Ferulic acid improves cardiovascular and kidney structure and function in hypertensive rats

Journal of Cardiovascular Pharmacology

Volumn 61, Issue 3, 2013, Pages 240-249

  Alam, Md Ashraful ^a   Sernia, Conrad ^a   Brown, Lindsay ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF SOUTHERN QUEENSLAND   (Australia)

Author keywords

ferulic acid; fibrosis; hypertension; oxidative stress; rats

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CATALASE; COLLAGEN; COPPER ZINC SUPEROXIDE DISMUTASE; CREATININE; FERRIC ION; FERULIC ACID; LACTATE DEHYDROGENASE; MALONALDEHYDE; MANGANESE SUPEROXIDE DISMUTASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; POTASSIUM; REACTIVE OXYGEN METABOLITE; SODIUM; UREA; URIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL INFILTRATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIASTOLE; ENZYME ACTIVATION; ENZYME REPRESSION; ERYTHROCYTE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE HYPERTROPHY; HEART PROTECTION; HEART WEIGHT; HYPERTENSION; INFLAMMATORY CELL; KIDNEY MASS; KIDNEY STRUCTURE; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER WEIGHT; MALE; NONHUMAN; OXIDATIVE STRESS; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; RAT; RENAL PROTECTION; RIGIDITY; SODIUM BLOOD LEVEL; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; THORACIC AORTA; TISSUE STRUCTURE; UREA BLOOD LEVEL; URIC ACID BLOOD LEVEL; VASODILATATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIHYPERTENSIVE AGENTS; ANTIOXIDANTS; CARDIOVASCULAR SYSTEM; COUMARIC ACIDS; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; FIBROSIS; HYPERTENSION; KIDNEY; MALE; MAST CELLS; OXIDATIVE STRESS; OXIDOREDUCTASES; RANDOM ALLOCATION; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, WISTAR;

EID: 84875232097     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e31827cb600     Document Type: Article

References (51)

