The Yin and Yang actions of North American ginseng root in modulating the immune function of macrophages

Chinese Medicine

Volumn 6, Issue , 2011, Pages

  Azike, Chike G ^a,b   Charpentier, Paul A ^a   Hou, Jirui ^a,b   Pei, Hua ^a,b   King Lui, Edmund M ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GINSENG ALCOHOLIC EXTRACT; GINSENG AQUEOUS EXTRACT; GINSENG EXTRACT; IMMUNOMODULATING AGENT; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PLANT MEDICINAL PRODUCT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG ACTIVITY; DRUG ISOLATION; FRACTIONATION; GEL PERMEATION CHROMATOGRAPHY; IN VITRO STUDY; MACROPHAGE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NORTH AMERICA;

EID: 79957467492     PISSN: None     EISSN: 17498546     Source Type: Journal    
DOI: 10.1186/1749-8546-6-21     Document Type: Article

References (28)

1. Angelova N, Kong HW, van der Heijden R, Yang SY, Choi YH, Kim HK, Wang M, Hankemeier T, van der Greef J, Xu G, Verpoorte R. Recent methodology in phytochemical analysis of ginseng. Phytochem Anal 2008, 19:2-16. 10.1002/pca.1049, 18058794.
2. Borchers AT, Keen CL, Stern JS, Gershwin ME. Inflammation and native American medicine: the role of botanicals. Am J Clin Nutr 2000, 72:339-47.
3. Agriculture and Agri-Food Canada, Overview of the Canadian Special Crops Industry - Ginseng. , http://www.ats-sea.agr.gc.ca/can/4752-eng.htm#j
4. Health Canada Drugs and Health Products, Natural Health Product Monograph Panax Ginseng. , http://www.hc-sc.gc.ca/dhp-mps/alt_formats/pacrb-dgapcr/pdf/prodnatur/applications/licen-prod/monograph/mono_panax_ginseng-eng.pdf
5. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology; multiple constituents and multiple actions. Biochem Pharmacol 1999, 58:1685-1693. 10.1016/S0006-2952(99)00212-9, 10571242.
6. Wood PJ. The immune system: recognition of infectious agents. Anaesth Intensive Care Med 2006, 7:179-180.
7. Bondeson J. The mechanisms of action of disease-modifying antirheumatic drugs: a review with emphasis on macrophage signal transduction and the induction of proinflammatory cytokines. Gen Pharmacol 1997, 29:127-150.
8. Lee MY, Park BY, Kwon OK, Yuk JE, Oh SR, Kim HS, Lee HK, Ahn KS. Anti-inflammatory activity of (-)-aptosimon isolated from Daphne genkwa in RAW264.7. Int Immunopharmacol 2009, 9:878-885. 10.1016/j.intimp.2009.03.012, 19328870.
9. Biondo PD, Goruk S, Ruth MR, O'Connell E, Field CJ. Effect of CVT-E002™ (COLD-fX®) versus a ginsenoside extract on systemic and gut-associated immune function. Int Immunopharmacol 2008, 8:1134-1142. 10.1016/j.intimp.2008.04.003, 18550018.
10. Wang M, Guilbert LJ, Li J, Wu Y, Pang P, Basu TK, Shan JJ. A proprietary extract from North American ginseng (Panax quinquefolium) enhances IL-2 and IFN-gamma productions in murine spleen cells induced by Con-A. Int Immunopharmacol 2004, 4:311-315. 10.1016/j.intimp.2003.12.002, 14996422.
11. Jie YH, Cammisuli S, Baggiolini M. Immunomodulatory effects of Panax Ginseng C.A. Meyer in the mouse. Agents Actions 1984, 15:3-4.
12. Friedl R, Moeslinger T, Kopp B, Spieckermann PG. Stimulation of nitric oxide synthesis by the aqueous extract of Panax ginseng root in RAW 264.7 cells. Br J Pharmacol 2001, 134:1663-1670. 10.1038/sj.bjp.0704425, 1572905, 11739242.
13. Assinewe VA, Arnason JT, Aubry A, Mullin J, Lemaire I. Extractable polysaccharides of Panax quinquefolius L. (North American ginseng) root stimulate TNF-α production by alveolar macrophages. Phytomedicine 2002, 9:398-404. 10.1078/09447110260571625, 12222658.
