Scale-up of human mesenchymal stem cell culture: Current technologies and future challenges

Current Opinion in Chemical Engineering

Volumn 2, Issue 1, 2013, Pages 8-16

  Rafiq, Qasim A ^a   Coopman, Karen ^a   Hewitt, Christopher J ^a  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; COST EFFECTIVENESS; MAMMALS; STEM CELLS;

COST EFFECTIVE; CURRENT TECHNOLOGY; FUTURE CHALLENGES; HUMAN MESENCHYMAL STEM CELLS; LARGE-SCALES; MAMMALIAN CELLS; SCALE-UP; THERAPEUTIC PRODUCTS;

CELL CULTURE;

EID: 84875246514     PISSN: None     EISSN: 22113398     Source Type: Journal    
DOI: 10.1016/j.coche.2013.01.005     Document Type: Review

References (66)

1. J.A. Rowley Developing cell therapy biomanufacturing processes Chem Eng Prog 106 2010 50 55
2. M. Werner, M. Ruffin, and E. West Regenerative medicines: a paradigm shift in healthcare Drug Discov World Spring 2011 2011 33 38
3. C. Mason, D.A. Brindley, E.J. Culme-Seymour, and N.L. Davie Cell therapy industry: billion dollar global business with unlimited potential Regen Med 6 2011 265 272
4. M. Mimeault, and S.K. Batra Concise review: recent advances on the significance of stem cells in tissue regeneration and cancer therapies Stem Cells 24 2006 2319 2345
5. M. Mimeault, R. Hauke, and S.K. Batra Stem cells: a revolution in therapeutics - recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies Clin Pharmacol Ther 82 2007 252 264
6. R. Tuan, G. Boland, and R. Tuli Adult mesenchymal stem cells and cell-based tissue engineering Arthritis Res Ther 5 2003 32 45
7. R. Brandenberger, S. Burger, A. Campbell, T. Fong, E. Lapinskas, and J.A. Rowley Cell therapy bioprocessing Bioprocess Int 9 2011 30 37
8. J. Carmen, S.R. Burger, M. McCaman, and J.A. Rowley Developing assays to address identity, potency, purity and safety: cell characterization in cell therapy process development Regen Med 7 2012 85 100
9. N. Idei, J. Soga, T. Hata, Y. Fujii, N. Fujimura, S. Mikami, T. Maruhashi, K. Nishioka, T. Hidaka, and Y. Kihara Autologous bone-marrow mononuclear cell implantation reduces long-term major amputation risk in patients with critical limb ischemia: a comparison of atherosclerotic peripheral arterial disease and Buerger disease Circ Cardiovasc Interv 4 2011 15 25
10. H. Filho Cerruti, I. Kerkis, A. Kerkis, N.H. Tatsui, A. da Costa Neves, D.F. Bueno, and M.C. da Silva Allogenous bone grafts improved by bone marrow stem cells and platelet growth factors: clinical case reports Artif Organs 31 2007 268 273
11. J. Rowley, E. Abraham, A. Campbell, H. Brandwein, and S. Oh Meeting lot-size challenges of manufacturing adherent cells for therapy Bioprocess Int 10 2012 16 22
12. C. Mason, and M. Hoare Regenerative medicine bioprocessing: the need to learn from the experience of other fields Regen Med 1 2006 615 623
13. R. Archer, and D.J. Williams Why tissue engineering needs process engineering Nat Biotechnol 23 2005 1353 1355
14. R.J. Thomas, A. Chandra, Y. Liu, P.C. Hourd, P.P. Conway, and D.J. Williams Manufacture of a human mesenchymal stem cell population using an automated cell culture platform Cytotechnology 55 2007 31 39
15. R.J. Thomas, D. Anderson, A. Chandra, N.M. Smith, L.E. Young, D. Williams, and C. Denning Automated, scalable culture of human embryonic stem cells in feeder-free conditions Biotechnol Bioeng 102 2009 1636 1644
