Murine atrial HL-1 cell line is a reliable model to study drug metabolizing enzymes in the heart

Vascular Pharmacology

Volumn 58, Issue 4, 2013, Pages 326-333

  Elshenawy, Osama H ^a   Anwar Mohamed, Anwar ^a   Abdelhamid, Ghada ^a   El Kadi, Ayman O S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Arachidonic acid metabolism; Cardiac hypertrophy; Cytochrome P450s; Dihydroxyeicosatrienoic acids; Epoxyeicosatrienoic acids; Epoxygenases; HL 1; Hydroxylases

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME; CYTOCHROME P450; CYTOCHROME P450 2B19; CYTOCHROME P450 2B9; CYTOCHROME P450 2C29; CYTOCHROME P450 2C38; CYTOCHROME P450 2C40; CYTOCHROME P450 2C44; CYTOCHROME P450 2D22; CYTOCHROME P450 2E1; CYTOCHROME P450 2J11; CYTOCHROME P450 2J13; CYTOCHROME P450 2J5; CYTOCHROME P450 2J6; CYTOCHROME P450 2J9; CYTOCHROME P450 3A11; CYTOCHROME P450 4A10; CYTOCHROME P450 4F13; CYTOCHROME P450 4F15; CYTOCHROME P450 4F16; CYTOCHROME P450 4F18; DRUG METABOLIZING ENZYME; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PREGNANE X RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; C57BL 6 MOUSE; ENZYME ACTIVITY; HEART DISEASE; HEART MUSCLE CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; ARACHIDONIC ACID; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; ENZYMES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART ATRIA; MALE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MYOCARDIUM; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER;

EID: 84875370693     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2012.12.002     Document Type: Article

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