In vivo efficacy of the anthelmintic tribendimidine against the cestode Hymenolepis microstoma in a controlled laboratory trial

Acta Tropica

Volumn 123, Issue 2, 2012, Pages 78-84

  Kulke, Daniel ^a   Krücken, Jürgen ^a   Welz, Claudia ^b   von Samson Himmelstjerna, Georg ^a   Harder, Achim ^b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b BAYER PHARMA AG   (Germany)

Author keywords

Anthelmintics; Antiparasitic; BAY d 9216; Cestocide; Cestodes; Chemotherapy; Deacylated amidantel; Hymenolepis microstoma; Tribendimidine

Indexed keywords

AMIDANTEL; ANTHELMINTIC AGENT; LEVAMISOLE; TRIBENDIMIDINE; UNCLASSIFIED DRUG;

DISEASE TREATMENT; DRUG; LABORATORY METHOD; METABOLITE; PARASITE; PARASITIC DISEASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTHELMINTIC ACTIVITY; ARTICLE; CESTODE; CONTROLLED STUDY; CYSTICERCOSIS; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG POTENTIATION; DRUG STRUCTURE; FEMALE; HYMENOLEPIS MICROSTOMA; IN VIVO STUDY; MOUSE; NONHUMAN; PARASITE SURVIVAL; TREATMENT RESPONSE;

ADMINISTRATION, ORAL; ANIMALS; ANTHELMINTICS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYMENOLEPIASIS; HYMENOLEPIS; MICE; PHENYLENEDIAMINES; TREATMENT OUTCOME;

CHINA;

CAENORHABDITIS ELEGANS; CESTODA; MUS; RODENTOLEPIS MICROSTOMA; TREMATODA;

EID: 84861349404     PISSN: 0001706X     EISSN: 18736254     Source Type: Journal    
DOI: 10.1016/j.actatropica.2012.03.008     Document Type: Article

References (45)

