Respiratory syncytial virus infection and recurrent wheezing in Chilean infants: A genetic background?

Infection, Genetics and Evolution

Volumn 16, Issue , 2013, Pages 54-61

  Tapia, Lorena I ^a   Ampuero, Sandra ^a   Palomino, M Angélica ^a,b   Luchsinger, Vivian ^a   Aguilar, Nelson ^a   Ayarza, Eliana ^a   Mamani, Rossana ^a   Larrañaga, Carmen ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b HOSPITAL ROBERTO DEL RÍO   (Chile)

Author keywords

Interleukin 13; Interleukin 4; Recurrent wheezing; Respiratory syncytial virus; Respiratory tract infection; Single nucleotide polymorphism

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR ALPHA;

ACUTE DISEASE; ALLELE; ARTICLE; CHILEAN; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE SEVERITY; ETHNIC GROUP; FEMALE; FOLLOW UP; GENE; GENE FREQUENCY; GENE INTERACTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; IL13 GENE; IL4 GENE; IL4R ALPHA GENE; INFANT; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MOLECULAR MECHANICS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RECURRENT DISEASE; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY SYNCYTIAL VIRUS INFECTION; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS DETECTION; WHEEZING;

CHILE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; INFANT, NEWBORN; INTERLEUKIN-13; INTERLEUKIN-4; LONGITUDINAL STUDIES; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RESPIRATORY SOUNDS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS;

EID: 84875249669     PISSN: 15671348     EISSN: 15677257     Source Type: Journal    
DOI: 10.1016/j.meegid.2012.12.030     Document Type: Article

References (67)

