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Volumn 54, Issue , 2013, Pages 43-58

A novel experimental model of cervical spondylotic myelopathy (CSM) to facilitate translational research

Author keywords

Cervical spondylotic myelopathy; Chronic cervical spinal cord compression; CSM; Nontraumatic cervical spinal cord injury

Indexed keywords

PROTEIN BAD; PROTEIN BAX; PROTEIN BCL XL;

EID: 84875333402     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.02.013     Document Type: Article
Times cited : (114)

References (44)
  • 1
    • 33751120151 scopus 로고    scopus 로고
    • Pathophysiology of cervical myelopathy
    • Baptiste D.C., Fehlings M.G. Pathophysiology of cervical myelopathy. Spine J. 2006, 6:190S-197S.
    • (2006) Spine J. , vol.6
    • Baptiste, D.C.1    Fehlings, M.G.2
  • 2
    • 34047255763 scopus 로고    scopus 로고
    • Cervical spondylotic myelopathy: a brief review of its pathophysiology, clinical course, and diagnosis
    • Baron E.M., Young W.F. Cervical spondylotic myelopathy: a brief review of its pathophysiology, clinical course, and diagnosis. Neurosurgery 2007, 60:S35-S41.
    • (2007) Neurosurgery , vol.60
    • Baron, E.M.1    Young, W.F.2
  • 3
    • 79957499628 scopus 로고    scopus 로고
    • Tight squeeze, slow burn: inflammation and the aetiology of cervical myelopathy
    • Beattie M.S., Manley G.T. Tight squeeze, slow burn: inflammation and the aetiology of cervical myelopathy. Brain. 2011, 134:1259-1261.
    • (2011) Brain. , vol.134 , pp. 1259-1261
    • Beattie, M.S.1    Manley, G.T.2
  • 4
    • 79960941570 scopus 로고    scopus 로고
    • Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway
    • Echeverry S., et al. Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway. J. Neurosci. 2011, 31:10819-10828.
    • (2011) J. Neurosci. , vol.31 , pp. 10819-10828
    • Echeverry, S.1
  • 5
    • 0035515964 scopus 로고    scopus 로고
    • Cervical spondylotic myelopathy: diagnosis and treatment
    • Emery S.E. Cervical spondylotic myelopathy: diagnosis and treatment. J. Am. Acad. Orthop. Surg. 2001, 9:376-388.
    • (2001) J. Am. Acad. Orthop. Surg. , vol.9 , pp. 376-388
    • Emery, S.E.1
  • 6
    • 0032535533 scopus 로고    scopus 로고
    • A review of the pathophysiology of cervical spondylotic myelopathy with insights for potential novel mechanisms drawn from traumatic spinal cord injury
    • Fehlings M.G., Skaf G. A review of the pathophysiology of cervical spondylotic myelopathy with insights for potential novel mechanisms drawn from traumatic spinal cord injury. Spine (Phila Pa 1976) 1998, 23:2730-2737.
    • (1998) Spine (Phila Pa 1976) , vol.23 , pp. 2730-2737
    • Fehlings, M.G.1    Skaf, G.2
  • 7
    • 0029012783 scopus 로고
    • The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury
    • Fehlings M.G., Tator C.H. The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury. Exp. Neurol. 1995, 132:220-228.
    • (1995) Exp. Neurol. , vol.132 , pp. 220-228
    • Fehlings, M.G.1    Tator, C.H.2
  • 8
    • 84860614345 scopus 로고    scopus 로고
    • Perioperative and delayed complications associated with the surgical treatment of cervical spondylotic myelopathy based on 302 patients from the AOSpine North America Cervical Spondylotic Myelopathy Study
    • Fehlings M.G., et al. Perioperative and delayed complications associated with the surgical treatment of cervical spondylotic myelopathy based on 302 patients from the AOSpine North America Cervical Spondylotic Myelopathy Study. J. Neurosurg. Spine. 2012, 16:425-432.
