Delayed RSV diagnosis in a stem cell transplant population due to mutations that result in negative polymerase chain reaction

Diagnostic Microbiology and Infectious Disease

Volumn 75, Issue 4, 2013, Pages 426-430

  Hawkinson, Dana ^a   Abhyankar, Sunil ^a   Aljitawi, Omar ^a   Ganguly, Siddhartha ^a   McGuirk, Joseph P ^a   Horvat, Rebecca ^b  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Hematopoietic stem cell transplant; Multiplex PCR; Respiratory syncytial virus

Indexed keywords

ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; LEVOFLOXACIN; PALIVIZUMAB; RIBAVIRIN;

ABDOMINAL DISTENSION; ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BASE PAIRING; CLINICAL ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; COMPUTER ASSISTED TOMOGRAPHY; COUGHING; DELAYED DIAGNOSIS; DYSPNEA; FALSE NEGATIVE RESULT; FEMALE; FEVER; GENE MUTATION; HUMAN; LOWER RESPIRATORY TRACT INFECTION; LUNG INFILTRATE; MALE; MULTIPLE MYELOMA; MULTIPLEX POLYMERASE CHAIN REACTION; NONHODGKIN LYMPHOMA; PLEURA EFFUSION; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY SYNCYTIAL VIRUS INFECTION; STEM CELL TRANSPLANTATION; THORAX PAIN; THORAX RADIOGRAPHY; VIRAL UPPER RESPIRATORY TRACT INFECTION; VIRUS CULTURE; VIRUS DETECTION;

AGED; CLINICAL LABORATORY TECHNIQUES; DELAYED DIAGNOSIS; FALSE NEGATIVE REACTIONS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOCOMPROMISED HOST; MALE; MULTIPLEX POLYMERASE CHAIN REACTION; POINT MUTATION; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; VIROLOGY;

EID: 84875265531     PISSN: 07328893     EISSN: 18790070     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2012.12.014     Document Type: Article

References (42)

