VOLUME; WISTAR RAT;

EID: 77953381381     PISSN: 09714065     EISSN: 19983662     Source Type: Journal    
DOI: 10.4103/0971-4065.59334     Document Type: Article

References (20)

1. Jungmann J, Reins HA, Schobert C, Jentsch S. Resistance to cadmium mediated by ubiquitin-dependent proteolysis. Nature 1993;361:369-371
2. Kopp SJ, Glonek T, Perry HM, Erlanger M, Perry EF. Cardiovascular actions of cadmium at environmental exposure levels. Science 1982;217:837-839
3. Cherian MG, O'Heany J, Kusiak RA. Health Effects of Cadmium and its Inorganic Compounds. Ontario Ministry of Labour. Toronto. 1985.
4. Friberg L, Elinder CG, Kjellstrom T, Nordberg GF. General summary and conclusions and some aspects of diagnosis and treatment of chronic cadmium poisoning. Cadmium and Health 1986; 2:247-255
5. Zwennis WC, Franssen AC. Assessment of occupational exposure to cadmium in the Netherlands, 1980-1989. Am J Ind Med 1992;21:793-805.
6. Prakash D, Singh BN, Upadhyay G. Antioxidant and free radical scavenging activities of phenols from onion (Allium cepa). Food chemistry 2007;102:1389-1393 (Pubitemid 46176462)
7. Nelson CA, Reginald AO, Okoro N, Janet K. Antibacterial activity of Allium cepa (Onions) and Zingiber officinale (Ginger) on Staphylococcus aureus and Pseudomonas aeruginosa Isolated From High Vaginal Swab. Int J Trop Med 2007;3(2):1-5.
8. Jaffe M. Ueber den Niederschlag, Welchen Pikrins aeure in normalem Harn erzeught und ueber eine neue Reaktion des Kreatinins Z. Physiol Chem 1886;10:391-400.
9. Ceriotti G, Spandro L. A spectrophotometric method for determination of urea. Clin Chim Acta 1963;8:295-299
10. Guyton AC, Hall JE. Textbook of medical physiology. 10th ed. India, New Delhi: Elsevier; 2001. p. 309-310
11. Fridovich I. Superoxide dismutases. Adv Enzymol Relat Areas Mol Biol 1986;58:61-97.
12. Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972;47:389-394
13. Varshney R, Kale RK. Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes. Int J Radiat Biol 1990;58:733-743
14. Campos KE, Diniz YS, Cataneo AC, Faine LA, Alves MJ, Novelli EL. Hypoglycaemic and antioxidant effects of onion, Allium cepa: Dietary onion addition, antioxidant activity and hypoglycaemic effects on diabetic rats. Int J Food Sci Nutr 2003;54:241-246
15. Nutrition Facts and Food Composition Analysis - Spices, onion powder. Available from: Http://www.nutritionanalyser.com/food-composition/?group= Dairy+and+Egg+Productsandfood=onion. [last accessed on 2008 July].
16. Nadir R, Suat E. Oral administration of lycopene reverses cadmium-suppressed body weight loss and lipid peroxidation in rats. Biol Trace Elem Res 2007;118:175-183
17. Asagba SO, Obi FO. Effects of oral cadmium exposure on renal glomerular and tubular functions in the rat. J Appl Sci Environ Management 2004;8:29-32.
18. Soisungwan S, Muneko N, Pailin U, Yuvaree V, Jason RB, Michael RM. Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects. Toxicology Letters 2004;148:187-197
19. Takashima M, Nishino K, Itokawa Y. Effect of cadmium administration on growth, excretion, and tissue accumulation of cadmium and histological alterations in calcium-sufficient and deficient rats: An equalized feeding study. Toxicol Appl Pharmacol 1978;45:591-598
20. Jamall IS, Crispin Smith J. Effects of cadmium on glutathione peroxidase, superoxide dismutase, and lipid peroxidation in the rat heart: A possible mechanism of cadmium cardiotoxicity. Toxicol Appl Pharmacol 1985;80:33-42.