메뉴 건너뛰기




Volumn 8, Issue 3, 2013, Pages

MicroRNA-21 is Induced by Rapamycin in a Model of Tuberous Sclerosis (TSC) and Lymphangioleiomyomatosis (LAM)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA 132; MICRORNA 21; MICRORNA 210; PROTEIN KINASE B; RAPAMYCIN;

EID: 84875519152     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060014     Document Type: Article
Times cited : (31)

References (51)
  • 1
    • 39449100827 scopus 로고    scopus 로고
    • Lymphangioleiomyomatosis: a clinical update
    • McCormack FX, (2008) Lymphangioleiomyomatosis: a clinical update. Chest 133: 507-516.
    • (2008) Chest , vol.133 , pp. 507-516
    • McCormack, F.X.1
  • 2
    • 84868624305 scopus 로고    scopus 로고
    • Lymphangioleiomyomatosis - a wolf in sheep's clothing
    • Henske EP, McCormack FX, (2012) Lymphangioleiomyomatosis- a wolf in sheep's clothing. J Clin Invest 122: 3807-3816.
    • (2012) J Clin Invest , vol.122 , pp. 3807-3816
    • Henske, E.P.1    McCormack, F.X.2
  • 3
    • 1642345487 scopus 로고    scopus 로고
    • The LAM cell: what is it, where does it come from, and why does it grow?
    • Finlay G, (2004) The LAM cell: what is it, where does it come from, and why does it grow? Am J Physiol Lung Cell Mol Physiol 286: L690-693.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286
    • Finlay, G.1
  • 4
    • 0034014735 scopus 로고    scopus 로고
    • Mutational analysis of the tuberous sclerosis gene TSC2 in patients with pulmonary lymphangioleiomyomatosis
    • Astrinidis A, Khare L, Carsillo T, Smolarek T, Au KS, et al. (2000) Mutational analysis of the tuberous sclerosis gene TSC2 in patients with pulmonary lymphangioleiomyomatosis. J Med Genet 37: 55-57.
    • (2000) J Med Genet , vol.37 , pp. 55-57
    • Astrinidis, A.1    Khare, L.2    Carsillo, T.3    Smolarek, T.4    Au, K.S.5
  • 5
    • 0034705207 scopus 로고    scopus 로고
    • Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis
    • Carsillo T, Astrinidis A, Henske EP, (2000) Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci U S A 97: 6085-6090.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6085-6090
    • Carsillo, T.1    Astrinidis, A.2    Henske, E.P.3
  • 6
    • 0031923762 scopus 로고    scopus 로고
    • Evidence that lymphangiomyomatosis is caused by TSC2 mutations: chromosome 16p13 loss of heterozygosity in angiomyolipomas and lymph nodes from women with lymphangiomyomatosis
    • Smolarek TA, Wessner LL, McCormack FX, Mylet JC, Menon AG, et al. (1998) Evidence that lymphangiomyomatosis is caused by TSC2 mutations: chromosome 16p13 loss of heterozygosity in angiomyolipomas and lymph nodes from women with lymphangiomyomatosis. Am J Hum Genet 62: 810-815.
    • (1998) Am J Hum Genet , vol.62 , pp. 810-815
    • Smolarek, T.A.1    Wessner, L.L.2    McCormack, F.X.3    Mylet, J.C.4    Menon, A.G.5
  • 7
    • 0036160714 scopus 로고    scopus 로고
    • Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis
    • Sato T, Seyama K, Fujii H, Maruyama H, Setoguchi Y, et al. (2002) Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis. J Hum Genet 47: 20-28.
    • (2002) J Hum Genet , vol.47 , pp. 20-28
    • Sato, T.1    Seyama, K.2    Fujii, H.3    Maruyama, H.4    Setoguchi, Y.5
  • 9
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, et al. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14: 1296-1302.
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5
  • 10
    • 0041821468 scopus 로고    scopus 로고
    • Raptor and mTOR: subunits of a nutrient-sensitive complex
    • Kim DH, Sabatini DM, (2004) Raptor and mTOR: subunits of a nutrient-sensitive complex. Curr Top Microbiol Immunol 279: 259-270.