1. Bennet E.M., Behm C., Bryant C. Effects of mebendazole and levamisole on tetrathyridia of Mesocestoides corti in the mouse. Int. J. Parasitol. 1978, 8:463-466.
2. Bentley G.N., Jones A.K., Agnew A. ShAR2beta, a divergent nicotinic acetylcholine receptor subunit from the blood fluke Schistosoma. Parasitology 2007, 134:833-840.
3. Bentley G.N., Jones A.K., Oliveros Parra W.G., Agnew A. ShAR1alpha and ShAR1beta: novel putative nicotinic acetylcholine receptor subunits from the platyhelminth blood fluke Schistosoma. Gene 2004, 329:27-38.
4. Brennan G.P., Fairweather I., Trudgett A., Hoey E., McCoy McConville M., Meaney M., Robinson M., McFerran N., Ryan L., Lanusse C., Mottier L., Alvarez L., Solana H., Virkel G., Brophy P.M. Understanding triclabendazole resistance. Exp. Mol. Pathol. 2007, 82:104-109.
5. Chance M.R., Mansour T.E. A contribution to the pharmacology of movement in the liver fluke. Br. J. Pharmacol. Chemother. 1953, 8:134-138.
6. Craig P., Ito A. Intestinal cestodes. Curr. Opin. Infect. Dis. 2007, 20:524-532.
7. Crompton D.W.T. World Health Organization, Preventive Chemotherapy in Human Helminthiasis: Coordinated use of Anthelminthic Drugs in Control Interventions: A Manual for Health Professionals and Programme Managers 2006, World Health Organization, Geneva, 62 p.
8. Cunningham L.J., Olson P.D. Description of Hymenolepis microstoma (Nottingham strain): a classical tapeworm model for research in the genomic era. Parasit. Vectors 2010, 3:123.
9. Deplazes P., van Knapen F., Schweiger A., Overgaauw P.A. Role of pet dogs and cats in the transmission of helminthic zoonoses in Europe, with a focus on echinococcosis and toxocarosis. Vet. Parasitol. 2011, 182:41-53.
10. Diawara L., Traore M.O., Badji A., Bissan Y., Doumbia K., Goita S.F., Konate L., Mounkoro K., Sarr M.D., Seck A.F., Toe L., Touree S., Remme J.H. Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and Senegal. PLoS Negl. Trop. Dis. 2009, 3:e497.
11. Doenhoff M.J., Cioli D., Utzinger J. Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Curr. Opin. Infect. Dis. 2008, 21:659-667.
12. Dorny P., Praet N., Deckers N., Gabriel S. Emerging food-borne parasites. Vet. Parasitol. 2009, 163:196-206.
13. Harder A. Chemotherapeutic approaches to trematodes (except schistosomes) and cestodes: current level of knowledge and outlook. Parasitol. Res. 2002, 88:587-590.
14. Hotez P.J., Bundy D.A.P., Beegle K., Brooker S., Drake L., de Silva N., Montresor A., Engels D., Jukes M., Chitsulo L., Chow J., Laxminarayan R., Michaud C., Bethony J., Correa-Oliveira R., Shuhua X., Fenwick A., Savioli L. Helminth infections: soil-transmitted Helminth infections and Schistosomiasis. Disease Control Priorities in Developing Countries 2006, 467-482. Oxford University Press, World Bank, New York, N.Y., Washington, D.C. D.T. Jamison, J.G. Breman, A.R. Measham, G. Alleyne, M. Claeson, D.B. Evans, P. Jha, A. Mills, P. Musgrove (Eds.).
15. Hu Y., Xiao S.H., Aroian R.V. The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl. Trop. Dis. 2009, 3:e499.
16. Keiser J., Shu-Hua X., Chollet J., Tanner M., Utzinger J. Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini. Antimicrob. Agents Chemother. 2007, 51:1096-1098.
17. Keiser J., Shu-Hua X., Utzinger J. Effect of tribendimidine on adult Echinostoma caproni harbored in mice, including scanning electron microscopic observations. J. Parasitol. 2006, 92:858-862.
18. Keiser J., Thiemann K., Endriss Y., Utzinger J. Strongyloides ratti: in vitro and in vivo activity of tribendimidine. PLoS Negl. Trop. Dis. 2008, 2:e136.
19. Koul P.A., Waheed A., Hayat M., Sofi B.A. Praziquantel in niclosamide-resistant Taenia saginata infection. Scand. J. Infect. Dis. 1999, 31:603-604.
20. Lateef M., Zargar S.A., Khan A.R., Nazir M., Shoukat A. Successful treatment of niclosamide- and praziquantel-resistant beef tapeworm infection with nitazoxanide. Int. J. Infect. Dis. 2008, 12:80-82.
21. Li R.H., Gao J.H., Wang S.F., Pei Y.J., Shen J.Y., Yan P.M., Yin G.R. Effect of oral administration of tribendimidine at different dosages against Trichinella spiralis encapsulated larvae in mice. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2011, 29:117-121.
22. Marchiondo A.A., White G.W., Smith L.L., Reinemeyer C.R., Dascanio J.J., Johnson E.G., Shugart J.I. Clinical field efficacy and safety of pyrantel pamoate paste (19.13%, w/w pyrantel base) against Anoplocephala spp. in naturally infected horses. Vet. Parasitol. 2006, 137:94-102.
