메뉴 건너뛰기




Volumn 44, Issue 1, 2012, Pages 45-51

The reno-protective effect of a phosphoinositide 3-kinase inhibitor wortmannin on streptozotocin-induced proteinuric renal disease rats

Author keywords

Albuminuria; Diabetic nephropathies; Nephrin; Podocin; Podocytes; Wortmannin

Indexed keywords

ALBUMIN; CREATININE; NEPHRIN; PODOCIN; PROTEIN CDC42; RAC1 PROTEIN; WORTMANNIN;

EID: 84863172385     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2012.44.1.004     Document Type: Article
Times cited : (28)

References (40)
  • 1
    • 33744969296 scopus 로고    scopus 로고
    • Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling
    • Asanuma K, Yanagida-Asanuma E, Faul C, Tomino Y, Kim K, Mundel P. Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat Cell Biol 2006;8:485-91
    • (2006) Nat Cell Biol , vol.8 , pp. 485-491
    • Asanuma, K.1    Yanagida-Asanuma, E.2    Faul, C.3    Tomino, Y.4    Kim, K.5    Mundel, P.6
  • 3
    • 77955314144 scopus 로고    scopus 로고
    • Zhen-wu-tang, a blended traditional Chinese herbal medicine, ameliorates proteinuria and renal damage of streptozotocin-induced diabetic nephropathy in rats
    • Cai Y, Chen J, Jiang J, Cao W, He L. Zhen-wu-tang, a blended traditional Chinese herbal medicine, ameliorates proteinuria and renal damage of streptozotocin-induced diabetic nephropathy in rats. J Ethnopharmacol 2010;131:88-94
    • (2010) J Ethnopharmacol , vol.131 , pp. 88-94
    • Cai, Y.1    Chen, J.2    Jiang, J.3    Cao, W.4    He, L.5
  • 4
    • 79952700753 scopus 로고    scopus 로고
    • Resveratrol ameliorates early diabetic nephropathy associated with suppression of augmented TGF-beta/smad and ERK1/2 signaling in streptozotocin-induced diabetic rats
    • Chen KH, Hung CC, Hsu HH, Jing YH, Yang CW, Chen JK. Resveratrol ameliorates early diabetic nephropathy associated with suppression of augmented TGF-beta/smad and ERK1/2 signaling in streptozotocin-induced diabetic rats. Chem Biol Interact 2011;190:45-53
    • (2011) Chem Biol Interact , vol.190 , pp. 45-53
    • Chen, K.H.1    Hung, C.C.2    Hsu, H.H.3    Jing, Y.H.4    Yang, C.W.5    Chen, J.K.6
  • 7
    • 33746770477 scopus 로고    scopus 로고
    • The glomerular basement membrane: Not gone, just forgotten
    • Farquhar MG. The glomerular basement membrane: not gone, just forgotten. J Clin Invest 2006;116:2090-3
    • (2006) J Clin Invest , vol.116 , pp. 2090-2093
    • Farquhar, M.G.1
  • 8
    • 34848907421 scopus 로고    scopus 로고
    • Actin up: Regulation of podocyte structure and function by components of the actin cytoskeleton
    • Faul C, Asanuma K, Yanagida-Asanuma E, Kim K, Mundel P. Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol 2007;17:428-37
    • (2007) Trends Cell Biol , vol.17 , pp. 428-437
    • Faul, C.1    Asanuma, K.2    Yanagida-Asanuma, E.3    Kim, K.4    Mundel, P.5
  • 9
    • 33845715343 scopus 로고    scopus 로고
    • The World Health Report 2006: Working together for health
    • Guilbert JJ. The World Health Report 2006: working together for health. Educ Health (Abingdon) 2006;19:385-7
    • (2006) Educ Health (Abingdon) , vol.19 , pp. 385-387
    • Guilbert, J.J.1
  • 10
    • 0018868302 scopus 로고
    • Glomerular epithelial foot processes in normal man and rats. Distribution of true width and its intra-and inter-individual variation
    • Gundersen HJ, Seefeldt T, Osterby R. Glomerular epithelial foot processes in normal man and rats. Distribution of true width and its intra-and inter-individual variation. Cell Tissue Res 1980;205:147-55
    • (1980) Cell Tissue Res , vol.205 , pp. 147-155
    • Gundersen, H.J.1    Seefeldt, T.2    Osterby, R.3
  • 11
    • 40449099586 scopus 로고    scopus 로고
    • Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration
    • Hidaka T, Suzuki Y, Yamashita M, Shibata T, Tanaka Y, Horikoshi S, Tomino Y. Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration. Am J Pathol 2008;172:603-14