    • (2004) Curr Top Microbiol Immunol , vol.279 , pp. 259-270
    • Kim, D.H.1    Sabatini, D.M.2
  • 11
    • 38049169559 scopus 로고    scopus 로고
    • Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
    • Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, et al. (2008) Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med 358: 140-151.
    • (2008) N Engl J Med , vol.358 , pp. 140-151
    • Bissler, J.J.1    McCormack, F.X.2    Young, L.R.3    Elwing, J.M.4    Chuck, G.5
  • 12
  • 13
    • 77953957633 scopus 로고    scopus 로고
    • A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
    • Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, et al. (2010) A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465: 1033-1038.
    • (2010) Nature , vol.465 , pp. 1033-1038
    • Poliseno, L.1    Salmena, L.2    Zhang, J.3    Carver, B.4    Haveman, W.J.5
  • 14
    • 55249119513 scopus 로고    scopus 로고
    • MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha
    • e1624
    • Wu F, Zikusoka M, Trindade A, Dassopoulos T, Harris ML, et al. (2008) MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha. Gastroenterology 135: 1624-1635 e1624.
    • (2008) Gastroenterology , vol.135 , pp. 1624-1635
    • Wu, F.1    Zikusoka, M.2    Trindade, A.3    Dassopoulos, T.4    Harris, M.L.5
  • 15
    • 33847038668 scopus 로고    scopus 로고
    • MicroRNAs play an essential role in the development of cardiac hypertrophy
    • Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M, (2007) MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res 100: 416-424.
    • (2007) Circ Res , vol.100 , pp. 416-424
    • Sayed, D.1    Hong, C.2    Chen, I.Y.3    Lypowy, J.4    Abdellatif, M.5
  • 16
    • 84862777565 scopus 로고    scopus 로고
    • MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach
    • Parikh VN, Jin RC, Rabello S, Gulbahce N, White K, et al. (2012) MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation 125: 1520-1532.
    • (2012) Circulation , vol.125 , pp. 1520-1532
    • Parikh, V.N.1    Jin, R.C.2    Rabello, S.3    Gulbahce, N.4    White, K.5
  • 19
    • 1642290141 scopus 로고    scopus 로고
    • Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways
    • Yu J, Astrinidis A, Howard S, Henske EP, (2004) Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways. Am J Physiol Lung Cell Mol Physiol 286: L694-700.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286
    • Yu, J.1    Astrinidis, A.2    Howard, S.3    Henske, E.P.4
  • 20
    • 42449098100 scopus 로고    scopus 로고
    • Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues
    • Peltier HJ, Latham GJ, (2008) Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. RNA 14: 844-852.
    • (2008) RNA , vol.14 , pp. 844-852
    • Peltier, H.J.1    Latham, G.J.2
  • 21
    • 84856283173 scopus 로고    scopus 로고
    • miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer
    • Augoff K, McCue B, Plow EF, Sossey-Alaoui K, (2012) miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer. Mol Cancer 11: 5.
    • (2012) Mol Cancer , vol.11 , pp. 5
    • Augoff, K.1    McCue, B.2    Plow, E.F.3    Sossey-Alaoui, K.4
  • 22
    • 84875448088 scopus 로고    scopus 로고
    • microRNA-31 sensitizes human breast cells to apoptosis by direct targeting of protein kinase C epsilon (PKC{varepsilon})
    • Koerner C, Keklikoglou I, Bender C, Woerner A, Muenstermann E, et al. (2013) microRNA-31 sensitizes human breast cells to apoptosis by direct targeting of protein kinase C epsilon (PKC{varepsilon}). J Biol Chem.
