Vascular smooth muscle cell polyploidy and cardiomyocyte hypertrophy due to chronic NOS inhibition in vivo

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 274, Issue 1 43-1, 1998, Pages

  Devlin, Alison M ^a   Brosnan, M Julia ^a   Graham, Delyth ^a   Morton, James J ^a   McPhaden, Allan R ^a   McIntyre, Martin ^a   Hamilton, Carlene A ^a   Reid, John L ^a   Dominiczak, Anna F ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Cell cycle; Hypertension; N(G) nitro L arginine methyl ester; Renin angiotensin system; Skeletal actin

Indexed keywords

ALPHA ACTIN; COLLAGEN TYPE 1; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CELL CYCLE; CONTROLLED STUDY; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; NONHUMAN; PLASMA RENIN ACTIVITY; POLYPLOIDY; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 33750880616     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.274.1.h52     Document Type: Article

References (32)

1. Arnal, J.-F., A.-I. El Amrani, G. Chatellier, J. Menard, and J.-B. Michel. Cardiac weight in hypertension induced by nitric oxide synthase blockade. Hypertension 22: 380-387, 1993.
2. Arnal, J.-F., L. Warin, and J.-B. Michel. Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase. J. Clin. Invest. 90: 647-652, 1992.
3. Baylis, C., B. Mitruka, and A. Deng. Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage. J. Clin. Invest. 90: 278-281, 1992.
4. 1-adrenoceptor-mediated hypertrophy of rat cardiac myocytes. J. Clin. Invest. 80: 1194-1199, 1987.
5. Bouriquet, N., M. Dupont, A. Herizi, A. Mimran, and D. Casellas. Preglomerular sudanophilia in L-NAME hypertensive rats: involvement of endothelin. Hypertension 27: 382-391, 1996.
6. Brilla, C. G., B. Maisch, and K. T. Weber. Renin-angiotensin system and myocardial collagen metabolism: in vivo and in vitro studies on collagen myocardial matrix regulation. J. Clin. Invest. 71: S35-S41, 1993.
7. Campbell, J. D., A. Kladis, and A. M. Duncan. Effects of converting enzyme inhibitors on angiotensin and bradykinin peptides. Hypertension 23: 439-449, 1994.
8. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
9. Deng, L. Y., G. Thibault, and E. L. Schiffrin. Effect of hypertension induced by nitric oxide synthase inhibition on structure and function of resistance arteries in the rat. Clin. Exp. Hypertens. 15: 527-537, 1993.
10. Devlin, A. M., J. F. Gordon, A. O. Davidson, J. S. Clark, C. A. Hamilton, J. J. Morton, A. M. Campbell, J. L. Reid, and A. F. Dominiczak. The effects of perindopril on vascular smooth muscle polyploidy in stroke-prone spontaneously hypertensive rats. J. Hypertens. 13: 211-218, 1995.
11. Dominiczak, A. F., A. M. Devlin, W. K. Lee, N. H. Anderson, D. F. Bohr, and J. L. Reid. Vascular smooth muscle polyploidy and cardiac hypertrophy in genetic hypertension. Hypertension 27: 752-759, 1996.
12. Dowell, F. J., D. Henrion, M. Duriez, and J.-B. Michel. Vascular reactivity in mesenteric resistance arteries following chronic nitric oxide synthase inhibition in Wistar rats. Br. J. Pharmacol. 117: 341-346, 1996.
13. Dunu, W. R., and S. M. Gardiner. No evidence for vascular remodelling during hypertension induced by chronic inhibition of nitric oxide synthase in Brattleboro rats. J. Hypertens. 13: 849-857, 1995.
14. Furchgott, R. F. Role of endothelium in responses of vascular smooth muscle. Circ. Res. 53: 557-573, 1983.
15. G-nitro-L-arginine methyl ester in conscious Brattleboro rats. Br. J. Pharmacol. 101: 10-12, 1990.
16. Grunfeld, S., C. A. Hamilton, S. Mesaros, S. W. McClain, A. F. Dominiczak, D. F. Bohr, and T. Malinski. Role of superoxide in the depressed nitric oxide production by the endothelium of genetically hypertensive rats. Hypertension 26: 854-857, 1995.
17. Hamilton, C. A., G. Berg, M. McIntyre, A. R. McPhaden, J. L. Reid, and A. F. Dominiczak. Effects of nitric oxide and superoxide on relaxation in human artery and vein. Atherosclerosis. 133: 77-86, 1997.
18. Kung, C. F., P. Moreau, H. Takase, and T. F. Luscher. L-NAME hypertension alters endothelial and smooth muscle function in rat aorta. Prevention by trandolapril and verapamil. Hypertension 26: 744-751, 1995.
19. Moncada, S., R. M. J. Palmer, and E. A. Higgs. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43: 109-142, 1991.
20. Moncada, S., D. D. Rees, R. Schulz, and R. M. J. Palmer. Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc. Natl. Acad. Sci. USA 88: 2166-2170, 1991.
21. Morton, J. J., E. C. Beattie, A. Speirs, and F. Gulliver. Persistent hypertension following inhibition of nitric oxide formation in the young Wistar rat: role of renin and vascular hypertrophy. J. Hypertens. 11: 1083-1088, 1993.
22. Morton, J. J., and E. C. H. Wallace. The importance of the renin-angiotensin system in the development and maintenance of hypertension in the two-kidney one-clip hypertensive rat. Clin. Sci. (Lond.) 64: 359-370, 1983.
23. Morton, J. J., and D. J. Webb. Measurement of plasma angiotensin II. Clin. Sci. (Lond.) 68: 483-484, 1985.
24. Owens, G. K. Control of hypertrophic versus hyperplastic growth of vascular smooth muscle cells. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H1755-H1765, 1989.
25. Owens, G. K., and S. M. Schwartz. Alterations in vascular smooth muscle mass in the spontaneously hypertensive rat. Role of cellular hypertrophy, hyperploidy and hyperplasia. Circ. Res. 51: 280-289, 1982.
26. Pollman, M. J., T. Yamada, M. Horiuchi, and G. H. Gibbons. Vasoactive substances regulate vascular smooth muscle cell apoptosis. Countervailing influences of nitric oxide and angiotensin II. Circ. Res. 79: 748-756, 1996.
27. 1 receptor subtype. Circ. Res. 73: 413-423, 1993.
28. Safar, M. E., S. L. Laurent, J. D. Bouthier, G. M. London, and A. R. Mimran. Effect of converting enzyme inhibitors on hypertensive large arteries in humans. J. Hypertens. 4, Suppl. 5: S285-S289, 1986.
29. Takase, H., P. Moreau, C. F. Kung, E. Nava, and T. F. Luscher. Antihypertensive therapy prevents endothelial dysfunction in chronic nitric oxide deficiency. Effect of verapamil and trandolapril. Hypertension 27: 25-31, 1996.
30. Tanase, H., Y. Yamori, C. T. Hansen, and W. Lovenberg. Heart size in inbred strains of rats. 2. Cardiovascular DNA and RNA contents during the development of cardiac enlargement in rats. Hypertension 4: 872-880, 1982.
31. Vindelov, L. L., I. J. Christensen, and N. I. Nissen. A detergent trypsin method of preparation of nuclei for flow cytometric DNA analysis. Cytometry 3: 323-327, 1983.
32. Xu, Y., J.-F. Arnal, N. Hinglais, M.-D. Appay, I. Laboulandine, J. Bariety, and J.-B. Michel. Renal hypertensive angiopathy. Comparison between chronic NO suppression and DOCA-salt intoxication. Am. J. Hypertens. 8: 167-176, 1995.