Molecular Regulation of Trypanosoma congolense-Induced Nitric Oxide Production in Macrophages

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Singh, Rani ^a   Kone, Bruce C ^b   Gounni, Abdelilah S ^a   Uzonna, Jude E ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STAT1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GAS1; TRANSCRIPTION FACTOR GAS2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; BONE MARROW CELL; CELL IMMORTALIZATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEMALE; GENE; GENE CONTROL; GENE EXPRESSION; HOST PATHOGEN INTERACTION; INDUCIBLE NITRIC OXIDE SYNTHASE GENE; MACROPHAGE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRYPANOSOMA CONGOLENSE;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE; DISEASE MODELS, ANIMAL; FEMALE; GPI-LINKED PROTEINS; INTERFERON-GAMMA; MACROPHAGES; MAP KINASE KINASE 4; MICE; MICROFILAMENT PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; STAT1 TRANSCRIPTION FACTOR; TRYPANOSOMA CONGOLENSE; TRYPANOSOMIASIS, AFRICAN;

MUS; TRYPANOSOMA CONGOLENSE;

EID: 84875450024     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059631     Document Type: Article

References (37)

1. Magez S, Radwanska M, (2009) African trypanosomiasis and antibodies: implications for vaccination, therapy and diagnosis. Future Microbiol 4: 1075-1087.
2. Schofield CJ, Kabayo JP, (2008) Trypanosomiasis vector control in Africa and Latin America. Parasit Vectors 1: 24.
3. Simarro PP, Jannin J, Cattand P, (2008) Eliminating human African trypanosomiasis: where do we stand and what comes next? PLoS Med 5: e55.
4. Fevre EM, Bronsvoort BM, Hamilton KA, Cleaveland S, (2006) Animal movements and the spread of infectious diseases. Trends Microbiol 14: 125-131.
5. Naessens J, (2006) Bovine trypanotolerance: A natural ability to prevent severe anaemia and haemophagocytic syndrome? Int J Parasitol 36: 521-528.
6. Ogunremi O, Tabel H, (1995) Genetics of resistance to Trypanosoma congolense in inbred mice: efficiency of apparent clearance of parasites correlates with long-term survival. J Parasitol 81: 876-881.
7. Coller SP, Mansfield JM, Paulnock DM, (2003) Glycosylinositolphosphate soluble variant surface glycoprotein inhibits IFN-gamma-induced nitric oxide production via reduction in STAT1 phosphorylation in African trypanosomiasis. J Immunol 171: 1466-1472.
8. Blanchette J, Jaramillo M, Olivier M, (2003) Signalling events involved in interferon-gamma-inducible macrophage nitric oxide generation. Immunology 108: 513-522.
9. Kaushik RS, Uzonna JE, Gordon JR, Tabel H, (1999) Innate resistance to Trypanosoma congolense infections: differential production of nitric oxide by macrophages from susceptible BALB/c and resistant C57Bl/6 mice. Exp Parasitol 92: 131-143.
10. Bhat NR, Zhang P, Lee JC, Hogan EL, (1998) Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 18: 1633-1641.
11. Galdiero M, Vitiello M, D'Isanto M, Raieta K, Galdiero E, (2006) STAT1 and STAT3 phosphorylation by porins are independent of JAKs but are dependent on MAPK pathway and plays a role in U937 cells production of interleukin-6. Cytokine 36: 218-228.
12. Cox GW, Mathieson BJ, Gandino L, Blasi E, Radzioch D, et al. (1989) Heterogeneity of hematopoietic cells immortalized by v-myc/v-raf recombinant retrovirus infection of bone marrow or fetal liver. J Natl Cancer Inst 81: 1492-1496.
13. Biragyn A, Nedospasov SA, (1995) Lipopolysaccharide-induced expression of TNF-alpha gene in the macrophage cell line ANA-1 is regulated at the level of transcription processivity. J Immunol 155: 674-683.
14. Descoteaux A, Matlashewski G, (1990) Regulation of tumor necrosis factor gene expression and protein synthesis in murine macrophages treated with recombinant tumor necrosis factor. J Immunol 145: 846-853.