    • (2013) J Biol Chem
    • Koerner, C.1    Keklikoglou, I.2    Bender, C.3    Woerner, A.4    Muenstermann, E.5
  • 23
    • 84871261049 scopus 로고    scopus 로고
    • Hypoxia-Induced Aggressiveness of Pancreatic Cancer Cells Is Due to Increased Expression of VEGF, IL-6 and miR-21, Which Can Be Attenuated by CDF Treatment
    • Bao B, Ali S, Ahmad A, Azmi AS, Li Y, et al. (2012) Hypoxia-Induced Aggressiveness of Pancreatic Cancer Cells Is Due to Increased Expression of VEGF, IL-6 and miR-21, Which Can Be Attenuated by CDF Treatment. PLoS One 7: e50165.
    • (2012) PLoS One , vol.7
    • Bao, B.1    Ali, S.2    Ahmad, A.3    Azmi, A.S.4    Li, Y.5
  • 24
    • 84871746640 scopus 로고    scopus 로고
    • Hypoxia-inducible Factor 1-alpha Induces miR-210 in Normoxic Differentiating Myoblasts
    • Cicchillitti L, Di Stefano V, Isaia E, Crimaldi L, Fasanaro P, et al. (2012) Hypoxia-inducible Factor 1-alpha Induces miR-210 in Normoxic Differentiating Myoblasts. J Biol Chem 287: 44761-44771.
    • (2012) J Biol Chem , vol.287 , pp. 44761-44771
    • Cicchillitti, L.1    Di Stefano, V.2    Isaia, E.3    Crimaldi, L.4    Fasanaro, P.5
  • 26
    • 0029004364 scopus 로고
    • Rodent model of reproductive tract leiomyomata. Clinical and pathological features
    • Everitt JI, Wolf DC, Howe SR, Goldsworthy TL, Walker C, (1995) Rodent model of reproductive tract leiomyomata. Clinical and pathological features. Am J Pathol 146: 1556-1567.
    • (1995) Am J Pathol , vol.146 , pp. 1556-1567
    • Everitt, J.I.1    Wolf, D.C.2    Howe, S.R.3    Goldsworthy, T.L.4    Walker, C.5
  • 27
    • 0347988005 scopus 로고    scopus 로고
    • Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
    • Zhang H, Cicchetti G, Onda H, Koon HB, Asrican K, et al. (2003) Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J Clin Invest 112: 1223-1233.
    • (2003) J Clin Invest , vol.112 , pp. 1223-1233
    • Zhang, H.1    Cicchetti, G.2    Onda, H.3    Koon, H.B.4    Asrican, K.5
  • 28
    • 77949819578 scopus 로고    scopus 로고
    • Animal models of lymphangioleiomyomatosis (LAM) and tuberous sclerosis complex (TSC)
    • Kwiatkowski DJ, (2010) Animal models of lymphangioleiomyomatosis (LAM) and tuberous sclerosis complex (TSC). Lymphat Res Biol 8: 51-57.
    • (2010) Lymphat Res Biol , vol.8 , pp. 51-57
    • Kwiatkowski, D.J.1
  • 29
    • 0035851205 scopus 로고    scopus 로고
    • Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
    • Tremblay F, Marette A, (2001) Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 276: 38052-38060.
    • (2001) J Biol Chem , vol.276 , pp. 38052-38060
    • Tremblay, F.1    Marette, A.2
  • 30
    • 23744516268 scopus 로고    scopus 로고
    • Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2
    • Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, et al. (2005) Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev 19: 1773-1778.
    • (2005) Genes Dev , vol.19 , pp. 1773-1778
    • Manning, B.D.1    Logsdon, M.N.2    Lipovsky, A.I.3    Abbott, D.4    Kwiatkowski, D.J.5
  • 31
    • 77951964981 scopus 로고    scopus 로고
    • Posttranscriptional regulation of microRNA biogenesis in animals
    • Siomi H, Siomi MC, (2010) Posttranscriptional regulation of microRNA biogenesis in animals. Mol Cell 38: 323-332.
    • (2010) Mol Cell , vol.38 , pp. 323-332
    • Siomi, H.1    Siomi, M.C.2
  • 32
    • 46449128469 scopus 로고    scopus 로고
    • SMAD proteins control DROSHA-mediated microRNA maturation
    • Davis BN, Hilyard AC, Lagna G, Hata A, (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454: 56-61.
