Clinical and radiological features of respiratory syncytial virus in solid organ transplant recipients: A single-center experience

Transplant Infectious Disease

Volumn 14, Issue 1, 2012, Pages 64-71

  Ariza Heredia, E J ^a   Fishman, J E ^b   Cleary, T ^b   Smith, L ^c   Razonable, R R ^a   Abbo, L ^b,c  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c JACKSON MEMORIAL HOSPITAL   (United States)

Author keywords

Radiological; Respiratory syncytical virus; Ribavirin; RSV; Solid organ transplantation

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; PALIVIZUMAB; RIBAVIRIN; VIRUS ANTIGEN;

ADOLESCENT; ADULT; AGED; ANTIGEN DETECTION; ANTIVIRAL THERAPY; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; COUGHING; DIARRHEA; DYSPNEA; FEMALE; FEVER; GRAFT RECIPIENT; HOSPITALIZATION; HUMAN; HYPOXEMIA; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; LOWER RESPIRATORY TRACT INFECTION; LUNG NODULE; LUNG TRANSPLANTATION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEDICAL AUDIT; MEDICAL RECORD REVIEW; MYALGIA; ORGAN TRANSPLANTATION; PLEURA EFFUSION; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL VIRUS INFECTION; RETROSPECTIVE STUDY; RHINORRHEA; SOLID ORGAN TRANSPLANTATION; THORAX RADIOGRAPHY; UPPER RESPIRATORY TRACT INFECTION; VIRUS SHEDDING; WEAKNESS; WHEEZING;

ADOLESCENT; ADULT; AGED; ANTIVIRAL AGENTS; FEMALE; FLORIDA; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; ORGAN TRANSPLANTATION; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; RESPIRATORY TRACT INFECTIONS; RETROSPECTIVE STUDIES; RIBAVIRIN; YOUNG ADULT;

EID: 84863406172     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/j.1399-3062.2011.00673.x     Document Type: Article

References (34)