    • (2012) J. Neurosurg. Spine. , vol.16 , pp. 425-432
    • Fehlings, M.G.1
  • 9
    • 0022189679 scopus 로고
    • Cervical spondylitic myelopathy
    • Ferguson R.J., Caplan L.R. Cervical spondylitic myelopathy. Neurol. Clin. 1985, 3:373-382.
    • (1985) Neurol. Clin. , vol.3 , pp. 373-382
    • Ferguson, R.J.1    Caplan, L.R.2
  • 10
    • 33847028065 scopus 로고    scopus 로고
    • Cervical spondylotic myelopathy due to chronic compression: the role of signal intensity changes in magnetic resonance images
    • Fernandez de Rota J.J., et al. Cervical spondylotic myelopathy due to chronic compression: the role of signal intensity changes in magnetic resonance images. J. Neurosurg. Spine 2007, 6:17-22.
    • (2007) J. Neurosurg. Spine , vol.6 , pp. 17-22
    • Fernandez de Rota, J.J.1
  • 11
    • 0021996766 scopus 로고
    • Sudden quadriplegia after a minor trauma. The role of preexisting spinal stenosis
    • Firooznia H., et al. Sudden quadriplegia after a minor trauma. The role of preexisting spinal stenosis. Surg. Neurol. 1985, 23:165-168.
    • (1985) Surg. Neurol. , vol.23 , pp. 165-168
    • Firooznia, H.1
  • 12
    • 31944432224 scopus 로고    scopus 로고
    • Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats
    • Gensel J.C., et al. Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats. J. Neurotrauma 2006, 23:36-54.
    • (2006) J. Neurotrauma , vol.23 , pp. 36-54
    • Gensel, J.C.1
  • 13
    • 0016293483 scopus 로고
    • Pathogenesis of myelopathy in cervical spondylosis
    • Gooding M.R. Pathogenesis of myelopathy in cervical spondylosis. Lancet 1974, 2:1180-1181.
    • (1974) Lancet , vol.2 , pp. 1180-1181
    • Gooding, M.R.1
  • 14
    • 0017182824 scopus 로고
    • Influence of laminectomy on the course of cervical myelopathy
    • Gorter K. Influence of laminectomy on the course of cervical myelopathy. Acta Neurochir. (Wien) 1976, 33:265-281.
    • (1976) Acta Neurochir. (Wien) , vol.33 , pp. 265-281
    • Gorter, K.1
  • 15
    • 47349084382 scopus 로고    scopus 로고
    • Xenografts of expanded primate olfactory ensheathing glia support transient behavioral recovery that is independent of serotonergic or corticospinal axonal regeneration in nude rats following spinal cord transection
    • Guest J.D., et al. Xenografts of expanded primate olfactory ensheathing glia support transient behavioral recovery that is independent of serotonergic or corticospinal axonal regeneration in nude rats following spinal cord transection. Exp. Neurol. 2008, 212:261-274.
    • (2008) Exp. Neurol. , vol.212 , pp. 261-274
    • Guest, J.D.1
  • 16
    • 33646550509 scopus 로고    scopus 로고
    • CatWalk-assisted gait analysis in the assessment of spinal cord injury
    • Hamers F.P., et al. CatWalk-assisted gait analysis in the assessment of spinal cord injury. J. Neurotrauma 2006, 23:537-548.
    • (2006) J. Neurotrauma , vol.23 , pp. 537-548
    • Hamers, F.P.1
  • 17
    • 77950671897 scopus 로고    scopus 로고
    • The role of oligodendrocytes in the molecular pathobiology and potential molecular treatment of cervical spondylotic myelopathy
    • Karadimas S.K., et al. The role of oligodendrocytes in the molecular pathobiology and potential molecular treatment of cervical spondylotic myelopathy. Curr. Med. Chem. 2010, 17:1048-1058.
    • (2010) Curr. Med. Chem. , vol.17 , pp. 1048-1058
    • Karadimas, S.K.1
  • 18
    • 76149105178 scopus 로고    scopus 로고
    • Synergistic effects of transplanted adult neural stem/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord
    • Karimi-Abdolrezaee S., et al. Synergistic effects of transplanted adult neural stem/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord. J. Neurosci. 2010, 30:1657-1676.
