The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression

Journal of Hepatology

Volumn 51, Issue 6, 2009, Pages 1010-1020

  Pardo Saganta, Ana ^a   Latasa, Maria Ujue ^a   Castillo, Josefa ^a   Alvarez Asiain, Laura ^a   Perugorría, María J ^a   Sarobe, Pablo ^a   Rodriguez Ortigosa, Carlos M ^a   Prieto, Jesús ^a,b   Berasain, Carmen ^a   Santamaría, Mónica ^a   Avila, Matías A ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Acute phase proteins; Amphiregulin; Liver regeneration; Oncostatin

Indexed keywords

ACUTE PHASE PROTEIN; AMPHIREGULIN; EPIDERMAL GROWTH FACTOR RECEPTOR; INTERLEUKIN 6; ONCOSTATIN M; STAT3 PROTEIN;

ACUTE PHASE RESPONSE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFLAMMATION; LIVER; LIVER CELL; LIVER CELL CARCINOMA; LIVER CELL CULTURE; LIVER REGENERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACUTE-PHASE PROTEINS; ACUTE-PHASE REACTION; ALPHA 1-ANTICHYMOTRYPSIN; ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; DNA PRIMERS; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HEPATOCYTES; HUMANS; INFLAMMATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; LIPOPOLYSACCHARIDES; LIVER; LIVER REGENERATION; MALE; MICE; MICE, KNOCKOUT; ONCOSTATIN M; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 71549138697     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2009.06.030     Document Type: Article

References (38)

