Type 1 diabetes development requires both CD4+ and CD8 + T cells and can be reversed by non-depleting antibodies targeting both T cell populations

Review of Diabetic Studies

Volumn 6, Issue 2, 2009, Pages 97-103

  Phillips, Jenny M ^a   Parish, Nicole M ^a   Raine, Tim ^a   Bland, Chris ^a   Sawyer, Yvonne ^a   De La Peña, Hugo ^a   Cooke, Anne ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

aCD3 antibody; CD4+; CD8 alpha chain; CD8+; Dendritic cell; IgG2 antibody; NOD; NOD.scid; Pancreas infiltration; T cell; Type 1 diabetes

Indexed keywords

ANTIBODY; CD11B ANTIGEN; CD4 ANTIBODY; CD8BETA ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; UNCLASSIFIED DRUG; YTS 105; YTS 177;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL TYPE; CONTROLLED STUDY; DISEASE COURSE; EFFECTOR CELL; FEMALE; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS;

EID: 70349690461     PISSN: 16136071     EISSN: 16140575     Source Type: Journal    
DOI: 10.1900/RDS.2009.6.97     Document Type: Article

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