A multi-centre study of candidate genes for wheeze and allergy: The international study of asthma and allergies in childhood phase 2

Clinical and Experimental Allergy

Volumn 39, Issue 12, 2009, Pages 1875-1888

  Genuneit, J ^a   Cantelmo, J L ^b   Weinmayr, G ^a   Wong, G W K ^c   Cooper, P J ^d   Riikjarv M A ^e   Gotua, M ^f   Kabesch, M ^g   Von Mutius, E ^h   Forastiere, F ⁱ   Crane, J ^j   Nystad, W ^k   El Sharif, N ^l   Batlles Garrido, J ^m   Garcia Marcos L ⁿ   Garcia Hernandez G ^o   Morales Suarez Varela, M ^p   Nilsson, L ^q   BrAback L ^r   Saraclar Y ^s   Weiland, S K ^t   Cookson, W O C ^b   Strachan, D ^a   Moffatt, M F ^b   more..

^a UNIVERSITY OF ULM   (Germany)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d Centro de Investigaciones FEPIS   (Ecuador)

^e TALLINN CHILDREN S HOSPITAL   (Estonia)

^f Center of Allergy and Immunology   (Georgia)

^g HANNOVER MEDICAL SCHOOL   (Germany)

^h LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

ⁱ Local Health Authority Rome E   (Italy)

^j UNIVERSITY OF OTAGO   (New Zealand)

^k NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^l AL QUDS UNIVERSITY   (Palestine)

^m HOSPITAL TORRECÁRDENAS   (Spain)

ⁿ CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^o HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^p HOSPITAL UNIVERSITARIO DR PESET   (Spain)

^q LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^r SUNDSVALL HOSPITAL   (Sweden)

^s HACETTEPE UNIVERSITY   (Turkey)

^t ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

more..

Author keywords

Allergy; Asthma; Candidate genes; Multi centre study

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4 RECEPTOR; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9;

ALLERGY; ARTICLE; ASTHMA; CHILD; CONTROLLED STUDY; ECZEMA; GENE IDENTIFICATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; WHEEZING;

ALLERGENS; ANTIGENS, CD14; ASIA; ASTHMA; CHILD; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; DNA-BINDING PROTEINS; ECUADOR; ECZEMA; EUROPE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; INTERLEUKIN-13; INTERLEUKIN-4 RECEPTOR ALPHA SUBUNIT; LINKAGE DISEQUILIBRIUM; NEW ZEALAND; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINASE INHIBITORY PROTEINS, SECRETORY; RECEPTORS, IGE; RESPIRATORY SOUNDS; RHINITIS, ALLERGIC, PERENNIAL; RHINITIS, ALLERGIC, SEASONAL; SKIN TESTS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 9; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 72449212236     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2009.03364.x     Document Type: Article

References (28)

1. Los H, Postmus PE, Boomsma DI. Asthma genetics and intermediate phenotypes: a review from twin studies. Twin Res 2001 4 : 81 93.
2. Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med 2006 355 : 2226 2235.
3. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 2008 8 : 169 182.
4. Cookson W. The immunogenetics of asthma and eczema: a new focus on the epithelium. Nat Rev Immunol 2004 4 : 978 988.
5. Ober C, Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 2006 7 : 95 100.
6. Moffatt MF, Kabesch M, Liang L et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007 448 : 470 473.
7. Cookson WO. Asthma genetics. Chest 2002 121 : 7S 13S.
8. Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, Martinez FD. A polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999 20 : 976 983.
9. Allen M, Heinzmann A, Noguchi E et al. Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet 2003 35 : 258 263.
10. Sandford AJ, Shirakawa T, Moffatt MF et al. Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. Lancet 1993 341 : 332 334.
11. Mitsuyasu H, Izuhara K, Mao XQ et al. Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma. Nat Genet 1998 19 : 119 120.
12. van der Pouw Kraan TC, van Veen A, Boeije LC et al. An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun 1999 1 : 61 5.
13. Zhang Y, Leaves NI, Anderson GG et al. Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat Genet 2003 34 : 181 186.
14. Walley AJ, Chavanas S, Moffatt MF et al. Gene polymorphism in Netherton and common atopic disease. Nat Genet 2001 29 : 175 178.
15. Hobbs K, Negri J, Klinnert M, Rosenwasser LJ, Borish L. Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma. Am J Respir Crit Care Med 1998 158 : 1958 1962.
16. Eder W, Klimecki W, Yu L et al. Toll-like receptor 2 as a major gene for asthma in children of European farmers. J Allergy Clin Immunol 2004 113 : 482 488.
17. Arbour NC, Lorenz E, Schutte BC et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000 25 : 187 191.
18. Lazarus R, Klimecki WT, Raby BA et al. Single-nucleotide polymorphisms in the toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies. Genomics 2003 81 : 85 91.
19. Moffatt MF, Cookson WO. Tumour necrosis factor haplotypes and asthma. Hum Mol Genet 1997 6 : 551 554.
20. Weiland SK, Bjorksten B, Brunekreef B, Cookson WO, von Mutius E, Strachan DP. Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC II): rationale and methods. Eur Respir J 2004 24 : 406 412.
21. Richardson DB, Rzehak P, Klenk J, Weiland SK. Analyses of case-control data for additional outcomes. Epidemiology 2007 18 : 441 445.
22. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002 21 : 1539 1558.
23. Hersh CP, Raby BA, Soto-Quiros ME et al. Comprehensive testing of positionally cloned asthma genes in two populations. Am J Respir Crit Care Med 2007 176 : 849 857.
24. Flohr C, Weiland SK, Weinmayr G et al. The role of atopic sensitization in flexural eczema: findings from the international study of asthma and allergies in childhood phase two. J Allergy Clin Immunol 2008 121 : 141 147.
25. Weinmayr G, Forastiere F, Weiland SK et al. International variation in prevalence of rhinitis and its relationship with sensitisation to perennial and seasonal allergens. Eur Respir J 2008 32 : 1250 1261.
26. Weinmayr G, Weiland SK, Bjorksten B et al. Atopic sensitization and the international variation of asthma symptom prevalence in children. Am J Respir Crit Care Med 2007 176 : 565 574.
27. Castro-Giner F, Kogevinas M, Machler M et al. TNFA -308G>A in two international population-based cohorts and risk of asthma. Eur Respir J 2008 32 : 350 361.
28. Blakey JD, Sayers I, Ring SM, Strachan DP, Hall IP. Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 birth cohort. Thorax 2009 64 : 381 387.