14. Lee JW, Takano-Ishikawa Y, Watanabe J, Kobori M, Tsushida T, Yamaki K. Effect of ginsenosides and red ginseng water extract on tumor necrosis factor-α production by rat peritoneal macrophages. Food Sci Technol Res 2002, 8:300-303.
15. Zhou DL, Kitts DD. Peripheral blood mononuclear cell production of TNF-α in response to North American ginseng stimulation. Can J Physiol Pharmacol 2002, 80:1030-1033. 10.1139/y02-116, 12450071.
16. Lee DC, Yang CL, Chik SC, Li JC, Rong JH, Chan GC, Lau AS. Bioactivity-guided identification and cell signalling technology to delineate the immunomodulatory effects of Panax ginseng on human promonocytic U937 cells. J Transl Med 2009, 34:1-10.
17. Park JS, Park EM, Kim DH, Jung K, Jung JS, Lee EJ, Hyun JW, Kang JL, Kim HS. Anti-inflammatory mechanism of ginseng saponins in activated microglia. J Neuroimmunol 2009, 209:40-49. 10.1016/j.jneuroim.2009.01.020, 19232442.
18. Li J, Ichikawa T, Nagarkatti P, Nagarkatti M, Hofseth LJ, Windust A, Cui T. American ginseng preferentially suppresses STAT/iNOS signaling in activated macrophages. J Ethnopharmacol 2009, 125:145-150. 10.1016/j.jep.2009.05.032, 2790430, 19505555.
19. Rhule A, Rase B, Smith JR, Shepherd DM. Toll-like receptor ligand-induced activation of murine DC2.4 cells is attenuated by Panax notoginseng. J Ethnopharmacol 2008, 28:179-186.
20. Rhule A, Navarro S, Smith JR, Shepherd DM. Panax notoginseng attenuates LPS-induced pro-inflammatory mediators in RAW264.7 cells. J Ethnopharmacol 2006, 106:121-128. 10.1016/j.jep.2005.12.012, 16427227.
21. Liou CJ, Huang WC, Tseng J. Long-term oral administration of ginseng extract modulates humoral immune response and spleen cell functions. Am J Chin Med 2005, 33:651-661. 10.1142/S0192415X05003247, 16173538.
22. Jin UH, Park SG, Suh SJ, Kim JK, Kim DS, Moon SK, Lee YC, Park WH, Kim CH. Inhibitory effect of Panax notoginseng on nitric oxide synthase, Cyclo-oxygenase-2 and neutrophil functions. Phytother Res 2007, 21:142-148. 10.1002/ptr.2018, 17128437.
23. Schepetkin IA, Quinn MT. Botanical polysaccharides: macrophage immunomodulation and therapeutic potential. Int Immunopharmacol 2006, 6:317-333. 10.1016/j.intimp.2005.10.005, 16428067.
24. Yue PY, Mak NK, Cheng YK, Leung KW, Ng TB, Fan DT, Yeung HW, Wong RN. Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides. Chin Med 2007, 2:1-21. 10.1186/1749-8546-2-1, 1800847, 17284322.
25. Iishi H, Tatsuta M, Baba M, Uehara H, Nakaizumi A, Shinkai K, Akedo H, Funai H, Ishiguro S, Kitagawa I. Inhibition by ginsenoside Rg3 of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in wistar rats. Clin Exp Metastasis 1997, 15:603-611. 10.1023/A:1018491314066, 9344044.
26. Tatsuka M, Maeda M, Ota T. Anticarcinogenic effect and enhancement of metastatic potential of BALB/c 3T3 cells by ginsenoside Rh (2). Jpn J Cancer Res 2001, 92:1184-1189.
27. Toth JM, Hewson GL, Frodermann V, Chau LA, Azike C, Lui E, Madrenas J. Modulatory effects of ginseng extracts on human innate and adaptive immune responses. Proceedings of the 10th International Symposium on Ginseng: 13-16 September, 2010; Seoul, Korea
28. Kim HA, Kim S, Chang SH, Hwang HJ, Choi YN. Anti-arthritic effect of ginsenoside Rb1 on collagen induced arthritis in mice. Int Immunopharmacol 2007, 7:1286-1291. 10.1016/j.intimp.2007.05.006, 17673143.