1. Anaissie E.J., Mahfouz T.H., Aslan T., Pouli A., Desikan R., Fassas A., et al. The natural history of respiratory syncytial virus infection in cancer and transplant patients: implications for management. Blood 2004, 103:1611-1617.
2. Arens M.Q., Buller R.S., Rankin A., Mason S., Whetsell A., Agapov E., et al. Comparison of the Eragen Multi-Code Respiratory Virus Panel with conventional viral testing and real-time multiplex PCR assays for detection of respiratory viruses. J Clin Microbiol 2010, 48:2387-2395.
3. Ariza-Heredia E.J., Fishman J.E., Cleary T., Smith L., Razonable R.R., Abbo L. Clinical and radiological features of respiratory syncytial virus in solid organ transplant recipients: a single-center experience. Transpl Infect Dis 2012, 14:64-71.
4. Avetisyan G., Mattsson J., Sparrelid E., Ljungman P. Respiratory syncytial virus infection in recipients of allogeneic stem-cell transplantation: a retrospective study of the incidence, clinical features, and outcome. Transplantation 2009, 88:1222-1226.
5. Borek A.P., Clemens S.H., Gaskins V.K., Aird D.Z., Valsamakis A. Respiratory syncytial virus detection by Remel Xpect, Binax Now RSV, direct immunofluorescent staining, and tissue culture. J Clin Microbiol 2006, 44:1105-1107.
6. Bowden R.A. Respiratory virus infections after marrow transplant: the Fred Hutchinson Cancer Research Center experience 6. Am J Med 1997, 102:27-30.
7. Brittain-Long R., Nord S., Olofsson S., Westin J., Anderson L.M., Lindh M. Multiplex real-time PCR for detection of respiratory tract infections. J Clin Virol 2008, 41:53-56.
8. CDC Respiratory syncytial virus-United States, July 2007-June 2011. MMWR Morb Mortal Wkly Rep 2011, 60:1203-1206.
9. Dabisch-Ruthe M., Vollmer T., Adams O., Knabbe C., Dreier J. Comparison of three multiplex PCR assays for the detection of respiratory viral infections: evaluation of xTAG respiratory virus panel fast assay, RespiFinder 19 assay and RespiFinder SMART 22 assay. BMC Infect Dis 2012, 12:163.
10. Domingo E., Holland J.J. RNA virus mutations and fitness for survival. Annu Rev Microbiol 1997, 51:151-178.
11. Englund J.A., Anderson L.J., Rhame F.S. Nosocomial transmission of respiratory syncytial virus in immunocompromised adults. J Clin Microbiol 1991, 29:115-119.
12. Falsey A.R., Walsh E.E. Respiratory syncytial virus infection in adults. Clin Microbiol Rev 2000, 13:371-384.
13. Freymuth F., Vabret A., Cuvillon-Nimal D., Simon S., Dina J., Legrand L., et al. Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness. J Med Virol 2006, 78:1498-1504.
14. Goins W.P., Talbot H.K., Talbot T.R. Health care-acquired viral respiratory diseases. Infect Dis Clin North Am 2011, 25:227-244.
15. Hall C.B. Nosocomial respiratory syncytial virus infections: the "Cold War" has not ended. Clin Infect Dis 2000, 31:590-596.
16. Hall C.B., Walsh E.E., Long C.E., Schnabel K.C. Immunity to and frequency of reinfection with respiratory syncytial virus. J Infect Dis 1991, 163:693-698.
17. Harrington R.D., Hooton T.M., Hackman R.C., Storch G.A., Osborne B., Gleaves C.A., et al. An outbreak of respiratory syncytial virus in a bone marrow transplant center. J Infect Dis 1992, 165(6):987-993.
18. Henrickson K.J., Hall C.B. Diagnostic assays for respiratory syncytial virus disease. Pediatr Infect Dis J 2007, 26:S36-S40.
19. Hertz M.I., Englund J.A., Snover D., Bitterman P.B., McGlave P.B. Respiratory syncytial virus-induced acute lung injury in adult patients with bone marrow transplants: a clinical approach and review of the literature. Medicine (Baltimore) 1989, 68:269-281.
20. Ison M.G. Respiratory viral infections in transplant recipients. Antivir Ther 2007, 12:627-638.
21. Khanna N., Widmer A.F., Decker M., Steffen I., Halter J., Heim D., et al. Respiratory syncytial virus infection in patients with hematological diseases: single-center study and review of the literature. Clin Infect Dis 2008, 46:402-412.
22. Khushalani N.I., Bakri F.G., Wentling D., Brown K., Mohr A., Anderson B., et al. Respiratory syncytial virus infection in the late bone marrow transplant period: report of three cases and review. Bone Marrow Transplant 2001, 27:1071-1073.
23. Klungthong C., Chinnawirotpisan P., Hussem K., Phonpakobsin T., Manasatienkij W., Ajariyakhajorn C., et al. The impact of primer and probe-template mismatches on the sensitivity of pandemic influenza A/H1N1/2009 virus detection by real-time RT-PCR. J Clin Virol 2010, 48:91-95.
24. Mahony J.B. Detection of respiratory viruses by molecular methods 7. Clin Microbiol Rev 2008, 21:716-747.
25. McCarthy A.J., Kingman H.M., Kelly C., Taylor G.S., Caul E.O., Grier D., et al. The outcome of 26 patients with respiratory syncytial virus infection following allogeneic stem cell transplantation. Bone Marrow Transplant 1999, 24:1315-1322.
26. McCarthy C.A., Hall C.B. Respiratory syncytial virus: concerns and control. Pediatr Rev 2003, 24:301-309.
27. Meqdam M.M., Nasrallah G.K. Enhanced detection of respiratory syncytial virus by shell vial in children hospitalised with respiratory illnesses in northern Jordan. J Med Virol 2000, 62:518-523.
28. Miernyk K., Bulkow L., DeByle C., Chikoyak L., Hummel K.B., Hennessy T., et al. Performance of a rapid antigen test (Binax NOW(R) RSV) for diagnosis of respiratory syncytial virus compared with real-time polymerase chain reaction in a pediatric population. J Clin Virol 2011, 50:240-243.
29. Mullooly J.P., Bridges C.B., Thompson W.W., Chen J., Weintraub E., Jackson L.A., et al. Influenza- and RSV-associated hospitalizations among adults. Vaccine 2007, 25:846-855.
30. Murata Y., Falsey A.R. Respiratory syncytial virus infection in adults. Antivir Ther 2007, 12:659-670.
31. Pabbaraju K., Wong S., Tokaryk K.L., Fonseca K., Drews S.J. Comparison of the Luminex xTAG respiratory viral panel with xTAG respiratory viral panel fast for diagnosis of respiratory virus infections. J Clin Microbiol 2011, 49:1738-1744.
32. Principi N., Esposito S. Antigen-based assays for the identification of influenza virus and respiratory syncytial virus: why and how to use them in pediatric practice. Clin Lab Med 2009, 29:649-660.
33. Rheem I., Park J., Kim T.H., Kim J.W. Evaluation of a multiplex real-time PCR assay for the detection of respiratory viruses in clinical specimens. Ann Lab Med 2012, 32:399-406.
34. Schiffer J.T., Kirby K., Sandmaier B., Storb R., Corey L., Boeckh M. Timing and severity of community acquired respiratory virus infections after myeloablative versus non-myeloablative hematopoietic stem cell transplantation. Haematologica 2009, 94:1101-1108.
35. Shah J.N., Chemaly R.F. Management of RSV infections in adult recipients of hematopoietic stem cell transplantation. Blood 2011, 117:2755-2763.
36. Simon-Loriere E., Holmes E.C. Why do RNA viruses recombine?. Nat Rev Microbiol 2011, 9:617-626.
37. Sommer C., Resch B., Simoes E.A. Risk factors for severe respiratory syncytial virus lower respiratory tract infection. Open Microbiol J 2011, 5:144-154.
38. Sullender W.M. Respiratory syncytial virus genetic and antigenic diversity. Clin Microbiol Rev 2000, 13:1-15. table.
39. Templeton K.E., Forde C.B., Loon A.M., Claas E.C., Niesters H.G., Wallace P., et al. A multi-centre pilot proficiency programme to assess the quality of molecular detection of respiratory viruses. J Clin Virol 2006, 35:51-58.
40. Thompson W.W., Shay D.K., Weintraub E., Brammer L., Cox N., Anderson L.J., et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003, 289:179-186.
41. Walsh E.E. Respiratory syncytial virus infection in adults. Semin Respir Crit Care Med 2011, 32:423-432.
42. Whimbey E., Champlin R.E., Couch R.B., Englund J.A., Goodrich J.M., Raad I., et al. Community respiratory virus infections among hospitalized adult bone marrow transplant recipients 8. Clin Infect Dis 1996, 22:778-782.