23. Min D.Y. Cestode infections in Korea. Kisaengchunghak Chapchi 1990, 28(Suppl.):123-144.
24. Moncayo A.L., Vaca M., Amorim L., Rodriguez A., Erazo S., Oviedo G., Quinzo I., Padilla M., Chico M., Lovato R., Gomez E., Barreto M.L., Cooper P.J. Impact of long-term treatment with ivermectin on the prevalence and intensity of soil-transmitted Helminth infections. PLoS Negl. Trop. Dis. 2008, 2:e293.
25. Rabbani G.H., Gilman R.H., Kabir I., Mondel G. The treatment of Fasciolopsis buski infection in children: a comparison of thiabendazole, mebendazole, levamisole, pyrantel pamoate, hexylresorcinol and tetrachloroethylene. Trans. R. Soc. Trop. Med. Hyg. 1985, 79:513-515.
26. Reinemeyer C.R., Hutchens D.E., Eckblad W.P., Marchiondo A.A., Shugart J.I. Dose-confirmation studies of the cestocidal activity of pyrantel pamoate paste in horses. Vet. Parasitol. 2006, 138:234-239.
27. Sangster N.C. Managing parasiticide resistance. Vet. Parasitol. 2001, 98:89-109.
28. Smith M.C., Sherman D.M. Goat Medicine 2009, Wiley-Blackwell, Ames, Iowa, pp. 454-456.
29. Steinmann P., Zhou X.N., Du Z.W., Jiang J.Y., Xiao S.H., Wu Z.X., Zhou H., Utzinger J. Tribendimidine and albendazole for treating soil-transmitted Helminths. PLoS Negl. Trop. Dis. 2008, 2:e322.
30. Sturchler D. Chemotherapy of human intestinal helminthiases: a review, with particular reference to community treatment. Adv. Pharmacol. Chemother. 1982, 19:129-154.
31. Thompson C.S., Mettrick D.F. Neuromuscular physiology of Hymenolepis diminuta and H. microstoma (Cestoda). Parasitology 1984, 89(Pt 3):567-578.
32. Tomlinson G., Albuquerque C.A., Woods R.A. The effects of amidantel (BAY d 8815) and its deacylated derivative (BAY d 9216) on Caenorhabditis elegans. Eur. J. Pharmacol. 1985, 113:255-262.
33. Tritten L., Nwosu U., Vargas M., Keiser J. In vitro and in vivo efficacy of tribendimidine and its metabolites alone and in combination against the hookworms Heligmosomoides bakeri and Ancylostoma ceylanicum. Acta Trop. 2011.
34. Winnen M., Plaisier A.P., Alley E.S., Nagelkerke N.J., van Oortmarssen G., Boatin B.A., Habbema J.D. Can ivermectin mass treatments eliminate onchocerciasis in Africa?. Bull. World Health Organ. 2002, 80:384-391.
35. Wollweber H., Niemers E., Flucke W., Andrews P., Schulz H.P., Thomas H. Amidantel, a potent anthelminthic from a new chemical class. Arzneimittelforschung 1979, 29:31-32.
36. Woods R.A., Malone K.M.B., Albuquerque C.A., Tomlinson G. The effects of amidantel (Bay D 8815) and its deacylated derivative (Bay D 9216) on wild-type and resistant mutants of Caenorhabditis-Elegans. Can. J. Zool. 1986, 64:1310-1316.
37. Wu Z.X., Fang Y.Y., Liu Y.S. Effect of a novel drug - enteric coated tribendimidine in the treatment of intestinal nematode infections. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2006, 24:23-26.
38. Xiao S.H., Hui-Ming W., Tanner M., Utzinger J., Chong W. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop. 2005, 94:1-14.
39. Xiao S.H., Wu Z.X., Zhang J.H., Wang S.Q., Wang S.H., Qiu D.C., Wang C. Clinical observation on 899 children infected with intestinal nematodes and treated with tribendimidine enteric coated tablets. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2007, 25:372-375.
40. Xiao S.H., Xue J., Xu L.L., Zheng Q., Qiang H.Q., Zhang Y.N. The in vitro and in vivo effect of tribendimidine and its metabolites against Clonorchis sinensis. Parasitol. Res. 2009, 105:1497-1507.
41. Xue J., Utzinger J., Zhang Y.N., Tanner M., Keiser J., Xiao S.H. Artemether and tribendimidine lack activity in experimental treatment of Paragonimus westermani in the dog. Parasitol. Res. 2008, 102:537-540.
42. Xue J., Xiao S.H., Xu L.L., Qiang H.Q. The effect of tribendimidine and its metabolites against Necator americanus in golden hamsters and Nippostrongylus braziliensis in rats. Parasitol. Res. 2010, 106:775-781.
43. Yuan G., Wang B., Wei C., Zhang R., Guo R. LC-MS determination of p-(1-dimethylamino ethylimino)aniline: a metabolite of Tribendimidine in human plasma. Chromatographia 2008, 68:139-142.
44. Yuan G., Xu J., Qu T., Wang B., Zhang R., Wei C., Guo R. Metabolism and disposition of tribendimidine and its metabolites in healthy Chinese volunteers. Drugs R&D 2010, 10:83-90.
45. Zhang J.H., Xiao S.H., Wu Z.X., Qiu D.C., Wang S.H., Wang S.Q., Wang C. Tribendimidine enteric coated tablet in treatment of 1292 cases with intestinal nematode infection - a phase IV clinical trial. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2008, 26:6-9.