    • (2008) Am J Pathol , vol.172 , pp. 603-614
    • Hidaka, T.1    Suzuki, Y.2    Yamashita, M.3    Shibata, T.4    Tanaka, Y.5    Horikoshi, S.6    Tomino, Y.7
  • 14
    • 45249108429 scopus 로고    scopus 로고
    • Proteinuria in diabetic kidney disease: A mechanistic viewpoint
    • Jefferson JA, Shankland SJ, Pichler RH. Proteinuria in diabetic kidney disease: a mechanistic viewpoint. Kidney Int 2008;74:22-36
    • (2008) Kidney Int , vol.74 , pp. 22-36
    • Jefferson, J.A.1    Shankland, S.J.2    Pichler, R.H.3
  • 16
    • 0037221437 scopus 로고    scopus 로고
    • Cloning of rat homologue of podocin: Expression in proteinuric states and in developing glomeruli
    • Kawachi H, Koike H, Kurihara H, Sakai T, Shimizu F. Cloning of rat homologue of podocin: expression in proteinuric states and in developing glomeruli. J Am Soc Nephrol 2003;14: 46-56
    • (2003) J Am Soc Nephrol , vol.14 , pp. 46-56
    • Kawachi, H.1    Koike, H.2    Kurihara, H.3    Sakai, T.4    Shimizu, F.5
  • 18
    • 77955620601 scopus 로고    scopus 로고
    • Urine albumin-to-creatinine ratio: What's in a number?
    • Kestenbaum B, De Boer IH. Urine albumin-to-creatinine ratio: what's in a number? J Am Soc Nephrol 2010;21:1243-4
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1243-1244
    • Kestenbaum, B.1    de Boer, I.H.2
  • 21
    • 34250349195 scopus 로고    scopus 로고
    • Streptozotocin-induced diabetes can be reversed by hepatic oval cell activation through hepatic transdifferentiation and pancreatic islet regeneration
    • Kim S, Shin JS, Kim HJ, Fisher RC, Lee MJ, Kim CW. Streptozotocin-induced diabetes can be reversed by hepatic oval cell activation through hepatic transdifferentiation and pancreatic islet regeneration. Lab Invest 2007b;87:702-12
    • (2007) Lab Invest , vol.87 , pp. 702-712
    • Kim, S.1    Shin, J.S.2    Kim, H.J.3    Fisher, R.C.4    Lee, M.J.5    Kim, C.W.6
  • 22
    • 3242883645 scopus 로고    scopus 로고
    • Characterization of streptozotocin-induced diabetic rats and pharmacodynamics of insulin formulations
    • Lee JJ, Yi HY, Yang JW, Shin JS, Kwon JH, Kim CW. Characterization of streptozotocin-induced diabetic rats and pharmacodynamics of insulin formulations. Biosci Biotechnol Biochem 2003;67:2396-401
    • (2003) Biosci Biotechnol Biochem , vol.67 , pp. 2396-2401
    • Lee, J.J.1    Yi, H.Y.2    Yang, J.W.3    Shin, J.S.4    Kwon, J.H.5    Kim, C.W.6
  • 23
    • 12344256951 scopus 로고    scopus 로고
    • Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase
    • Liu Y, Shreder KR, Gai W, Corral S, Ferris DK, Rosenblum JS. Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase. Chem Biol 2005;12:99-107
    • (2005) Chem Biol , vol.12 , pp. 99-107
    • Liu, Y.1    Shreder, K.R.2    Gai, W.3    Corral, S.4    Ferris, D.K.5    Rosenblum, J.S.6
  • 25
    • 77949541746 scopus 로고    scopus 로고
    • Proteinuria: An enzymatic disease of the podocyte?
    • Mundel P, Reiser J. Proteinuria: an enzymatic disease of the podocyte? Kidney Int 2010;77:571-80
    • (2010) Kidney Int , vol.77 , pp. 571-580
    • Mundel, P.1    Reiser, J.2
  • 26
    • 0024506474 scopus 로고
    • Improved competitive enzymelinked immunoassay (ELISA) for albuminuria
    • Neuman RG, Cohen MP. Improved competitive enzymelinked immunoassay (ELISA) for albuminuria. Clin Chim Acta 1989;179:229-37
    • (1989) Clin Chim Acta , vol.179 , pp. 229-237
    • Neuman, R.G.1    Cohen, M.P.2
  • 27
    • 70349673847 scopus 로고    scopus 로고
    • Tolvaptan, a selective oral vasopressin V2 receptor antagonist, ameliorates podocyte injury in puromycin aminonucleoside nephrotic rats
    • Okada T, Sakaguchi T, Hatamura I, Saji F, Negi S, Otani H, Muragaki Y, Kawachi H, Shigematsu T. Tolvaptan, a selective oral vasopressin V2 receptor antagonist, ameliorates podocyte injury in puromycin aminonucleoside nephrotic rats. Clin Exp Nephrol 2009;13:438-46
