Identification of novel HLA-A 0201-restricted cytotoxic T lymphocyte epitopes from Zinc Transporter 8

Vaccine

Volumn 31, Issue 12, 2013, Pages 1610-1615

  Li, Shufa ^a,b   Li, Haiying ^b   Chen, Bing ^c   Lu, Debin ^c   Deng, Wuquan ^c   Jiang, Youzhao ^c   Zhou, Zhongqi ^d   Yang, Zhao ^a  

^a LINYI PEOPLE'S HOSPITAL   (China)

^b The First Municipal Hospital of Guiyang City   (China)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

^d People's Hospital of Linyi City   (China)

Author keywords

0201; Cytotoxic T lymphocyte; Epitopes; HLA A; Zinc Transporter 8

Indexed keywords

EPITOPE; HLA A ANTIGEN; UNCLASSIFIED DRUG; ZINC TRANSPORTER; ZINC TRANSPORTER 8;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; CATION TRANSPORT PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; DIABETES MELLITUS, TYPE 1; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; HLA-A2 ANTIGEN; HUMANS; MICE; MICE, TRANSGENIC; PEPTIDES;

EID: 84875259796     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2012.12.008     Document Type: Article

References (39)

1. Li X., Liao L., Yan X., Huang G., Lin J., Lei M., et al. Protective effects of 1-alpha-hydroxyvitamin D3 on residual beta-cell function in patients with adult-onset latent autoimmune diabetes (LADA). Diabetes Metab Res Rev 2009, 25(July (5)):411-416.
2. Pechhold K., Koczwara K., Zhu X., Harrison V.S., Walker G., Lee J., et al. Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice. PLoS ONE 2009, 4(3):e4827.
3. Madec A.M., Mallone R., Afonso G., Abou Mrad E., Mesnier A., Eljaafari A., et al. Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells. Diabetologia 2009, 52(July (7)):1391-1399.
4. + T cells and can be reversed by non-depleting antibodies targeting both T cell populations. Rev Diabet Stud 2009, 6(2):97-103.
5. + T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes. Diabetologia 2009, 52(July (7)):1381-1390.
6. + cytotoxic T lymphocyte responses in wild-type and MHC II gene knockout C57BL/6 mice and transgenic RIP-mOVA mice expressing islet beta-cell ovalbumin antigen leading to diabetes. Autoimmunity 2008, 41(November (7)):501-511.
7. Tian J., Kaufman D.L. Antigen-based therapy for the treatment of type 1 diabetes. Diabetes 2009, 58(September (9)):1939-1946.
8. Michels A.W., von Herrath M. Update: antigen-specific therapy in type 1 diabetes. Curr Opin Endocrinol Diab Obes 2011, 18(August (4)):235-240.
9. Kanazawa Y., Shimada A., Oikawa Y., Okubo Y., Tada A., Imai T., et al. Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes. J Autoimmun 2009, 32(March (2)):104-109.
10. Jasinski J.M., Eisenbarth G.S. Insulin as a primary autoantigen for type 1A diabetes. Clin Dev Immunol 2005, 12(September (3)):181-186.
11. Wijesekara N., Chimienti F., Wheeler M.B. Zinc, a regulator of islet function and glucose homeostasis. Diabetes Obes Metab 2009, 11(November (Suppl. 4)):202-214.
12. Egefjord L., Jensen J.L., Bang-Berthelsen C.H., Petersen A.B., Smidt K., Schmitz O., et al. Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?. BMC Endocr Dis 2009, 9:7.
13. Tamaki M., Fujitani Y., Uchida T., Hirose T., Kawamori R., Watada H. Downregulation of ZnT8 expression in pancreatic beta-cells of diabetic mice. Islets 2009, 1(September-October (2)):124-128.
14. Wenzlau J.M., Juhl K., Yu L., Moua O., Sarkar S.A., Gottlieb P., et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA 2007, 104(October (43)):17040-17045.
15. Wenzlau J.M., Frisch L.M., Gardner T.J., Sarkar S., Hutton J.C., Davidson H.W. Novel antigens in type 1 diabetes: the importance of ZnT8. Curr Diab Rep 2009, 9(April (2)):105-112.
16. Wenzlau J.M., Moua O., Sarkar S.A., Yu L., Rewers M., Eisenbarth G.S., et al. SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes. Ann NY Acad Sci 2008, 1150:256-259.
17. Hildesheim A., Apple R.J., Chen C.J., Wang S.S., Cheng Y.J., Klitz W., et al. Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan. J Natl Cancer Inst 2002, 94(December (23)):1780-1789.
