Interleukin-8 and CXCL10 expression in oral keratinocytes and fibroblasts via Toll-like receptors

Microbiology and Immunology

Volumn 57, Issue 3, 2013, Pages 198-206

  Fukui, Akiko ^a   Ohta, Kouji ^a   Nishi, Hiromi ^a   Shigeishi, Hideo ^a   Tobiume, Kei ^a   Takechi, Masaaki ^a   Kamata, Nobuyuki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Chemokine; Oral fibroblasts; Oral keratinocytes; Toll like receptor

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 8; MESSENGER RNA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST;

ARTICLE; CELL IMMORTALIZATION; CONTROLLED STUDY; FIBROBLAST; GINGIVA; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; KERATINOCYTE; MOLECULAR RECOGNITION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; TOLL LIKE RECEPTOR 1 GENE; TOLL LIKE RECEPTOR 10 GENE; TOLL LIKE RECEPTOR 2 GENE; TOLL LIKE RECEPTOR 3 GENE; TOLL LIKE RECEPTOR 4 GENE; TOLL LIKE RECEPTOR 5 GENE; TOLL LIKE RECEPTOR 6 GENE; TOLL LIKE RECEPTOR 7 GENE; TOLL LIKE RECEPTOR 8 GENE; TOLL LIKE RECEPTOR 9 GENE;

BACTERIA; CELLS, CULTURED; CHEMOKINE CXCL10; FIBROBLASTS; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-8; KERATINOCYTES; TOLL-LIKE RECEPTORS; VIRUSES;

EID: 84875251350     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/1348-0421.12022     Document Type: Article

References (32)

