Preclinical activity of simvastatin induces cell cycle arrest in G1 via blockade of cyclin D-Cdk4 expression in non-small cell lung cancer (NSCLC)

International Journal of Molecular Sciences

Volumn 14, Issue 3, 2013, Pages 5806-5816

  Liang, Yu Wei ^a   Chang, Chi Chang ^b   Hung, Chao Ming ^c   Chen, Tzu Yu ^d   Huang, Tzuu Yuan ^e   Hsu, Yi Chiang ^d  

^a Chi Shan Hospital   (Taiwan)

^b E DA HOSPITAL   (Taiwan)

^c I SHOU UNIVERSITY   (Taiwan)

^d CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

^e TAINAN SIN LAU HOSPITAL   (Taiwan)

Author keywords

Cell cycle arrest; CyclinD Cdk4; Non small cell lung cancer; Simvastatin

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; CYCLIN D; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2A; SIMVASTATIN; TRANSFORMING GROWTH FACTOR BETA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME INHIBITION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PROTEIN EXPRESSION; WESTERN BLOTTING;

EID: 84875484315     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14035806     Document Type: Article

References (21)

1. Ou, J.P.; Lin, H.Y.; Su, K.Y.; Yu, S.L.; Tseng, I.H.; Chen, C.J.; Hsu, H.C.; Chan, D.C.; Sophia Chen, Y.L. Potential therapeutic role of Z-isochaihulactone in lung cancer through induction of apoptosis via notch signaling. Evid. Based Complement. Alternat. Med. 2012, 2012, doi:10.1155/2012/809204.
2. Chien, C.R.; Shih, Y.C. Economic evaluation of bevacizumab in the treatment of non-small cell lung cancer (NSCLC). Clinicoecon. Outcomes Res. 2012, 4, 201-208.
3. Kah, J.; Wüstenberg, A.; Keller, A.D.; Sirma, H.; Montalbano, R.; Ocker, M.; Volz, T.; Dandri, M.; Tiegs, G.; Sass, G. Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression. Oncol. Rep. 2012, 28, 1077-1083.
4. Alexandre, L.; Clark, A.B.; Cheong, E.; Lewis, M.P.; Hart, A.R. Systematic review: Potential preventive effects of statins against oesophageal adenocarcinoma. Aliment. Pharmacol. Ther. 2012, 36, 301-311.
5. Broughton, T.; Sington, J.; Beales, I.L. Statin use is associated with a reduced incidence of colorectal cancer: A colonoscopy-controlled case-control study. BMC Gastroenterol. 2012, 12, 36.
6. Papadopoulos, G.; Delakas, D.; Nakopoulou, L.; Kassimatis, T. Statins and prostate cancer: Molecular and clinical aspects. Eur. J. Cancer 2011, 47, 819-830.
7. Zhou, P.; Cheng, S.W.; Yang, R.; Wang, B.; Liu, J. Combination chemoprevention: Future direction of colorectal cancer prevention. Eur. J. Cancer Prev. 2012, 21, 231-240.
8. Piechota-Polanczyk, A.; Goraca, A.; Demyanets, S.; Mittlboeck, M.; Domenig, C.; Neumayer, C.; Wojta, J.; Nanobachvili, J.; Huk, I.; Klinger, M. Simvastatin decreases free radicals formation in the human abdominal aortic aneurysm wall via NF-κB. Eur. J. Vasc. Endovasc. Surg. 2012, 44, 133-137.
9. Tu, Y.S.; Kang, X.L.; Zhou, J.G.; Lv, X.F.; Tang, Y.B.; Guan, Y.Y. Involvement of Chk1-Cdc25A-cyclin A/CDK2 pathway in simvastatin induced S-phase cell cycle arrest and apoptosis in multiple myeloma cells. Eur. J. Pharmacol. 2011, 670, 356-364.
10. Higgins, M.J.; Prowell, T.M.; Blackford, A.L.; Byrne, C.; Khouri, N.F.; Slater, S.A.; Jeter, S.C.; Armstrong, D.K.; Davidson, N.E.; Emens, L.A.; et al. A short-term biomarker modulation study of simvastatin in women at increased risk of a new breast cancer. Breast Cancer Res. Treat. 2012, 131, 915-924.
11. Podhorecka, M.; Halicka, D.; Klimek, P.; Kowal, M.; Chocholska, S.; Dmoszynska, A. Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann. Hematol. 2010, 89, 1115-1124.
12. Kochuparambil, S.T.; Al-Husein, B.; Goc, A.; Soliman, S.; Somanath, P.R. Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression. J. Pharmacol. Exp. Ther. 2011, 336, 496-505.
13. Bababeygy, S.R.; Polevaya, N.V.; Youssef, S.; Sun, A.; Xiong, A.; Prugpichailers, T.; Veeravagu, A.; Hou, L.C.; Steinman, L.; Tse, V. HMG-CoA reductase inhibition causes increased necrosis and apoptosis in an in vivo mouse glioblastoma multiforme model. Anticancer Res. 2009, 29, 4901-4908.
14. Polo, M.P.; Crespo, R.; de Bravo, M.G. Geraniol and simvastatin show a synergistic effect on a human hepatocarcinoma cell line. Cell Biochem. Funct. 2011, 29, 452-458.
15. Ruggenenti, P.; Cattaneo, D.; Rota, S.; Iliev, I.; Parvanova, A.; Diadei, O.; Ene-Iordache, B.; Ferrari, S.; Bossi, A.C.; Trevisan, R.; et al. Effects of combined ezetimibe and simvastatin therapy as compared with simvastatin alone in patients with type 2 diabetes: A prospective randomized double-blind clinical trial. Diabetes Care. 2010, 33, 1954-1956.
16. Schaafsma, D.; McNeill, K.D.; Mutawe, M.M.; Ghavami, S.; Unruh, H.; Jacques, E.; Laviolette, M.; Chakir, J.; Halayko, A.J. Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts. Respir. Res. 2011, 12, 113.
17. Karadeniz Cakmak, G.; Irkorucu, O.; Ucan, B.H.; Emre, A.U.; Bahadir, B.; Demirtas, C.; Tascilar, O.; Karakaya, K.; Acikgoz, S.; et al. Simvastatin improves wound strength after intestinal anastomosis in the rat. J. Gastrointest. Surg. 2009, 13, 1707-1716.
18. Lei, J.; Gu, X.; Ye, Z.; Shi, J.; Zheng, X. Antiaging effects of simvastatin on vascular endothelial cells. Clin. Appl. Thromb. Hemost. 2012, doi:10.1177/1076029612458967.
19. Murtaza, G. Solubility enhancement of simvastatin: A review. Acta Pol. Pharm. 2012, 69, 581-590.
20. Chen, M.J.; Tang, W.Y.; Hsu, C.W.; Tsai, Y.T.; Wu, J.F.; Lin, C.W.; Cheng, Y.M.; Hsu, Y.C. Apoptosis induction in primary human colorectal cancer cell lines and retarded tumor growth in SCID mice by sulforaphane. Evid. Based Complement. Alternat. Med. 2012, 2012, 415231.
21. Kim, Y.R.; Byun, H.S.; Jeon, J.; Choi, B.L.; Park, K.A.; Won, M.; Zhang, T.; Shin, S.; Lee, H.; Oh, J. Apoptosis signal-regulating kinase1 is inducible by protein kinase Cδ and contributes to phorbol ester-mediated G1 phase arrest through persistent JNK activation. Cell Biochem. Biophys. 2011, 61, 199-207.