메뉴 건너뛰기




Volumn 43, Issue 16-17, 2010, Pages 1333-1339

Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and macro-albuminuria and progression of diabetic nephropathy among Iranians with type 2 diabetes mellitus

Author keywords

Macroalbuminuria; Microalbuminuria; MTHFR C677T MTHFR A1298C; Type 2 diabetes mellitus; Western Iran

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

EID: 77957335780     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2010.08.019     Document Type: Article
Times cited : (44)

References (30)
  • 1
    • 4544365404 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphism is not related to diabetic nephropathy in Japanese type 2 diabetic patients
    • Teh M.M., Brooks A.P., Li Voon Chong J.S. Methylenetetrahydrofolate reductase gene polymorphism is not related to diabetic nephropathy in Japanese type 2 diabetic patients. Diab Med 2004, 21:1051-1058.
    • (2004) Diab Med , vol.21 , pp. 1051-1058
    • Teh, M.M.1    Brooks, A.P.2    Li Voon Chong, J.S.3
  • 2
    • 33845200050 scopus 로고    scopus 로고
    • MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients
    • Mtiraoui N., Ezzidi I., Chaieb M., Marmouche H., Aouni Z., Chaieb A., et al. MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients. Diab Res Clin Pract 2007, 75:99-106.
    • (2007) Diab Res Clin Pract , vol.75 , pp. 99-106
    • Mtiraoui, N.1    Ezzidi, I.2    Chaieb, M.3    Marmouche, H.4    Aouni, Z.5    Chaieb, A.6
  • 3
    • 38949127276 scopus 로고    scopus 로고
    • MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients
    • Maeda M., Yamamoto I., Fukuda M., Motomura T., Nishida M., Nonen Sh., et al. MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients. J Diab Complications 2008, 22:119-125.
    • (2008) J Diab Complications , vol.22 , pp. 119-125
    • Maeda, M.1    Yamamoto, I.2    Fukuda, M.3    Motomura, T.4    Nishida, M.5    Nonen, S.6
  • 4
    • 0043166547 scopus 로고    scopus 로고
    • Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for diabetic nephropathy
    • Moczulski D., Fojcik H., Zukowska-Szczechowska E., Szydlowska I., Grzeszczak W. Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for diabetic nephropathy. Nephrol Dial Transplant 2003, 18:1535-1540.
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 1535-1540
    • Moczulski, D.1    Fojcik, H.2    Zukowska-Szczechowska, E.3    Szydlowska, I.4    Grzeszczak, W.5
  • 5
    • 36749104379 scopus 로고    scopus 로고
    • The relationship of the methylenetetrahydrofolate reductase C677T gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy
    • Eroglu Z., Erdogan M., Tetik A., Karadeniz M., Cetinalp S., Kosova B., et al. The relationship of the methylenetetrahydrofolate reductase C677T gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy. Diab Metab Res Rev 2007, 23:621-624.
    • (2007) Diab Metab Res Rev , vol.23 , pp. 621-624
    • Eroglu, Z.1    Erdogan, M.2    Tetik, A.3    Karadeniz, M.4    Cetinalp, S.5    Kosova, B.6
  • 6
    • 0033802994 scopus 로고    scopus 로고
    • The Association between two common mutations C677T and A1298C in human methylenetetrahydrofolate reductase gene and the risk for diabetic nephropathy in type II diabetic patients
    • Shpichinetsky V., Raz I., Friedlander Y., Goldschmidt N., Wexler I.D., Ben-Yehuda A., et al. The Association between two common mutations C677T and A1298C in human methylenetetrahydrofolate reductase gene and the risk for diabetic nephropathy in type II diabetic patients. J Nutr 2000, 130:2493-2497.
