메뉴 건너뛰기




Volumn 22, Issue 7, 2013, Pages 1300-1315

Dual effects of increased glycogen synthase kinase-3β activity on adult neurogenesis

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLECORTIN; DOXYCYCLINE; EOTAXIN; GLYCOGEN SYNTHASE KINASE 3BETA; TET PROTEIN; UNCLASSIFIED DRUG;

EID: 84875238106     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/dds533     Document Type: Article
Times cited : (46)

References (67)
  • 1
    • 13844264520 scopus 로고    scopus 로고
    • Young and excitable: the function of new neurons in the adult mammalian brain
    • Doetsch, F. and Hen, R. (2005) Young and excitable: the function of new neurons in the adult mammalian brain. Curr. Opin. Neurobiol., 15, 121-128.
    • (2005) Curr. Opin. Neurobiol. , vol.15 , pp. 121-128
    • Doetsch, F.1    Hen, R.2
  • 3
    • 33745698913 scopus 로고    scopus 로고
    • Potential role for adult neurogenesis in the encoding of time in new memories
    • Aimone, J.B., Wiles, J. and Gage, F.H. (2006) Potential role for adult neurogenesis in the encoding of time in new memories. Nat. Neurosci., 9, 723-727.
    • (2006) Nat. Neurosci. , vol.9 , pp. 723-727
    • Aimone, J.B.1    Wiles, J.2    Gage, F.H.3
  • 4
    • 30644474606 scopus 로고    scopus 로고
    • Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
    • Zhao, C., Teng, E.M., Summers, R.G. Jr, Ming, G.L. and Gage, F.H. (2006) Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J. Neurosci., 26, 3-11.
    • (2006) J. Neurosci. , vol.26 , pp. 3-11
    • Zhao, C.1    Teng, E.M.2    Summers Jr., R.G.3    Ming, G.L.4    Gage, F.H.5
  • 5
    • 0029586276 scopus 로고
    • Age-related production of new granule cells in the adult dentate gyrus
    • Seki, T. and Arai, Y. (1995) Age-related production of new granule cells in the adult dentate gyrus. Neuroreport, 6, 2479-2482.
    • (1995) Neuroreport , vol.6 , pp. 2479-2482
    • Seki, T.1    Arai, Y.2
  • 6
    • 0036325981 scopus 로고    scopus 로고
    • Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
    • Kempermann, G., Gast, D. and Gage, F.H. (2002) Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann. Neurol., 52, 135-143.
    • (2002) Ann. Neurol. , vol.52 , pp. 135-143
    • Kempermann, G.1    Gast, D.2    Gage, F.H.3
  • 7
    • 79952579942 scopus 로고    scopus 로고
    • Neurodegenerative disease and adult neurogenesis
    • Winner, B., Kohl, Z. and Gage, F.H. (2011) Neurodegenerative disease and adult neurogenesis. Eur. J. Neurosci., 33, 1139-1151.
    • (2011) Eur. J. Neurosci. , vol.33 , pp. 1139-1151
    • Winner, B.1    Kohl, Z.2    Gage, F.H.3
  • 9
    • 0025286104 scopus 로고
    • Molecular cloning and expression of glycogen synthase kinase-3/factor A
    • Woodgett, J.R. (1990) Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J., 9, 2431-2438.
    • (1990) EMBO J. , vol.9 , pp. 2431-2438
    • Woodgett, J.R.1
  • 10
    • 34547940516 scopus 로고    scopus 로고
    • Neural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3
    • Eom, T.Y., Roth, K.A. and Jope, R.S. (2007) Neural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3. J. Biol. Chem., 282, 22856-22864.
    • (2007) J. Biol. Chem. , vol.282 , pp. 22856-22864
    • Eom, T.Y.1    Roth, K.A.2    Jope, R.S.3
  • 11
    • 1842419074 scopus 로고    scopus 로고
    • Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo
    • Kim, J.S., Chang, M.Y., Yu, I.T., Kim, J.H., Lee, S.H., Lee, Y.S. and Son, H. (2004) Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo. J. Neurochem., 89, 324-336.