1. Baumann H., and Gauldie J. The acute phase response. Immunol Today 15 (1994) 74-80
2. Gabay C.G., and Kushner I. Acute-phase proteins and other systemic responses to inflammation. New Engl J Med 340 (1999) 448-454
3. Moshage H. Cytokines and the hepatic acute phase response. J Pathol 181 (1997) 257-266
4. Streetz K.L., Wüstefeld T., Klein C., Manns M.P., and Trautwein C. Mediators of inflammation and acute phase response in the liver. Cell Mol Biol (Noysi-le-grand) 47 (2001) 661-673
5. Poli V. The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J Biol Chem 273 (1998) 29279-29282
6. Alonzi T., Maritano D., Gorgoni B., Rizzuto G., Libert C., and Poli V. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene activation in the liver. Mol Cell Biol 21 (2001) 1621-1632
7. Heinrich P.C., Behrmann I., Haan S., Hermanns H.M., Müller-Newen G., and Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374 (2003) 1-20
8. Tanaka M., Miyajima A., and Oncostatin M. A multifunctional cytokine. Rev Physiol Biochem Pharmacol 149 (2003) 39-52
9. Kordula T., Rydel R.E., Brigham E.F., Horn F., Heinrich P.C., and Travis J. Oncostatin M and the interleukin-6 and soluble interleukin-6 receptor complex regulate α1-antichymotrypsin expression in human cortical astrocytes. J Biol Chem 273 (1998) 4112-4118
10. Kim H., and Baumann H. Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells. Mol Cell Biol 19 (1999) 5326-5338
11. Kino T., Rice K.C., and Chrousos G.P. The PPARδ agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition. Eur J Clin Invest 37 (2007) 425-433
12. Milland J., Tsykin A., Thomas T., Aldred A.R., Cole T., and Schreiber G. Gene expression in regenerating and acute-phase rat liver. Am J Physiol Gastrointest Liver Physiol 259 (1990) G340-G347
13. Scotté M., Masson S., Lyoumi S., Hiron M., Ténière P., Lebreton J.P., et al. Cytokine gene expression in liver following minor or major hepatectomy. Cytokine 9 (1997) 859-867
14. Kimura F., Miyazaki M., Suwa T., Kaizaki S., Itoh H., Kaiho T., et al. Increased serum interleukin-6 level and reduction of hepatic acute-phase response after major hepatectomy. Eur Surg Res 28 (1996) 96-103
15. Bernuau D., Rogier E., Moreau A., Bernuau J., and Feldmann G. Inhibitory effect of the acute inflammatory reaction on liver regeneration after partial hepatectomy in the rat. Gastroenterology 90 (1986) 268-273
16. Dierssen U., Beraza N., Lutz H.H., Liedtke C., Ernst M., Wasmuth H.E., et al. Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration. J Biol Chem 283 (2008) 9886-9895
17. Fausto N., Campbell J.S., and Riehle K.J. Liver regeneration. Hepatology 43 (2006) S45-S53
18. Michalopoulos G.K. Liver regeneration. J Cell Physiol 213 (2007) 286-300
19. Guillén M.I., Gómez-Lechón M.J., Nakamura T., and Castell J.V. The hepatocyte growth factor regulates the synthesis of acute-phase proteins in human hepatocytes: divergent effect on interleukin-6-stimulated genes. Hepatology 23 (1996) 1345-1352
20. Bereta J., Szuba K., Fiers W., Gauldie J., and Koj A. Transforming growth factor-beta and epidermal growth factor modulate basal and interleukin-6 induced amino acid uptake and acute phase protein synthesis in cultured rat hepatocytes. FEBS Lett 266 (1990) 48-50
21. Wang Y., Ripperger J., Fey G.H., Samols D., Kordula T., Wetzler M., et al. Modulation of hepatic acute phase gene expression by epidermal growth factor and src protein tyrosine kinases in murine and human hepatic cells. Hepatology 30 (1999) 682-697
22. Berasain C., Castillo J., Prieto J., and Avila M.A. New molecular targets for hepatocellular carcinoma: the ErbB1 signaling system. Liver Int 27 (2007) 174-185
23. Berasain C., García-Trevijano E.R., Castillo J., Erroba E., Lee D.C., Prieto J., et al. Amphiregulin: an early trigger for liver regeneration in mice. Gastroenterology 128 (2005) 424-432
24. Berasain C., García-Trevijano E.R., Castillo J., Erroba E., Santamaría M., Lee D.C., et al. Novel role for amphiregulin in protection from liver injury. J Biol Chem 280 (2005) 19012-19020
25. Castillo J., Erroba E., Perugorría M.J., Santamaría M., Lee D.C., Prieto J., et al. Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells. Cancer Res 66 (2006) 6129-6138
26. Wu J.C., Merlino G., and Fausto N. Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor α. Proc Natl Acad Sci USA 91 (1994) 674-678
27. Gschwind A., Hart S., Fischer O.M., and Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. EMBO J 22 (2003) 2411-2421
28. Fattori E., Cappelletti M., Costa P., Sellitto C., Cantoni L., Carelli M., et al. Defective inflammatory response in interleukin 6-deficient mice. J Exp Med 180 (1994) 1243-1250
29. Desbois-Mouthon C., Cacheux W., Blivet-Van Eggelpoël M.J., Barvu V., Fartoux L., Poupon R., et al. Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib. Int J Cancer 119 (2006) 2557-2566
30. Richards C.D., Brown T.J., Shoyab M., Baumann H., and Gauldie J. Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cell and rat primary hepatocytes in vitro. J Immunol 148 (1992) 1731-1736
31. Wang Y., Robledo O., Kinzie E., Blanchard F., Richards C., Miyajima A., et al. Receptor subunit-specific action of oncostatin M in hepatic cells and its modulation by leukemia inhibitory factor. J Biol Chem 275 (2000) 25273-25285
32. Stross C., Radtke S., Clahsen T., Gerlach C., Volkmer-Engert R., Schaper F., et al. Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism. J Biol Chem 281 (2006) 8458-8468
33. Lu W., Gong D., Bar-Sagi D., and Cole P.A. Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling. Mol Cell 8 (2001) 759-769
34. Andersson C.X., Sopasakis V.R., Wallerstedt E., and Smith U. Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes. J Biol Chem 282 (2007) 9430-9435
35. Natarajan A., Wagner B., and Sibilia M. The EGF receptor is required for efficient liver regeneration. Proc Natl Acad Sci USA 104 (2007) 17081-17086
36. Mitchell C., Nivison M., Jackson L.F., Fox R., Lee D.C., Campbell J.S., et al. Heparin-binding epidermal growth factor-like growth factor links hepatocyte priming with cell cycle progression during liver regeneration. J Biol Chem 280 (2005) 2562-2568
37. Perugorria M.J., Latasa M.U., Nicou A., Cartagena-Lirola H., Castillo J., Goñi S., et al. The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis. Hepatology 48 (2008) 1251-1261
38. Quesnelle K.M., Boehm A.L., and Grandis J.R. STAT-mediated EGFR signalling in cancer. J Cell Biochem 102 (2007) 311-319