Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof: Implications for drug delivery

Journal of Controlled Release

Volumn 156, Issue 3, 2011, Pages 337-344

  Nogueiras Nieto, L ^a   Gomez Amoza J L ^a   Delgado Charro, M B ^b   Otero Espinar, F J ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b University of Bath   (United Kingdom)

Author keywords

Hydration; Intrusion porosimetry; Microstructure; N acetyl l cysteine; Nail; Porosity

Indexed keywords

DIFFUSION STUDIES; DRUG DIFFUSION; DRUG PENETRATION; FAST SCREENING; HUMAN NAILS; INTRUSION POROSIMETRY; MERCURY INTRUSION POROSIMETRY; MICRO-STRUCTURAL; MICROSTRUCTURAL CHANGES; MICROSTRUCTURAL MODIFICATION; N-ACETYL L-CYSTEINE; PENETRATION ENHANCERS; PERMEABILITY CHANGE; SEM IMAGE ANALYSIS; SIMULATED STRUCTURE; SURFACE PORES; SURFACE POROSITY; TRI-DIMENSIONAL STRUCTURE; TRIAMCINOLONE;

DRUG DELIVERY; HYDRATION; MAMMALS; MERCURY (METAL); MICROSTRUCTURE; NAILS; POROSITY; SOLVENTS;

AMINO ACIDS;

ACETYLCYSTEINE; MERCURY; TRIAMCINOLONE; WATER;

ARTICLE; COW; DIFFUSION; HOOF AND CLAW; HUMAN; HYDRATION; NAIL; NONHUMAN; PERMEABILITY; POROSITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY;

ACETYLCYSTEINE; ANIMALS; CATTLE; EXPECTORANTS; HOOF AND CLAW; HUMANS; NAILS; PERMEABILITY; POROSITY; WATER;

EID: 82755189404     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.08.021     Document Type: Article

References (43)

