Thermogelling hydrogels of cyclodextrin/poloxamer polypseudorotaxanes as aqueous-based nail lacquers: Application to the delivery of triamcinolone acetonide and ciclopirox olamine

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 83, Issue 3, 2013, Pages 370-377

  Nogueiras Nieto, Luis ^a,b   Begona Delgado Charro M ^b   Otero Espinar, Francisco J ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b University of Bath   (United Kingdom)

Author keywords

Ciclopirox; Cyclodextrin; Hoof; Nail; Polypseudorotaxanes; Triamcinolone

Indexed keywords

ACETYLCYSTEINE; BETA CYCLODEXTRIN; CICLOPIROXOLAMINE; CYCLODEXTRIN; GELLING AGENT; PAINT; POLOXAMER; POLYPSEUDOROTAXANE; ROTAXANE; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG; UREA;

ADULT; AQUEOUS SOLUTION; ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; FEMALE; HOOF AND CLAW; HUMAN; HYDROGEL; MICELLE; NAIL; SCANNING ELECTRON MICROSCOPY;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLODEXTRINS; FEMALE; HUMANS; HYDROGELS; MICROSCOPY, ELECTRON, SCANNING; NAIL DISEASES; NAILS; POLOXAMER; PYRIDONES; TAXOIDS; TRIAMCINOLONE ACETONIDE;

EID: 84875227480     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.11.004     Document Type: Article

References (40)

