Reversal of cardiovascular remodelling with candesartan

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 2, Issue SUPPL. 1, 2001, Pages

  Brown, Lindsay ^a   Fenning, Andrew ^a   Shek, Annie ^a   Burstow, Darryl ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b THE PRINCE CHARLES HOSPITAL   (Australia)

Author keywords

AT1 receptors; Cardiac remodelling; Hypertrophy fibrosis

Indexed keywords

EID: 0042765072     PISSN: 14703203     EISSN: None     Source Type: Journal    
DOI: 10.1177/14703203010020012501     Document Type: Article

References (23)

1. Vila-Petroff MG, Lakatta EG. Nitric oxide: a multifaceted modulator of cardiac contractility. Asia Pacific Heart J 1998;7:38-42.
2. MacCarthy PA, Shah AM. The role of nitric oxide in the regulation of myocardial relaxation and diastolic function. Asia Pacific Heart J 1998;7:29-37.
3. Takemoto M, Egashira K, Tomita H et al. Chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade. Effects on cardiovascular remodeling in rats induced by the long-term blockade of nitric oxide synthesis. Hypertension 1997;30:1621-7.
4. Bartunek J, Weinberg EO, Tajima M et al. Chronic NG-nitro-L-arginine methyl ester-induced hypertension. Novel molecular adaptation to systolic load in absence of hypertrophy. Circulation 2000;101:423-9.
5. Katz A. Angiotensin II: hemodynamic regulator or growth factor? J Mol Cell Cardiol 1990;22:739-47.
6. Fernández-Alfonso MS, González C. Nitric oxide and the renin-angiotensin system. Is there a physiological interplay between the systems? J Hypertens 1999;17:1355-61.
7. Katoh M, Egashira K, Usui M et al. Cardiac angiotensin II receptors are upregulated by long-term inhibition of nitric oxide synthesis in rats. Circ Res 1998;83:743-51.
8. Usui M, Egashira K, Timita H et al. Important role of local angiotensin II activity mediated via type 1 receptor in the pathogenesis of cardiovascular inflammatory changes induced by chronic blockade of nitric oxide synthesis in rats. Circulation 2000;101:305-10.
9. Weber KT, Brilla CG, Janicki JS. Myocardial fibrosis: functional significance and regulatory factors. Cardiovasc Res 1993;27:341-8.
10. Brown L, Duce B, Miric G, Sernia C. Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system. J Am Soc Nephrol 1999; 10:S143-S148.
11. Brown L, Sernia C, Newling R, Fletcher P. Comparison of inotropic and chronotropic responses in rat isolated atria and ventricles. Clin Exp Pharmacol Physiol 1991;18:753-60.
12. + exchange. Naunyn-Schmiedeberg's Arch Pharmacol 1991;344:220-4.
13. Mirsky I, Parmley WW. Assessment of passive elastic stiffness for isolated heart muscle and the intact heart. Circ Res 1973;33:233-43.
14. Loscalzo J, Welch G. Nitric oxide and its role in the cardiovascular system. Progr Cardiovasc Dis 1995;38:87-104.
15. Doggrell SA, Brown L. Rat models of hypertension, cardiac hypertrophy and failure. Cardiovasc Res 1998;39:89-105.
16. Bernátová I, Pecháñová O, Pelouch V, Simko F. Regression of chronic L-NAME-treatment-induced left ventricular hypertrophy: effect of captopril. J Mol Cell Cardiol 2000;32:177-85.
17. Marchant C, Brown L, Sernia C. Renin-angiotensin system in thyroid dysfunction in rats. J Cardiovasc Pharmacol 1993;22:449-55.
18. Litwin SE, Katz SE, Weinberg EO, Lorell BH, Aurigemma GP, Douglas PS. Serial echocardiographic-Doppler assessment of left ventricular geometry and function in rats with pressure-overload hypertrophy. Chronic angiotensin-converting enzyme inhibition attenuates the transition to heart failure. Circulation 1995;91:2642-54.
19. Yoshiyama M, Takeuchi K, Omura T et al. Effects of candesartan and cilazapril on rats with myocardial infarction assessed by echocardiography. Hypertension 1999;33:961-8.
20. Norton GR, Tsotetsi J, Trifunovic B, Hartford C, Candy GP, Woodiwiss AJ. Myocardial stiffness is attributed to alterations in cross-linked collagen rather than total collagen or phenotypes in spontaneously hypertensive rats. Circulation 1997;96:1991-8.
21. Brown L, Sernia C, Newling R, Fletcher P. Cardiac responses after norepinephrine-induced ventricular hypertrophy in rats. J Cardiovasc Pharmacol 1992;20:316-23.
22. Pecháñová O, Bernátová I, Pelouch V, Simko F. Protein remodelling of the heart in NO deficient hypertension: the effect of captopril. J Mol Cell Cardiol 1997;29:3365-74.
23. Pollock DM, Polakowski JS, Opgenorth TJ, Pollock JS. Role of endothelin ETA receptors in the hypertension produced by 4-day L-nitroarginine methyl ester and cyclosporine treatment. Eur J Pharmacol 1998;346:43-50.