Activatable cell penetrating peptide-conjugated nanoparticles with enhanced permeability for site-specific targeting delivery of anticancer drug

Bioconjugate Chemistry

Volumn 24, Issue 3, 2013, Pages 419-430

  Xia, Huimin ^a,c   Gu, Guangzhi ^a   Hu, Quanyin ^a   Liu, Zhongyang ^a   Jiang, Mengyin ^d   Kang, Ting ^a   Miao, Deyu ^d   Song, Qingxiang ^b   Yao, Lei ^b   Tu, Yifan ^a   Chen, Hongzhuan ^b   Gao, Xiaoling ^b   Chen, Jun ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SHANGHAI INSTITUTE FOR FOOD AND DRUG CONTROL   (China)

^d SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CONTROLLED DRUG DELIVERY; CYTOLOGY; DRUG PRODUCTS; MOLECULAR BIOLOGY; MOLECULAR WEIGHT; PARTICLE SIZE; PEPTIDES; POLYETHYLENE GLYCOLS; TARGETED DRUG DELIVERY; TUMORS;

ACTIVATABLE CELL PENETRATING PEPTIDES; ANTICANCER DRUG; ENHANCED PERMEABILITY; FUNCTIONALIZED NANOPARTICLES; LOW MOLECULAR WEIGHT PROTAMINES; OVEREXPRESSIONS; PACLITAXEL; SITE-SPECIFIC; TARGETING DELIVERIES; TUMOR SITE;

NANOPARTICLES;

ACTIVATABLE LOW MOLECULAR WEIGHT PROTAMINE; CELL PENETRATING PEPTIDE; LOW MOLECULAR WEIGHT PROTAMINE; MATRIX METALLOPROTEINASE; NANOPARTICLE; PACLITAXEL; POLY(ETHYLENE GLYCOL) POLY(LACTIC ACID) NANOPARTICLE; PROTAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CELL INTERACTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG RELEASE; DRUG TARGETING; ENDOCYTOSIS; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MALE; MAXIMUM PLASMA CONCENTRATION; MOLECULAR WEIGHT; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PERMEABILITY; RAT; ZETA POTENTIAL;

MUS;

EID: 84875443853     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc300520t     Document Type: Article

References (32)