    • (2000) J Nutr , vol.130 , pp. 2493-2497
    • Shpichinetsky, V.1    Raz, I.2    Friedlander, Y.3    Goldschmidt, N.4    Wexler, I.D.5    Ben-Yehuda, A.6
  • 7
    • 2342477858 scopus 로고    scopus 로고
    • Genetic polymorphism of methylenetetrahydrofolate reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients
    • Sun J., Xu Y., Zhu Y., Lu H. Genetic polymorphism of methylenetetrahydrofolate reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients. J Diab Complications 2004, 64:185-190.
    • (2004) J Diab Complications , vol.64 , pp. 185-190
    • Sun, J.1    Xu, Y.2    Zhu, Y.3    Lu, H.4
  • 8
    • 36148965526 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis
    • Zintzaras E., Uhlig K., Koukoulis G.N., Papathanasiou A.A., Stefanidis I. Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis. J Hum Genet 2007, 52:881-890.
    • (2007) J Hum Genet , vol.52 , pp. 881-890
    • Zintzaras, E.1    Uhlig, K.2    Koukoulis, G.N.3    Papathanasiou, A.A.4    Stefanidis, I.5
  • 9
    • 73349125452 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy
    • Ukinc K., Ersoz H.O., Karahan C., Erem C., Eminagaoglu S., Hacihasanoglu A.B., et al. Methylenetetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy. Endocrine 2009, 36:255-261.
    • (2009) Endocrine , vol.36 , pp. 255-261
    • Ukinc, K.1    Ersoz, H.O.2    Karahan, C.3    Erem, C.4    Eminagaoglu, S.5    Hacihasanoglu, A.B.6
  • 10
    • 18244416187 scopus 로고    scopus 로고
    • Association of methylenetetrahydrofolate reductase polymorphism and diabetic nephropathy in type 2 diabetes
    • Bluthner M., Bruntgens A., Schmidt S., Strojek K., Grzeszczak W., Ritz E. Association of methylenetetrahydrofolate reductase polymorphism and diabetic nephropathy in type 2 diabetes. Nephrol Dial Transplant 1999, 14:56-57.
    • (1999) Nephrol Dial Transplant , vol.14 , pp. 56-57
    • Bluthner, M.1    Bruntgens, A.2    Schmidt, S.3    Strojek, K.4    Grzeszczak, W.5    Ritz, E.6
  • 11
    • 34447132863 scopus 로고    scopus 로고
    • Implications of the genetic epidemiology of globin haplotypes linked to the sickle gene in Southern Iran
    • Rahimi Z., Merat A., Gerard N., Krishnamoorthy R., Nagel R.L. Implications of the genetic epidemiology of globin haplotypes linked to the sickle gene in Southern Iran. Hum Biol 2006, 78:719-731.
    • (2006) Hum Biol , vol.78 , pp. 719-731
    • Rahimi, Z.1    Merat, A.2    Gerard, N.3    Krishnamoorthy, R.4    Nagel, R.L.5
  • 12
    • 49749092700 scopus 로고    scopus 로고
    • Prevalence of type 2 diabetes mellitus in Iran and its relationship with gender, urbanisation, education, marital status and occupation
    • Azimi-Nezhad M., Ghayour-Mobarhan M., Parizadeh MR, Safarian M, Esmaeili H, Parizadeh SMJ, et al. Prevalence of type 2 diabetes mellitus in Iran and its relationship with gender, urbanisation, education, marital status and occupation. Singapore Med J 2008, 49:571-576.
    • (2008) Singapore Med J , vol.49 , pp. 571-576
    • Azimi-Nezhad, M.1    Ghayour-Mobarhan, M.2    Parizadeh, M.R.3    Safarian, M.4    Esmaeili, H.5    Parizadeh, S.M.J.6
  • 13
    • 56349152011 scopus 로고    scopus 로고
    • Prevalence of thrombotic risk factors among β-thalassemia patients from Western Iran
    • Rahimi Z., Ghaderi M., Nagel R.L., Muniz A. Prevalence of thrombotic risk factors among β-thalassemia patients from Western Iran. J Thromb Thrombolysis 2008, 26:229-233.
