-
1
-
-
33750953227
-
Whole-genome re-sequencing
-
Bentley DR.Whole-genome re-sequencing.Curr Opin Genet Dev. 2006;16:545-52.
-
(2006)
Curr Opin Genet Dev
, vol.16
, pp. 545-552
-
-
Bentley, D.R.1
-
2
-
-
82655184653
-
Personalized oncology through integrative high-throughput sequencing: a pilot study
-
Roychowdhury S,Iyer MK,Robinson DR, et al.Personalized oncology through integrative high-throughput sequencing: a pilot study.Sci Transl Med. 2011;3:111ra121.
-
(2011)
Sci Transl Med
, vol.3
-
-
Roychowdhury, S.1
Iyer, M.K.2
Robinson, D.R.3
-
4
-
-
79957558437
-
Emerging tactical strategies for fighting the war on cancer based on the genetic landscape
-
Burbelo PD,Ching KH,Bren KE,Iadarola MJ.Emerging tactical strategies for fighting the war on cancer based on the genetic landscape.Am J Transl Res. 2011;3:251-8.
-
(2011)
Am J Transl Res
, vol.3
, pp. 251-258
-
-
Burbelo, P.D.1
Ching, K.H.2
Bren, K.E.3
Iadarola, M.J.4
-
5
-
-
78349310118
-
Phosphoproteomics in cancer
-
Harsha HC,Pandey A.Phosphoproteomics in cancer.Mol Oncol. 2010;4:482-95.
-
(2010)
Mol Oncol
, vol.4
, pp. 482-495
-
-
Harsha, H.C.1
Pandey, A.2
-
6
-
-
77955942384
-
Functional proteomics to dissect tyrosine kinase signalling pathways in cancer
-
Kolch W,Pitt A.Functional proteomics to dissect tyrosine kinase signalling pathways in cancer.Nat Rev Cancer. 2010;10:618-29.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 618-629
-
-
Kolch, W.1
Pitt, A.2
-
7
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D,Weinberg RA.Hallmarks of cancer: the next generation.Cell. 2011;144:646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
8
-
-
84861541343
-
Mutational processes molding the genomes of 21 breast cancers
-
Nik-Zainal S,Alexandrov LB,Wedge DC, et al.Mutational processes molding the genomes of 21 breast cancers.Cell. 2012;149:979-93.
-
(2012)
Cell
, vol.149
, pp. 979-993
-
-
Nik-Zainal, S.1
Alexandrov, L.B.2
Wedge, D.C.3
-
9
-
-
0035893740
-
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models
-
Lobell RB,Omer CA,Abrams MT, et al.Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.Cancer Res. 2001;61:8758-68.
-
(2001)
Cancer Res
, vol.61
, pp. 8758-8768
-
-
Lobell, R.B.1
Omer, C.A.2
Abrams, M.T.3
-
10
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Kantarjian H,Sawyers C,Hochhaus A, et al.Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia.N Engl J Med. 2002;346:645-52.
-
(2002)
N Engl J Med
, vol.346
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
-
11
-
-
77952291403
-
Kinases as targets in the treatment of solid tumors
-
Giamas G,Man YL,Hirner H, et al.Kinases as targets in the treatment of solid tumors.Cell Signal. 2010;22:984-1002.
-
(2010)
Cell Signal
, vol.22
, pp. 984-1002
-
-
Giamas, G.1
Man, Y.L.2
Hirner, H.3
-
12
-
-
0036769119
-
Regulation and targets of receptor tyrosine kinases
-
Pawson T.Regulation and targets of receptor tyrosine kinases.Eur J Cancer. 2002;38:S3-10.
-
(2002)
Eur J Cancer
, vol.38
, pp. 3-10
-
-
Pawson, T.1
-
13
-
-
77953896432
-
Cell signaling by receptor tyrosine kinases
-
Lemmon MA,Schlessinger J.Cell signaling by receptor tyrosine kinases.Cell. 2010;141:1117-34.
-
(2010)
Cell
, vol.141
, pp. 1117-1134
-
-
Lemmon, M.A.1
Schlessinger, J.2
-
14
-
-
22044442973
-
Tyrosine kinases as targets for cancer therapy
-
Krause DS,Van Etten RA.Tyrosine kinases as targets for cancer therapy.N Engl J Med. 2005;353:172-87.
