An increase in dietary non-structural carbohydrates alters the structure and metabolism of the rumen epithelium in lambs

Canadian Journal of Animal Science

Volumn 92, Issue 2, 2012, Pages 123-130

  Steele, M A ^a   Greenwood, S L ^a,b   Croom, J ^c   McBride, B W ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b LINCOLN UNIVERSITY   (New Zealand)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Histology; Metabolism; Parakeratosis; Rumen epithelium; Sheep

Indexed keywords

EID: 84875436394     PISSN: 00083984     EISSN: 19181825     Source Type: Journal    
DOI: 10.4141/CJAS2011-095     Document Type: Article

References (30)

1. Aschenbach, J. R., Kristensen, N. B., Donkin, S. S., Hammon, H., Al-Trad, B. and Penner, G. B. 2010. Critical review: Gluconeogenesis in dairy cows: the secret of making sweet milk from sour dough. IUBMB Life. 62: 869-877.
2. Bull, L. S., Bush, L. J., Friend, J D., Harris, B. and Jones E. W. 1965. Incidence of ruminal parakeratosis in calves fed different rations and its relation to volatile fatty acid absorption. J. Dairy Sci. 48: 1459-1466.
3. Canadian Council on Animal Care. 1993. Guide to the care and use of experimental animals. CCAC, Ottawa, ON.
4. Duffield, T. F., Lissemore, K. D., McBride, B. W. and Leslie K. E. 2009. Impact of hyperketonemia in early lactation dairy cows on health and production. J. Dairy Sci. 92: 571-580.
5. Gäbel, G., Aschenbach, J. R. and Müller, F. 2002. Transfer of energy substrates across the ruminal epithelium: Implications and limitations. Anim. Health Res. Rev. 31: 15-30.
6. Greenwood, S. L., Steele, M., AlZahal, O., Hook, S. E., Swanson, K. C. and McBride, B. W. 2010. Differential regulation of components of the apoptotic and ubiquitin mediated proteolytic pathway in slow- and fast- twitch muscle type in lambs receiving increasing amounts of dietary nonstructural carbohydrate. Can. J. Anim. Sci. 90: 421-428.
7. Hegardt, F. G. 1999. Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: A control enzyme in ketogenesis. Biochem. J. 338: 569-582.
8. Hinders, R. G. and Owen, F. G. 1965. Relation of ruminal parakeratosis development to volatile fatty acid absorption. J. Dairy Sci. 48: 1069-1073.
9. Horton, J. D. 2002. Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem. Soc. Trans. 30: 1091-1095.
10. Krehbiel, C. R., Britton, R. A., Harmon, D. L., Wester, T. J. and Stock, R. A. 1995. The effects of ruminal acidosis on volatile fatty acid absorption and plasma activities of pancreatic enzymes in lambs. J. Anim. Sci. 73: 3111-3121.
11. Kristensen, N. B., Pierzynowski, S. G. and Danfaer, A. 2000. Net portal appearance of volatile fatty acids in sheep intraruminally infused with mixtures of acetate, propionate, isobutyrate, butyrate, and valerate. J. Anim. Sci. 78: 1372-1379.
12. Leighton, B., Nicholas, A. R. and Pogson, C. I. 1983. The pathway of ketogenesis in rumen epithelium of the sheep. Biochem. J. 216: 769-772.
13. Nagaraja, T. G. and Titgemeyer, E. C. 2007. Ruminal acidosis in beef cattle: the current microbiological and nutritional outlook. J. Dairy Sci. 90: E17-E38.
14. Neiva, M. G. S., Da Mota, D. L., Batista, V. A. M. and Sousa-Rodrigues, C. 2006. Mucous membrane of the rumen of ovines, fed with spinleless, forage cactus or palm (barbary fig): Hystochemical study by means of light microscopy. Int. J. Morphol. 24: 723-728.
15. Nocek, J. E. 1997. Bovine acidosis: Implications on laminitis. J. Dairy Sci. 80: 1005-1028.
16. Penner, G. B., Steele, M. A., Aschenbach, J. R. and McBride, B. W. 2011. Molecular adaptation of ruminal epithelia to highly fermentable diets. J. Anim. Sci. 89: 1108-1119.
17. Penner, G. B., Oba, M., Gäbel, G. and Aschenbach, J. R. 2010. A single mild episode of subacute ruminal acidosis does not affect ruminal barrier function in the short term. J. Dairy Sci. 93: 4838-4845.
18. Penner, G. B., Taniguchi, M., Guan, L. L., Beauchemin, K. A. and Oba, M. 2009. Effect of dietary forage to concentrate ratio on volatile fatty acid absorption and the expression of genes related to volatile fatty acid absorption and metabolism in ruminal tissue. J. Dairy Sci. 92: 2767-2781.
19. Pfaffl, M. W. 2007. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29: 2002-2007.
20. Plaizier, J. C., Krause, D. O., Gozho, G. N. and McBride B. W. 2008. Subacute ruminal acidosis in dairy cows: The physiological causes, incidence and consequences. Vet. J. 176: 21-31.
21. Rémond, D., Ortigues, I. and Jouany, J-P. 1995. Energy substrates for the rumen epithelium. Proc. Nutr. Soc. 54: 95-105.
22. SAS Institute, Inc. 2004. SAS/STAT user's guide. Release 9.1. SAS Institute, Inc., Cary, NC.
23. Steele, M. A., AlZahal, O., Hook, S. E., Croom, J. and McBride, B. W. 2009. Ruminal acidosis and the rapid onset of ruminal parakeratosis in a mature dairy cow: a case report. Acta. Vet. Scand. 51: 39.
24. Steele, M. A., Croom, J., Kahler, M., AlZahal, O., Hook, S. E., Plaizier, K. and McBride, B. W. 2011a. Bovine rumen epithelium undergoes dramatic structural adaptations during grain-induced ruminal acidosis epithelial adaptation. Am. J. Physiol. Integr. Comp. Phys. 300: R1515-R1523.
25. Steele, M. A., Dionissopoulos, L., AlZahal, O., Doelman, J. and McBride, B. W. 2012. Rumen epithelial adaptation to ruminal acidosis in lactating cattle involves the coordinated expression of insulin-like growth factor-binding proteins and a cholesterolgenic enzyme. J. Dairy Sci. 95: 318-327.
26. Steele, M. A., Vandervoort, G., AlZahal, O., Hook, S. E., Matthews, J. C. and McBride, B. W. 2011b. Rumen epithelial adaptation to high-grain diets involves the coordinated regulation of genes involved in cholesterol homeostasis. Physiol. Genomics 43: 308-316.
27. Tamate, H. and Kikuchi, T. 1978. Electron microscopic study on parakeratotic rumen epithelium in beef cattle. Jpn. J. Vet. Sci. 40: 21-30.
28. Wallace, C. A., Pichardo, R. O., Yosipovitch, G., Hancox, J. and Sangueza, O. P. 2003. Granular parakeratosis: a case report and literature review. J. Cutan. Pathol. 30: 332-335.
29. Williamson, D. H., Mellanby, J. and Krebs, H. A. 1962. Enzymatic determination of d(-)-β-hydroxybutyric acid and acetoacetic acid in blood. Biochem. J. 82: 90-96.
30. Von Englehardt, W. and Hales, J. R. S. 1977. Partition of capillary blood flow in rumen, reticulum, and omasum of sheep. Am. J. Physiol. 232: E53-E66.