    • (2010) J. Neurosci. , vol.30 , pp. 1657-1676
    • Karimi-Abdolrezaee, S.1
  • 19
    • 80455164671 scopus 로고    scopus 로고
    • New experimental rabbit animal model for cervical spondylotic myelopathy
    • Klironomos G., et al. New experimental rabbit animal model for cervical spondylotic myelopathy. Spinal Cord. 2011, 49:1097-1102.
    • (2011) Spinal Cord. , vol.49 , pp. 1097-1102
    • Klironomos, G.1
  • 20
    • 14744288038 scopus 로고    scopus 로고
    • The assessment of locomotor function in spinal cord injured rats: the importance of objective analysis of coordination
    • Koopmans G.C., et al. The assessment of locomotor function in spinal cord injured rats: the importance of objective analysis of coordination. J. Neurotrauma 2005, 22:214-225.
    • (2005) J. Neurotrauma , vol.22 , pp. 214-225
    • Koopmans, G.C.1
  • 21
    • 0345517141 scopus 로고    scopus 로고
    • Analysis of gait in cervical myelopathy
    • Kuhtz-Buschbeck J.P., et al. Analysis of gait in cervical myelopathy. Gait Posture 1999, 9:184-189.
    • (1999) Gait Posture , vol.9 , pp. 184-189
    • Kuhtz-Buschbeck, J.P.1
  • 22
    • 27744519515 scopus 로고    scopus 로고
    • Effect of spinal cord injury severity on alterations of the H-reflex
    • Lee J.K., et al. Effect of spinal cord injury severity on alterations of the H-reflex. Exp. Neurol. 2005, 196:430-440.
    • (2005) Exp. Neurol. , vol.196 , pp. 430-440
    • Lee, J.K.1
  • 23
    • 62149148833 scopus 로고    scopus 로고
    • Better functional outcome of compression spinal cord injury in mice is associated with enhanced H-reflex responses
    • Lee H.J., et al. Better functional outcome of compression spinal cord injury in mice is associated with enhanced H-reflex responses. Exp. Neurol. 2009, 216:365-374.
    • (2009) Exp. Neurol. , vol.216 , pp. 365-374
    • Lee, H.J.1
  • 24
    • 84863369604 scopus 로고    scopus 로고
    • Development and characterization of a novel rat model of cervical spondylotic myelopathy: the impact of chronic cord compression on clinical, neuroanatomical, and neurophysiological outcomes
    • Lee J., et al. Development and characterization of a novel rat model of cervical spondylotic myelopathy: the impact of chronic cord compression on clinical, neuroanatomical, and neurophysiological outcomes. J. Neurotrauma. 2012, 29:1012-1027.
    • (2012) J. Neurotrauma. , vol.29 , pp. 1012-1027
    • Lee, J.1
  • 25
    • 0018893474 scopus 로고
    • Anterior surgery for cervical disc disease. Part 2: treatment of cervical spondylotic myelopathy in 32 cases
    • Lunsford L.D., et al. Anterior surgery for cervical disc disease. Part 2: treatment of cervical spondylotic myelopathy in 32 cases. J. Neurosurg. 1980, 53:12-19.
    • (1980) J. Neurosurg. , vol.53 , pp. 12-19
    • Lunsford, L.D.1
  • 26
    • 0034752225 scopus 로고    scopus 로고
    • Gait analysis of spastic walking in patients with cervical compressive myelopathy
    • Maezawa Y., et al. Gait analysis of spastic walking in patients with cervical compressive myelopathy. J. Orthop. Sci. 2001, 6:378-384.