1. Avendaño L.F., Larrañaga C., Palomino M.A., Gaggero A., Montaldo G., Suarez M., Diaz A. Community-and hospital-acquired respiratory syncytial virus infections in chile. Pediatr. Infect. Dis. J. 1991, 10:564-568.
2. Avendaño L.F., Palomino M.A., Larranaga C. Surveillance for respiratory syncytial virus in infants hospitalized for acute lower respiratory infection in chile (1989-2000). J. Clin. Microbiol. 2003, 41:4879-4882.
3. Battle N.C., Choudhry S., Tsai H.-J., Eng C., Kumar G., Beckman K.B., Naqvi M., Meade K., Watson H.G., Lenoir M., Burchard E.G. Ethnicity-specific gene-gene interaction between IL-13 and IL-4R alpha among african americans with asthma. Am. J. Respir. Crit. Care Med. 2007, 175:881-887.
4. Beghé B., Barton S., Rorke S., Peng Q., Sayers I., Gaunt T., Keith T.P., Clough J.B., Holgate S.T., Holloway J.W. Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a caucasian population. Clin. Exp. Allergy 2003, 33:1111-1117.
5. Berce V., Potocnik U. Association of Q551R polymorphism in the interleukin 4 receptor gene with nonatopic asthma in slovenian children. Wien. Klin. Wochenschr. 2010, 122(Suppl):11-18.
6. Bottema R.W.B., Nolte I.M., Howard T.D., Koppelman G.H., Dubois A.E.J., de Meer G., Kerkhof M., Bleecker E.R., Meyers D.A., Postma D.S. Interleukin 13 and interleukin 4 receptor-α polymorphisms in rhinitis and asthma. Int. Arch. Allergy Immunol. 2010, 153:259-267.
7. Brand P.L.P., Baraldi E., Bisgaard H., Boner A.L., Castro-Rodriguez J., Custovic A., de Blic J., de Jongste J.C., Eber E., Everard M.L., Frey U., Gappa M., Garcia-Marcos L., Grigg J., Lenney W., Le Souëf P., McKenzie S., Merkus P.J.F.M., Midulla F., Paton J.Y., Piacentini G., Pohunek P., Rossi G.A., Seddon P., Silverman M., Sly P.D., Stick S., Valiulis A., Van Aalderen W.M.C., Wildhaber J.H., Wennergren G., Wilson N., Zivkovic Z., Bush A. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur. Respir. J. 2008, 32:1096-1110.
8. Calvo C., Pozo F., García-García M.L., Sanchez M., Lopez-Valero M., Pérez-Breña P., Casas I. Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year prospective study. Acta Paediatr. 2010, 99:883-887.
9. Cane P.A., Pringle C.R. Molecular epidemiology of respiratory syncytial virus: rapid identification of subgroup a lineages. J. Virol. Methods 1992, 40:297-306.
10. Chan I.H.S., Leung T.F., Tang N.L.S., Li C.Y., Sung Y.M., Wong G.W.K., Wong C.K., Lam C.W.K. Gene-gene interactions for asthma and plasma total IgE concentration in Chinese children. J. Allergy Clin. Immunol. 2006, 117:127-133.
11. Choi E.-H., Lee H.J., Yoo T., Chanock S.J. A common haplotype of interleukin-4 gene IL4 is associated with severe respiratory syncytial virus disease in korean children. J. Infect. Dis. 2002, 186:1207-1211.
12. Chomczynski P., Sacchi N. The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on. Nat. Protocols 2006, 1:581-585.
13. Dudbridge F. Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum. Hered. 2008, 66:87-98.
14. Ermers M.J., Hoebee B., Hodemaekers H.M., Kimman T.G., Kimpen J.L.L., Bont L. IL-13 genetic polymorphism identifies children with late wheezing after respiratory syncytial virus infection. J. Allergy Clin. Immunol. 2007, 119:1086-1091.
15. Forton J.T., Rowlands K., Rockett K., Hanchard N., Herbert M., Kwiatkowski D.P., Hull J. Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster. Thorax 2009, 64:345-352.
16. Genuneit J., Cantelmo J.L., Weinmayr G., Wong G.W.K., Cooper P.J., Riikjärv M., Gotua M., Kabesch M., von Mutius E., Forastiere F., Crane J., Nystad W., El-Sharif N., Batlles-Garrido J., García-Marcos L., García-Hernández G., Morales-Suarez-Varela M., Nilsson L., Bråbäck L., Saraçlar Y., Weiland S.K., Cookson W.O.C., Strachan D., Moffatt M.F. A multi-centre study of candidate genes for wheeze and allergy: the international study of asthma and allergies in childhood phase 2. Clin. Exp. Allergy 2009, 39:1875-1888.
17. Goetghebuer T., Isles K., Moore C., Thomson A., Kwiatkowski D., Hull J. Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. Clin. Exp. Allergy 2004, 34:801-803.
18. Graves P.E., Kabesch M., Halonen M., Holberg C.J., Baldini M., Fritzsch C., Weiland S.K., Erickson R.P., von Mutius E., Martinez F.D. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J. Allergy Clin. Immunol. 2000, 105:506-513.
19. Hall C.B., Weinberg G.A., Iwane M.K., Blumkin A.K., Edwards K.M., Staat M.A., Auinger P., Griffin M.R., Poehling K.A., Erdman D., Grijalva C.G., Zhu Y., Szilagyi P. The burden of respiratory syncytial virus infection in young children. N. Engl. J. Med. 2009, 360:588-598.
20. Heinzmann A., Ahlert I., Kurz T., Berner R., Deichmann K.A. Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. J. Allergy Clin. Immunol. 2004, 114:671-676.
