Unraveling the adipocyte inflammomodulatory pathways activated by North American ginseng

International Journal of Obesity

Volumn 37, Issue 3, 2013, Pages 350-356

  Wilson, S A F ^a   Wong, M H T ^a   Stryjecki, C ^a   De Boer, A ^a   Lui, E M K ^b   Mutch, D M ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b WESTERN UNIVERSITY   (Canada)

Author keywords

3T3 L1 adipocyte; inflammation; microarray; North American ginseng; TLR4

Indexed keywords

GINSENG EXTRACT; GINSENOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; RANTES; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE RELEASE; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; INFLAMMATION; MOUSE; NONHUMAN; NORTH AMERICA; PANAX QUINQUEFOLIUS; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN MOTIF; SIGNAL TRANSDUCTION; UPREGULATION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CHEMOKINES; ETHANOL; INFLAMMATION; INTERLEUKIN-6; MICE; NF-KAPPA B P50 SUBUNIT; PLANT EXTRACTS; POLYSACCHARIDES; SAPONINS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

PANAX GINSENG; PANAX QUINQUEFOLIUS;

EID: 84875223470     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2012.50     Document Type: Article

References (22)

1. Banz WJ, Iqbal MJ, Bollaert M, Chickris N, James B, Higginbotham DA et al. Ginseng modifies the diabetic phenotype and genes associated with diabetes in the male ZDF rat. Phytomedicine 2007; 14: 681-689.
2. Pannacci M, Lucini V, Colleoni F, Martucci C, Grosso S, Sacerdote P et al. Panax ginseng C.A. Mayer G115 modulates pro-inflammatory cytokine production in mice throughout the increase of macrophage toll-like receptor expression during physical stress. Brain Behav Immun 2006; 20: 546-551.
3. Azike C, Charpentier P, Hou J, Pei H, King Lui E. The Yin and Yang actions of North American ginseng root in modulating the immune function of macrophages. Chin Med 2011; 6: 21.
4. Attele AS, Wu JA, Yuan C-S. Ginseng pharmacology: Multiple constituents and multiple actions. Biochem Pharmacol 1999; 58: 1685-1693.
5. Schepetkin IA, Quinn MT. Botanical polysaccharides: macrophage immunomodulation and therapeutic potential. Int Immunopharmacol 2006; 6: 317-333.
6. Shang W, Yang Y, Zhou L, Jiang B, Jin H, Chen M. Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes. J Endocrinol 2008; 198: 561-569.
7. Karastergiou K, Mohamed-Ali V. The autocrine and paracrine roles of adipokines. Mol Cell Endocrinol 2010; 318: 69-78.
8. Deng Y, Scherer PE. Adipokines as novel biomarkers and regulators of the metabolic syndrome. Ann NY Acad Sci 2010; 1212: E1-E19.
9. McElhaney JE, Goel V, Toane B, Hooten J, Shan JJ. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial. J Altern Complement Med 2006; 12: 153-157
10. Pillitteri JL, Shiffman S, Rohay JM, Harkins AM, Burton SL, Wadden TA. Use of dietary supplements for weight loss in the United States: Results of a national survey. Obesity 2008; 16: 790-796
11. Mutch DM, Rouault C, Keophiphath M, Lacasa D, Clement K. Using gene expression to predict the secretome of differentiating human preadipocytes. Int J Obes 2009; 33: 354-363
12. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011; 11: 85-97
13. Babish JG, Pacioretty LM, Bland JS, Minich DM, Hu J, Tripp ML. Antidiabetic screening of commercial botanical products in 3T3-L1 adipocytes and db/db mice. J Med Food 2010; 13: 535-547
14. Yeo C-R, Lee S-M, Popovich DG. Ginseng (Panax quinquefolius) Reduces Cell Growth, Lipid Acquisition and Increases Adiponectin Expression in 3T3-L1 Cells. Evid Based Complement Alternat Med 2011; 2011: 1-9
15. Wu Y, Lu X, Xiang F-L, Lui EMK, Feng Q. North American ginseng protects the heart from ischemia and reperfusion injury via upregulation of endothelial nitric oxide synthase. Pharmacol res 2011; 64: 195-202
16. Prifti E, Zucker JD, Clement K, Henegar C. FunNet: an integrative tool for exploring transcriptional interactions. Bioinformatics 2008; 24: 2636-2638
17. Subramanian A. From the cover: Gene set enrichment analysis: A knowledgebased approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci 2005; 102: 15545-15550
18. Tsukumo DML, Carvalho-Filho MA, Carvalheira JBC, Prada PO, Hirabara SM, Schenka AA et al. Loss-of-function mutation in Toll-like receptor 4 prevents dietinduced obesity and insulin resistance. Diabetes 2007; 56: 1986-1998
19. Rot A, von Andrian UH. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 2004; 22: 891-928
20. Choi Y-J, Yoon J-H, Cha S-W, Lee S-G. Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway. Fitoterapia 2011; 82: 911-919
21. Lee DC, Lau AS. Effects of panax ginseng on tumor necrosis factor-a-mediated inflammation: a mini-review. Molecules 2011; 16: 2802-2816
22. Greenbaum D, Colangelo C, Williams K, Gerstein M. Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biol 2003; 4: 117.