Nuclear α1-antichymotrypsin promotes chromatin condensation and inhibits proliferation of human hepatocellular carcinoma cells

Gastroenterology

Volumn 144, Issue 4, 2013, Pages

  Santamaria, Mónica ^a   Pardo Saganta, Ana ^a   Alvarez Asiain, Laura ^a   Di Scala, Marianna ^a   Qian, Cheng ^b   Prieto, Jesús ^a,c   Avila, Matías A ^a,c  

^a UNIVERSITY OF NAVARRA   (Spain)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

DNA Binding; Liver Cancer; Mouse Model; Nuclear Factor

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; AMINO ACID; LENTIVIRUS VECTOR; MESSENGER RNA; ONCOSTATIN M;

ADENO ASSOCIATED VIRUS; ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CARCINOMA CELL; CELL CULTURE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CELL STRAIN HEPG2; CHROMATIN CONDENSATION; CONTROLLED STUDY; IN VITRO STUDY; LIVER CELL; LIVER CELL CARCINOMA; LIVER REGENERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; RNA INTERFERENCE;

EID: 84875276894     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.12.029     Document Type: Article

References (70)

1. C.G. Gabay, I. Kushner Acute-phase proteins and other systemic responses to inflammation N Engl J Med 340 1999 448 454
2. H. Moshage Cytokines and the hepatic acute phase response J Pathol 181 1997 257 266
3. J. Milland, A. Tsykin, T. Thomas Gene expression in regenerating and acute-phase rat liver Am J Physiol Gastrointest Liver Physiol 259 1990 G340 G347
4. M. Scotté, S. Masson, S. Lyoumi Cytokine gene expression in liver following minor or major hepatectomy Cytokine 9 1997 859 867
5. F. Kimura, M. Miyazaki, T. Suwa Increased serum interleukin-6 level and reduction of hepatic acute-phase response after major hepatectomy Eur Surg Res 28 1996 96 103
6. D. Bernuau, E. Rogier, A. Moreau Inhibitory effect of the acute inflammatory reaction on liver regeneration after partial hepatectomy in the rat Gastroenterology 90 1986 268 273
7. S.A. Jensen Liver gene regulation in rats following both 70 or 90% hepatectomy and endotoxin treatment J Gastroenterol Hepatol 26 2001 525 530
8. U. Dierssen, N. Beraza, H.H. Lutz Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration J Biol Chem 283 2008 9886 9895
9. K. Kusashio, H. Shimizu, F. Kimura Effect of excessive acute-phase response on liver regeneration after partial hepatectomy in rats Hepatogastroenterology 56 2009 824 828
10. Y. Wang, J. Ripperger, G.H. Fey Modulation of hepatic acute phase gene expression by epidermal growth factor and src protein tyrosine kinases in murine and human hepatic cells Hepatology 30 1999 682 697
11. A. Pardo-Saganta, M.U. Latasa, J. Castillo The EGFR ligand amphiregulin is a negative regulator of hepatic acute phase gene expression J Hepatol 51 2009 1010 1020
12. M.I. Guillén, M.J. Gómez-Lechón, T. Nakamura The hepatocyte growth factor regulates the synthesis of acute-phase proteins in human hepatocytes: divergent effect on interleukin-6-stimulated genes Hepatology 23 1996 1345 1352
13. H. Kim, H. Baumann Dual signalling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells Mol Cell Biol 19 1999 5326 5338
14. C. Berasain, E.R. García-Trevijano, J. Castillo Amphiregulin: an early trigger for liver regeneration in mice Gastroenterology 128 2005 424 432
15. C. Baker, O. Belbin, N. Kalsheker SERPINA3 (aka alpha-1-antichymotrypsin) Front Biosci 12 2007 2821 2835
16. N. Naidoo, B.S. Cooperman, Z. Wang Identification of lysines within α1-antichymotrypsin important for DNA binding J Biol Chem 270 1995 14548 14555
17. K. Rothbarth, T. Kempf, B. Juodka Intracellular location and nuclear targeting of the Spi-1, Spi-2 and Spi-3 gene-derived serine protease inhibitors in non-secretory cells Eur J Cell Biol 80 2001 341 348
18. J. Cichy, J. Potema, R.K. Chawla Stimulatory effect of inflammatory cytokines on α1-antichymotrypsin expression in human lung-derived epithelial cells J Clin Invest 95 1995 2729 2733