-
(2005)
N Engl J Med
, vol.353
, pp. 172-187
-
-
Krause, D.S.1
van Etten, R.A.2
-
15
-
-
63749113783
-
Tyrosine phosphorylation: thirty years and counting
-
Hunter T.Tyrosine phosphorylation: thirty years and counting.Curr Opin Cell Biol. 2009;21:140-6.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 140-146
-
-
Hunter, T.1
-
16
-
-
2342591455
-
The discovery of receptor tyrosine kinases: targets for cancer therapy
-
Gschwind A,Fischer OM,Ullrich A.The discovery of receptor tyrosine kinases: targets for cancer therapy.Nat Rev Cancer. 2004;4:361-70.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 361-370
-
-
Gschwind, A.1
Fischer, O.M.2
Ullrich, A.3
-
17
-
-
33744493376
-
Targeting tyrosine kinases in cancer: the second wave
-
Baselga J.Targeting tyrosine kinases in cancer: the second wave.Science. 2006;312:1175-8.
-
(2006)
Science
, vol.312
, pp. 1175-1178
-
-
Baselga, J.1
-
18
-
-
84858669035
-
Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): a better mousetrap? A review of the clinical evidence
-
Ou SH.Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): a better mousetrap? A review of the clinical evidence.Crit Rev Oncol Hematol. 2012;83:407-21.
-
(2012)
Crit Rev Oncol Hematol
, vol.83
, pp. 407-421
-
-
Ou, S.H.1
-
19
-
-
77955970259
-
Antibody-based proteomics: fast-tracking molecular diagnostics in oncology
-
Brennan DJ,O'Connor DP,Rexhepaj E,Ponten F,Gallagher WM.Antibody-based proteomics: fast-tracking molecular diagnostics in oncology.Nat Rev Cancer. 2010;10:605-17.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 605-617
-
-
Brennan, D.J.1
O'Connor, D.P.2
Rexhepaj, E.3
Ponten, F.4
Gallagher, W.M.5
-
20
-
-
84855572697
-
Mapping in vivo signal transduction defects by phosphoproteomics
-
Stasyk T,Huber LA.Mapping in vivo signal transduction defects by phosphoproteomics.Trends Mol Med. 2012;18:43-51.
-
(2012)
Trends Mol Med
, vol.18
, pp. 43-51
-
-
Stasyk, T.1
Huber, L.A.2
-
21
-
-
21144458164
-
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells
-
Rush J,Moritz A,Lee KA, et al.Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.Nat Biotechnol. 2005;23:94-101.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 94-101
-
-
Rush, J.1
Moritz, A.2
Lee, K.A.3
-
22
-
-
36849065315
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
-
Rikova K,Guo A,Zeng Q, et al.Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.Cell. 2007;131:1190-203.
-
(2007)
Cell
, vol.131
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
-
23
-
-
77952226764
-
Super-SILAC mix for quantitative proteomics of human tumor tissue
-
Geiger T,Cox J,Ostasiewicz P,Wisniewski JR,Mann M.Super-SILAC mix for quantitative proteomics of human tumor tissue.Nat Methods. 2010;7:383-5.
-
(2010)
Nat Methods
, vol.7
, pp. 383-385
-
-
Geiger, T.1
Cox, J.2
Ostasiewicz, P.3
Wisniewski, J.R.4
Mann, M.5
-
24
-
-
79953330541
-
Lysate microarrays enable high-throughput, quantitative investigations of cellular signaling
-
M110.005363
-
Sevecka M,Wolf-Yadlin A,MacBeath G.Lysate microarrays enable high-throughput, quantitative investigations of cellular signaling.Mol Cell Proteomics. 2011;10:M110.005363.
-
(2011)
Mol Cell Proteomics
, vol.10
-
-
Sevecka, M.1
Wolf-Yadlin, A.2
MacBeath, G.3
-
25
-
-
0035923582
-
Profiling the global tyrosine phosphorylation state by Src homology 2 domain binding
-
Nollau P,Mayer BJ.Profiling the global tyrosine phosphorylation state by Src homology 2 domain binding.Proc Natl Acad Sci U S A. 2001;98:13531-6.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 13531-13536
-
-
Nollau, P.1
Mayer, B.J.2
-
26
-
-
34250641161
-
High-throughput phosphotyrosine profiling using SH2 domains
-
Machida K,Thompson CM,Dierck K, et al.High-throughput phosphotyrosine profiling using SH2 domains.Mol Cell. 2007;26:899-915.
-
(2007)
Mol Cell
, vol.26
, pp. 899-915
-
-
Machida, K.1
Thompson, C.M.2
Dierck, K.3
-
27
-
-
33747769612
-
Quantitative multiplexed profiling of cellular signaling networks using phosphotyrosine-specific DNA-tagged SH2 domains
-
Dierck K,Machida K,Voigt A, et al.Quantitative multiplexed profiling of cellular signaling networks using phosphotyrosine-specific DNA-tagged SH2 domains.Nat Methods. 2006;3:737-44.
-
(2006)
Nat Methods
, vol.3
, pp. 737-744
-
-
Dierck, K.1
Machida, K.2
Voigt, A.3
-
28
-
-
12844283323
-
The SH2 domain: versatile signaling module and pharmaceutical target
-
Machida K,Mayer BJ.The SH2 domain: versatile signaling module and pharmaceutical target.Biochim Biophys Acta. 2005;1747:1-25.
