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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 8, 2013, Pages 2432-2435

Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor

(13) Priestley, E Scott a De Lucca, Indawati a Zhou, Jinglan b Zhou, Jiacheng b Saiah, Eddine b Stanton, Robert b Robinson, Leslie b Luettgen, Joseph M a Wei, Anzhi a Wen, Xiao a Knabb, Robert M a Wong, Pancras C a Wexler, Ruth R a

a BRISTOL MYERS SQUIBB (United States)

b DUPONT COMPANY (United States)

Author keywords

Anticoagulant; Antithrombotic; Benzamidine; Coagulation factor VIIa; FVIIa; Inhibitor; Povarov annulation; Tetrahydroquinoline; Thrombosis

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 7A INHIBITOR; BMS 593214; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANNULATION REACTION; ARTERY THROMBOSIS; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; ENANTIOMER; MOLECULAR LIBRARY; NONHUMAN; REACTION OPTIMIZATION;

ANIMALS; BENZOATES; DISEASE MODELS, ANIMAL; FACTOR VIIA; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOSIS;

ORYCTOLAGUS CUNICULUS;

EID: 84875466556 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.02.013 Document Type: Article

Times cited : (25)

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