    • (2004) J. Neurochem. , vol.89 , pp. 324-336
    • Kim, J.S.1    Chang, M.Y.2    Yu, I.T.3    Kim, J.H.4    Lee, S.H.5    Lee, Y.S.6    Son, H.7
  • 13
    • 62149083806 scopus 로고    scopus 로고
    • Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    • Mao, Y., Ge, X., Frank, C.L., Madison, J.M., Koehler, A.N., Doud, M.K., Tassa, C., Berry, E.M., Soda, T., Singh, K.K. et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell, 136, 1017-1031.
    • (2009) Cell , vol.136 , pp. 1017-1031
    • Mao, Y.1    Ge, X.2    Frank, C.L.3    Madison, J.M.4    Koehler, A.N.5    Doud, M.K.6    Tassa, C.7    Berry, E.M.8    Soda, T.9    Singh, K.K.10
  • 14
    • 68049121855 scopus 로고    scopus 로고
    • Blocked inhibitory serine-phosphorylation of glycogen synthase kinase-3alpha/beta impairs in vivo neural precursor cell proliferation
    • Eom, T.Y. and Jope, R.S. (2009) Blocked inhibitory serine-phosphorylation of glycogen synthase kinase-3alpha/beta impairs in vivo neural precursor cell proliferation. Biol. Psychiatry, 66, 494-502.
    • (2009) Biol. Psychiatry , vol.66 , pp. 494-502
    • Eom, T.Y.1    Jope, R.S.2
  • 16
    • 84862908964 scopus 로고    scopus 로고
    • Inhibition of GSK3beta improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome
    • Guo, W., Murthy, A.C., Zhang, L., Johnson, E.B., Schaller, E.G., Allan, A.M. and Zhao, X. (2012) Inhibition of GSK3beta improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome. Hum. Mol. Genet., 21, 681-691.
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 681-691
    • Guo, W.1    Murthy, A.C.2    Zhang, L.3    Johnson, E.B.4    Schaller, E.G.5    Allan, A.M.6    Zhao, X.7
  • 19
    • 58149335393 scopus 로고    scopus 로고
    • Microglia in normal condition and pathology
    • Pivneva, T.A. (2008) Microglia in normal condition and pathology. Fiziol. Zh., 54, 81-89.
    • (2008) Fiziol. Zh. , vol.54 , pp. 81-89
    • Pivneva, T.A.1
  • 20
    • 61449224570 scopus 로고    scopus 로고
    • Microglia: gatekeepers of central nervous system immunology
    • Tambuyzer, B.R., Ponsaerts, P. and Nouwen, E.J. (2009) Microglia: gatekeepers of central nervous system immunology. J. Leukoc. Biol., 85, 352-370.
    • (2009) J. Leukoc. Biol. , vol.85 , pp. 352-370
    • Tambuyzer, B.R.1    Ponsaerts, P.2    Nouwen, E.J.3
  • 21
    • 0034651767 scopus 로고    scopus 로고
    • Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells
    • Aloisi, F., De Simone, R., Columba-Cabezas, S., Penna, G. and Adorini, L. (2000) Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells. J. Immunol., 164, 1705-1712.
    • (2000) J. Immunol. , vol.164 , pp. 1705-1712
    • Aloisi, F.1    De Simone, R.2    Columba-Cabezas, S.3    Penna, G.4    Adorini, L.5
  • 22
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    • Lucas, J.J., Hernandez, F., Gomez-Ramos, P., Moran, M.A., Hen, R. and Avila, J. (2001) Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J., 20, 27-39.
    • (2001) EMBO J. , vol.20 , pp. 27-39
    • Lucas, J.J.1    Hernandez, F.2    Gomez-Ramos, P.3    Moran, M.A.4    Hen, R.5    Avila, J.6
  • 24
    • 33646922314 scopus 로고    scopus 로고
    • Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3
    • Engel, T., Hernandez, F., Avila, J. and Lucas, J.J. (2006) Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3. J. Neurosci., 26, 5083-5090.
    • (2006) J. Neurosci. , vol.26 , pp. 5083-5090
    • Engel, T.1    Hernandez, F.2    Avila, J.3    Lucas, J.J.4
  • 25
    • 0030828073 scopus 로고    scopus 로고
    • Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
    • Hendzel, M.J., Wei, Y., Mancini, M.A., Van Hooser, A., Ranalli, T., Brinkley, B.R., Bazett-Jones, D.P. and Allis, C.D. (1997) Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma, 106, 348-360.