    • (2008) J Thromb Thrombolysis , vol.26 , pp. 229-233
    • Rahimi, Z.1    Ghaderi, M.2    Nagel, R.L.3    Muniz, A.4
  • 14
    • 67649531257 scopus 로고    scopus 로고
    • Factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase C677T polymorphism are not associated with coronary artery disease and type 2 diabetes mellitus in Western Iran
    • Rahimi Z., Nomani H., Mozafari H., Vaisi-Raygani A., Madani H., Malek-Khosravi Sh., et al. Factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase C677T polymorphism are not associated with coronary artery disease and type 2 diabetes mellitus in Western Iran. Blood Coagul Fibrinolysis 2009, 20:252-256.
    • (2009) Blood Coagul Fibrinolysis , vol.20 , pp. 252-256
    • Rahimi, Z.1    Nomani, H.2    Mozafari, H.3    Vaisi-Raygani, A.4    Madani, H.5    Malek-Khosravi, S.6
  • 16
    • 77957358420 scopus 로고    scopus 로고
    • Mild hyperhomocysteinemia, C677T polymorphism on methylenetetrahydrofolate reductase gene and the risk of macroangiopathy in type 2 diabetes: a prospective study. Acta Diabetol. in press.
    • Russo GT, Di Benedetto A, Magazzu D, Giandalia A, Giorda CB, Ientile R, et al. Mild hyperhomocysteinemia, C677T polymorphism on methylenetetrahydrofolate reductase gene and the risk of macroangiopathy in type 2 diabetes: a prospective study. Acta Diabetol. in press.
    • Russo, G.T.1    Di Benedetto, A.2    Magazzu, D.3    Giandalia, A.4    Giorda, C.B.5    Ientile, R.6
  • 17
    • 0037643521 scopus 로고    scopus 로고
    • The association between end-stage diabetic nephropathy and methylenetetrahydrofolate reductase genotype with macroangiopathy in type 2 diabetes mellitus
    • Hasegawa G., Obayashi H., Kamiuchi K., Nakai M., Kanatsuna T., Yamaguchi M., et al. The association between end-stage diabetic nephropathy and methylenetetrahydrofolate reductase genotype with macroangiopathy in type 2 diabetes mellitus. Exp Clin Endocrinol Diab 2003, 111:132-138.
    • (2003) Exp Clin Endocrinol Diab , vol.111 , pp. 132-138
    • Hasegawa, G.1    Obayashi, H.2    Kamiuchi, K.3    Nakai, M.4    Kanatsuna, T.5    Yamaguchi, M.6
  • 18
    • 67349267674 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthetase, methylenetetrahydrofolate reductase polymorphisms, and cardiovascular complications in Tunisian patients with nondiabetic renal disease
    • Kerkeni M., Letaief A., Achour A., Miled A., Trivin F., Maaroufi K. Endothelial nitric oxide synthetase, methylenetetrahydrofolate reductase polymorphisms, and cardiovascular complications in Tunisian patients with nondiabetic renal disease. Clin Biochem 2009, 42:958-964.
    • (2009) Clin Biochem , vol.42 , pp. 958-964
    • Kerkeni, M.1    Letaief, A.2    Achour, A.3    Miled, A.4    Trivin, F.5    Maaroufi, K.6
  • 19
    • 1042302788 scopus 로고    scopus 로고
    • Nephropathy in diabetes
    • American Diabetes Association
    • American Diabetes Association Nephropathy in diabetes. Diab Care 2004, 27:S79-S83.
    • (2004) Diab Care , vol.27
  • 22
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
    • Frosst P., Blom H.J., Milos R., Goyette P., Sheppard C.A., Matthews R.G., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995, 10:111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3    Goyette, P.4    Sheppard, C.A.5    Matthews, R.G.6
  • 23
    • 77953165868 scopus 로고    scopus 로고
    • Butyrylcholinesterase K variant and the APOE-e4 allele work in synergy to increase the risk of coronary artery disease especially in diabetic patients
