Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: A genome-wide association study of 13,372 participants

Heart Rhythm

Volumn 10, Issue 3, 2013, Pages 401-408

  Deo, R ^a   Nalls, M A ^b   Avery, C L ^c   Smith, J G ^d,e   Evans, D S ^f   Keller, M F ^b,h   Butler, A M ^c   Buxbaum, S G ⁱ   Li, G ^j   Miguel Quibrera, P ^c   Smith, E N ^k,l   Tanaka, T ^b   Akylbekova, E L ^m   Alonso, A ⁿ   Arking, D E ^o   Benjamin, E J ^p,q,r   Berenson, G S ^s   Bis, J C ^j   Chen, L Y ^t   Chen, W ^s   Cummings, S R ^f   Ellinor, P T ^g   Evans, M K ^w   Ferrucci, L ^b   Fox, E R ^m   Heckbert, S R ^x   Heiss, G ^c   Hsueh, W C ^y   Kerr, K F ^x   Limacher, M C ^z   Liu, Y ^u   Lubitz, S A ^g   Magnani, J W ^r,aa   Mehra, R ^ab   Marcus, G M ^ac   Murray, S S ^ad   Newman, A B ^ae   Njajou, O ^ac   North, K E ^c,af   Paltoo, D N ^w   Psaty, B M ^j,ag   Redline, S S ^ah   Reiner, A P ^x   Robinson, J G ^ai   Rotter, J I ^aj   Samdarshi, T E ^ak   Schnabel, R B ^al   Schork, N J ^ad   Singleton, A B ^b   Siscovick, D ^j   Soliman, E Z ^u   Sotoodehnia, N ^j   Srinivasan, S R ^s   Taylor, H A ^m   Trevisan, M ^am   Zhang, Z ^u   Zonderman, A B ^b,w   Newton Cheh, C ^e,g   Whitsel, E A ^v   more..

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c The University of North Carolina at Chapel Hill   (United States)

^d LUND UNIVERSITY   (Sweden)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

^h TEMPLE UNIVERSITY   (United States)

ⁱ JACKSON STATE UNIVERSITY   (United States)

^j UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^k UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^l UNIVERSITY OF CALIFORNIA   (United States)

^m UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

ⁿ UNIVERSITY OF MINNESOTA   (United States)

^o JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^p NHLBI's Framingham Study   (United States)

^q BOSTON UNIVERSITY   (United States)

^r BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^s TULANE UNIVERSITY   (United States)

^t UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^u WAKE FOREST SCHOOL OF MEDICINE   (United States)

^v UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^w NATIONAL INSTITUTES OF HEALTH   (United States)

^x UNIVERSITY OF WASHINGTON   (United States)

^y UNIVERSITY OF CALIFORNIA   (United States)

^z UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^aa FRAMINGHAM HEART STUDY   (United States)

^ab CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ac UNIVERSITY OF CALIFORNIA   (United States)

^ad SCRIPPS RESEARCH INSTITUTE   (United States)

^ae UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^af Carolina Center for Genome Sciences   (United States)

^ag CENTER FOR HEALTH STUDIES   (United States)

^ah BRIGHAM AND WOMEN S HOSPITAL   (United States)

^ai UNIVERSITY OF IOWA   (United States)

^aj CEDARS SINAI MEDICAL CENTER   (United States)

^ak UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^al UNIVERSITY HEART CENTER HAMBURG   (Germany)

^am CITY UNIVERSITY OF NEW YORK MEDICAL SCHOOL   (United States)

more..

Author keywords

African Americans; Heart rate; Meta analysis; Single nucleotide polymorphisms

Indexed keywords

CONNEXIN 43;

ADULT; AFRICAN AMERICAN; AGED; ALLELE; ARTICLE; CHROMOSOME 6Q; COHORT ANALYSIS; ELECTROCARDIOGRAM; EUROPEAN AMERICAN; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RR INTERVAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AFRICAN AMERICANS; AGED; ARRHYTHMIAS, CARDIAC; CONNEXIN 43; ELECTROCARDIOGRAPHY; FEMALE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEART RATE; HUMANS; MALE; META-ANALYSIS AS TOPIC; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; REST; UNITED STATES;

EID: 84875318876     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2012.11.014     Document Type: Article

References (35)