1. Nair H, Nokes DJ, Gessner BD, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 2010; 375 (9725): 1545-1555.
2. Whimbey E, Champlin RE, Couch RB, et al. Community respiratory virus infections among hospitalized adult bone marrow transplant recipients. Clin Infect Dis 1996; 22 (5): 778-782.
3. Anaissie EJ, Mahfouz TH, Aslan T, et al. The natural history of respiratory syncytial virus infection in cancer and transplant patients: implications for management. Blood 2004; 103 (5): 1611-1617.
4. Champlin RE, Whimbey E. Community respiratory virus infections in bone marrow transplant recipients: the M.D. Anderson Cancer Center experience. Biol Blood Marrow Transplant 2001; 7 (Suppl l): 8S-10S.
5. Ghosh S, Champlin RE, Englund J, et al. Respiratory syncytial virus upper respiratory tract illnesses in adult blood and marrow transplant recipients: combination therapy with aerosolized ribavirin and intravenous immunoglobulin. Bone Marrow Transplant 2000; 25 (7): 751-755.
6. Krinzman S, Basgoz N, Kradin R, et al. Respiratory syncytial virus-associated infections in adult recipients of solid organ transplants. J Heart Lung Transplant 1998; 17 (2): 202-210.
7. Uckay I, Gasche-Soccal PM, Kaiser L, et al. Low incidence of severe respiratory syncytial virus infections in lung transplant recipients despite the absence of specific therapy. J Heart Lung Transplant 2010; 29 (3): 299-305.
8. Ison MG, Michaels MG. RNA respiratory viral infections in solid organ transplant recipients. Am J Transplant 2009; 9 (Suppl 4): S166-S172.
9. Chakinala MM, Walter MJ. Community acquired respiratory viral infections after lung transplantation: clinical features and long-term consequences. Semin Thorac Cardiovasc Surg 2004; 16 (4): 342-349.
10. Centers for Disease Control and Prevention. Respiratory syncytial virus activity - United States, July 2007-December 2008. MMWR Morb Mortal Wkly Rep 2008; 57 (50): 1355-1358.
11. Bauman J, Eggleston M, Oquist N, Malinoski F. Respiratory syncytial virus: seasonal data for regions of Florida and implications for palivizumab. South Med J 2007; 100 (7): 669-676.
12. Milstone AP, Brumble LM, Barnes J, et al. A single-season prospective study of respiratory viral infections in lung transplant recipients. Eur Respir J 2006; 28 (1): 131-137.
13. McCurdy LH, Milstone A, Dummer S. Clinical features and outcomes of paramyxoviral infection in lung transplant recipients treated with ribavirin. J Heart Lung Transplant 2003; 22 (7): 745-753.
14. El Saleeby CM, Somes GW, DeVincenzo JP, Gaur AH. Risk factors for severe respiratory syncytial virus disease in children with cancer: the importance of lymphopenia and young age. Pediatrics 2008; 121 (2): 235-243.
15. Lopez-Medrano F, Aguado JM, Lizasoain M, et al. Clinical implications of respiratory virus infections in solid organ transplant recipients: a prospective study. Transplantation 2007; 84 (7): 851-856.
16. Soccal PM, Aubert JD, Bridevaux PO, et al. Upper and lower respiratory tract viral infections and acute graft rejection in lung transplant recipients. Clin Infect Dis 2010; 51 (2): 163-170.
17. Kumar D, Erdman D, Keshavjee S, et al. Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant. Am J Transplant 2005; 5 (8): 2031-2036.
18. Khanna N, Widmer AF, Decker M, et al. Respiratory syncytial virus infection in patients with hematological diseases: single-center study and review of the literature. Clin Infect Dis 2008; 46 (3): 402-412.
19. Casiano-Colon AE, Hulbert BB, Mayer TK, Walsh EE, Falsey AR. Lack of sensitivity of rapid antigen tests for the diagnosis of respiratory syncytial virus infection in adults. J Clin Virol 2003; 28 (2): 169-174.
20. Hall CB, Long CE, Schnabel KC. Respiratory syncytial virus infections in previously healthy working adults. Clin Infect Dis 2001; 33 (6): 792-796.
21. Leekha S, Zitterkopf NL, Espy MJ, Smith TF, Thompson RL, Sampathkumar P. Duration of influenza A virus shedding in hospitalized patients and implications for infection control. Infect Control Hosp Epidemiol 2007; 28 (9): 1071-1076.
22. Franquet T, Rodriguez S, Martino R, Gimenez A, Salinas T, Hidalgo A. Thin-section CT findings in hematopoietic stem cell transplantation recipients with respiratory virus pneumonia. AJR Am J Roentgenol 2006; 187 (4): 1085-1090.
23. Ko JP, Shepard JA, Sproule MW, et al. CT manifestations of respiratory syncytial virus infection in lung transplant recipients. J Comput Assist Tomogr 2000; 24 (2): 235-241.
24. Ison MG, Hayden FG. Viral infections in immunocompromised patients: what's new with respiratory viruses? Curr Opin Infect Dis 2002; 15 (4): 355-367.
25. Avetisyan G, Mattsson J, Sparrelid E, Ljungman P. Respiratory syncytial virus infection in recipients of allogeneic stem-cell transplantation: a retrospective study of the incidence, clinical features, and outcome. Transplantation 2009; 88 (10): 1222-1226.
26. Palmer SM Jr, Henshaw NG, Howell DN, Miller SE, Davis RD, Tapson VF. Community respiratory viral infection in adult lung transplant recipients. Chest 1998; 113 (4): 944-950.
27. Dykewicz CA. Summary of the guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. Clin Infect Dis 2001; 33 (2): 139-144.
28. Ison MG. Respiratory viral infections in transplant recipients. Antivir Ther 2007; 12 (4 Pt B): 627-638.
29. Liu V, Dhillon GS, Weill D. A multi-drug regimen for respiratory syncytial virus and parainfluenza virus infections in adult lung and heart-lung transplant recipients. Transpl Infect Dis 2010; 12 (1): 38-44.
30. Black CP. Systematic review of the biology and medical management of respiratory syncytial virus infection. Respir Care 2003; 48 (3): 209-231; discussion: 231-233.
31. Glanville AR, Scott AI, Morton JM, et al. Intravenous ribavirin is a safe and cost-effective treatment for respiratory syncytial virus infection after lung transplantation. J Heart Lung Transplant 2005; 24 (12): 2114-2119.
32. Pelaez A, Lyon GM, Force SD, et al. Efficacy of oral ribavirin in lung transplant patients with respiratory syncytial virus lower respiratory tract infection. J Heart Lung Transplant 2009; 28 (1): 67-71.
33. Singhal S, Muir DA, Ratcliffe DA, et al. Respiratory viruses in adult liver transplant recipients. Transplantation 1999; 68 (7): 981-984.
34. Morales R, Kirkpatrick M, Browne B, Emovon O. Respiratory syncytial virus pneumonia in an adult renal transplant patient: an unexpected nosocomial infection. Infect Control Hosp Epidemiol 2003; 24 (7): 548-550.