    • (2009) Clin Exp Nephrol , vol.13 , pp. 438-446
    • Okada, T.1    Sakaguchi, T.2    Hatamura, I.3    Saji, F.4    Negi, S.5    Otani, H.6    Muragaki, Y.7    Kawachi, H.8    Shigematsu, T.9
  • 28
    • 0037207471 scopus 로고    scopus 로고
    • Cell biology of the glomerular podocyte
    • Pavenstädt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev 2003;83:253-307
    • (2003) Physiol Rev , vol.83 , pp. 253-307
    • Pavenstädt, H.1    Kriz, W.2    Kretzler, M.3
  • 31
    • 0036791605 scopus 로고    scopus 로고
    • Co-localization of nephrin, podocin, and the actin cytoskeleton: Evidence for a role in podocyte foot process formation
    • Saleem MA, Ni L, Witherden I, Tryggvason K, Ruotsalainen V, Mundel P, Mathieson PW. Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation. Am J Pathol 2002;161: 1459-66
    • (2002) Am J Pathol , vol.161 , pp. 1459-1466
    • Saleem, M.A.1    Ni, L.2    Witherden, I.3    Tryggvason, K.4    Ruotsalainen, V.5    Mundel, P.6    Mathieson, P.W.7
  • 32
    • 39349117091 scopus 로고    scopus 로고
    • Nephrin AKTs on actin: The slit diaphragmactin cytoskeleton signaling network expands
    • Schlondorff J. Nephrin AKTs on actin: The slit diaphragmactin cytoskeleton signaling network expands. Kidney Int 2008;73:524-6
    • (2008) Kidney Int , vol.73 , pp. 524-526
    • Schlondorff, J.1
  • 33
    • 4344716629 scopus 로고    scopus 로고
    • Podocalyxin activates RhoA and induces actin reorganization through NHERF1 and Ezrin in MDCK cells
    • Schmieder S, Nagai M, Orlando RA, Takeda T, Farquhar MG. Podocalyxin activates RhoA and induces actin reorganization through NHERF1 and Ezrin in MDCK cells. J Am Soc Nephrol 2004;15:2289-98
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2289-2298
    • Schmieder, S.1    Nagai, M.2    Orlando, R.A.3    Takeda, T.4    Farquhar, M.G.5
  • 34
    • 33645455275 scopus 로고    scopus 로고
    • Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling
    • Shibata S, Nagase M, Fujita T. Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling. J Am Soc Nephrol 2006;17:754-64
    • (2006) J Am Soc Nephrol , vol.17 , pp. 754-764
    • Shibata, S.1    Nagase, M.2    Fujita, T.3
  • 36
    • 0031910264 scopus 로고    scopus 로고
    • Regulation of podocyte structure during the development of nephrotic syndrome
    • Smoyer WE, Mundel P. Regulation of podocyte structure during the development of nephrotic syndrome. J Mol Med 1998;76:172-83
    • (1998) J Mol Med , vol.76 , pp. 172-183
    • Smoyer, W.E.1    Mundel, P.2
  • 38
    • 46749123888 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase contributes to diabetes-induced abnormal vascular reactivity in rat perfused mesenteric bed
    • Yousif MH. Phosphoinositide 3-kinase contributes to diabetes-induced abnormal vascular reactivity in rat perfused mesenteric bed. Cell Biochem Funct 2008;26: 451-8
    • (2008) Cell Biochem Funct , vol.26 , pp. 451-458
    • Yousif, M.H.1
  • 39
    • 49749123825 scopus 로고    scopus 로고
    • Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro
    • Zheng CX, Chen ZH, Zeng CH, Qin WS, Li LS, Liu ZH. Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro. Kidney Int 2008;74: 596-612
    • (2008) Kidney Int , vol.74 , pp. 596-612
    • Zheng, C.X.1    Chen, Z.H.2    Zeng, C.H.3    Qin, W.S.4    Li, L.S.5    Liu, Z.H.6
  • 40
    • 39349104907 scopus 로고    scopus 로고
    • Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes
    • Zhu J, Sun N, Aoudjit L, Li H, Kawachi H, Lemay S, Takano T. Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes. Kidney Int 2008;73:556-66
    • (2008) Kidney Int , vol.73 , pp. 556-566
    • Zhu, J.1    Sun, N.2    Aoudjit, L.3    Li, H.4    Kawachi, H.5    Lemay, S.6    Takano, T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.