    • (1997) Chromosoma , vol.106 , pp. 348-360
    • Hendzel, M.J.1    Wei, Y.2    Mancini, M.A.3    Van Hooser, A.4    Ranalli, T.5    Brinkley, B.R.6    Bazett-Jones, D.P.7    Allis, C.D.8
  • 27
    • 80455129781 scopus 로고    scopus 로고
    • Different susceptibility to neurodegeneration of dorsal and ventral hippocampal dentate gyrus: a study with transgenic mice overexpressing GSK3beta
    • Fuster-Matanzo, A., Llorens-Martin, M., de Barreda, E.G., Avila, J. and Hernandez, F. (2011) Different susceptibility to neurodegeneration of dorsal and ventral hippocampal dentate gyrus: a study with transgenic mice overexpressing GSK3beta. PLoS One, 6, e27262.
    • (2011) PLoS One , vol.6
    • Fuster-Matanzo, A.1    Llorens-Martin, M.2    de Barreda, E.G.3    Avila, J.4    Hernandez, F.5
  • 31
    • 84862776613 scopus 로고    scopus 로고
    • A role for primary cilia in glutamatergic synaptic integration of adult-born neurons
    • Kumamoto, N., Gu, Y., Wang, J., Janoschka, S., Takemaru, K., Levine, J. and Ge, S. (2012) A role for primary cilia in glutamatergic synaptic integration of adult-born neurons. Nat. Neurosci., 15, 399-405, S1.
    • (2012) Nat. Neurosci. , vol.15
    • Kumamoto, N.1    Gu, Y.2    Wang, J.3    Janoschka, S.4    Takemaru, K.5    Levine, J.6    Ge, S.7
  • 33
    • 0345189366 scopus 로고    scopus 로고
    • Inflammatory blockade restores adult hippocampal neurogenesis
    • Monje, M.L., Toda, H. and Palmer, T.D. (2003) Inflammatory blockade restores adult hippocampal neurogenesis. Science, 302, 1760-1765.
    • (2003) Science , vol.302 , pp. 1760-1765
    • Monje, M.L.1    Toda, H.2    Palmer, T.D.3
  • 35
    • 33748299477 scopus 로고    scopus 로고
    • The paradoxical proand anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways
    • Beurel, E. and Jope, R.S. (2006) The paradoxical proand anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog. Neurobiol., 79, 173-189.
    • (2006) Prog. Neurobiol. , vol.79 , pp. 173-189
    • Beurel, E.1    Jope, R.S.2
  • 36
    • 0034175688 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal
    • Hetman, M., Cavanaugh, J.E., Kimelman, D. and Xia, Z. (2000) Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal. J. Neurosci., 20, 2567-2574.
    • (2000) J. Neurosci. , vol.20 , pp. 2567-2574
    • Hetman, M.1    Cavanaugh, J.E.2    Kimelman, D.3    Xia, Z.4
  • 37
    • 0034602179 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal
    • Crowder, R.J. and Freeman, R.S. (2000) Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal. J. Biol.Chem., 275, 34266-34271.
    • (2000) J. Biol.Chem. , vol.275 , pp. 34266-34271
    • Crowder, R.J.1    Freeman, R.S.2
  • 39
    • 0037160134 scopus 로고    scopus 로고
    • Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation
    • Song, L., De Sarno, P. and Jope, R.S. (2002) Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation. J. Biol.Chem., 277, 44701-44708.
    • (2002) J. Biol.Chem. , vol.277 , pp. 44701-44708
    • Song, L.1    De Sarno, P.2    Jope, R.S.3
  • 40
    • 0027240081 scopus 로고
    • Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity
    • Takashima, A., Noguchi, K., Sato, K., Hoshino, T. and Imahori, K. (1993) Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity. Proc. Natl Acad. Sci. USA, 90, 7789-7793.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 7789-7793
    • Takashima, A.1    Noguchi, K.2    Sato, K.3    Hoshino, T.4    Imahori, K.5
  • 42
    • 33746210131 scopus 로고    scopus 로고
    • Coexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration
    • Engel, T., Lucas, J.J., Gomez-Ramos, P., Moran, M.A., Avila, J. and Hernandez, F. (2006) Coexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration. Neurobiol. Aging, 27, 1258-1268.
