Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis

Cancer Research

Volumn 73, Issue 6, 2013, Pages 1912-1921

  Martini, Miriam ^a,f   Russo, Mariangela ^a   Lamba, Simona ^b   Vitiello, Elisa ^b,g   Crowley, Emily Hannah ^a,c   Sassi, Francesco ^b   Romanelli, Davide ^d   Frattini, Milo ^d   Marchetti, Antonio ^e   Bardelli, Alberto ^a,b,c  

^a CANDIOLO CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^d INSTITUTE OF PATHOLOGY   (Switzerland)

^e UNIVERSITY OF CHIETI   (Italy)

^f Molecular Biotechnology Center   (Italy)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; K RAS PROTEIN; MIXED LINEAGE KINASE; MIXED LINEAGE KINASE 4; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL TRANSFORMATION; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; EXPRESSION VECTOR; FEMALE; GENE DISRUPTION; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GENE SILENCING; GENETIC TRANSFORMATION; GLIOBLASTOMA; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; MISSENSE MUTATION; MLK4 GENE; MOUSE; NONHUMAN; ONCOGENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; SOMATIC MUTATION; TUMOR XENOGRAFT;

ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; ENZYME ACTIVATION; FEMALE; HUMANS; MAP KINASE KINASE KINASES; MICE; MICE, NUDE; ONCOGENE PROTEIN P21(RAS); PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84875425466     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-3074     Document Type: Article

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