-
(2005)
Biochim Biophys Acta
, vol.1747
, pp. 1-25
-
-
Machida, K.1
Mayer, B.J.2
-
29
-
-
33745185987
-
The human and mouse complement of SH2 domain proteins: establishing the boundaries of phosphotyrosine signaling
-
Liu BA,Jablonowski K,Raina M,Arce M,Pawson T,Nash PD.The human and mouse complement of SH2 domain proteins: establishing the boundaries of phosphotyrosine signaling.Mol Cell. 2006;22:851-68.
-
(2006)
Mol Cell
, vol.22
, pp. 851-868
-
-
Liu, B.A.1
Jablonowski, K.2
Raina, M.3
Arce, M.4
Pawson, T.5
Nash, P.D.6
-
30
-
-
42649123723
-
Defining the specificity space of the human SRC homology 2 domain
-
Huang H,Li L,Wu C, et al.Defining the specificity space of the human SRC homology 2 domain.Mol Cell Proteomics. 2008;7:768-84.
-
(2008)
Mol Cell Proteomics
, vol.7
, pp. 768-784
-
-
Huang, H.1
Li, L.2
Wu, C.3
-
31
-
-
68049110634
-
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site
-
Bae JH,Lew ED,Yuzawa S,Tome F,Lax I,Schlessinger J.The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.Cell. 2009;138:514-24.
-
(2009)
Cell
, vol.138
, pp. 514-524
-
-
Bae, J.H.1
Lew, E.D.2
Yuzawa, S.3
Tome, F.4
Lax, I.5
Schlessinger, J.6
-
32
-
-
78149333493
-
SH2 domains recognize contextual peptide sequence information to determine selectivity
-
Liu BA,Jablonowski K,Shah EE,Engelmann BW,Jones RB,Nash PD.SH2 domains recognize contextual peptide sequence information to determine selectivity.Mol Cell Proteomics. 2010;9:2391-404.
-
(2010)
Mol Cell Proteomics
, vol.9
, pp. 2391-2404
-
-
Liu, B.A.1
Jablonowski, K.2
Shah, E.E.3
Engelmann, B.W.4
Jones, R.B.5
Nash, P.D.6
-
33
-
-
77956141521
-
Phosphotyrosine signaling: evolving a new cellular communication system
-
Lim WA,Pawson T.Phosphotyrosine signaling: evolving a new cellular communication system.Cell. 2010;142:661-7.
-
(2010)
Cell
, vol.142
, pp. 661-667
-
-
Lim, W.A.1
Pawson, T.2
-
34
-
-
84864577164
-
The application of modular protein domains in proteomics
-
Jadwin JA,Ogiue-Ikeda M,Machida K.The application of modular protein domains in proteomics.FEBS Lett. 2012;586:2586-96.
-
(2012)
FEBS Lett
, vol.586
, pp. 2586-2596
-
-
Jadwin, J.A.1
Ogiue-Ikeda, M.2
Machida, K.3
-
35
-
-
84862642911
-
High-throughput analysis of peptide-binding modules
-
Liu BA,Engelmann B,Nash PD.High-throughput analysis of peptide-binding modules.Proteomics. 2012;10:1527-46.
-
(2012)
Proteomics
, vol.10
, pp. 1527-1546
-
-
Liu, B.A.1
Engelmann, B.2
Nash, P.D.3
-
36
-
-
30544449081
-
A quantitative protein interaction network for the ErbB receptors using protein microarrays
-
Jones RB,Gordus A,Krall JA,MacBeath G.A quantitative protein interaction network for the ErbB receptors using protein microarrays.Nature. 2006;439:168-74.
-
(2006)
Nature
, vol.439
, pp. 168-174
-
-
Jones, R.B.1
Gordus, A.2
Krall, J.A.3
MacBeath, G.4
-
39
-
-
67649208715
-
Detection of protein-protein interactions by far-Western blotting
-
Machida K,Mayer BJ.Detection of protein-protein interactions by far-Western blotting.Methods Mol Biol. 2009;536:313-29.
-
(2009)
Methods Mol Biol
, vol.536
, pp. 313-329
-
-
Machida, K.1
Mayer, B.J.2
-
40
-
-
78149463029
-
Characterizing tyrosine phosphorylation signaling in lung cancer using SH2 profiling
-
Machida K,Eschrich S,Li J, et al.Characterizing tyrosine phosphorylation signaling in lung cancer using SH2 profiling.PLoS One. 2010;5:e13470.
-
(2010)
PLoS One
, vol.5
-
-
Machida, K.1
Eschrich, S.2
Li, J.3
-
41
-
-
24644500492
-
Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains
-
Sweeney MC,Wavreille AS,Park J,Butchar JP,Tridandapani S,Pei D.Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains.Biochemistry. 2005;44:14932-47.