1. D.A.R. De Berker, J. André, and R. Baran Nail biology and nail science Int. J. Cosmet. Sci. 29 2007 241 275 (Pubitemid 47101101)
2. J. Thomas, G.A. Jacobson, C.K. Narkowicz, G.M. Peterson, G.H. Burnett, and C. Sharpe Toenail onychomycosis: an important global disease burden J. Clin. Pharm. Ther. 35 2010 497 519
3. J. Obadiah, and R. Scher Nail disorders: unapproved treatments Clin. Dermatol. 20 2002 643 648 (Pubitemid 35472048)
4. S. Murdan Enhancing the nail permeability of topically applied drugs Expert Opin. Drug Deliv. 5 2008 1267 1282
5. S. Kumar, and A.B. Kimball New antifungal therapies for the treatment of onychomycosis Expert Opin. Investig. Drugs 18 2009 727 734
6. K. Hashimoto Ultrastructure of the human toenail. Cell migration, keratinization, and formation of the intercellular cement Arch. Dermatol. Forsch. 240 1971 1 22
7. K. Hashimoto Ultrastructure of the human toenail. II. Keratinization and formation of the marginal band J. Ultrastruct. Res. 36 1971 391 410
8. T. Kitahara, and H. Ogawa Cellular features of differentiation in the nail Microsc. Res. Tech. 38 1997 436 442 (Pubitemid 27377655)
9. J.C. Garson, F. Baltenneck, F. Leroy, C. Riekel, and M. Müller Histological structure of human nail as studied by synchroton X-ray Cell. Mol. Biol. 46 2000 1025 1034
10. A. Jarrett, and R.I.C. Spearman The histochemistry of the human nail Arch. Dermatol. 94 1966 652 657
11. D. Parent, G. Achten, and F. Stouffs-Vanhoof Ultrastructure of the normal human nail Am. J. Dermatopathol. 7 1985 529 536
12. H.H. Bragulla, and D.G. Homberger Structure and functions of keratin proteins in simple stratified and cornified epithelia J. Anat. 214 2009 516 559
13. Y. Kobayashi, T. Komatsu, M. Sumi, S. Numajiri, M. Miyamoto, D. Kobayashi, K. Sugibayashi, and Y. Morimoto In vitro permeation of several drugs through the human nail plate: relationship between physicochemical properties and nail permeability of drugs Eur. J. Pharm. Sci. 21 2004 471 477 (Pubitemid 38283920)
14. S. Murdan Drug delivery to the nail following topical application Int. J. Pharm. 236 2002 1 26 (Pubitemid 34219369)
15. Y. Kobayashi, M. Miyamoto, K. Sugibayashi, and Y. Morimoto Enhancing effect of N-acetyl-l-cysteine or 2-mercaptoethanol on the in vitro permeation of 5-fluorouracil or tolnaftate through the human nail plate Chem. Pharm. Bull. 46 1998 1797 1802
16. H.B. Gunt, and G.B. Kasting Effect of hydration on the permeation of ketoconazole through human nail plate in vitro Eur. J. Pharm. Sci. 32 2007 254 260 (Pubitemid 350051888)
17. R. Elkeeb, A. Alikhan, L. Elkeeb, X. Hui, and H.I. Maibach Transungual drug delivery: current status Int. J. Pharm. 384 2010 1 8
18. D. Mertin, and B.C. Lippold In-vitro permeability of the human nail and of a keratin membrane from human hooves: prediction of the penetration rate of antimycotics through the nail plate and their efficacy J. Pharm. Pharmacol. 49 1997 866 872 (Pubitemid 27424864)
19. R.C. Marshall Genetic variation in the proteins of human nail J. Investig. Dermatol. 75 1980 264 269 (Pubitemid 10047137)
20. H.P. Baden, and J. Kubilus Fibrous proteins of bovine hoof J. Investig. Dermatol. 81 1983 220 224 (Pubitemid 13045257)
21. G.M. Laudone, G.P. Matthews, and P.A.C. Gane Modelling diffusion from simulated porous structures Chem. Eng. Sci. 63 2008 1987 1996 (Pubitemid 351391792)
22. A. Gómez-Carracedo, C. Alvarez-Lorenzo, R. Coca, R. Martínez-Pacheco, A. Concheiro, and J.L. Gómez-Amoza Fractal analysis of SEM images and mercury intrusion porosimetry data for the microstructural characterization of microcrystalline cellulose-based pellets Acta Mater. 57 2009 295 303
23. J.M. Zalc, S.C. Reyes, and E. Iglesia Monte-Carlo simulations of surface and gas phase diffusion in complex porous structures Chem. Eng. Sci. 58 2003 4605 4617 (Pubitemid 37274545)
24. J.M. Zalc, S.C. Reyes, and E. Iglesia The effects of diffusion mechanism and void structure on transport rates and tortuosity factors in complex porous structures Chem. Eng. Sci. 59 2004 2947 2960 (Pubitemid 38814608)
25. J. Kloubek Investigation of porous structures using mercury reintrusion and retention J. Colloid Interface Sci. 163 1994 10 18
26. J. Wood, and L.F. Gladden Modelling diffusion and reaction accompanied by capillary condensation using three-dimensional pore networks. Part 1. Fickian diffusion and pseudo-first-order reaction kinetics Chem. Eng. Sci. 57 2002 3033 3045
27. J. Wood, L.F. Gladden, and F.J. Keil Modelling diffusion and reaction accompanied by capillary condensation using three-dimensional pore networks. Part 2. Dusty gas model and general reaction kinetics Chem. Eng. Sci. 57 2002 3047 3059
28. D.A.L. Holtham, G.P. Matthews, and D.S. Scholefield Measurement and simulation of void structure and hydraulic changes caused by root-induced soil structuring under white clover compared to ryegrass Geoderma 142 2007 142 151 (Pubitemid 47496151)
29. A. Gomez-Carracedo, R. Martinez-Pacheco, A. Concheiro, and J.L. Gomez-Amoza Modelling of porosity and waterfronts in cellulosic pellets for understanding drug release behavior Int. J. Pharm. 388 2010 101 106
30. G. Mabilleau, M.F. Baslé, and D. Chappard Evaluation of surface roughness of hydrogels by fractal texture analysis during swelling Langmuir 22 2006 4843 4845 (Pubitemid 43829173)
31. D. Chappard, I. Degasne, G. Huré, E. Legrand, M. Audran, and M.F. Baslé Image analysis measurements of roughness by texture and fractal analysis correlate with contact profilometry Biomaterials 24 2003 1399 1407 (Pubitemid 36069106)
32. C. Ridgway, P. Gane, A. Abd, and A. Czachor Water absorption into construction materials: comparison of neutron radiography data with network absorption models Transp. Porous Media 63 2006 503 525 (Pubitemid 43958332)
33. A. Johnson, I.M. Roy, G.P. Matthews, and D. Patel An improved simulation of void structure, water retention and hydraulic conductivity in soil with the Pore-Cor three-dimensional network Eur. J. Soil Sci. 54 2003 477 490
34. D.M.W. Peat, G.P. Matthews, P.J. Worsfold, and S.C. Jarvis Simulation of water retention and hydraulic conductivity in soil using a three-dimensional network Eur. J. Soil Sci. 51 2000 65 79 (Pubitemid 30147347)
35. R.K. Ahuja, M. Kodialam, A.K. Mishra, and J.B. Orlin Computational investigations of maximum flow algorithms Eur. J. Oper. Res. 97 1997 509 542 (Pubitemid 127418515)
36. S. Sudsakorn, L. Kaplan, and D.A. Williams Simultaneous determination of triamcinolone acetonide and oxymetazoline hydrochloride in nasal spray formulations by HPLC J. Pharm. Biomed. Anal. 40 2006 1273 1280 (Pubitemid 43247471)
37. G.V. Gupchup, and J.L. Zatz Structural characteristics and permeability properties of the human nail: a review J. Cosmet. Sci. 50 1999 363 385
38. J.L. Pérez Bernal, and M.A. Bello Fractal geometry and mercury porosimetry: comparison and application of proposed models on building stones Appl. Surf. Sci. 185 2001 99 107 (Pubitemid 33126034)
39. S. Wessel, M. Gniadecka, G.B.E. Jemec, and H.C. Wulf Hydration of human nails investigated by NIR-FT-Raman spectroscopy Biochim. Biophys. Acta, Protein Struct. Mol. Enzymol. 1433 1999 210 216 (Pubitemid 29369056)
40. M. Gniadecka, O.F. Nielsen, D.H. Christensen, and H.C. Wulf Structure of water, proteins, and lipids in intact human skin, hair, and nail J. Investig. Dermatol. 110 1998 393 398 (Pubitemid 28158656)
41. R.H. Khengar, S.A. Jones, R.B. Turner, B. Forbes, and M.B. Brown Nail swelling as a pre-formulation screen for the selection and optimisation of ungual penetration enhancers Pharm. Res. 24 2007 2207 2212 (Pubitemid 350064249)
42. G.P. Matthews, A.K. Moss, M.C. Spearing, and F. Voland Network calculation of mercury intrusion and absolute permeability in sandstone and other porous media Powder Technol. 76 1993 95 107
43. J. Schoelkopf, P.A.C. Gane, and C.J. Ridgway A comparison of the various liquid interaction radii derived from experiment and network modelling of porous pigmented structures Colloids Surf., A 251 2004 149 159 (Pubitemid 39574286)