State-dependent FRET reports calcium- and voltagedependent gating-ring motions in BK channels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 13, 2013, Pages 5217-5222

  Miranda, Pablo ^a,b   Contreras, Jorge E ^c,g   Plested, Andrew J R ^d,e   Sigworth, Fred J ^f   Holmgren, Miguel ^c   Giraldez, Teresa ^a  

^a HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^b UNIVERSIDAD DE LA LAGUNA   (Spain)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^d LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Allosteric regulation; Fluorescence; SLO1 channel

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; GREEN FLUORESCENT PROTEIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

ARTICLE; CALCIUM BINDING; CHANNEL GATING; CONFORMATIONAL TRANSITION; ELECTRIC POTENTIAL; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUOROMETRY; HUMAN; HUMAN CELL; NERVE CELL EXCITABILITY; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ANIMALS; CALCIUM; CRYSTALLOGRAPHY, X-RAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; XENOPUS;

EID: 84875540194     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219611110     Document Type: Article

References (41)

1. 2+ and voltage. Biol Res 39(3):385-401.
2. Toro L, Wallner M, Meera P, Tanaka Y (1998) Maxi-K(Ca), a unique member of the voltage-gated K channel superfamily. News Physiol Sci 13:112-117.
3. Grimm PR, Irsik DL, Settles DC, Holtzclaw JD, Sansom SC (2009) Hypertension of Kcnmb1-/- is linked to deficient K secretion and aldosteronism. Proc Natl Acad Sci USA 106(28):11800-11805.
4. Bloch M, et al. (2007) KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer. Oncogene 26(17):2525-2534.
5. 2+ sensing. Neuron 66(6):871-883.
6. Díaz L, et al. (1998) Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel. J Biol Chem 273(49):32430-32436.
7. Jiang Y, et al. (2002) Crystal structure and mechanism of a calcium-gated potassium channel. Nature 417(6888):515-522.
8. Wang L, Sigworth FJ (2009) Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy. Nature 461(7261):292-295.
9. 2+-activation apparatus at 3.0 A resolution. Science 329(5988):182-186.
10. + channel. Nature 466(7304):393-397.
11. + channel. Nature 481(7379): 94-97.
12. + channel. J Gen Physiol 110(3):257-281.
13. + channels described by a two-tiered allosteric gating mechanism. J Gen Physiol 116(1):75-99.
14. + channels. Biochemistry 39(50):15612-15619.
15. 2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol 120(3):267-305.
16. 2+ binding constants: Effects of membrane voltage. J Gen Physiol 132(5):491-505.
17. 2+-dependent potassium channel (BK) gating ring apparatus. J Biol Chem 286(23):20701-20709.
18. Lingle CJ (2007) Gating rings formed by RCK domains: Keys to gate opening. J Gen Physiol 129(2):101-107.
19. Cui J, Yang H, Lee US (2009) Molecular mechanisms of BK channel activation. Cell Mol Life Sci 66(5):852-875.
20. Zheng J, Zagotta WN (2003) Patch-clamp fluorometry recording of conformational rearrangements of ion channels. Sci STKE 2003(176):PL7.
21. Giraldez T, Hughes TE, Sigworth FJ (2005) Generation of functional fluorescent BK channels by random insertion of GFP variants. J Gen Physiol 126(5):429-438.
22. Heim R (1999) Green fluorescent protein forms for energy transfer. Methods Enzymol 302:408-423.
23. 2+ sensitivity. J Gen Physiol 120(2):173-189.
24. 2+ sensing. J Gen Physiol 123(5):475-489.
25. Wei A, Solaro C, Lingle C, Salkoff L (1994) Calcium sensitivity of BK-type KCa channels determined by a separable domain. Neuron 13(3):671-681.
26. Schreiber M, Salkoff L (1997) A novel calcium-sensing domain in the BK channel. Biophys J 73(3):1355-1363.
27. Schreiber M, Yuan A, Salkoff L (1999) Transplantable sites confer calcium sensitivity to BK channels. Nat Neurosci 2(5):416-421.
28. Xia X-M, Zeng X, Lingle CJ (2002) Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature 418(6900):880-884.
29. Zhang G, et al. (2010) Ion sensing in the RCK1 domain of BK channels. Proc Natl Acad Sci USA 107(43):18700-18705.
30. 2+-dependent activation. Proc Natl Acad Sci USA 98(8):4776-4781.
31. Dale RE, Eisinger J, Blumberg WE (1979) The orientational freedom of molecular probes. The orientation factor in intramolecular energy transfer. Biophys J 26(2): 161-193.
32. + channel. J Gen Physiol 112(4):391-408.
33. Hink MA, et al. (2000) Structural dynamics of green fluorescent protein alone and fused with a single chain Fv protein. J Biol Chem 275(23):17556-17560.
34. 2+-calmodulin modulation of cyclic nucleotide-gated channels. J Neurosci 23(22):8167-8175.
35. Hu L, Yang H, Shi J, Cui J (2006) Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels. J Gen Physiol 127(1):35-49.
36. 2+. J Gen Physiol 128(4):389-404.
37. Villalba-Galea CA, Sandtner W, Starace DM, Bezanilla F (2008) S4-based voltage sensors have three major conformations. Proc Natl Acad Sci USA 105(46):17600- 17607.
38. + channel (hslo). Proc Natl Acad Sci USA 94(10):5427-5431.
39. 2+ buffers. Methods Cell Biol 40:3-29.
40. Taraska JW, Zagotta WN (2007) Structural dynamics in the gating ring of cyclic nucleotide-gated ion channels. Nat Struct Mol Biol 14(9):854-860.
41. Winn MD, et al. (2011) Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr 67(Pt 4):235-242.