Synthesis and biological evaluation of novel hydroxylphenethyl-S-DACOs as high active anti-HIV agents

Letters in Drug Design and Discovery

Volumn 10, Issue 3, 2013, Pages 271-276

  Wu, Dao Chun ^a   Zhuang, Dao Ming ^b   Liu, Xiao Feng ^a   Lu, Li He ^a   Wang, Hua ^a   Li, Cong ^a   Lai, Christopher Cong ^c   Li, Jing Yun ^b   He, Yan Ping ^a  

^a YUNNAN UNIVERSITY   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Anti HIV 1 activity; Molecular Docking; NNRTIs; Pyrimidone; S DACOs.; Water solubility

Indexed keywords

5 ALKY 6 (CYCLOHEXYLMETHYL) 2 [(2 HYDROXY 2 PHENYLETHYL)THIO]PYRIMIDIN 4(3H) ONE DERIVATIVE; 6 (CYCLOHEXYLMEHYL) 5 ETHYL 2 [[2 (4 FLUOROPHENYL) 2 HYDROXYETHYL]THIO]PYRIMIDIN 4(3H)ONE; 6 (CYCLOHEXYLMETHYL) 2 [(2 HYDROXY 2 PHENYLETHYL)THIO] 5 METHYLPYRIMIDIN 4(3H) ONE; 6 (CYCLOHEXYLMETHYL) 2 [2 (4 FLUOROPHENYL) 2 HYDROOXYETHYL)THIO] 5 METHYLPYRIMIDIN 4(3H) ONE; 6 (CYCLOHEXYLMETHYL) 2 [[2 HYDROOXY 2 (4 METHOXYPHENY)ETHYL]THIO] 5 METHYLPYRIMIDIN 4(3H) ONE; 6 (CYCLOHEXYLMETHYL) 2 [[2 HYDROXY 2 (4 HYDROXYPHENYL)ETHYL]THIO] 5 METHYLPYRIMIDIN 4(3H) ONE; 6 (CYCLOHEXYLMETHYL) 5 ETHYL 2 [(2 HYDROXY 2 PHENYLETHYL)THIO]PYRIMIDIN 4(3H) ONE; 6 (CYCLOHEXYLMETHYL) 5 ETHYL 2 [[2 HYDRO 2 (4 HYDROXYPHENYL)ETHYL]THIO]PYRIMIDIN 4(3H) ONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; EFAVIRENZ; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; MOLECULAR MODEL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 84875464439     PISSN: 15701808     EISSN: 1875628X     Source Type: Journal    
DOI: 10.2174/157018013804999726     Document Type: Article

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