    • (2006) Neurobiol. Aging , vol.27 , pp. 1258-1268
    • Engel, T.1    Lucas, J.J.2    Gomez-Ramos, P.3    Moran, M.A.4    Avila, J.5    Hernandez, F.6
  • 45
    • 70349813944 scopus 로고    scopus 로고
    • Immune influence on adult neural stem cell regulation and function
    • Carpentier, P.A. and Palmer, T.D. (2009) Immune influence on adult neural stem cell regulation and function. Neuron, 64, 79-92.
    • (2009) Neuron , vol.64 , pp. 79-92
    • Carpentier, P.A.1    Palmer, T.D.2
  • 46
    • 59349110661 scopus 로고    scopus 로고
    • Brain inflammation and adult neurogenesis: the dual role of microglia
    • Ekdahl, C.T., Kokaia, Z. and Lindvall, O. (2009) Brain inflammation and adult neurogenesis: the dual role of microglia. Neuroscience, 158, 1021-1029.
    • (2009) Neuroscience , vol.158 , pp. 1021-1029
    • Ekdahl, C.T.1    Kokaia, Z.2    Lindvall, O.3
  • 49
    • 0036734833 scopus 로고    scopus 로고
    • Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
    • Lee, J., Duan, W. and Mattson, M.P. (2002) Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J. Neurochem., 82, 1367-1375.
    • (2002) J. Neurochem. , vol.82 , pp. 1367-1375
    • Lee, J.1    Duan, W.2    Mattson, M.P.3
  • 50
    • 0034597430 scopus 로고    scopus 로고
    • Vascular niche for adult hippocampal neurogenesis
    • Palmer, T.D., Willhoite, A.R. and Gage, F.H. (2000) Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol., 425, 479-494.
    • (2000) J. Comp. Neurol. , vol.425 , pp. 479-494
    • Palmer, T.D.1    Willhoite, A.R.2    Gage, F.H.3
  • 52
    • 36048937547 scopus 로고    scopus 로고
    • Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments
    • Zhu, L.Q., Wang, S.H., Liu, D., Yin, Y.Y., Tian, Q., Wang, X.C., Wang, Q., Chen, J.G. and Wang, J.Z. (2007) Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments. J. Neurosci., 27, 12211-12220.
    • (2007) J. Neurosci. , vol.27 , pp. 12211-12220
    • Zhu, L.Q.1    Wang, S.H.2    Liu, D.3    Yin, Y.Y.4    Tian, Q.5    Wang, X.C.6    Wang, Q.7    Chen, J.G.8    Wang, J.Z.9
  • 54
    • 33745276538 scopus 로고    scopus 로고
    • Long-term potentiation enhances neurogenesis in the adult dentate gyrus
    • Bruel-Jungerman, E., Davis, S., Rampon, C. and Laroche, S. (2006) Long-term potentiation enhances neurogenesis in the adult dentate gyrus. J. Neurosci., 26, 5888-5893.
    • (2006) J. Neurosci. , vol.26 , pp. 5888-5893
    • Bruel-Jungerman, E.1    Davis, S.2    Rampon, C.3    Laroche, S.4
  • 55
    • 24144483438 scopus 로고    scopus 로고
    • BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis
    • Bramham, C.R. and Messaoudi, E. (2005) BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog. Neurobiol., 76, 99-125.
    • (2005) Prog. Neurobiol. , vol.76 , pp. 99-125
    • Bramham, C.R.1    Messaoudi, E.2
  • 56
    • 70450250252 scopus 로고    scopus 로고
    • Imbalance between GABAergic and glutamatergic transmission impairs adult neurogenesis in an animal model of Alzheimer's disease
    • Sun, B., Halabisky, B., Zhou, Y., Palop, J.J., Yu, G., Mucke, L. and Gan, L. (2009) Imbalance between GABAergic and glutamatergic transmission impairs adult neurogenesis in an animal model of Alzheimer's disease. Cell Stem Cell, 5, 624-633.
    • (2009) Cell Stem Cell , vol.5 , pp. 624-633
    • Sun, B.1    Halabisky, B.2    Zhou, Y.3    Palop, J.J.4    Yu, G.5    Mucke, L.6    Gan, L.7
  • 57
    • 0041306120 scopus 로고    scopus 로고
    • Injury-induced neurogenesis in the adult mammalian brain
    • Parent, J.M. (2003) Injury-induced neurogenesis in the adult mammalian brain. Neuroscientist, 9, 261-272.