16. V. Pakos, and A. Johansson Large scale production of human fibroblast interferon in multitray battery systems Dev Biol Stand 60 1985 317 320
17. L. Randers-Eichhorn, R.A. Bartlett, J. Sipior, D.D. Frey, G.M. Carter, J.R. Lakowicz, and G. Rao Fluorescence-lifetime-based sensors: oxygen sensing and other biomedical applications Photonics West'96 1996 International Society for Optics and Photonics 147 158
18. G.O. Gey An improved technique for massive tissue culture Am J Cancer 17 1939 752 756
19. Y.L. Liu, K. Wagner, N. Robinson, D. Sabatino, P. Margaritis, W. Xiao, and R.W. Herzog Optimized production of high-titer recombinant adeno-associated virus in roller bottles Biotechniques 34 2003 184 189
20. Cohen M, McNiece I, Preparation and use of stromal cells for treatment of cardiac diseases. US Patent 12/899,267, 2011.
21. 2-free atmosphere Stem Cells Dev 20 2011 593 598
22. J.M. Melero-Martin, and M. Al-Rubeai In vitro expansion of chondrocytes N. Ashammakhi, R. Reis, E. Chiellini, Topics in Tissue Engineering vol 3 2007 University of Oulu 1 37
23. R. Kunitake, A. Suzuki, H. Ichihashi, S. Matsuda, O. Hirai, and K. Morimoto Fully-automated roller bottle handling system for large scale culture of mammalian cells J Biotechnol 52 1997 289 294
24. A.L. van Wezel Growth of cell-strains and primary cells on micro-carriers in homogeneous culture Nature 216 1967 64 65
25. A.W. Nienow Reactor engineering in large scale animal cell culture Cytotechnology 50 2006 9 33
26. Amersham Pharmacia Biotech: Microcarrier cell culture - principles and methods, vol 18, edn AA. Sweden; 1999.
27. S. Frauenschuh, E. Reichmann, Y. Ibold, P.M. Goetz, M. Sittinger, and J. Ringe A microcarrier-based cultivation system for expansion of primary mesenchymal stem cells Biotechnol Prog 23 2007 187 193
28. D. Schop, R. van Dijkhuizen-Radersma, E. Borgart, F.W. Janssen, H. Rozemuller, H.J. Prins, and J.D. de Bruijn Expansion of human mesenchymal stromal cells on microcarriers: growth and metabolism J Tissue Eng Regen Med 4 2010 131 140
29. C. Ferrari, F. Balandras, E. Guedon, E. Olmos, I. Chevalot, and A. Marc Limiting cell aggregation during mesenchymal stem cell expansion on microcarriers Biotechnol Prog 28 2012 780 787
30. C.J. Hewitt, K. Lee, A.W. Nienow, R.J. Thomas, M. Smith, and C.R. Thomas Expansion of human mesenchymal stem cells on microcarriers Biotechnol Lett 33 2011 2325 2335
31. Y. Yu, K. Li, C. Bao, T. Liu, Y. Jin, H. Ren, and W. Yun Ex vitro expansion of human placenta-derived mesenchymal stem cells in stirred bioreactor Appl Biochem Biotechnol 159 2009 110 118
32. H.S. Yang, O. Jeon, S.H. Bhang, S.H. Lee, and B.S. Kim Suspension culture of mammalian cells using thermosensitive microcarrier that allows cell detachment without proteolytic enzyme treatment Cell Transplant 19 2010 1123 1132
33. G. Eibes, F. dos Santos, P.Z. Andrade, J.S. Boura, M.M. Abecasis, C.L. da Silva, and J.M. Cabral Maximizing the ex vivo expansion of human mesenchymal stem cells using a microcarrier-based stirred culture system J Biotechnol 146 2010 194 197
34. S. Sart, Y.-J. Schneider, and S.N. Agathos Ear mesenchymal stem cells: an efficient adult multipotent cell population fit for rapid and scalable expansion J Biotechnol 139 2009 291 299