18. Pelte C., Cherepnev G., Wang Y., Schoenemann C., Volk H.D., Kern F. Random screening of proteins for HLA-A*0201-binding nine-amino acid peptides is not sufficient for identifying CD8 T cell epitopes recognized in the context of HLA-A*0201. J Immunol 2004, 172(June (11)):6783-6789.
19. Rivoltini L., Loftus D.J., Barracchini K., Arienti F., Mazzocchi A., Biddison W.E., et al. Binding and presentation of peptides derived from melanoma antigens MART-1 and glycoprotein-100 by HLA-A2 subtypes. Implications for peptide-based immunotherapy. J Immunol 1996, 156(May (10)):3882-3891.
20. Parker K.C., Bednarek M.A., Coligan J.E. Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains. J Immunol 1994, 152(January (1)):163-175.
21. Rammensee H., Bachmann J., Emmerich N.P., Bachor O.A., Stevanovic S. SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics 1999, 50(November (3-4)):213-219.
22. Tsirogianni A., Pipi E., Soufleros K. Specificity of islet cell autoantibodies and coexistence with other organ specific autoantibodies in type 1 diabetes mellitus. Autoimmun Rev 2009, 8(July (8)):687-691.
23. Vija L., Farge D., Gautier J.F., Vexiau P., Dumitrache C., Bourgarit A., et al. Mesenchymal stem cells: stem cell therapy perspectives for type 1 diabetes. Diabetes Metab 2009, 35(April (2)):85-93.
24. Pozzilli P., Leslie R.D. New prospects for immunotherapy at diagnosis of type 1 diabetes. Diabetes Metab Res Rev 2009, 25(May (4)):299-301.
25. Wang B., Tisch R. Parameters influencing antigen-specific immunotherapy for type 1 diabetes. Immunol Res 2008, 42(1-3):246-258.
26. Faustman D.L. Immunotherapy on trial for new-onset type 1 diabetes. N Engl J Med 2008, 359(October (18)):1956-1958.
27. Chou F.C., Shieh S.J., Sytwu H.K. Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice. Eur J Immunol 2009, 39(September (9)):2403-2411.
28. Bollyky P.L., Bice J.B., Sweet I.R., Falk B.A., Gebe J.A., Clark A.E., et al. The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury. PLoS ONE 2009, 4(4):e5063.
29. Faresjo M.K., Vaarala O., Thuswaldner S., Ilonen J., Hinkkanen A., Ludvigsson J. Diminished IFN-gamma response to diabetes-associated autoantigens in children at diagnosis and during follow up of type 1 diabetes. Diabetes Metab Res Rev 2006, 22(November-December (6)):462-470.
30. Fife B.T., Guleria I., Gubbels Bupp M., Eagar T.N., Tang Q., Bour-Jordan H., et al. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. J Exp Med 2006, 203(November (12)):2737-2747.
31. Chimienti F., Devergnas S., Pattou F., Schuit F., Garcia-Cuenca R., Vandewalle B., et al. In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci 2006, 119(October (Pt 20)):4199-4206.
32. Lemaire K., Ravier M.A., Schraenen A., Creemers J.W., Van de Plas R., Granvik M., et al. Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl Acad Sci USA 2009, 106(September (35)):14872-14877.
33. Nicolson T.J., Bellomo E.A., Wijesekara N., Loder M.K., Baldwin J.M., Gyulkhandanyan A.V., et al. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes 2009, 58(September (9)):2070-2083.
34. Chimienti F., Devergnas S., Favier A., Seve M. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 2004, 53(September (9)):2330-2337.
35. Saudek F., Brogren C.H., Manohar S. Imaging the beta-cell mass: why and how. Rev Diabet Stud 2008, 5(Spring (1)):6-12.
36. Smidt K., Jessen N., Petersen A.B., Larsen A., Magnusson N., Jeppesen J.B., et al. SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress. PLoS ONE 2009, 4(5). e5684.
37. Kim I., Kang E.S., Yim Y.S., Ko S.J., Jeong S.H., Rim J.H., et al. A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion. Pharmacogenomics J 2011, 11(June (3)):191-198.
38. + T cell-recognized autoantigen in pediatric type 1 diabetes. Diabetes 2012, 61(July (7)):1779-1784.
39. Vermeulen I., Weets I., Asanghanwa M., Ruige J., Van Gaal L., Mathieu C., et al. Contribution of antibodies against IA-2beta and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age. Diabetes Care 2011, 34(August (8)):1760-1765.