1. Bae, Y. H. and Park, K. (2011) Targeted drug delivery to tumors: myths, reality and possibility J. Controlled Release 153, 198-205
2. Maeda, H. (2010) Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects Bioconjugate Chem. 21, 797-802
3. Kuil, J., Velders, A. H., and van Leeuwen, F. W. (2010) Multimodal tumor-targeting peptides functionalized with both a radio-and a fluorescent label Bioconjugate Chem. 21, 1709-1719
4. Muro, S. (2012) Challenges in design and characterization of ligand-targeted drug delivery systems J. Controlled Release 164, 125-137
5. Kwon, I. K., Lee, S. C., Han, B., and Park, K. (2012) Analysis on the current status of targeted drug delivery to tumors J. Controlled Release 164, 108-114
6. Nori, A., Jensen, K. D., Tijerina, M., Kopeckova, P., and Kopecek, J. (2003) Tat-conjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells Bioconjugate Chem. 14, 44-50
7. Ifediba, M. A., Medarova, Z., Ng, S. W., Yang, J., and Moore, A. (2010) siRNA delivery to CNS cells using a membrane translocation peptide Bioconjugate Chem. 21, 803-806
8. Bendifallah, N., Rasmussen, F. W., Zachar, V., Ebbesen, P., Nielsen, P. E., and Koppelhus, U. (2006) Evaluation of cell-penetrating peptides (CPPs) as vehicles for intracellular delivery of antisense peptide nucleic acid (PNA) Bioconjugate Chem. 17, 750-758
9. Saalik, P., Elmquist, A., Hansen, M., Padari, K., Saar, K., Viht, K., Langel, U., and Pooga, M. (2004) Protein cargo delivery properties of cell-penetrating peptides. A comparative study Bioconjugate Chem. 15, 1246-1253
10. Tsui, B., Singh, V. K., Liang, J. F., and Yang, V. C. (2001) Reduced reactivity towards anti-protamine antibodies of a low molecular weight protamine analogue Thromb. Res. 101, 417-420
11. Liang, J. F., Zhen, L., Chang, L. C., and Yang, V. C. (2003) A less toxic heparin antagonist -low molecular weight protamine Biochemistry (Moscow) 68, 116-120
12. Lee, L. M., Chang, L. C., Wrobleski, S., Wakefield, T. W., and Yang, V. C. (2001) Low molecular weight protamine as nontoxic heparin/low molecular weight heparin antidote (III): preliminary in vivo evaluation of efficacy and toxicity using a canine model AAPS Pharmsci. 3, E19
13. Teesalu, T., Sugahara, K. N., Kotamraju, V. R., and Ruoslahti, E. (2009) C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration Proc. Natl. Acad. Sci. U. S. A. 106, 16157-16162
14. Olson, E. S., Aguilera, T. A., Jiang, T., Ellies, L. G., Nguyen, Q. T., Wong, E. H., Gross, L. A., and Tsien, R. Y. (2009) In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer Integr. Biol. (Camb.) 1, 382-393
15. Curran, S. and Murray, G. I. (1999) Matrix metalloproteinases in tumour invasion and metastasis J. Pathol. 189, 300-308
16. Erster, O., Thomas, J. M., Hamzah, J., Jabaiah, A. M., Getz, J. A., Schoep, T. D., Hall, S. S., Ruoslahti, E., and Daugherty, P. S. (2012) Site-specific targeting of antibody activity in vivo mediated by disease-associated proteases J. Controlled Release 161, 804-812
17. Gao, X., Wu, B., Zhang, Q., Chen, J., Zhu, J., Zhang, W., Rong, Z., Chen, H., and Jiang, X. (2007) Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration J. Controlled Release 121, 156-167
18. Zeng, N., Hu, Q., Liu, Z., Gao, X., Hu, R., Song, Q., Gu, G., Xia, H., Yao, L., Pang, Z., Jiang, X., Chen, J., and Fang, L. (2012) Preparation and characterization of paclitaxel-loaded DSPE-PEG-liquid crystalline nanoparticles (LCNPs) for improved bioavailability Int. J. Pharm. 424, 58-66
19. Jiang, T., Olson, E. S., Nguyen, Q. T., Roy, M., Jennings, P. A., and Tsien, R. Y. (2004) Tumor imaging by means of proteolytic activation of cell-penetrating peptides Proc. Natl. Acad. Sci. U. S. A. 101, 17867-17872
20. Weissleder, R. and Mahmood, U. (2001) Molecular imaging Radiology 219, 316-333
21. Hu, K., Li, J., Shen, Y., Lu, W., Gao, X., Zhang, Q., and Jiang, X. (2009) Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: in vitro and in vivo evaluations J. Controlled Release 134, 55-61
22. Xia, H., Gao, X., Gu, G., Liu, Z., Zeng, N., Hu, Q., Song, Q., Yao, L., Pang, Z., Jiang, X., Chen, J., and Chen, H. (2011) Low molecular weight protamine-functionalized nanoparticles for drug delivery to the brain after intranasal administration Biomaterials 32, 9888-9898
23. Scott, A. J. and Woods, J. P. (2000) Monitoring internalization of Histoplasma capsulatum by mammalian cell lines using a fluorometric microplate assay Med. Mycol. 38, 15-22
24. Coussens, L. M., Fingleton, B., and Matrisian, L. M. (2002) Matrix metalloproteinase inhibitors and cancer: trials and tribulations Science 295, 2387-2392
25. Guo, J., Gao, X., Su, L., Xia, H., Gu, G., Pang, Z., Jiang, X., Yao, L., Chen, J., and Chen, H. (2011) Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery Biomaterials 32, 8010-8020
26. Chen, J., Liu, T. W., Lo, P. C., Wilson, B. C., and Zheng, G. (2009) 'Zipper' molecular beacons: a generalized strategy to optimize the performance of activatable protease probes Bioconjugate Chem. 20, 1836-1842
27. Liu, T. W., Chen, J., and Zheng, G. (2011) Peptide-based molecular beacons for cancer imaging and therapy Amino Acids 41, 1123-1134
28. Lovell, J. F., Liu, T. W., Chen, J., and Zheng, G. (2010) Activatable photosensitizers for imaging and therapy Chem. Rev. 110, 2839-2857
29. Liu, T. W., Akens, M. K., Chen, J., Wise-Milestone, L., Wilson, B. C., and Zheng, G. (2011) Imaging of specific activation of photodynamic molecular beacons in breast cancer vertebral metastases Bioconjugate Chem. 22, 1021-1030
30. Liu, D., Mori, A., and Huang, L. (1992) Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes Biochim. Biophys. Acta 1104, 95-101
31. Langer, R. (1997) Tissue engineering: a new field and its challenges Pharm. Res. 14, 840-841
32. Adams, M. L., Lavasanifar, A., and Kwon, G. S. (2003) Amphiphilic block copolymers for drug delivery J. Pharm. Sci. 92, 1343-1355