Use of the combination index to determine interactions between plant-derived phenolic acids on hepatotoxicity endpoints in human and rat hepatoma cells

Phytomedicine

Volumn 20, Issue 5, 2013, Pages 461-468

  Liu, Yitong ^a,b   Flynn, Thomas J ^a   Ferguson, Martine S ^a   Hoagland, Erica M ^a,c  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b OAK RIDGE INSTITUTE FOR SCIENCE AND EDUCATION   (United States)

^c Allen County Kentucky School   (United States)

Author keywords

Dietary phenolic acids; Hepatotoxicity; Interactions; Mixtures; Species differences

Indexed keywords

PHENOL DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL TYPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG SCREENING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CULTURE; LIVER TOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

ANIMALS; CAFFEIC ACIDS; CINNAMATES; COUMARIC ACIDS; CYTOCHROME P-450 CYP1A1; DEPSIDES; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIVER; OXIDATIVE STRESS; RATS; RHODAMINE 123;

RATTUS;

EID: 84875221909     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.12.013     Document Type: Article

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