21. Henderson J., Hilliard T.N., Sherriff A., Stalker D., Al Shammari N., Thomas H.M. Hospitalization for RSV bronchiolitis before 12months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study. Pediatr. Allergy Immunol. 2005, 16:386-392.
22. Hesselmar B., Bergin A.-M., Park H., Hahn-Zoric M., Eriksson B., Hanson L., Padyukov L. Interleukin-4 receptor polymorphisms in asthma and allergy: relation to different disease phenotypes. Acta Paediatr. 2010, 99:399-403.
23. Hoebee B., Rietveld E., Bont L., Oosten M.V., Hodemaekers H.M., Nagelkerke N.J.D., Neijens H.J., Kimpen J.L.L., Kimman T.G. Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. J. Infect. Dis. 2003, 187:2-11.
24. Howard T.D., Koppelman G.H., Xu J., Zheng S.L., Postma D.S., Meyers D.A., Bleecker E.R. Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am. J. Hum. Genet. 2002, 70:230-236.
25. Hull J. Association of respiratory syncytial virus bronchiolitis with the interleukin eight gene region in UK families. Thorax 2000, 55:1023-1027.
26. Instituto Nacional de Estadísticas., Censo 2002, 2003. Comisión Nacional del XVII Censo de Poblaciones y VI de Vivienda. Empresa Periodística La Nación (Eds.), Santiago de Chile. pp. 1-50. http://www.ine.cl/cd2002/sintesiscensal.pdf.
27. Isidoro-García M., Dávila I., Laffond E., Moreno E., Lorente F., González-Sarmiento R. Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study. Clin. Mol. Allergy 2005, 3:15.
28. Iwane M.K., Prill M.M., Lu X., Miller E.K., Edwards K.M., Hall C.B., Griffin M.R., Staat M.A., Anderson L.J., Williams J.V., Weinberg G.A., Ali A., Szilagyi P.G., Zhu Y., Erdman D.D. Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children. J. Infect. Dis. 2011, 204:1702-1710.
29. Kabesch M., Tzotcheva I., Carr D., Höfler C., Weiland S.K., Fritzsch C., Mutius E.V., Martinez F.D. A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood. J. Allergy Clin. Immunol. 2003, 112:893-898.
30. Kelly-Welch A.E., Hanson E.M., Boothby M.R., Keegan A.D. Interleukin-4 and interleukin-13 signaling connections maps. Science 2003, 300:1527-1528.
31. Korppi M., Kotaniemi-Syrjanen A., Waris M., Vainionpaa R., Reijonen T.M. Rhinovirus-associated wheezing in infancy: comparison with respiratory syncytial virus bronchiolitis. Pediatr. Infect. Dis. J. 2004, 23:995-999.
32. Kurukulaaratchy R.J., Fenn M.H., Waterhouse L.M., Matthews S.M., Holgate S.T., Arshad S.H. Characterization of wheezing phenotypes in the first 10years of life. Clin. Exp. Allergy 2003, 33:573-578.
33. Larrañaga C., Ampuero S., Luchsinger V., Carrión F., Aguilar N., Morales P., Palomino M.A., Tapia L., Avendaño L.F. Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus. Pediatr. Infect. Dis. J. 2009, 28:867-873.
34. Lee S.-G., Kim B.-S., Kim J.-H., Lee S.-Y., Choi S.-O., Shim J.-Y., Hong T.-J., Hong S.-J. Gene-gene interaction between interleukin-4 and interleukin-4 receptor alpha in korean children with asthma. Clin. Exp. Allergy 2004, 34:1202-1208.
35. Louie J.K., Roy-Burman A., Guardia-Labar L., Boston E.J., Kiang D., Padilla T., Yagi S., Messenger S., Petru A.M., Glaser C.A., Schnurr D.P. Rhinovirus associated with severe lower respiratory tract infections in children. Pediatr. Infect. Dis. J. 2009, 28:337-339.
36. López J.A., Bustos R., Orvell C., Berois M., Arbiza J., García-Barreno B., Melero J.A. Antigenic structure of human respiratory syncytial virus fusion glycoprotein. J. Virol. 1998, 72:6922-6928.
37. Mansbach J.M., Piedra P.A., Teach S.J., Sullivan A.F., Forgey T., Clark S., Espinola J.A., Camargo C.A. Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis. Arch. Pediatr. Adolesc. Med. 2012, 166:700-706.
38. Martinez F.D., Wright A.L., Taussig L.M., Holberg C.J., Halonen M., Morgan W.J. Asthma and wheezing in the first six years of life. N. Engl. J. Med. 1995, 332:133-138.
39. Miller E.K., Bugna J., Libster R., Shepherd B.E., Scalzo P.M., Acosta P.L., Hijano D., Reynoso N., Batalle J.P., Coviello S., Klein M.I., Bauer G., Benitez A., Kleeberger S.R., Polack F.P. Human rhinoviruses in severe respiratory disease in very low birth weight infants. Pediatrics 2012, 129:e60-e67.
40. Mitsuyasu H., Yanagihara Y., Mao X.Q., Gao P.S., Arinobu Y., Ihara K., Takabayashi A., Hara T., Enomoto T., Sasaki S., Kawai M., Hamasaki N., Shirakawa T., Hopkin J.M., Izuhara K. Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis. J. Immunol. 1999, 162:1227-1231.
41. Miyairi I., DeVincenzo J.P. Human genetic factors and respiratory syncytial virus disease severity. Clin. Microbiol. Rev. 2008, 21:686-703.
42. Noble V., Murray M., Webb M.S.C., Alexander J., Swarbrick A.S., Milner A.D. Respiratory status and allergy nine to 10years after acute bronchiolitis. Arch. Dis. Child 1997, 76:315-319.