15. Fortier AH, Falk LA (2001) Isolation of Murine Macrophages. Current Protocols in Immunology: John Wiley & Sons, Inc.
16. Tabel H, (1982) Activation of the alternative pathway of bovine complement by Trypanosoma congolense. Parasite Immunol 4: 329-335.
17. Lanham SM, Godfrey DG, (1970) Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose. Exp Parasitol 28: 521-534.
18. Shan L, Redhu NS, Saleh A, Halayko AJ, Chakir J, et al. (2010) Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways. J Immunol 184: 7134-7143.
19. Mou Z, Jia P, Kuriakose S, Khadem F, Uzonna JE, (2010) Interleukin-17-mediated control of parasitemia in experimental Trypanosoma congolense infection in mice. Infect Immun 78: 5271-5279.
20. Meli R, Raso GM, Bentivoglio C, Nuzzo I, Galdiero M, et al. (1996) Recombinant human prolactin induces protection against Salmonella typhimurium infection in the mouse: role of nitric oxide. Immunopharmacology 34: 1-7.
21. Mabbott NA, Sutherland IA, Sternberg JM, (1994) Trypanosoma brucei is protected from the cytostatic effects of nitric oxide under in vivo conditions. Parasitol Res 80: 687-690.
22. Vincendeau P, Daulouede S, Veyret B, Darde ML, Bouteille B, et al. (1992) Nitric oxide-mediated cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei. Exp Parasitol 75: 353-360.
23. Lu W, Wei G, Pan W, Tabel H, (2011) Trypanosoma congolense Infections: Induced Nitric Oxide Inhibits Parasite Growth In Vivo. J Parasitol Res 2011: 316067.
24. Bogdan C, (2001) Nitric oxide and the immune response. Nat Immunol 2: 907-916.
25. Bergeron M, Olivier M, (2006) Trypanosoma cruzi-mediated IFN-gamma-inducible nitric oxide output in macrophages is regulated by iNOS mRNA stability. J Immunol 177: 6271-6280.
26. Yang KY, Liu Y, Zhang S, (2001) Activation of a mitogen-activated protein kinase pathway is involved in disease resistance in tobacco. Proc Natl Acad Sci U S A 98: 741-746.
27. Durbin JE, Fernandez-Sesma A, Lee CK, Rao TD, Frey AB, et al. (2000) Type I IFN modulates innate and specific antiviral immunity. J Immunol 164: 4220-4228.
28. Yang J, Stark GR, (2008) Roles of unphosphorylated STATs in signaling. Cell Res 18: 443-451.
29. Gao J, Morrison DC, Parmely TJ, Russell SW, Murphy WJ, (1997) An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide. J Biol Chem 272: 1226-1230.
30. Magez S, Radwanska M, Drennan M, Fick L, Baral TN, et al. (2006) Interferon-gamma and nitric oxide in combination with antibodies are key protective host immune factors during trypanosoma congolense Tc13 Infections. J Infect Dis 193: 1575-1583.
31. Lopez R, Demick KP, Mansfield JM, Paulnock DM, (2008) Type I IFNs play a role in early resistance, but subsequent susceptibility, to the African trypanosomes. J Immunol 181: 4908-4917.
32. Magez S, Stijlemans B, Radwanska M, Pays E, Ferguson MA, et al. (1998) The glycosyl-inositol-phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophage-activating factors. J Immunol 160: 1949-1956.
33. Mathias S, Perez R, Diffley P, (1990) The kinetics of gene expression and maturation of IL-1 alpha after induction with the surface coat of Trypanosoma brucei rhodesiense or lipopolysaccharide. J Immunol 145: 3450-3455.
34. Mansfield JM (1995) Immunobiology of African trypanosomiasis: a revisionist view. In: Boothroyd, J C, Komuniecki, R, editors Molecular Approaches to Parasitology Wiley-Liss; New York: 477-496.
35. Paulnock DM, Freeman BE, Mansfield JM, (2010) Modulation of innate immunity by African trypanosomes. Parasitology 137: 2051-2063.
36. Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW, (2002) Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 285: 1-24.
37. Marrero MB, Venema VJ, He H, Caldwell RB, Venema RC, (1998) Inhibition by the JAK/STAT pathway of IFNgamma- and LPS-stimulated nitric oxide synthase induction in vascular smooth muscle cells. Biochem Biophys Res Commun 252: 508-512.