1. Takeda K., Akira S. (2001) Roles of Toll-like receptors in innate immune responses. Genes Cells 6: 733-42.
2. Kawai T., Akira S. (2007) Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med 13: 460-9.
3. Akira S., Hemmi H. (2003) Recognition of pathogen-associated molecular patterns by TLR family. Immunol Lett 85: 85-95.
4. Beklen A., Hukkanen M., Richardson R., Konttinen Y.T. (2008) Immunohistochemical localization of Toll-like receptors 1-10 in periodontitis. Oral Microbiol Immunol 23: 425-31.
5. Takashiba S., Takigawa M., Takahashi K., Myokai F., Nishimura F., Chihara T., Kurihara H., Nomura Y., Murayama Y. (1992) Interleukin-8 is a major neutrophil chemotactic factor derived from cultured human gingival fibroblasts stimulated with interleukin-1 beta or tumor necrosis factor alpha. Infect Immun 60: 5253-8.
6. Garlet GP., Martins W, Jr., Ferreira B.R., Milanezi CM., Silva J.S. (2003) Patterns of chemokines and chemokine receptors expression in different forms of human periodontal disease. J Periodontal Res 38: 210-7.
7. Iijima W., Ohtani H., Nakayama T., Sugawara Y., Sato E., Nagura H., Yoshie O., Sasano T. (2003) Infiltrating CD8+ T-cells in oral lichen planus predominantly express CCR5 and CXCR3 and carry respective chemokine ligands RANTES/CCL5 and IP-10/CXCL10 in their cytolytic granules: a potential self-recruiting mechanism. Am J Pathol 163: 261-8.
8. Sha Q., Truong-Tran A.Q., Plitt J.R., Beck L.A., Schleimer R.P. (2004) Activation of airway epithelial cells by Toll-like receptor agonists. Am J Respir Cell Mol Biol 31: 358-64.
9. Spurrell J.C., Wiehler S., Zaheer R.S., Sanders S.P., Proud D. (2005) Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection. Am J Physiol Lung Cell Mol Physiol 289: 85-95.
10. Otte J.M., Rosenberg I.M., Podolsky D.K. (2003) Intestinal myofibroblasts in innate immune responses of the intestine. Gastroenterology 124: 1866-78.
11. Taubman M.A., Kawai T. (2001) Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption. Crit Rev Oral Biol Med 12: 125-35.
12. Ohta K., Shigeishi H., Taki M., Nishi H., Higashikawa K., Takechi M., Kamata N. (2008) Different regulation of CXCL9, CXCL10, and CXCL11 expression induced by IFN-γ, TNF-α and IL-4 in human oral keratinocytes and fibroblasts. J Dent Res 87: 1161-5.
13. Li J., Ireland G.W., Farthing P.M., Thornhill M.H. (1996) Epidermal and oral keratinocytes are induced to produce RANTES and IL-8 by cytokine stimulation. J Invest Dermatol 106: 661-6.
14. Fujimoto R., Kamata N., Yokoyama K., Taki M., Tomonari M., Tsutsumi S., Yamanouchi H., Tomonari M., Nagayama M. (2002) Establishment of immortalized human oral keratinocytes by gene transfer of a telomerase component. J Jpn Oral Muco Membr 8: 1-8.
15. Kamata N., Fujimoto R., Tomonari M., Taki M., Nagayama M., Yasumoto S. (2004) Immortalization of human dental papilla, dental pulp, periodontal ligament cells and gingival fibroblasts by telomerase reverse transcriptase. J Oral Pathol Med 33: 417-23.
16. Akira S., Uematsu S., Takeuchi O. (2006) Pathogen recognition and innate immunity. Cell 124: 783-801.
17. Kinane D.F., Shiba H., Stathopoulou P.G., Zhao H., Lappin D.F., Singh A., Eskan M.A., Beckers S., Waigel S., Alpert B., Knudsen T.B. (2006) Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399ile are hypo-responsive to Porphyromonas gingivalis. Genes Immun 7: 190-200.
18. Mahanonda R., Sa-Ard-Iam N., Montreekachon P., Pimkhaokham A., Yongvanichit K., Fukuda M.M., Pichyangkul S. (2007) IL-8 and IDO expression by human gingival fibroblasts via TLRs. J Immunol 178: 1151-7.
19. Onishi S., Honma K., Liang S., Stathopoulou P., Kinane D., Hajishengallis G., Sharma A. (2007) Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA. Infect Immun 76: 198-205.
20. Kim Y., Jo A.R., Jang D.H., Cho Y.J., Chun J., Min B.M., Choi Y. (2011) Toll-like receptor 9 mediates oral bacteria-induced IL-8 expression in gingival epithelial cells. Immunol Cell Biol 90: 655-63, doi: 10.1038/icb.2011.85
21. Qin S., Rottman J.B., Myers P., Kassam N., Weinblatt M., Loetscher M., Koch A.E., Moser B., Mackay CR. (1998) The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest 101: 746-54.
22. Garlet G.P., Martins W. Jr., Ferreira B.R., Milanezi C.M., Silva J.S. (2003) Patterns of chemokines and chemokine receptors expression in different forms of human periodontal disease. J Periodontal Res 38: 210-7.
23. Lundberg A.M., Drexler S.K., Monaco C., Williams L.M., Sacre S.M., Feldmann M., Foxwell B.M. (2007) Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems. Blood 110: 3245-52.
24. Górska R., Gregorek H., Kowalski J., Laskus-Perendyk A., Syczewska M., Madaliński K. (2003) Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis. J Clin Periodontol 30: 1046-52.
25. Manetsch M., Seidel P., Heintz U., Che W., Hughes J.M., Ge Q., Sukkar M.B., Ammit A.J. (2012) TLR2 ligand engagement upregulates airway smooth muscle TNFα-induced cytokine production. Am J Physiol Lung Cell Mol Physiol 302: 838-45.
26. Morris G.E., Parker L.C., Ward J.R., Jones E.C., Whyte M.K., Brightling C.E., Bradding P., Dower S.K., Sabroe I. (2006) Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses. FASEB 20: 2153-5.
27. Dorn A., Ludwig R.J., Bock A., Thaci D., Hardt K., Bereiter-Hahn J Kaufmann R., Bernd A., Kippenberg (2007) Oligonucleotides suppress IL-8 in skin keratinocytes in vitro and offer anti-inflammatory properties in vivo. J Invest Dermatol 127: 846-54.
28. Proost P., Vynckier A.K., Mahieu F., Put W., Grillet B., Struyf S., Wuyts A., Opdenakker G., Van Damme J. (2003) Microbial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclear leukocytes in synergy with IFN-gamma and provide a mechanism for enhanced synovial chemokine levels in septic arthritis. Eur J Immunol 33: 3146-53.
29. Hofmann C., Dunger N., Grunwald N., Hämmerling G.J., Hoffmann P., Schölmerich J., Falk W., Obermeier F. (2010) T cell-dependent protective effects of CpG motifs of bacterial DNA in experimental colitis are mediated by CD11c+ dendritic cells. Gut 59: 1347-54.
30. Takeda K., Akira S. (2004) TLR signaling pathways. Semin Immunol 16: 3-9.
31. Li J., Kartha S., Iasvovskaia S., Tan A., Bhat R.K., Manaligod J.M., Page K., Brasier A.R., Hershenson M.B. (2002) Regulation of human airway epithelial cell IL-8 expression by MAP kinases. Am J Physiol Lung Cell Mol Physiol 283: 690-9.
32. Honda K., Taniguchi T. (2006) IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol 6: 644-58.