Modulation of hepatocyte nuclear factor-4α function by the peroxisome-proliferator-activated receptor-γ co-activator-1α in the acute-phase response

Biochemical Journal

Volumn 415, Issue 2, 2008, Pages 289-296

  Wang, Zhongyan ^a   Burke, Peter A ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute phase response (APR); Cytokine; Gene regulation; HNF 4 (hepatocyte nuclear factor 4 ); Transcriptional co activator

Indexed keywords

BINDING ENERGY; BIOCHEMISTRY; CYTOLOGY; DIFFRACTIVE OPTICAL ELEMENTS; DNA; ELECTROPHORETIC MOBILITY; GENE EXPRESSION; GENES; LAWS AND LEGISLATION; MARINE RISERS; MODULATION; NUCLEIC ACIDS; ORGANIC ACIDS; PROBABILITY DENSITY FUNCTION; TRANSCRIPTION;

ACTIVATED RECEPTORS; ACUTE-PHASE RESPONSE (APR); ANTITRYPSIN; APOLIPOPROTEIN B; BINDING ABILITIES; CELL MODELS; CHROMATIN IMMUNOPRECIPITATION ASSAYS; CYTOKINE; CYTOKINE STIMULATIONS; CYTOKINE TREATMENTS; CYTOKINES; DNA-BINDING; GENE REGULATION; HEPATOCYTE NUCLEAR FACTORS; IN VITRO; IN-VIVO; KEY REGULATORS; LESSER EXTENTS; OVEREXPRESSION; PHASE RESPONSES; PROLIFERATOR; PROTEIN LEVELS; REGULATORY MECHANISMS; SHIFT-AND; STEROID RECEPTORS; TRANSACTIVATION; TRANSCRIPTIONAL ACTIVITIES; TRANSCRIPTIONAL CO-ACTIVATOR; TRANSCRIPTIONAL LEVELS; TRANSTHYRETIN;

BINDING SITES;

ALPHA 1 ANTITRYPSIN; APOLIPOPROTEIN B; CYTOKINE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PREALBUMIN; PROTEIN P300; PROTEIN SRC ALPHA; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL DAMAGE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG DNA BINDING; EMBRYO; GEL MOBILITY SHIFT ASSAY; GENE ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

ACUTE-PHASE REACTION; ALPHA 1-ANTITRYPSIN; APOLIPOPROTEINS B; BINDING SITES; CELL LINE; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; CYTOKINES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HEPATOCYTE NUCLEAR FACTOR 4; HISTONE ACETYLTRANSFERASES; HUMANS; IMMUNOBLOTTING; P300-CBP TRANSCRIPTION FACTORS; PREALBUMIN; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 54049099951     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20080355     Document Type: Article

References (28)

