IL-13 genetic polymorphism identifies children with late wheezing after respiratory syncytial virus infection

Journal of Allergy and Clinical Immunology

Volumn 119, Issue 5, 2007, Pages 1086-1091

  Ermers, Marieke J J ^a   Hoebee, Barbara ^b   Hodemaekers, Hennie M ^b   Kimman, Tjeerd G ^c   Kimpen, Jan L L ^a   Bont, Louis ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b Pathology and Genetics

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Asthma; atopy; bronchiolitis; children; genetics; IL 13; IL 4; infant; postbronchiolitis wheezing; respiratory syncytial virus

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 13;

ALLELE; ARTICLE; ASTHMA; ATOPY; BRONCHIOLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; FEMALE; GENETIC POLYMORPHISM; HUMAN; INFANT; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY AIRFLOW; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; VIRAL RESPIRATORY TRACT INFECTION; WHEEZING;

AGE FACTORS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INTERLEUKIN-13; MALE; POLYMORPHISM, GENETIC; RESPIRATORY SOUNDS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS;

EID: 34247512207     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2006.12.655     Document Type: Article

References (25)

1. Bont L., Aalderen W.M., and Kimpen J.L. Long-term consequences of respiratory syncytial virus (RSV) bronchiolitis. Paediatr Respir Rev 1 (2000) 221-227
2. Sigurs N., Gustafsson P.M., Bjarnason R., Lundberg F., Schmidt S., Sigurbergsson F., et al. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am J Respir Crit Care Med 171 (2005) 137-141
3. Stein R.T., Sherrill D., Morgan W.J., Holberg C.J., Halonen M., Taussig L.M., et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 354 (1999) 541-545
4. Bont L., Steijn M., van Aalderen W.M., Brus F., Th Draaisma J.M., Diemen-Steenvoorde R.A., et al. Seasonality of long term wheezing following respiratory syncytial virus lower respiratory tract infection. Thorax 59 (2004) 512-516
5. Bont L., van Aalderen W.M., Versteegh J., Brus F., Draaisma J.T., Pekelharing-Berghuis M., et al. Airflow limitation during respiratory syncytial virus lower respiratory tract infection predicts recurrent wheezing. Pediatr Infect Dis J 20 (2001) 277-282
6. van Woensel J.B., Kimpen J.L., Sprikkelman A.B., Ouwehand A., and van Aalderen W.M. Long-term effects of prednisolone in the acute phase of bronchiolitis caused by respiratory syncytial virus. Pediatr Pulmonol 30 (2000) 92-96
7. Bont L., Heijnen C.J., Kavelaars A., van Aalderen W.M., Brus F., Draaisma J.T., et al. Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a one-year follow-up study. Am J Respir Crit Care Med 161 (2000) 1518-1523
8. Bont L., Heijnen C.J., Kavelaars A., van Aalderen W.M., Brus F., Draaisma J.M., et al. Local interferon-gamma levels during respiratory syncytial virus lower respiratory tract infection are associated with disease severity. J Infect Dis 184 (2001) 355-358
9. Hoebee B., Rietveld E., Bont L., Oosten M., Hodemaekers H.M., Nagelkerke N.J., et al. Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. J Infect Dis 187 (2003) 2-11
10. Hoebee B., Bont L., Rietveld E., van Oosten M., Hodemaekers H.M., Nagelkerke N.J., et al. Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. J Infect Dis 189 (2004) 239-247
11. Bont L., Steijn M., van Aalderen W.M., and Kimpen J.L. Impact of wheezing after respiratory syncytial virus infection on health-related quality of life. Pediatr Infect Dis J 23 (2004) 414-417
12. Pattemore P.K., Ellison-Loschmann L., Asher M.I., Barry D.M., Clayton T.O., Crane J., et al. Asthma prevalence in European, Maori, and Pacific children in New Zealand: ISAAC study. Pediatr Pulmonol 37 (2004) 433-442
13. Hull J., Thomson A., and Kwiatkowski D. Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax 55 (2000) 1023-1027
14. Choi E.H., Lee H.J., Yoo T., and Chanock S.J. A common haplotype of interleukin-4 gene IL4 is associated with severe respiratory syncytial virus disease in Korean children. J Infect Dis 186 (2002) 1207-1211
15. Goetghebuer T., Isles K., Moore C., Thomson A., Kwiatkowski D., and Hull J. Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. Clin Exp Allergy 34 (2004) 801-803
16. Wills-Karp M., and Chiaramonte M. Interleukin-13 in asthma. Curr Opin Pulm Med 9 (2003) 21-27
17. Zhu Z., Homer R.J., Wang Z., Chen Q., Geba G.P., Wang J., et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 103 (1999) 779-788
18. Bancroft A.J., McKenzie A.N., and Grencis R.K. A critical role for IL-13 in resistance to intestinal nematode infection. J Immunol 160 (1998) 3453-3461
19. Howard T.D., Whittaker P.A., Zaiman A.L., Koppelman G.H., Xu J., Hanley M.T., et al. Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. Am J Respir Cell Mol Biol 25 (2001) 377-384
20. Heinzmann A., Mao X.Q., Akaiwa M., Kreomer R.T., Gao P.S., Ohshima K., et al. Genetic variants of IL-13 signalling and human asthma and atopy. Hum Mol Genet 9 (2000) 549-559
21. Graves P.E., Kabesch M., Halonen M., Holberg C.J., Baldini M., Fritzsch C., et al. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol 105 (2000) 506-513
22. Heinzmann A., Ahlert I., Kurz T., Berner R., and Deichmann K.A. Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol 114 (2004) 671-676
23. Vladich F.D., Brazille S.M., Stern D., Peck M.L., Ghittoni R., and Vercelli D. IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation. J Clin Invest 115 (2005) 747-754
24. Arima K., Umeshita-Suyama R., Sakata Y., Akaiwa M., Mao X.Q., Enomoto T., et al. Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma. J Allergy Clin Immunol 109 (2002) 980-987
25. Kabesch M., Schedel M., Carr D., Woitsch B., Fritzsch C., Weiland S.K., et al. IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma. J Allergy Clin Immunol 117 (2006) 269-274