Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells

Annals of Hematology

Volumn 89, Issue 11, 2010, Pages 1115-1124

  Podhorecka, Monika ^a   Halicka, Dorota ^b   Klimek, Piotr ^a   Kowal, Malgorzata ^a   Chocholska, Sylwia ^a   Dmoszynska, Anna ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Apoptosis; CLL; DNA damage; Purine analogs; Simvastatin

Indexed keywords

ATM PROTEIN; BETA 2 MICROGLOBULIN; CASPASE 3; CD38 ANTIGEN; CLADRIBINE; FLUDARABINE; HISTONE H2AX; LACTATE DEHYDROGENASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE ZAP 70; PURINE DERIVATIVE; SIMVASTATIN; ANTINEOPLASTIC AGENT; ATM PROTEIN, HUMAN; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; H2AFX PROTEIN, HUMAN; HISTONE; HYPOCHOLESTEROLEMIC AGENT; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN; VIDARABINE; ZAP70 PROTEIN, HUMAN;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; BONE MARROW CELL; CANCER GROWTH; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; EX VIVO STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHOCYTE COUNT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; METABOLISM; PROGNOSIS; TUMOR CELL CULTURE;

ANTICHOLESTEREMIC AGENTS; ANTIGENS, CD38; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL CYCLE PROTEINS; CLADRIBINE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HISTONES; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; PROGNOSIS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; PURINES; SIMVASTATIN; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; VIDARABINE; ZAP-70 PROTEIN-TYROSINE KINASE; ATAXIA TELANGIECTASIA MUTATED PROTEINS;

EID: 77956969727     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-010-0988-z     Document Type: Article

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