    • (2001) J. Orthop. Sci. , vol.6 , pp. 378-384
    • Maezawa, Y.1
  • 27
    • 84875359405 scopus 로고    scopus 로고
    • Cervical spondylotic myelopathy: pathophysiology, diagnosis, and surgical techniques
    • (Epub 2011 Sep 28)
    • Mattei T.A., Goulart C.R., Milano J.B., Dutra L.P., Fasset D.R. Cervical spondylotic myelopathy: pathophysiology, diagnosis, and surgical techniques. ISRN Neurol. 2011, 2011:463729. http://dx.doi.org/10.5402/2011/463729 (Epub 2011 Sep 28).
    • (2011) ISRN Neurol. , vol.2011 , pp. 463729
    • Mattei, T.A.1    Goulart, C.R.2    Milano, J.B.3    Dutra, L.P.4    Fasset, D.R.5
  • 29
    • 0142248744 scopus 로고    scopus 로고
    • Cervical spondylotic myelopathy: make the difficult diagnosis, then refer for surgery
    • McCormick W.E., et al. Cervical spondylotic myelopathy: make the difficult diagnosis, then refer for surgery. Cleve. Clin. J. Med. 2003, 70:899-904.
    • (2003) Cleve. Clin. J. Med. , vol.70 , pp. 899-904
    • McCormick, W.E.1
  • 30
    • 0030914701 scopus 로고    scopus 로고
    • A prospective survey of the causes of non-traumatic spastic paraparesis and tetraparesis in 585 patients
    • Moore A.P., Blumhardt L.D. A prospective survey of the causes of non-traumatic spastic paraparesis and tetraparesis in 585 patients. Spinal Cord 1997, 35:361-367.
    • (1997) Spinal Cord , vol.35 , pp. 361-367
    • Moore, A.P.1    Blumhardt, L.D.2
  • 31
    • 0035369210 scopus 로고    scopus 로고
    • Correlation between operative outcomes of cervical compression myelopathy and MRI of the spinal cord
    • Morio Y., et al. Correlation between operative outcomes of cervical compression myelopathy and MRI of the spinal cord. Spine 2001, 26:1238-1245.
    • (2001) Spine , vol.26 , pp. 1238-1245
    • Morio, Y.1
  • 32
    • 0019211712 scopus 로고
    • H-reflex of the upper extremities in cervical myelopathy
    • Okamoto N., et al. H-reflex of the upper extremities in cervical myelopathy. Int. Orthop. 1980, 4:193-203.
    • (1980) Int. Orthop. , vol.4 , pp. 193-203
    • Okamoto, N.1
  • 33
    • 0036901338 scopus 로고    scopus 로고
    • Analysis of the spastic gait caused by cervical compression myelopathy
    • Suzuki E., et al. Analysis of the spastic gait caused by cervical compression myelopathy. J. Spinal Disord. Tech. 2002, 15:519-522.
    • (2002) J. Spinal Disord. Tech. , vol.15 , pp. 519-522
    • Suzuki, E.1
  • 34
    • 0028525641 scopus 로고
    • Cervical spondylotic myelopathy: a cause of gait disturbance and falls in the elderly
    • Swagerty D.L. Cervical spondylotic myelopathy: a cause of gait disturbance and falls in the elderly. Kans. Med. 1994, 95(226-7):229.
    • (1994) Kans. Med. , vol.95 , Issue.7-226 , pp. 229
    • Swagerty, D.L.1
  • 35
    • 58249096916 scopus 로고    scopus 로고
    • Expression of apoptosis signal-regulating kinase 1 in mouse spinal cord under chronic mechanical compression: possible involvement of the stress-activated mitogen-activated protein kinase pathways in spinal cord cell apoptosis
    • Takenouchi T., et al. Expression of apoptosis signal-regulating kinase 1 in mouse spinal cord under chronic mechanical compression: possible involvement of the stress-activated mitogen-activated protein kinase pathways in spinal cord cell apoptosis. Spine (Phila Pa 1976) 2008, 33:1943-1950.
    • (2008) Spine (Phila Pa 1976) , vol.33 , pp. 1943-1950
    • Takenouchi, T.1
  • 36
    • 0002311205 scopus 로고
    • Vascular factors in the myelopathy associated with cervical spondylosis
    • Taylor A.R. Vascular factors in the myelopathy associated with cervical spondylosis. Neurology 1964, 14:62-68.
