Synthesis and biological evaluation of substituted imidazoquinoline derivatives as mPGES-1 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 2068-2078

  Shiro, Tomoya ^a   Kakiguchi, Keisuke ^a   Takahashi, Hirotada ^a   Nagata, Hidetaka ^a   Tobe, Masanori ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Imidazoquinoline; mPGES 1; PGE2; Selective alkylation

Indexed keywords

3 BENZYL 7 BROMO 2 (2 CHLOROPHENYL) 3H IMIDAZO[4,5 C]QUINOLIN 4(5H)ONE; 5 BENZYL 7 BROMO 2 (2 CHLOROPHENYL)IMIDAZO[4,5 C]QUINOLIN 4(5H)ONE; 7 BROMO 2 (2 CHLOROPHENYL) 1 METHYL 1H IMIDAZO [4,5 C]QUINOLIN 4(5H)ONE; 7 BROMO 2 (2 CHLOROPHENYL) 3 (1 PROPYL) 3H IMIDAZO[4,5 C]QUINOLIN 4(5H)ONE; 7 BROMO 2 (2 CHLOROPHENYL) 3 (2 HYDROXYETHYL) 3H IMIDAZO[4,5 C]QUINOLIN 4(5H)ONE; 7 BROMO 2 (2 CHLOROPHENYL) 3 (PYRIDIN 2 YLMETHYL) 3H IMIDAZO[4,5 C]QUINOLIN 4(5H)ONE; 7 BROMO 2 (2 CHLOROPHENYL) 3 [[(TRIMETHYLSILYL)ETHOXY]METHYL] 3H IMIDAZO[4,5 C]QUINOLIN 4(5H)ONE; 7 BROMO 2 (2 CHLOROPHENYL) 3 ETHYL 3H IMIDAZO[4,5 C]QUINOLIN 4(5H)ONE; 7 BROMO 2 (2 CHLOROPHENYL) 3 METHYL 3H IMIDAZO[4,5 C]QUINOLIN 4(5H)ONE; 7 BROMO 2 (2 CHLOROPHENYL) 3,5 DIMETHYL 3H IMIDAZO[4,5 C]QUINOLIN 4(5H)ONE; 7 BROMO 2 (2 CHLOROPHENYL) 4 (ETHYLTHIO)IMIDAZO[4,5 C]QUINOLINE; 7 BROMO 2 (2 CHLOROPHENYL) 4 (METHYLTHIO)IMIDAZO[4,5 C]QUINOLINE; 7 BROMO 2 (2 CHLOROPHENYL) 5 ETHYLIMIDAZO[4,5 C]QUINOLIN 4(5H)ONE; 7 BROMO 2 (2 CHLOROPHENYL) 5 METHYL 3 [[(TRIMETHYLSILYL)ETHOXY]METHYL] 3H IMIDAZO[4,5 C]QUINOLIN 4(5H)ONE; 7 BROMO 2 (2 CHLOROPHENYL) 5 METHYLIMIDAZO[4,5 C]QUINOLIN 4(5H)ONE; 7 BROMO 2 (2 CHLOROPHENYL) N METHYLIMIDAZO[4,5 C]QUINOLIN 4 AMINE; 7 BROMO 2 (2 CHLOROPHENYL) N,N DIMETHYLIMIDAZO[4,5 C]QUINOLIN 4 AMINE; 7 BROMO 2 (2 CHLOROPHENYL)IMIDAZO[4,5 C]QUINOLIN 4 AMINE; 7 BROMO 2 (2 CHLOROPHENYL)IMIDAZO[4,5 C]QUINOLINE 4(5H)THIONE; 7 BROMO 2 (2 CHLOROPHENYL)IMIDAZOQUINOLIN 4(5H)ONE; 7 BROMO 4 CHLORO 2 (2 CHLOROPHENYL) 1 METHYL 1H IMIDAZO[4,5 C]QUINOLINE; 7 BROMO 4 CHLORO 2 (2 CHLOROPHENYL) 3 METHYL 3H IMIDAZO[4,5 C]QUINOLINE; IMIDAZOQUINOLINE DERIVATIVE; MICROSOMAL PROSTAGLANDIN E2 SYNTHASE 1; PROSTAGLANDIN SYNTHASE; TERT BUTYL 7 BROMO 2 (2 CHLOROPHENYL) 4 OXO 4,5 DIHYDRO 3H IMIDAZO[4,5 C]QUINOLINE 3 CARBOXYLATE; TERT BUTYL 7 BROMO 2 (2 CHLOROPHENYL) 5 METHYL 4 OXO 4,5 DIHYDRO 3H IMIDAZO[4,5 C]QUINOLINE 3 CARBOXYLATE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

ALKYLATION; HEK293 CELLS; HUMANS; IMIDAZOLES; INTRAMOLECULAR OXIDOREDUCTASES; QUINOLINES;

EID: 84875221988     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.018     Document Type: Article

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