1. F. Edwards, and D. de Berker Nail psoriasis. Clinical presentation and best practice recommendations Drugs 69 2009 2351 2361
2. M.M. Jiaravuthisan, D. Sasseville, R.B. Vender, F. Murphy, and C.Y. Muhn Psoriasis of the nail: anatomy, pathology, clinical presentation, and a review of literature on therapy J. Am. Acad. Dermatol. 57 2007 1 27
3. M. Sánchez-Regaña, and P. Umbert Diagnosis and management of nail psoriasis Actas Dermosifiliogr. 99 2008 34 43
4. O. Welsh, L. Vera-Cabreara, and E. Welsh Onychomycosis Clin. Dermatol. 28 2010 151 159
5. J. Thomas, G.A. Jacobson, C.K. Narkowicz, G.M. Peterson, H. Burnet, and C. Sharpe Toenail onychomycosis: an important global disease burden J. Clin. Pharm. Ther. 35 2010 497 519
6. F. Crawford, and S. Hollis Topical treatments for fungal infections of the skin and nails of the foot Cochrane Collabor. Cochrane Libr. 3 2007 1 122
7. R. Elkeeb, A. Alikhan, L. Elkeeb, X. Hui, and H.I. Maibach Transungual drug delivery: current status Int. J. Pharm. 384 2010 1 8
8. D.M. Green, K.R. Brain, and K.A. Walters Nail delivery second ed. M.J. Rathbone, J. Hadgraft, M.S. Roberts, M.E. Lane, Modified-release Drug Delivery Technology vol. 2 2008 Informa Healthcare New York 383 393
9. M.B. Delgado-Charro Iontophoretic drug delivery across the nail Expert Opin. Drug Deliv. 9 2012 91 103
10. S. Murdan Drug delivery to the nail following topical application Int. J. Pharm. 236 2002 1 26
11. D. Monti, L. Saccomani, P. Chetoni, S. Burgalassi, S. Senesi, E. Ghelardi, and F. Mailland Hydrosoluble medicated nail lacquers: in vitro drug permeation and corresponding antimycotic activity Br. J. Dermatol. 162 2010 311 317
12. R. Baran, A. Tosti, I. Hartmane, P. Altmeyer, J. Hercogova, V. Koudelkova, T. Ruzicka, P. Combemale, and I. Mikazans An innovative water-soluble biopolymer improves efficacy of ciclopirox nail lacquer in the management of onychomycosis J. Eur. Acad. Dermatol. Venereol. 23 2009 773 781
13. H.B. Gunt, and G.B. Kasting Effect of hydration on the permeation of ketoconazole through human nail plate in vitro Eur. J. Pharm. Sci. 32 2007 254 260
14. D. Monti, L. Saccomani, P. Chetoni, S. Burgalassi, M.F. Saettone, and F. Mailland In vitro transungual permeation of ciclopirox from a hydroxypropyl chitosan based, water soluble nail lacquer Drug Dev. Ind. Pharm. 31 2005 11 17
15. D. Monti, L. Saccomani, P. Chetoni, S. Burgalassi, S. Tampucci, and F. Mailland Validation of bovine hoof slices as a model for infected human toenails: in vitro ciclopirox transungual permeation Br. J. Dermatol. 165 2011 99 105
16. Ciclopoli®. Martindale: The Complete Drug Reference, Medicines Complete. < http://www.medicinescomplete.com > (last accessed 08.08.12).
17. L. Nogueiras-Nieto, J.L. Gómez-Amoza, M.B. Delgado-Charro, and F.J. Otero-Espinar Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof: implications for drug delivery J. Control. Release 156 2011 337 344
18. L. Nogueiras-Nieto, C. Alvarez-Lorenzo, I. Sandez-Macho, A. Concheiro, and F.J. Otero-Espinar Hydrosoluble cyclodextrin/poloxamer polypseudorotaxanes at the air/water interface, in bulk solution, and in the gel state J. Phys. Chem. B 113 2009 2773 2782
19. L. Nogueiras-Nieto, E. Sobarzo-Sánchez, J.L. Gómez-Amoza, and F.J. Otero-Espinar Competitive displacement of drugs from cyclodextrin inclusion complex by polypseudorotaxane formation with poloxamer: implications in drug solubilization and delivery Eur. J. Pharm. Biopharm. 80 2012 585 595
20. F.J. Otero-Espinar, L. Nogueiras-Nieto, S.F. Anguiano Igea, Aqueous Pharmaceutical System for the Administration of Drugs to the Nails, Patent, WO 2011/138484, 2012.
21. S.R. Van Tomme, G. Storm, and W.E. Hennink In situ gelling hydrogels for pharmaceutical and biomedical applications Int. J. Pharm. 355 2008 1 18
22. B. Jeong, S.W. Kim, and Y.H. Bae Thermosensitive sol-gel reversible hydrogels Adv. Drug. Deliv. Rev. 54 2002 37 51
23. R.H. Neubert, C. Gensbügel, A. Jäckel, and S. Wartewig Different physicochemical properties of antimycotic agents are relevant for penetration into and through human nails Pharmazie 61 2006 604 607
24. T. Loftsson, H. Frikdriksdóttir, A.M. Sigurkdardóttir, and H. Ueda The effect of water-soluble polymers on drug-cyclodextrin complexation Int. J. Pharm. 110 1994 169 177
25. J.H. Kim, C.H. Lee, and H.K. Choi A method to measure the amount of drug penetrated across the nail plate Pharm. Res. 18 2001 1468 1471
26. S. Sudsakorn, L. Kaplan, and D.A. Williams Simultaneous determination of triamcinolone acetonide and oxymetazoline hydrochloride in nasal spray formulations by HPLC J. Pharm. Biomed. Anal. 40 2006 1273 1280
27. J. Hao, K.A. Smith, and S.K. Li Iontophoretically enhanced ciclopirox delivery into and across human nail plate J. Pharm. Sci. 98 2009 3608 3616
28. M.E. Villar López, L. Nieto Reyes, S. Anguiano Igea, F.J. Otero Espinar, and J. Blanco-Méndez Formulation of triamcinolone acetonide pellets suitable for coating and colon targeting Int. J. Pharm. 179 1999 229 235
29. K. Nidhi, S. Indrajeet, M. Khushboo, K. Gauri, and D.J. Sen Hydrotropy: a promising tool for solubility enhancement: a review Int. J. Drug Dev. Res. 3 2011 26 33
30. R.C. da Silva, M. Spitzer, L.H.M. da Silva, and W. Loh Investigations on the mechanism of aqueous solubility increase caused by some hydrotropes Thermochim. Acta 328 1999 161 167
31. R.E. Coffman, and D.O. Kildsig Effect of nicotinamide and urea on the solubility of riboflavin in various solvents J. Pharm. Sci. 85 1996 951 954
32. D. Mertin, and B.C. Lippold In-vitro permeability of the human nail and of a keratin membrane from bovine hooves: prediction of the penetration rate of antimycotics through the nail plate and their efficacy J. Pharm. Pharmacol. 49 1997 866 872
33. M.S. Roberts, Y.G. Anissimov, and R.A. Gonsalvez Mathematical models in percutaneous absorption J. Toxicol. Cutaneous Ocul. Toxicol. 20 2001 221 270
34. S. Murdan Enhancing the nail permeability of topically applied drugs Expert Opin. Drug Deliv. 5 2008 1267 1282
35. R.H. Guy, and J. Hadgraft Rate control in transdermal drug delivery Int. J. Pharm. 82 1992 R1 R6
36. C.M. Chiang, G.L. Flyinn, N.D. Weiner, W.J. Addicks, and G.J. Szpunar Bioavailability assessment of topical delivery systems: in vitro delivery of minoxidil from prototypical semi-solid formulations Int. J. Pharm. 49 1989 109 114
37. R.H. Guy, J. Hadgraft, I.W. Kellaway, and M.J. Taylor Calculations of drug release rates from spherical particles Int. J. Pharm. 11 1982 199 207
38. X. Hui, R.C. Wester, S. Barbadillo, C. Lee, B. Patel, M. Wortzmman, E.H. Gans, and H.I. Maibach Ciclopirox delivery into the human nail plate J. Pharm. Sci. 93 2004 2545 2548
39. G. Togni, and F. Mailland Antifungal activity, experimental infections and nail permeation of an innovative ciclopirox nail lacquer based on a water-soluble biopolymer J. Drugs Dermatol. 9 2010 525 530
40. M. Schaller, C. Borelli, U. Berger, B. Walker, S. Schmidt, G. Weindl, and A. Jäckel Susceptibility testing of amorolfine, bifonazole and ciclopiroxolamine against Trichophyton rubrum in an in vitro model of dermatophyte nail infection Med. Mycol. 47 2009 753 758