43. Palomino M.A., Larrañaga C., Villagra E., Camacho J., Avendaño L.F. Adenovirus and respiratory syncytial virus-adenovirus mixed acute lower respiratory infections in Chilean infants. Pediatr. Infect. Dis. J. 2004, 23:337-341.
44. Park B.L., Kim L.H., Choi Y.H., Lee J.-H., Rhim T., Lee Y.M., Uh S.-T., Park H.-S., Choi B.W., Hong S.-J., Park C.-S., Shin H.D. Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. J. Hum. Genet. 2004, 49:517-527.
45. Piippo-Savolainen E., Remes S., Kannisto S., Korhonen K., Korppi M. Asthma and lung function 20years After wheezing in Infancy. Arch. Pediatr. Adolesc. Med. 2004, 158:1070-1076.
46. Pullan C.R., Hey E.N. Wheezing, asthma, and pulmonary dysfunction 10years after infection with respiratory syncytial virus in infancy. BMJ 1982, 284:1665-1669.
47. Puthothu B., Krueger M., Forster J., Heinzmann A. Association between severe respiratory syncytial virus infection and IL13/IL4 haplotypes. J. Infect. Dis. 2006, 193:438-441.
48. Puthothu B., Krueger M., Heinze J., Forster J., Heinzmann A. Impact of IL8 and IL8-receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infections. Clin. Mol. Allergy 2006, 4:2.
49. Salvador García C., Moreno Docón A., Piñero J.A., Alfayate Miguelez S., Iborra Bendicho M.A. Aetiology of bronchiolitis in hospitalised children in South-East Spain. An. Pediatr. (Barc) 2011, 77:386-390.
50. Schauer U., Hoffjan S., Bittscheidt J., Kochling A., Hemmis S., Bongartz S., Stephan V. RSV bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life. Eur. Respir. J. 2002, 20:1277-1283.
51. Sigurs N., Aljassim F., Kjellman B., Robinson P.D., Sigurbergsson F., Bjarnason R., Gustafsson P.M. Asthma and allergy patterns over 18years after severe RSV bronchiolitis in the first year of life. Thorax 2010, 65:1045-1052.
52. Sigurs N., Bjarnason R., Sigurbergsson F., Kjellman B., Bjorksten B. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls. Pediatrics 1995, 95:500-505.
53. Sigurs N., Gustafsson P.M., Bjarnason R., Lundberg F., Schmidt S., Sigurbergsson F., Kjellman B. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am. J. Respir. Crit. Care Med. 2005, 171:137-141.
54. Slager R.E., Hawkins G.A., Ampleford E.J., Bowden A., Stevens L.E., Morton M.T., Tomkinson A., Wenzel S.E., Longphre M., Bleecker E.R., Meyers D.A. IL-4 receptor α polymorphisms are predictors of a pharmacogenetic response to a novel IL-4/IL-13 antagonist. J. Allergy Clin. Immunol. 2010, 126:875-878.
55. Smyth R.L., Openshaw P.J.M. Bronchiolitis. Lancet 2006, 368:312-322.
56. Sommer C., Resch B., Simões E.A. Risk factors for severe respiratory syncytial virus lower respiratory tract infection. Open Microbiol. J. 2011, 5:144-154.
57. Spycher B.D., Silverman M., Kuehni C.E. Phenotypes of childhood asthma: are they real?. Clin. Exp. Allergy 2010, 40:1130-1141.
58. Stein R.T., Sherrill D.L., Morgan W.J., Holberg C.J., Halonen M., Taussig L.M., Wright A.L., Martinez F.D. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13years. Lancet 1999, 354:541-545.
59. Tachdjian R., Mathias C., Al Khatib S., Bryce P.J., Kim H.S., Blaeser F., O'Connor B.D., Rzymkiewicz D., Chen A., Holtzman M.J., Hershey G.K., Garn H., Harb H., Renz H., Oettgen H.C., Chatila T.A. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. J. Exp. Med. 2009, 206:2191-2204.
60. Thomsen S.F., Stensballe L.G., Skytthe A., Kyvik K.O., Backer V., Bisgaard H. Increased concordance of severe respiratory syncytial virus infection in identical twins. Pediatrics 2008, 121:493-496.
61. Thomsen S.F., Van der Sluis S., Stensballe L.G., Posthuma D., Skytthe A., Kyvik K.O., Duffy D.L., Backer V., Bisgaard H. Exploring the association between severe respiratory syncytial virus infection and asthma: a registry-based twin study. Am. J. Respir. Crit. Care Med. 2009, 179:1091-1097.
62. Valenzuela C.Y. On sociogenetic clines. Ethol. Sociobiol. 1988, 9:259-268.
63. Van Piggelen R.O., Van Loon A.M., Krediet T.G., Verboon-Maciolek M.A. Human rhinovirus causes severe infection in preterm infants. Pediatr. Infect. Dis. J. 2010, 29:364-365.
64. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat. Rev. Immunol. 2008, 8:169-182.
65. Wilson J., Rowlands K., Rockett K., Moore C., Lockhart E., Sharland M., Kwiatkowski D., Hull J. Genetic variation at the IL10 gene locus is associated with severity of respiratory syncytial virus bronchiolitis. J. Infect. Dis. 2005, 191:1705-1709.
66. Young S., Keeffe P.T.O., Arnott J., Landau L.I. Lung function, airway responsiveness, and respiratory symptoms before and after bronchiolitis. Arch. Dis. Child 1995, 72:16-24.
67. Zorc J.J., Hall C.B. Bronchiolitis: recent evidence on diagnosis and management. Pediatrics 2010, 125:342-349.