35. Y. Yuan, M.S. Kallos, C. Hunter, and A. Sen Improved expansion of human bone marrow-derived mesenchymal stem cells in microcarrier-based suspension culture J Tissue Eng Regen Med 2012 10.1002/term.1515
36. L.Y. Sun, D.K. Hsieh, W.S. Syu, Y.S. Li, H.T. Chiu, and T.W. Chiou Cell proliferation of human bone marrow mesenchymal stem cells on biodegradable microcarriers enhances in vitro differentiation potential Cell Prolif 43 2010 445 456
37. F. Dos Santos, P.Z. Andrade, M.M. Abecasis, J.M. Gimble, L.G. Chase, A.M. Campbell, S. Boucher, M.C. Vemuri, C.L. Silva, and J.M. Cabral Toward a clinical-grade expansion of mesenchymal stem cells from human sources: a microcarrier-based culture system under xeno-free conditions Tissue Eng Part C Methods 17 2011 1201 1210
38. D. James Therapies of tomorrow require more than factories of the past Bioprocess Int 9 2011 4 11
39. D.G. Phinney, G. Kopen, W. Righter, S. Webster, N. Tremain, and D.J. Prockop Donor variation in the growth properties and osteogenic potential of human marrow stromal cells J Cell Biochem 75 1999 424 436
40. R. Siddappa, R. Licht, C. van Blitterswijk, and J. de Boer Donor variation and loss of multipotency during in vitro expansion of human mesenchymal stem cells for bone tissue engineering J Orthop Res 25 2007 1029 1041
41. D.A. Brindley, N.L. Davie, E.J. Culme-Seymour, C. Mason, D.W. Smith, and J.A. Rowley Peak serum: implications of serum supply for cell therapy manufacturing Regen Med 7 2012 7 13
42. T. Felka, R. Schafer, P. De Zwart, and W.K. Aicher Animal serum-free expansion and differentiation of human mesenchymal stromal cells Cytotherapy 12 2010 143 153
43. S. Jung, K.M. Panchalingam, L. Rosenberg, and L.A. Behie Ex vivo expansion of human mesenchymal stem cells in defined serum-free media Stem Cells Int 2012 2012 123030
44. L. Chase, U. Lakshmipathy, L. Solchaga, M. Rao, and M. Vemuri A novel serum-free medium for the expansion of human mesenchymal stem cells Stem Cell Res Ther 1 2010 8
45. S. Jung, A. Sen, L. Rosenberg, and L.A. Behie Human mesenchymal stem cell culture: rapid and efficient isolation and expansion in a defined serum-free medium J Tissue Eng Regen Med 6 2012 391 403
46. M.E. Bernardo, M.A. Avanzini, C. Perotti, A.M. Cometa, A. Moretta, E. Lenta, C. Del Fante, F. Novara, A. de Silvestri, and G. Amendola Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: further insights in the search for a fetal calf serum substitute J Cell Physiol 211 2007 121 130
47. H. Miwa, Y. Hashimoto, K. Tensho, S. Wakitani, and M. Takagi Xeno-free proliferation of human bone marrow mesenchymal stem cells Cytotechnology 64 2012 301 308
48. T. Hatlapatka, P. Moretti, A. Lavrentieva, R. Hass, N. Marquardt, R. Jacobs, and C. Kasper Optimization of culture conditions for the expansion of umbilical cord-derived mesenchymal stem or stromal cell-like cells using xeno-free culture conditions Tissue Eng Part C Methods 17 2011 485 493
49. S. Jung, K.M. Panchalingam, R.D. Wuerth, L. Rosenberg, and L.A. Behie Large-scale production of human mesenchymal stem cells for clinical applications Biotechnol Appl Biochem 59 2012 106 120
50. S.K. Both, A.J. van der Muijsenberg, C.A. van Blitterswijk, J. de Boer, and J.D. de Bruijn A rapid and efficient method for expansion of human mesenchymal stem cells Tissue Eng 13 2007 3 9