    • (2008) Nature , vol.454 , pp. 56-61
    • Davis, B.N.1    Hilyard, A.C.2    Lagna, G.3    Hata, A.4
  • 33
    • 77956339881 scopus 로고    scopus 로고
    • OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma
    • Medina PP, Nolde M, Slack FJ, (2010) OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 467: 86-90.
    • (2010) Nature , vol.467 , pp. 86-90
    • Medina, P.P.1    Nolde, M.2    Slack, F.J.3
  • 34
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, et al. (2008) MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27: 2128-2136.
    • (2008) Oncogene , vol.27 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.2    Nikolova, D.A.3    Leupold, J.H.4    Colburn, N.H.5
  • 35
    • 79959918202 scopus 로고    scopus 로고
    • Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis
    • Ma X, Kumar M, Choudhury SN, Becker Buscaglia LE, Barker JR, et al. (2011) Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis. Proc Natl Acad Sci U S A 108: 10144-10149.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 10144-10149
    • Ma, X.1    Kumar, M.2    Choudhury, S.N.3    Becker Buscaglia, L.E.4    Barker, J.R.5
  • 36
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, et al. (2007) MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133: 647-658.
    • (2007) Gastroenterology , vol.133 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5
  • 37
    • 54249096193 scopus 로고    scopus 로고
    • MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths
    • Sayed D, Rane S, Lypowy J, He M, Chen IY, et al. (2008) MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths. Mol Biol Cell 19: 3272-3282.
    • (2008) Mol Biol Cell , vol.19 , pp. 3272-3282
    • Sayed, D.1    Rane, S.2    Lypowy, J.3    He, M.4    Chen, I.Y.5
  • 38
    • 77957370442 scopus 로고    scopus 로고
    • Control of HIF-1{alpha} and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock
    • Scott CL, Walker DJ, Cwiklinski E, Tait C, Tee AR, et al. (2010) Control of HIF-1{alpha} and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock. Am J Physiol Lung Cell Mol Physiol 299: L455-471.
    • (2010) Am J Physiol Lung Cell Mol Physiol , vol.299
    • Scott, C.L.1    Walker, D.J.2    Cwiklinski, E.3    Tait, C.4    Tee, A.R.5
  • 39
    • 80052148252 scopus 로고    scopus 로고
    • MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities
    • Wang M, Li W, Chang GQ, Ye CS, Ou JS, et al. (2011) MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities. Arterioscler Thromb Vasc Biol 31: 2044-2053.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2044-2053
    • Wang, M.1    Li, W.2    Chang, G.Q.3    Ye, C.S.4    Ou, J.S.5
  • 40
    • 76349093390 scopus 로고    scopus 로고
    • Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression
    • Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, et al. (2010) Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J 29: 559-573.
    • (2010) EMBO J , vol.29 , pp. 559-573
    • Chan, M.C.1    Hilyard, A.C.2    Wu, C.3    Davis, B.N.4    Hill, N.S.5
  • 41
    • 33645695725 scopus 로고    scopus 로고
    • Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2
    • Goncharova EA, Goncharov DA, Spaits M, Noonan DJ, Talovskaya E, et al. (2006) Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2. Am J Respir Cell Mol Biol 34: 561-572.
    • (2006) Am J Respir Cell Mol Biol , vol.34 , pp. 561-572
    • Goncharova, E.A.1    Goncharov, D.A.2    Spaits, M.3    Noonan, D.J.4    Talovskaya, E.5
  • 43
    • 79952409681 scopus 로고    scopus 로고
    • Lymphangioleiomyomatosis: what do we know and what are we looking for?
    • Harari S, Torre O, Moss J, (2011) Lymphangioleiomyomatosis: what do we know and what are we looking for? Eur Respir Rev 20: 34-44.