19. K.M. Wagstaff, H. Sivakumaran, S.M. Heaton Ivermectin is a specific inhibitor of importin a/b-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus Biochem J 443 2012 851 856
20. T. Kinoshita, A. Miyajima Cytokine regulation of liver development Biochim Biophys Acta 1592 2002 303 312
21. P. Klausen, L. Pedersen, J. Jurlander Oncostatin M and interleukin 6 inhibit cell cycle progression by prevention of p27kip1 degradation in HepG2 cells Oncogene 19 2000 3675 3683
22. H. Rubin, Z. Wang, E.B. Nickbarg Cloning, expression, purification, and biological activity of recombinant native and variant human α1- antichymotrypsins J Biol Chem 265 1990 1199 1207
23. A. Kamiya, T. Kinoshita, Y. Ito Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer EMBO J 18 1999 2127 2136
24. M. Tsuda, M. Masuyama, T. Katsunuma Inhibition of human DNA polymerase a by α1-antichymotrypsin Cancer Res 46 1986 6139 6142
25. S. Takada, M. Tsuda, M. Yamamura Effect of alpha-1-antichymotrypsin on activity of DNA primase isolated from human stomach adenocarcinoma cells Biochem Biophys Res Commun 16 1988 949 954
26. D.C. Crowther, L.C. Serpell, T.R. Dafforn Nucleation of α1-antichymotrypsin polymerization Biochemistry 42 2003 2355 2363
27. A.J. Bannister, T. Kouzarides Regulation of chromatin by histone modifications Cell Res 21 2011 381 395
28. C. Schöfer, K. Weipoltschammer Gene dynamics and nuclear architecture during differentiation Differentiation 76 2008 41 56
29. S.A. Grigoryev, T. Nikitina, J.R. Pehrson Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence J Cell Sci 117 2004 6153 6162
30. J.S. Rawlings, M. Gatzka, P.G. Thomas Chromatin condensation via the condensing II complex is required for peripheral T-cell quiescence EMBO J 30 2011 263 276
31. P. Trojer, D. Reinberg Facultative heterochromatin: is there a distinctive molecular signature? Mol Cell 28 2007 1 13
32. G. Gerlitz, M. Bustin Efficient cell migration requires global chromatin condensation J Cell Sci 123 2010 2207 2217
33. M. Tsuda, Y. Umezawa, M. Masuyama Effect of alpha-1-antichymotrypsin on DNA synthesis in permeabilized human cells Biochem Biophys Res Commun 144 1987 409 414
34. J. Migdall-Wilson, C. Batas, J. Schlegel Prolonged exposure to a mer ligand in leukemia: Gas6 favors expression of a partial mer glycoform and reveals a novel role for mer in the nucleus PLoS One 7 2012 e31635
35. N. Li, A. Zoubeidi, E. Beraldi GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer Oncogene 2012 [Epub ahead of print]
36. M. Surjit, S. Jameel, S.K. Lal Cytoplasmic localization of the ORF2 protein of hepatitis E virus is dependent on its ability to undergo retrotranslocation from the endoplasmic reticulum J Virol 81 2007 3339 3345
37. N. Afshar, B.E. Black, B.M. Paschal Retrotranslocation of the chaperone calreticulin from the endoplasmic reticulum lumen to the cytosol Mol Cell Biol 25 2005 8844 8853
38. J. Adams The proteasome: structure, function, and role in the cell Cancer Treat Revs 29 2003 3 9
39. C.L. Fisher, A.G. Fisher Chromatin states in pluripotent, differentiated, and reprogrammed cells Curr Opin Genet Dev 21 2011 140 148
40. B. Zhang, J.G. Abreu, K. Zhou Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family Proc Natl Acad Sci U S A 107 2010 6900 6905
41. M. Benchabane, C. Saint-Jore-Dupas, L. Faye Nucleocytoplasmic transit of human a1-antichymotrypsin in tobacco leaf epidermal cells Plant Biotechnol J 7 2009 161 171
42. C. Addison, J.R. Jenkins, H.W. Stürzbecher The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif Oncogene 5 1990 423 426
43. M.T. Hayashi, H. Masukata Regulation of DNA replication by chromatin structures: accessibility and recruitment Chromosoma 120 2011 39 46