1. Baumann, H. and Gauldie, J. (1994) The acute phase response. Immunol. Today 15, 74-80
2. Gruys. E., Toussaint, M. J., Niewold, T. A. and Koopmans, S. J. (2005) Acute phase reaction and acute phase proteins. J. Zhejiang Univ. Sci. B 6, 1045-1056
3. Koj, A. (1996) Initiation of acute phase response and synthesis of cytokines. Biochim. Biophys. Acta 1317, 84-94
4. Derman, E., Krauter, K.. Walling, L., Weinberger, C., Ray, M. and Darnell, Jr, J. E. (1981) Transcriptional control in the production of liver-specific mRNAs. Cell 23, 731-739
5. Milland, J., Tsykin, A., Thomas, T., Aldred, A. R., Cole, T. and Schreiber, G. (1990) Gene expression in regenerating and acute-phase rat liver. Am. J. Physiol. 259. G340-G347
6. Hayhurst, G. P., Lee, Y. H., Lambert, G., Ward, J. M. and Gonzalez, F. J. (2001) Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Blol. 21, 1393-1403
7. Li, J., Ning, G. and Duncan, S. A. (2000) Mammalian hepatocyte differentiation requires the transcription factor HNF-4α. Genes Dev. 14, 464-474
8. Sladek, F. M. (1994) Orphan receptor HNF-4 and liver-specific gene expression. Receptor 4, 64
9. Spath, G. F. and Weiss, M. C. (1997) Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells. Mol. Cell. Biol. 17, 1913-1922
10. Chen, W. S., Manova, K., Weinstein, D. C., Duncan, S. A., Plump, A. S., Prezioso, V. R., Bachvarova, R. F. and Darnell, Jr, J. E. (1994) Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 8, 2466-2477
11. Odom, D. T., Zizlsperger, N., Gordon, D. B., Bell, G. W., Rinaldi, N. J., Murray, H. L., Volkert, T. L., Schreiber, J., Rolfe, P. A., Gifford, D. K. et al. (2004) Control of pancreas and liver gene expression by HNF transcription factors. Science 303, 1378-1381
12. Iordanidou, P., Aggelidou, E., Demetriades, C. and Hadzopoulou-Cladaras, M. (2005) Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4α. J. Biol. Chem. 280, 21810-21819
13. Sladek, F. M., Ruse, M. D., Jr., Nepomuceno, L., Huang, S. M. and Stallcup, M. R. (1999) Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4α1. Mol. Cell. Biol. 19, 6509-6522
14. Wang, J. C., Stafford, J. M. and Granner, D. K. (1998) SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4. J. Biol. Chem. 273, 30847-30850
15. Dell, H. and Hadzopoulou-Cladaras, M. (1999) CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression. J. Biol. Chem. 274, 9013-9021
16. Eeckhoute, J., Formstecher, P. and Laine, B. (2001) Maturity-onset diabetes of the young Type 1 (MODY1)-associated mutations R154X and E276Q in hepatocyte nuclear factor 4α (HNF4α) gene impair recruitment of p300, a key transcriptional co-activator. Mol. Endocrinol. 15, 1200-1210
17. Rhee, J., Inoue, Y., Yoon, J. C., Puigserver, P., Fan, M., Gonzalez, F. J. and Spiegelman, B. M. (2003) Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): requirement for hepatocyte nuclear factor 4α in gluconeogenesis. Proc. Natl. Acad. Sci. U.S.A. 100, 4012-4017
18. Yoon, J. C., Puigserver, P., Chen, G., Donovan. J., Wu. Z., Rhee, J., Adelmant. G., Stafford, J., Kahn, C. R,, Granner, D. K. et al. (2001) Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413, 131-138
19. Jiang, G., Nepomuceno, L,, Hopkins, K. and Sladek, F. M. (1995) Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors. Mol. Cell. Biol. 15, 5131-5143
20. Wang, Z. and Burke. P. A. (2007) Effects of hepatocyte nuclear factor-4α on the regulation of the hepatic acute phase response. J. Mol. Biol. 371, 323-335
21. Viollet, B., Kahn, A. and Raymondjean, M. (1997) Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4. Mol. Cell. Biol. 17, 4208-A219
22. Martinez-Jimenez, C. P., Gomez-Lechon, M. J., Castell, J. V. and Jover, R. (2006) Underexpressed coactivators PGC1α and SRC1 impair hepatocyte nuclear factor 4α function and promote dedifferentiation in human hepatoma cells. J. Biol. Chem. 281, 29840-29849
23. Burke, P. A., Drotar, M., Luo, M., Yaffe, M. and Forse, R. A. (1994) Rapid modulation of liver-specific transcription factors after injury. Surgery 116, 285-293
24. Li, X., Salisbury-Rowswell, J., Murdock. A. D., Forse. R. A. and Burke, P. A. (2002) Hepatocyte nuclear factor 4 response to injury involves a rapid decrease in DNA binding and transactivation via a JAK2 signal transduction pathway. Biochem. J. 368, 203-211
25. Rhee, J., Ge, H., Yang, W., Fan, M., Handschin, C., Cooper, M., Lin, J., Li, C. and Spiegelman, B. M. (2006) Partnership of PGC-lα and HNF4α in the regulation of lipoprotein metabolism. J. Biol. Chem. 281, 14683-14690
26. Leung, T. H., Hoffmann, A. and Baltimore, D. (2004) One nucleotide in a κB site can determine cofactor specificity for NF-κB dimers. Cell 118, 453-464
27. Qian, X., Samadani, U., Porcella, A. and Costa, R. H. (1995) Decreased expression of hepatocyte nuclear factor 3α during the acute-phase response influences transthyretin gene transcription. Mol. Cell. Biol. 15, 1364-1376
28. Costa, R. H. and Grayson, D. R. (1991) Site-directed mutagenesis of hepatocyte nuclear factor (HNF) binding sites in the mouse transthyretin (TTR) promoter reveal synergistic interactions with its enhancer region. Nucleic Acids Res. 19, 4139-4145