    • (2011) Eur Respir Rev , vol.20 , pp. 34-44
    • Harari, S.1    Torre, O.2    Moss, J.3
  • 44
    • 67650825898 scopus 로고    scopus 로고
    • A link between the interleukin-6/Stat3 anti-apoptotic pathway and microRNA-21 in preimplantation mouse embryos
    • Shen XH, Han YJ, Zhang DX, Cui XS, Kim NH, (2009) A link between the interleukin-6/Stat3 anti-apoptotic pathway and microRNA-21 in preimplantation mouse embryos. Mol Reprod Dev 76: 854-862.
    • (2009) Mol Reprod Dev , vol.76 , pp. 854-862
    • Shen, X.H.1    Han, Y.J.2    Zhang, D.X.3    Cui, X.S.4    Kim, N.H.5
  • 45
    • 24344479933 scopus 로고    scopus 로고
    • Interferon-gamma-Jak-Stat signaling in pulmonary lymphangioleiomyomatosis and renal angiomyolipoma: a potential therapeutic target
    • El-Hashemite N, Kwiatkowski DJ, (2005) Interferon-gamma-Jak-Stat signaling in pulmonary lymphangioleiomyomatosis and renal angiomyolipoma: a potential therapeutic target. Am J Respir Cell Mol Biol 33: 227-230.
    • (2005) Am J Respir Cell Mol Biol , vol.33 , pp. 227-230
    • El-Hashemite, N.1    Kwiatkowski, D.J.2
  • 46
    • 80755141303 scopus 로고    scopus 로고
    • Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions
    • Magri L, Cambiaghi M, Cominelli M, Alfaro-Cervello C, Cursi M, et al. (2011) Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions. Cell Stem Cell 9: 447-462.
    • (2011) Cell Stem Cell , vol.9 , pp. 447-462
    • Magri, L.1    Cambiaghi, M.2    Cominelli, M.3    Alfaro-Cervello, C.4    Cursi, M.5
  • 47
    • 79957655519 scopus 로고    scopus 로고
    • MiRNA in innate immune responses: novel players in wound inflammation
    • Roy S, Sen CK, (2011) MiRNA in innate immune responses: novel players in wound inflammation. Physiol Genomics 43: 557-565.
    • (2011) Physiol Genomics , vol.43 , pp. 557-565
    • Roy, S.1    Sen, C.K.2
  • 48
    • 54949109311 scopus 로고    scopus 로고
    • The TSC-mTOR signaling pathway regulates the innate inflammatory response
    • Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, et al. (2008) The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 29: 565-577.
    • (2008) Immunity , vol.29 , pp. 565-577
    • Weichhart, T.1    Costantino, G.2    Poglitsch, M.3    Rosner, M.4    Zeyda, M.5
  • 49
    • 63149180675 scopus 로고    scopus 로고
    • Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene
    • Pacheco-Rodriguez G, Kumaki F, Steagall WK, Zhang Y, Ikeda Y, et al. (2009) Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene. J Immunol 182: 1270-1277.
    • (2009) J Immunol , vol.182 , pp. 1270-1277
    • Pacheco-Rodriguez, G.1    Kumaki, F.2    Steagall, W.K.3    Zhang, Y.4    Ikeda, Y.5
  • 50
    • 80655125015 scopus 로고    scopus 로고
    • MicroRNA miR-21 regulates the metastatic behavior of B16 melanoma cells
    • Yang CH, Yue J, Pfeffer SR, Handorf CR, Pfeffer LM, (2011) MicroRNA miR-21 regulates the metastatic behavior of B16 melanoma cells. J Biol Chem 286: 39172-39178.
    • (2011) J Biol Chem , vol.286 , pp. 39172-39178
    • Yang, C.H.1    Yue, J.2    Pfeffer, S.R.3    Handorf, C.R.4    Pfeffer, L.M.5
  • 51
    • 57749168828 scopus 로고    scopus 로고
    • MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    • Thum T, Gross C, Fiedler J, Fischer T, Kissler S, et al. (2008) MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456: 980-984.
    • (2008) Nature , vol.456 , pp. 980-984
    • Thum, T.1    Gross, C.2    Fiedler, J.3    Fischer, T.4    Kissler, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.