44. G. Mazzotti, P. Gobbi, L. Manzoli Nuclear morphology during the S phase Microscopy Res Tech 40 1998 418 431
45. R. Centore, C.G. Havens, A.L. Manning CRL4cdt2-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase Mol Cell 40 2010 22 33
46. Y. Zhang, M. Cooke, S. Panjwani Histone H1 depletion impairs embryonic stem cell differentiation PLoS Genet 8 2012 e1002691
47. E.M. Springhetti, N.E. Istomina, J.C. Whisstock Role of the M-loop and reactive center loop domains in the folding and bringing of nucleosome arrays by MENT J Biol Chem 278 2003 43384 43393
48. J.A. Irving, S.S. Shushanov, R.N. Pike Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation J Biol Chem 277 2002 13192 13201
49. Y. Wang, H. Jiang, D. Dai Alpha 1 antichymotrypsin is aberrantly expressed during melanoma progression and predicts poor survival for patients with metastatic melanoma Pigment Cell Melanoma Res 23 2010 575 578
50. J.N. Kloth, A. Gorter, G.J. Fleuren Elevated expression of SerpinA1 and SerpinA3 in HLA-positive cervical carcinoma J Pathol 215 2008 222 230
51. M.H. Chapman, R. Tidswell, J.S. Dooley Whole genome RNA expression profiling of endoscopic biliary brushings provides data suitable for biomarker discovery in cholangiocarcinoma J Hepatol 56 2012 877 885
52. F. Blanchard, E. Tracy, J. Smith DNA methylation controls the responsiveness of hepatoma cells to leukemia inhibitory factor Hepatology 38 2003 1516 1528
53. A. Pardo-Saganta, M.U. Latasa, J. Castillo The EGFR ligand amphiregulin is a negative regulator of hepatic acute phase gene expression J Hepatol 51 2009 1010 1020
54. J. Castillo, E. Erroba, M.J. Perugorría Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells Cancer Res 66 2006 6129 6138
55. C. Berasain, E.R. García-Trevijano, J. Castillo Amphiregulin: an early trigger for liver regeneration in mice Gastroenterology 128 2005 424 432
56. J.S. Rawlings, M. Gatzka, P.G. Thomas Chromatin condensation via the condensing II complex is required for peripheral T-cell quiescence EMBO J 30 2011 263 276
57. M. Niepmann, J. Zheng Discontinuous native protein gel electrophoresis Electrophoresis 27 2006 3949 3951
58. T.R. Dafforn, R.N. Pike, S.P. Bottomley Physical characterization of serpin conformations Methods 32 2004 150 158
59. J. Méndez, B. Stillman Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis Mol Cell Biol 20 2000 8602 8612
60. V.S. Thakur, K. Gupta, S. Gupta Green tea polyphenols cause cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases Carcinogenesis 3 2012 377 384
61. S.A. Grigoryev, J. Bednar, C.L. Woodcock MENT, a heterochromatin protein that mediates higher order chromatin folding, is a new serpin family member J Biol Chem 274 1999 5626 5636
62. G. Gerlitz, M. Bustin Efficient cell migration requires global chromatin condensation J Cell Sci 123 2010 2207 2217
63. M. Zabala, L. Wang, R. Hernandez-Alcoceba Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors Cancer Res 64 2004 2799 2804
64. A. Pañeda, L. Vanrell, I. Mauleon Effect of adeno-associated virus serotype and genomic structure on liver transduction and biodistribution in mice of both genders Hum Gene Ther 20 2009 908 917
65. J.C. Rain, L. Selig, H.D. Reuse The protein-protein interaction map of Helicobacter pylori Nature 2001 211 215
66. E.K. Tung, C.K. Mak, S. Fatima Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma Liver Int 31 2011 1494 1504
67. S. Roessler, H.L. Jia, A. Budhu A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients Cancer Res 70 2010 10202 10212
68. H.L. Jia, Q.H. Ye, L.X. Qin Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma Clin Cancer Res 13 2007 1133 1139
69. Q.H. Ye, L.X. Qin, M. Forgues Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning Nat Med 9 2003 416 423
70. J.S. Lee, J. Heo, L. Libbrecht A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells Nat Med 12 2006 410 416