    • Vaisi-Raygani A., Rahimi Z., Tavilani H., Pourmotabbed T. Butyrylcholinesterase K variant and the APOE-e4 allele work in synergy to increase the risk of coronary artery disease especially in diabetic patients. Mol Biol Rep 2010, 37:2083-2091.
    • (2010) Mol Biol Rep , vol.37 , pp. 2083-2091
    • Vaisi-Raygani, A.1    Rahimi, Z.2    Tavilani, H.3    Pourmotabbed, T.4
  • 24
    • 0032497143 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy in NIDDM patients
    • Neugebauer S., Baba T., Watanabe T. Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy in NIDDM patients. Lancet 1998, 352:454.
    • (1998) Lancet , vol.352 , pp. 454
    • Neugebauer, S.1    Baba, T.2    Watanabe, T.3
  • 25
    • 0342545889 scopus 로고    scopus 로고
    • MTHFR gene polymorphism as an exacerbation factor of diabetic nephropathy in type 2 diabetes. Analysis in Japanese male hemodialysis patients
    • Noiri E., Taguchi J.I., Nakao A., Fujita T. MTHFR gene polymorphism as an exacerbation factor of diabetic nephropathy in type 2 diabetes. Analysis in Japanese male hemodialysis patients. Diab Care 2000, 23:260.
    • (2000) Diab Care , vol.23 , pp. 260
    • Noiri, E.1    Taguchi, J.I.2    Nakao, A.3    Fujita, T.4
  • 26
    • 77955444027 scopus 로고    scopus 로고
    • Differential contribution of MTHFR C677T variant to the risk of diabetic nephropathy in Lebenese and Bahraini Arabs
    • Nemr R., Salman R.A., Jawad L.H., Juma E.A., Keleshian S.H., Almawi W.Y. Differential contribution of MTHFR C677T variant to the risk of diabetic nephropathy in Lebenese and Bahraini Arabs. Clin Chem Lab Med 2010, 48:1091-1094.
    • (2010) Clin Chem Lab Med , vol.48 , pp. 1091-1094
    • Nemr, R.1    Salman, R.A.2    Jawad, L.H.3    Juma, E.A.4    Keleshian, S.H.5    Almawi, W.Y.6
  • 27
    • 4544365404 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphism is not related to diabetic nephropathy in Japanese type 2 diabetic patients
    • Yoshioka K., Yoshida T., Umekawat T., Kogure A., Takakurat H., Toda H., et al. Methylenetetrahydrofolate reductase gene polymorphism is not related to diabetic nephropathy in Japanese type 2 diabetic patients. Diab Med 2004, 21:1051-1058.
    • (2004) Diab Med , vol.21 , pp. 1051-1058
    • Yoshioka, K.1    Yoshida, T.2    Umekawat, T.3    Kogure, A.4    Takakurat, H.5    Toda, H.6
  • 28
    • 33845995081 scopus 로고    scopus 로고
    • Effect of MTHFR C677T genotype on survival in type 2 diabetes patients with end-stage diabetic nephropathy
    • Boger C.A., Stubanus M., Haak T., Gotz A.K., Christ J., Hoffmann U., et al. Effect of MTHFR C677T genotype on survival in type 2 diabetes patients with end-stage diabetic nephropathy. Nephrol Dial Transplant 2007, 22:154-162.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 154-162
    • Boger, C.A.1    Stubanus, M.2    Haak, T.3    Gotz, A.K.4    Christ, J.5    Hoffmann, U.6
  • 29
    • 0033647409 scopus 로고    scopus 로고
    • Hyperhomocysteinemia in type 2 diabetes: relationship to macroangiopathy, nephropathy, and insulin resistance
    • Buysschaert M., Dramais A.S., Wallemacq P.E., Hermans M.P. Hyperhomocysteinemia in type 2 diabetes: relationship to macroangiopathy, nephropathy, and insulin resistance. Diab Care 2000, 23:1816-1822.
    • (2000) Diab Care , vol.23 , pp. 1816-1822
    • Buysschaert, M.1    Dramais, A.S.2    Wallemacq, P.E.3    Hermans, M.P.4
  • 30


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.