    • (1964) Neurology , vol.14 , pp. 62-68
    • Taylor, A.R.1
  • 37
    • 77956341653 scopus 로고    scopus 로고
    • Diagnostic criteria of traumatic central cord syndrome. Part 2: a questionnaire survey among spine specialists
    • van Middendorp J.J., et al. Diagnostic criteria of traumatic central cord syndrome. Part 2: a questionnaire survey among spine specialists. Spinal Cord 2010, 48:657-663.
    • (2010) Spinal Cord , vol.48 , pp. 657-663
    • van Middendorp, J.J.1
  • 38
    • 0014642364 scopus 로고
    • Experimental cervical myelopathy. II. Acute ischemic myelopathy
    • Wilson C.B., et al. Experimental cervical myelopathy. II. Acute ischemic myelopathy. Arch. Neurol. 1969, 21:571-589.
    • (1969) Arch. Neurol. , vol.21 , pp. 571-589
    • Wilson, C.B.1
  • 39
    • 0036119784 scopus 로고    scopus 로고
    • Mechanism of destructive pathologic changes in the spinal cord under chronic mechanical compression
    • Yamaura I., et al. Mechanism of destructive pathologic changes in the spinal cord under chronic mechanical compression. Spine (Phila Pa 1976) 2002, 27:21-26.
    • (2002) Spine (Phila Pa 1976) , vol.27 , pp. 21-26
    • Yamaura, I.1
  • 40
    • 0034283594 scopus 로고    scopus 로고
    • Cervical spondylotic myelopathy: a common cause of spinal cord dysfunction in older persons
    • Young W.F. Cervical spondylotic myelopathy: a common cause of spinal cord dysfunction in older persons. Am. Fam. Physician 2000, 62(1064-70):1073.
    • (2000) Am. Fam. Physician , vol.62 , Issue.70-1064 , pp. 1073
    • Young, W.F.1
  • 41
    • 0023789617 scopus 로고
    • Cervical myelopathy due to ossification of the posterior longitudinal ligament. A clinical, radiological and evoked potentials study in six Chinese patients
    • Yu Y.L., et al. Cervical myelopathy due to ossification of the posterior longitudinal ligament. A clinical, radiological and evoked potentials study in six Chinese patients. Brain 1988, 111(Pt 4):769-783.
    • (1988) Brain , vol.111 PART 4 , pp. 769-783
    • Yu, Y.L.1
  • 42
    • 58249118699 scopus 로고    scopus 로고
    • Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy
    • Yu W.R., et al. Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy. Neurobiol. Dis. 2009, 33:149-163.
    • (2009) Neurobiol. Dis. , vol.33 , pp. 149-163
    • Yu, W.R.1
  • 43
    • 79957474401 scopus 로고    scopus 로고
    • Human neuropathological and animal model evidence supporting a role for Fas-mediated apoptosis and inflammation in cervical spondylotic myelopathy
    • Yu W.R., et al. Human neuropathological and animal model evidence supporting a role for Fas-mediated apoptosis and inflammation in cervical spondylotic myelopathy. Brain. 2011, 134:1277-1292.
    • (2011) Brain. , vol.134 , pp. 1277-1292
    • Yu, W.R.1
  • 44
    • 0035881467 scopus 로고    scopus 로고
    • The Torg-Pavlov ratio in cervical spondylotic myelopathy: a comparative study between patients with cervical spondylotic myelopathy and a nonspondylotic, nonmyelopathic population
    • Yue W.M., et al. The Torg-Pavlov ratio in cervical spondylotic myelopathy: a comparative study between patients with cervical spondylotic myelopathy and a nonspondylotic, nonmyelopathic population. Spine (Phila Pa 1976) 2001, 26:1760-1764.
    • (2001) Spine (Phila Pa 1976) , vol.26 , pp. 1760-1764
    • Yue, W.M.1


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