Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands - Potential novel positron emitting tomography imaging agents

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 8, 2013, Pages 2368-2372

  O'Shea, Dennis ^a   Ahmad, Rabia ^a   Arstad, Erik ^a   Avory, Michelle ^a   Chau, Wai Fung ^a   Durrant, Clare ^a   Hirani, Ella ^a   Jones, Paul A ^a   Khan, Imtiaz ^a   Luthra, Sajinder K ^a   Mantzilas, Dimitrios ^b   Morisson Iveson, Véronique ^a   Passmore, Joanna ^a   Robins, Edward G ^a   Shan, Bo ^a   Wadsworth, Harry ^a   Walton, Sarah ^a   Zhao, Yongjun ^a   Trigg, William ^a  

^a GE HEALTHCARE   (United Kingdom)

^b GE Healthcare   (United States)

Author keywords

Neuroinflammation; PBR; PET; Synthesis; TSPO

Indexed keywords

CARRIER PROTEIN; FLUORINE 18; LIGAND; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; TRACER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; IN VIVO STUDY; ISOTOPE LABELING; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; LIGANDS; POSITRON-EMISSION TOMOGRAPHY; PROTEIN TRANSPORT; RATS; RECEPTORS, GABA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875454152     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.057     Document Type: Article

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