-
(2005)
Biochemistry
, vol.44
, pp. 14932-14947
-
-
Sweeney, M.C.1
Wavreille, A.S.2
Park, J.3
Butchar, J.P.4
Tridandapani, S.5
Pei, D.6
-
42
-
-
77749264814
-
Tyrosine phosphatases Shp1 and Shp2 have unique and opposing roles in oligodendrocyte development
-
Kuo E,Park DK,Tzvetanova ID,Leiton CV,Cho BS,Colognato H.Tyrosine phosphatases Shp1 and Shp2 have unique and opposing roles in oligodendrocyte development.J Neurochem. 2010;113:200-12.
-
(2010)
J Neurochem
, vol.113
, pp. 200-212
-
-
Kuo, E.1
Park, D.K.2
Tzvetanova, I.D.3
Leiton, C.V.4
Cho, B.S.5
Colognato, H.6
-
43
-
-
77955272284
-
Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells
-
Dubielecka PM,Machida K,Xiong X, et al.Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells.FEBS Lett. 2010;584 (15): 3279-86.
-
(2010)
FEBS Lett
, vol.584
, Issue.15
, pp. 3279-3286
-
-
Dubielecka, P.M.1
Machida, K.2
Xiong, X.3
-
44
-
-
78649741585
-
Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation
-
Kelley LC,Ammer AG,Hayes KE, et al.Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation.J Cell Sci. 2010;123 (Pt 22): 3923-32.
-
(2010)
J Cell Sci
, vol.123
, Issue.Pt 22
, pp. 3923-3932
-
-
Kelley, L.C.1
Ammer, A.G.2
Hayes, K.E.3
-
45
-
-
77954934945
-
Tyrosine residues at the carboxy-terminus of Vav1 play an important role in regulation of its biological activity
-
Lazer G,Pe'er L,Farago M,Machida K,Mayer BJ,Katzav S.Tyrosine residues at the carboxy-terminus of Vav1 play an important role in regulation of its biological activity.J Biol Chem. 2010;285 (30): 23075-85.
-
(2010)
J Biol Chem
, vol.285
, Issue.30
, pp. 23075-23085
-
-
Lazer, G.1
Pe'er, L.2
Farago, M.3
Machida, K.4
Mayer, B.J.5
Katzav, S.6
-
46
-
-
81255171678
-
Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation
-
Sriram G,Reichman C,Tunceroglu A, et al.Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation.Oncogene. 2011;30 (46): 4645-55.
-
(2011)
Oncogene
, vol.30
, Issue.46
, pp. 4645-4655
-
-
Sriram, G.1
Reichman, C.2
Tunceroglu, A.3
-
47
-
-
52749099497
-
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
-
Linardou H,Dahabreh IJ,Kanaloupiti D, et al.Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer.Lancet Oncol. 2008;9:962-72.
-
(2008)
Lancet Oncol
, vol.9
, pp. 962-972
-
-
Linardou, H.1
Dahabreh, I.J.2
Kanaloupiti, D.3
-
48
-
-
77954580523
-
Multiplicity of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC) patients treated with tyrosine kinase inhibitors
-
Benesova L,Minarik M,Jancarikova D,Belsanova B,Pesek M.Multiplicity of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC) patients treated with tyrosine kinase inhibitors.Anticancer Res. 2010;30:1667-71.
-
(2010)
Anticancer Res
, vol.30
, pp. 1667-1671
-
-
Benesova, L.1
Minarik, M.2
Jancarikova, D.3
Belsanova, B.4
Pesek, M.5
-
49
-
-
72449130415
-
Adequacy and complications of computed tomography-guided core needle biopsy on non-small cell lung cancers for epidermal growth factor receptor mutations demonstration: 18-gauge or 20-gauge biopsy needle
-
Cheung YC,Chang JW,Hsieh JJ,Lin G,Tsai YH.Adequacy and complications of computed tomography-guided core needle biopsy on non-small cell lung cancers for epidermal growth factor receptor mutations demonstration: 18-gauge or 20-gauge biopsy needle.Lung Cancer. 2010;67:166-9.
-
(2010)
Lung Cancer
, vol.67
, pp. 166-169
-
-
Cheung, Y.C.1
Chang, J.W.2
Hsieh, J.J.3
Lin, G.4
Tsai, Y.H.5
-
50
-
-
84864587950
-
From modules to medicine: How modular domains and their associated networks can enable personalized medicine
-
Haura EB.From modules to medicine: How modular domains and their associated networks can enable personalized medicine.FEBS letters. 2012;586:2580-5.
-
(2012)
FEBS Letters
, vol.586
, pp. 2580-2585
-
-
Haura, E.B.1
|