Molecular dynamics and brownian dynamics investigation of ion permeation and anesthetic halothane effects on a proton-gated ion channel

Journal of the American Chemical Society

Volumn 132, Issue 46, 2010, Pages 16442-16449

  Cheng, Mary Hongying ^a   Coalson, Rob D ^a   Tang, Pei ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROWNIAN DYNAMICS; BROWNIAN DYNAMICS SIMULATIONS; CHANNEL CONDUCTANCE; CHANNEL GATING; ELECTROSTATIC GATES; ENERGY PROFILE; ENERGY WELLS; EXPERIMENTAL DATA; EXTRACELLULAR DOMAINS; GATE REGION; ION CHANNEL; ION CONDUCTION; ION MOVEMENTS; ION PERMEATION; LIGAND-GATED ION CHANNELS; OPEN CHANNELS; PERMEABILITY RATIO; POTENTIAL OF MEAN FORCE; PROTONATION STATE; SALT BRIDGES; SIGNIFICANT IMPACTS; SINGLE ION; SOLUTION PH; TRANS-MEMBRANE DOMAINS; X RAY CRYSTAL STRUCTURES;

ACTIVATION ANALYSIS; ANESTHETICS; BIOPHYSICS; BROWNIAN MOVEMENT; DYNAMICS; ELECTROSTATICS; ENERGY BARRIERS; ENZYME ACTIVITY; HYDROPHOBICITY; MOLECULAR DYNAMICS;

IONS;

CHLORIDE; HALOTHANE; ION CHANNEL; SODIUM;

ARTICLE; CHANNEL GATING; CONDUCTANCE; CONDUCTION APHASIA; CRYSTAL STRUCTURE; ELECTRICITY; HYDROPHOBICITY; ION PERMEABILITY; ION TRANSPORT; MODULATION; MOLECULAR DYNAMICS; PROTON TRANSPORT; SIMULATION; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY;

ANESTHETICS, INHALATION; HALOTHANE; ION CHANNEL GATING; ION CHANNELS; IONS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTONS;

EID: 78649979016     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja105001a     Document Type: Article

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