1. Zhao Z, Moghadasian MH. Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: a review. Food Chem. 2008;109:691-702.
2. Duarte J, Pérez-Palencia R, Vargas F, et al. Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br J Pharmacol. 2001;133:117-124.
3. Ghosh D, Scheepens A. Vascular action of polyphenols. Mol Nutr Food Res. 2009;53:322-331.
4. Paran E, Novack V, Engelhard Y, et al. The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients. Cardiovasc Drugs Ther. 2009;23:145-151.
5. Shukla SK, Gupta S, Ojha SK, et al. Cardiovascular friendly natural products: a promising approach in the management of CVD. Nat Prod Res. 2010;24:873-898.
6. Tirapelli CR, Ambrosio SR, de Oliveira AM, et al. Hypertensive action of naturally occurring diterpenes: a therapeutic promise for the treatment of hypertension. Fitoterapia. 2010;81:690-702.
7. Suzuki A, Yamamoto M, Jokura H, et al. Ferulic acid restores endothelium- dependent vasodilation in aortas of spontaneously hypertensive rats. Am J Hypertens. 2007;20:508-513.
8. Ardiansyah A, Ohsaki Y, Shirakawa H, et al. Novel effects of a single administration of ferulic acid on the regulation of blood pressure and the hepatic lipid metabolic profile in stroke-prone spontaneously hypertensive rats. J Agric Food Chem. 2008;56:2825-2830.
9. Srinivasan M, Sudheer AR, Menon VP. Ferulic acid: therapeutic potential through its antioxidant property. J Clin Biochem Nutr. 2007;40:92-100.
10. Wang BH, Ou-Yang JP. Pharmacological actions of sodium ferulate in cardiovascular system. Cardiovasc Drug Rev. 2005;23:161-172.
11. Yogeeta SK, Gnanapragasam A, Senthilkumar S, et al. Synergistic salubrious effect of ferulic acid and ascorbic acid on membrane-bound phosphatases and lysosomal hydrolases during experimental myocardial infarction in rats. Life Sci. 2006;80:258-263.
12. Hou YZ, Yang J, Zhao GR, et al. Ferulic acid inhibits vascular smooth muscle cell proliferation induced by angiotensin II. Eur J Pharmacol. 2004;499:85-90.
13. Panchal SK, Poudyal H, Iyer A, et al. High-carbohydrate high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats. J Cardiovasc Pharmacol. 2011;57:611-624.
14. Poudyal H, Campbell F, Brown L. Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats. J Nutr. 2010;140:946-953.
15. Panchal S, Poudyal H, Brown L. Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats. J Nutr. 2012;142:1026-1032.
16. Weydert CJ, Cullen JJ. Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nat Protoc. 2010; 5:51-66.
17. Tetsuka T, Baier LD, Morrison AR. Antioxidants inhibit interleukin-1- induced cyclooxygenase and nitric-oxide synthase expression in rat mesangial cells. Evidence for post-transcriptional regulation. J Biol Chem. 1996;271:11689-11693.
18. Ohnishi M, Matuo T, Tsuno T, et al. Antioxidant activity and hypoglycemic effect of ferulic acid in STZ-induced diabetic mice and KK-Ay mice. Biofactors. 2004;21:315-319.
19. Ou L, Kong LY, Zhang XM, et al. Oxidation of ferulic acid by Momordica charantia peroxidase and related anti-inflammation activity changes. Biol Pharm Bull. 2003;26:1511-1516.
20. Jin Son M, WR C, Hyun Nam S, et al. Influence of oryzanol and ferulic acid on the lipid metabolism and antioxidative status in high fat-fed mice. J Clin Biochem Nutr. 2010;46:150-156.
21. Scapagnini G, Butterfield DA, Colombrita C, et al. Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid Redox Signal. 2004;6:811-818.
22. Wilcox C. Reactive oxygen species: roles in blood pressure and kidney function. Curr Hypertens Rep. 2002;4:160-166.
23. Schnackenberg CG, Welch WJ, Wilcox CS. Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide. Hypertension. 1998; 32:59-64.
24. Baylis C, Mitruka B, Deng A. Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage. J Clin Invest. 1992;90:278-281.
25. Suzuki A, Kagawa D, Fujii A, et al. Short- and long-term effects of ferulic acid on blood pressure in spontaneously hypertensive rats. Am J Hypertens. 2002;15:351-357.
26. Chen GP, Ye Y, Li L, et al. Endothelium-independent vasorelaxant effect of sodium ferulate on rat thoracic aorta. Life Sci. 2009;84:81-88.
27. Brown L, Fenning A, Shek A, et al. Reversal of cardiovascular remodelling with candesartan. J Renin Angiotensin Aldosterone Syst. 2001;2: S141-S147.
28. Paulis L, Zicha J, Kunes J, et al. Regression of L-NAME-induced hypertension: the role of nitric oxide and endothelium-derived constricting factor. Hypertens Res. 2008;31:793-803.
29. Pechanova O, Bernatova I, Pelouch V, et al. L-NAME-induced protein remodeling and fibrosis in the rat heart. Physiol Res. 1999;48:353-362.
30. Bernátová I, Pechánová O, Babál P, et al. Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension. Am J Physiol Heart Circ Physiol. 2002;282:H942-H948.
31. Devlin AM, Brosnan MJ, Graham D, et al. Vascular smooth muscle cell polyploidy and cardiomyocyte hypertrophy due to chronic NOS inhibition in vivo. Am J Physiol. 1998;274:H52-H59.
32. Neves SR, Machado CR, Pinto AM, et al. Macrophage populations and cardiac sympathetic denervation during L-NAME-induced hypertension in rats. Histol Histopathol. 2006;21:803-812.
33. Levick SP, McLarty JL, Murray DB, et al. Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart. Hypertension. 2009;53: 1041-1047.
34. Dvorak AM. Mast-cell degranulation in human hearts. N Engl J Med. 1986;315:969-970.
35. Panizo A, Mindan FJ, Galindo MF, et al. Are mast cells involved in hypertensive heart disease? J Hypertens. 1995;13:1201-1208.
36. Patella V, Marino I, Arbustini E, et al. Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy. Circulation. 1998;97:971-978.
37. Kutty RK, Kutty G, Wiggert B, et al. Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea. Proc Natl Acad Sci U S A. 1995;92:1177-1181.
38. Poss KD, Tonegawa S. Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A. 1997;94:10919-10924.
39. Yachie A, Niida Y, Wada T, et al. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest. 1999;103:129-135.
40. Li L, Storey P, Kim D, et al. Kidneys in hypertensive rats show reduced response to nitric oxide synthase inhibition as evaluated by BOLD MRI. J Magn Reson Imaging. 2003;17:671-675.
41. Arndt H, Smith C, Granger D. Leukocyte-endothelial cell adhesion in spontaneously hypertensive and normotensive rats. Hypertension. 1993; 21:667-673.
42. Ikeda H, Tsuruya K, Toyonaga J, et al. Spironolactone suppresses inflammation and prevents L-NAME-induced renal injury in rats. Kidney Int. 2009;75:147-155.
43. Polichnowski AJ, Lu L, Cowley AW. Renal injury in angiotensin II +L-NAME-induced hypertensive rats is independent of elevated blood pressure. Am J Physiol Renal Physiol. 2011;300:F1008-F1016.
44. Lahera V, Navarro-Cid J, Cachofeiro V, et al. Nitric oxide, the kidney, and hypertension. Am J Hypertens. 1997;10:129-140.
45. Fujita A, Sasaki H, Doi A, et al. Ferulic acid prevents pathological and functional abnormalities of the kidney in Otsuka Long-Evans Tokushima Fatty diabetic rats. Diabetes Res Clin Pract. 2008;79:11-17.
46. Choi R, Kim BH, Naowaboot J, et al. Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes. Exp Mol Med. 2011;43: 676-683.
47. Meng LQ, Tang JW, Wang Y, et al. Astragaloside IV synergizes with ferulic acid to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy. Br J Pharmacol. 2011;162:1805-1818.
48. Shokeir AA, Hussein AA, Soliman SA, et al. Recoverability of renal functions after relief of partial ureteric obstruction of solitary kidney: impact of ferulic acid. BJU Int. 2012;110:904-911.
49. Ramar M, Manikandan B, Raman T, et al. Protective effect of ferulic acid and resveratrol against alloxan-induced diabetes in mice. Eur J Pharmacol. 2012;690;226-235.
50. Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J. 2008;22:659-661.
51. Anson NA, Aura A-M, Selinheimo E, et al. Bioprocessing of wheat bran in whole wheat bread increases the bioavailability of phenolic acids in men and exerts antiinflammatory effects ex vivo. J Nutr. 2011;141:137-143.