1. P. Greenland, M.L. Daviglus, and A.R. Dyer Resting heart rate is a risk factor for cardiovascular and noncardiovascular mortality: the Chicago Heart Association Detection Project in Industry Am J Epidemiol 149 1999 853 862
2. J. Nauman, T.I. Nilsen, U. Wisloff, and L.J. Vatten Combined effect of resting heart rate and physical activity on ischaemic heart disease: mortality follow-up in a population study (the HUNT study, Norway) J Epidemiol Community Health 64 2010 175 181
3. E. Kristal-Boneh, H. Silber, G. Harari, and P. Froom The association of resting heart rate with cardiovascular, cancer and all-cause mortality: eight year follow-up of 3527 male Israeli employees (the CORDIS Study) Eur Heart J 21 2000 116 124
4. M. Chang, R.J. Havlik, M.C. Corti, P.H. Chaves, L.P. Fried, and J.M. Guralnik Relation of heart rate at rest and mortality in the Women's Health and Aging Study Am J Cardiol 92 2003 1294 1299
5. X. Jouven, J.P. Empana, and S. Escolano Relation of heart rate at rest and long-term (>20 years) death rate in initially healthy middle-aged men Am J Cardiol 103 2009 279 283
6. X. Jouven, M. Zureik, M. Desnos, C. Guerot, and P. Ducimetiere Resting heart rate as a predictive risk factor for sudden death in middle-aged men Cardiovasc Res 50 2001 373 378
7. K. Fox, J.S. Borer, and A.J. Camm Resting heart rate in cardiovascular disease J Am Coll Cardiol 50 2007 823 830
8. J. Osztovits, T. Horvath, and L. Littvay Effects of genetic vs. environmental factors on cardiovascular autonomic function: a twin study Diabet Med 28 2011 1241 1248
9. M.W. Russell, I. Law, P. Sholinsky, and R.R. Fabsitz Heritability of ECG measurements in adult male twins J Electrocardiol 30 1998 64 68
10. J.P. Singh, M.G. Larson, C.J. O'Donnell, H. Tsuji, J.C. Evans, and D. Levy Heritability of heart rate variability: the Framingham Heart Study Circulation 99 1999 2251 2254
11. L.J. Martin, A.G. Comuzzie, and G.E. Sonnenberg Major quantitative trait locus for resting heart rate maps to a region on chromosome 4 Hypertension 43 2004 1146 1151
12. F. Marroni, A. Pfeufer, and Y.S. Aulchenko A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project Circ Cardiovasc Genet 2 2009 322 328
13. M. Eijgelsheim, C. Newton-Cheh, and N. Sotoodehnia Genome-wide association analysis identifies multiple loci related to resting heart rate Hum Mol Genet 19 2010 3885 3894
14. Y.S. Cho, M.J. Go, and Y.J. Kim A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits Nat Genet 41 2009 527 534
15. H. Holm, D.F. Gudbjartsson, and D.O. Arnar Several common variants modulate heart rate, PR interval and QRS duration Nat Genet 42 2010 117 122
16. A haplotype map of the human genome. Nature 2005;437:1299-1320.
17. S.A. Tishkoff, and S.M. Williams Genetic analysis of African populations: human evolution and complex disease Nat Rev Genet 3 2002 611 621
18. J.A. Tennessen, A.W. Bigham, and T.D. O'Connor Evolution and functional impact of rare coding variation from deep sequencing of human exomes Science 337 2012 64 69
19. K. Musunuru, G. Lettre, and T. Young Candidate gene association resource (CARe): design, methods, and proof of concept Circ Cardiovasc Genet 3 2010 267 275
20. A.P. Reiner, G. Lettre, and M.A. Nalls Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT) PLoS Genet 7 2011 e1002108
21. The CSE Working Party. Recommendations for measurement standards in quantitative electrocardiography. Eur Heart J 1985;6:815-825.
22. A.L. Price, N.J. Patterson, R.M. Plenge, M.E. Weinblatt, N.A. Shadick, and D. Reich Principal components analysis corrects for stratification in genome-wide association studies Nat Genet 38 2006 904 909
23. Y. Li, C. Willer, S. Sanna, and G. Abecasis Genotype imputation Annu Rev Genom Hum Genet 10 2009 387 406
24. M.H. Chen, and Q. Yang GWAF: an R package for genome-wide association analyses with family data Bioinformatics 26 2010 580 581
25. B. Devlin, and K. Roeder Genomic control for association studies Biometrics 55 1999 997 1004
26. I. Pe'er, R. Yelensky, D. Altshuler, and M.J. Daly Estimation of the multiple testing burden for genomewide association studies of nearly all common variants Genet Epidemiol 32 2008 381 385
27. D.B. Gros, and H.J. Jongsma Connexins in mammalian heart function Bioessays 18 1996 719 730
28. M.R. Boyett, S. Inada, and S. Yoo Connexins in the sinoatrial and atrioventricular nodes Adv Cardiol 42 2006 175 197
29. A. Hagendorff, B. Schumacher, S. Kirchhoff, B. Luderitz, and K. Willecke Conduction disturbances and increased atrial vulnerability in connexin40-deficient mice analyzed by transesophageal stimulation Circulation 99 1999 1508 1515
30. H. Dobrzynski, M.R. Boyett, and R.H. Anderson New insights into pacemaker activity: promoting understanding of sick sinus syndrome Circulation 115 2007 1921 1932
31. O. Harismendy, D. Notani, and X. Song 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response Nature 470 2011 264 268
32. T.E. Callis, K. Pandya, and H.Y. Seok Microrna-208a is a regulator of cardiac hypertrophy and conduction in mice J Clin Invest 119 2009 2772 2786
33. A.M. Simon, D.A. Goodenough, and D.L. Paul Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block Curr Biol 8 1998 295 298
34. Holm H, Gudbjartsson DF, Sulem P, et al. A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Nat Genet 2011;43:316-320.
35. N.A. Rosenberg, L. Huang, E.M. Jewett, Z.A. Szpiech, I. Jankovic, and M. Boehnke Genome-wide association studies in diverse populations Nat Rev Genet 11 2010 356 366