    • (2003) Neuroscientist , vol.9 , pp. 261-272
    • Parent, J.M.1
  • 58
    • 79958230697 scopus 로고    scopus 로고
    • Neurogenesis in Alzheimer's disease
    • Rodriguez, J.J. and Verkhratsky, A. (2011) Neurogenesis in Alzheimer's disease. J. Anat., 219, 78-89.
    • (2011) J. Anat. , vol.219 , pp. 78-89
    • Rodriguez, J.J.1    Verkhratsky, A.2
  • 59
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
    • Wyss-Coray, T. (2006) Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat. Med., 12, 1005-1015.
    • (2006) Nat Med. , vol.12 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 60
    • 77249119371 scopus 로고    scopus 로고
    • Multiplex analysis of cytokines in the serum and cerebrospinal fluid of patients with Alzheimer's disease by color-coded bead technology
    • Choi, C., Jeong, J.H., Jang, J.S., Choi, K., Lee, J., Kwon, J., Choi, K.G., Lee, J.S. and Kang, S.W. (2008) Multiplex analysis of cytokines in the serum and cerebrospinal fluid of patients with Alzheimer's disease by color-coded bead technology. J. Clin. Neurol., 4, 84-88.
    • (2008) J. Clin. Neurol. , vol.4 , pp. 84-88
    • Choi, C.1    Jeong, J.H.2    Jang, J.S.3    Choi, K.4    Lee, J.5    Kwon, J.6    Choi, K.G.7    Lee, J.S.8    Kang, S.W.9
  • 61
    • 0031848322 scopus 로고    scopus 로고
    • Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains
    • Xia, M.Q., Qin, S.X., Wu, L.J., Mackay, C.R. and Hyman, B.T. (1998) Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am. J. Pathol., 153, 31-37.
    • (1998) Am. J. Pathol. , vol.153 , pp. 31-37
    • Xia, M.Q.1    Qin, S.X.2    Wu, L.J.3    Mackay, C.R.4    Hyman, B.T.5
  • 62
    • 3042558276 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3: a drug target for CNS therapies
    • Bhat, R.V., Budd Haeberlein, S.L. and Avila, J. (2004) Glycogen synthase kinase 3: a drug target for CNS therapies. J. Neurochem., 89, 1313-1317.
    • (2004) J. Neurochem. , vol.89 , pp. 1313-1317
    • Bhat, R.V.1    Budd Haeberlein, S.L.2    Avila, J.3
  • 63
    • 33845530335 scopus 로고    scopus 로고
    • Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert
    • Engel, T., Goni-Oliver, P., Lucas, J.J., Avila, J. and Hernandez, F. (2006) Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert. J. Neurochem., 99, 1445-1455.
    • (2006) J. Neurochem. , vol.99 , pp. 1445-1455
    • Engel, T.1    Goni-Oliver, P.2    Lucas, J.J.3    Avila, J.4    Hernandez, F.5
  • 65
    • 77957872719 scopus 로고    scopus 로고
    • Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis
    • Llorens-Martin, M., Tejeda, G.S. and Trejo, J.L. (2010) Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis. PLoS One, 5, e12188.
    • (2010) PLoS One , vol.5
    • Llorens-Martin, M.1    Tejeda, G.S.2    Trejo, J.L.3
  • 66
    • 33745173141 scopus 로고    scopus 로고
    • Pronounced individual variation in the response to the stimulatory action of exercise on immature hippocampal neurons
    • Llorens-Martin, M., Torres-Aleman, I. and Trejo, J.L. (2006) Pronounced individual variation in the response to the stimulatory action of exercise on immature hippocampal neurons. Hippocampus, 16, 480-490.
    • (2006) Hippocampus , vol.16 , pp. 480-490
    • Llorens-Martin, M.1    Torres-Aleman, I.2    Trejo, J.L.3
  • 67
    • 82355188382 scopus 로고    scopus 로고
    • Mifepristone prevents stress-induced apoptosis in newborn neurons and increases AMPA receptor expression in the dentate gyrus of C57/BL6 mice
    • Llorens-Martin, M. and Trejo, J.L. (2011) Mifepristone prevents stress-induced apoptosis in newborn neurons and increases AMPA receptor expression in the dentate gyrus of C57/BL6 mice. PLoS One, 6, e28376.
    • (2011) PLoS One , vol.6
    • Llorens-Martin, M.1    Trejo, J.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.