51. E. Fossett, and W.S. Khan Optimising human mesenchymal stem cell numbers for clinical application: A literature review Stem Cells International 2012 2012
52. S.P. Forestell, N. Kalogerakis, L.A. Behie, and D.F. Gerson Development of the optimal inoculation conditions for microcarrier cultures Biotechnol Bioeng 39 1992 305 313
53. Y.S. Tsao, A.G. Cardoso, R.G. Condon, M. Voloch, P. Lio, J.C. Lagos, B.G. Kearns, and Z. Liu Monitoring Chinese hamster ovary cell culture by the analysis of glucose and lactate metabolism J Biotechnol 118 2005 316 327
54. M. Doverskog, J. Ljunggren, L. Ohman, and L. Haggstrom Physiology of cultured animal cells J Biotechnol 59 1997 103 115
55. I.A. Potapova, P.R. Brink, I.S. Cohen, and S.V. Doronin Culturing of human mesenchymal stem cells as three-dimensional aggregates induces functional expression of CXCR4 that regulates adhesion to endothelial cells J Biol Chem 283 2008 13100 13107
56. J.M. Hare, J.E. Fishman, G. Gerstenblith, D.L. DiFede Velazquez, J.P. Zambrano, V.Y. Suncion, M. Tracy, E. Ghersin, P.V. Johnston, and J.A. Brinker Comparison of allogeneic vs. autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial JAMA 308 2012 2369 2379
57. L. Mazzini, I. Ferrero, V. Luparello, D. Rustichelli, M. Gunetti, K. Mareschi, L. Testa, A. Stecco, R. Tarletti, and M. Miglioretti Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: a phase I clinical trial Exp Neurol 223 2010 229 237
58. O. Honmou, K. Houkin, T. Matsunaga, Y. Niitsu, S. Ishiai, R. Onodera, S.G. Waxman, and J.D. Kocsis Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke Brain 134 2011 1790 1807
59. J.A. Perez-Simon, O. Lopez-Villar, E.J. Andreu, J. Rifon, S. Muntion, M.D. Campelo, F.M. Sanchez-Guijo, C. Martinez, D. Valcarcel, and C.D. Canizo Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial Haematologica 96 2011 1072 1076
60. S. Wakitani, K. Imoto, T. Yamamoto, M. Saito, N. Murata, and M. Yoneda Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees Osteoarthritis Cartilage 10 2002 199 206
61. B. Yamout, R. Hourani, H. Salti, W. Barada, T. El-Hajj, A. Al-Kutoubi, A. Herlopian, E.K. Baz, R. Mahfouz, and R. Khalil-Hamdan Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study J Neuroimmunol 227 2010 185 189
62. P. Connick, M. Kolappan, R. Patani, M.A. Scott, C. Crawley, X.L. He, K. Richardson, K. Barber, D.J. Webber, and C.A. Wheeler-Kingshott The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments Trials 12 2011 62
63. P. Kebriaei, L. Isola, E. Bahceci, K. Holland, S. Rowley, J. McGuirk, M. Devetten, J. Jansen, R. Herzig, and M. Schuster Adult human mesenchymal stem cells added to corticosteroid therapy for the treatment of acute graft-versus-host disease Biol Blood Marrow Transplant 15 2009 804 811
64. R. Herrmann, M. Sturm, K. Shaw, D. Purtill, J. Cooney, M. Wright, M. Phillips, and P. Cannell Mesenchymal stromal cell therapy for steroid-refractory acute and chronic graft versus host disease: a phase 1 study Int J Hematol 95 2012 182 188
65. J.M. Hare, J.H. Traverse, T.D. Henry, N. Dib, R.K. Strumpf, S.P. Schulman, G. Gerstenblith, A.N. DeMaria, A.E. Denktas, and R.S. Gammon A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction J Am Coll Cardiol 54 2009 2277 2286
66. R. Jiang, Z. Han, G. Zhuo, X. Qu, X. Li, X. Wang, Y. Shao, S. Yang, and Z.C. Han Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study Front Med 5 2011 94 100