In Glycine and GABAA Channels, Different Subunits Contribute Asymmetrically to Channel Conductance via Residues in the Extracellular Domain

Journal of Biological Chemistry

Volumn 286, Issue 15, 2011, Pages 13414-13422

  Moroni, Mirko ^a   Meyer, James O ^a   Lahmann, Carolina ^a   Sivilotti, Lucia G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATIONIC CHANNELS; CHANNEL CONDUCTANCE; CHARGE REVERSAL; CHARGED RESIDUES; COPY NUMBER; EXTRACELLULAR; EXTRACELLULAR DOMAINS; ION CONDUCTION; ION FLOW; NICOTINIC RECEPTOR; POSITIVELY CHARGED; SECOND TRANSMEMBRANE DOMAIN; SIMILAR PATTERN; SINGLE-CHANNEL;

ACTIVATION ANALYSIS; DYES; ENZYME ACTIVITY; STOICHIOMETRY;

AMINO ACIDS;

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; CHLORIDE ION; GLUTAMIC ACID; GLYCINE; GLYCINE RECEPTOR; LYSINE; NICOTINIC RECEPTOR; PROTEIN SUBUNIT;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CATION EXCHANGE; CELL MEMBRANE; CHANNEL GATING; CONTROLLED STUDY; EMBRYO; EXTRACELLULAR MATRIX; FEMALE; FLOW RATE; HUMAN; HUMAN CELL; ION CONDUCTANCE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POTENTIAL DIFFERENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STOICHIOMETRY; ANIMAL; CELL STRAIN HEK293; GENETICS; METABOLISM; MISSENSE MUTATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; XENOPUS LAEVIS;

AMINO ACID SUBSTITUTION; ANIMALS; GLYCINE; HEK293 CELLS; HUMANS; MUTATION, MISSENSE; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, GABA-A; XENOPUS LAEVIS;

EID: 79953874257     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.204610     Document Type: Article

References (42)

1. Unwin, N. (2005) J. Mol. Biol. 346, 967-989
2. Hilf, R. J., and Dutzler, R. (2009) Nature 457, 115-118
3. Bocquet, N., Nury, H., Baaden, M., Le, Poupon, C., Changeux, J. P., Delarue, M., and Corringer, P. J. (2009) Nature 457, 111-114
4. Imoto, K., Busch, C., Sakmann, B., Mishina, M., Konno, T., Nakai, J., Bujo, H., Mori, Y., Fukuda, K., and Numa, S. (1988) Nature 335, 645-648
5. Kelley, S. P., Dunlop, J. I., Kirkness, E. F., Lambert, J. J., and Peters, J. A. (2003) Nature 424, 321-324
6. Hansen, S. B., Wang, H. L., Taylor, P., and Sine, S. M. (2008) J. Biol. Chem. 283, 36066-36070
7. Brams, M., Gay, E. A., Sáez, J. C., Guskov, A., van, Elk, R., van der Schors, R. C., Peigneur, S., Tytgat, J., Strelkov, S. V., Smit, A. B., Yakel, J. L., and Ulens, C. (2011) J. Biol. Chem. 286, 4420-4428
8. Livesey, M., Cooper, M., Lambert, J., and Peters, J. (2010) Proc. Br. Pharmacol. Soc. 7, 37P
9. Groot-Kormelink, P. J., Beato, M., Finotti, C., Harvey, R. J., and Sivilotti, L. G. (2002) J. Neurosci. Methods 113, 207-214
10. Burzomato, V., Groot-Kormelink, P. J., Sivilotti, L. G., and Beato, M. (2003) Recept. Channels 9, 353-361
11. Grudzinska, J., Schemm, R., Haeger, S., Nicke, A., Schmalzing, G., Betz, H., and Laube, B. (2005) Neuron 45, 727-739
12. Bormann, J., Hamill, O. P., and Sakmann, B. (1987) J. Physiol. 385, 243-286
13. Mortensen, M., Ebert, B., Wafford, K., and Smart, T. G. (2010) J. Physiol 588, 1251-1268
14. Carland, J. E., Cooper, M. A., Sugiharto, S., Jeong, H. J., Lewis, T. M., Barry, P. H., Peters, J. A., Lambert, J. J., and Moorhouse, A. J. (2009) J. Biol. Chem. 284, 2023-2030
15. Konno, T., Busch, C., von Kitzing, E., Imoto, K., Wang, F., Nakai, J., Mishina, M., Numa, S., and Sakmann, B. (1991) Proc. Roy. Soc. Lond. 244, 69-79
16. Kienker, P., Tomaselli, G., Jurman, M., and Yellen, G. (1994) Biophys. J. 66, 325-334
17. Langosch, D., Thomas, L., and Betz, H. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 7394-7398
18. Kuhse, J., Laube, B., Magalei, D., and Betz, H. (1993) Neuron 11, 1049-1056
19. Groot-Kormelink, P. J., Broadbent, S. D., Boorman, J. P., and Sivilotti, L. G. (2004) J. Gen. Physiol. 123, 697-708
20. Zhou, Y., Nelson, M. E., Kuryatov, A., Choi, C., Cooper, J., and Lindstrom, J. (2003) J. Neurosci. 23, 9004-9015
21. Minier, F., and Sigel, E. (2004) Trends Pharmacol. Sci. 25, 499-503
22. Sieghart, W., and Sperk, G. (2002) Curr. Top. Med. Chem. 2, 795-816
23. Meltzer, R. H., Lurtz, M. M., Wensel, T. G., and Pedersen, S. E. (2006) Biophys. J. 91, 1315-1324
24. Song, C., and Corry, B. (2009) Biochim. Biophys. Acta 1788, 1466-1473
25. Keramidas, A., Moorhouse, A. J., Schofield, P. R., and Barry, P. H. (2004) Prog. Biophys. Mol. Biol. 86, 161-204
26. Bormann, J., Rundström, N., Betz, H., and Langosch, D. (1993) EMBO J. 12, 3729-3737
27. Imoto, K., Konno, T., Nakai, J., Wang, F., Mishina, M., and Numa, S. (1991) FEBS Lett. 289, 193-200
28. Villarroel, A., Herlitze, S., Koenen, M., and Sakmann, B. (1991) Proc. Roy. Soc. Lond. B 243, 69-74
29. Villarroel, A., Herlitze, S., Koenen, M., and Sakmann, B. (1992) Proc. Roy. Soc. Lond. B 249, 317-324
30. Shan, Q., Nevin, S. T., Haddrill, J. L., and Lynch, J. W. (2003) J. Neurochem. 86, 498-507
31. Jensen, M. L., Timmermann, D. B., Johansen, T. H., Schousboe, A., Varming, T., and Ahring, P. K. (2002) J. Biol. Chem. 277, 41438-41447
32. Chang, Y., Wang, R., Barot, S., and Weiss, D. S. (1996) J. Neurosci. 16, 5415-5424
33. Dalziel, J. E., Cox, G. B., Gage, P. W., and Birnir, B. (2000) Mol. Pharmacol. 57, 875-882
34. Gonzales, E. B., Bell-Horner, C. L., Dibas, M. I., Huang, R. Q., and Dillon, G. H. (2008) Neurosci. Lett. 431, 184-189
35. Wilkins, M. E., Hosie, A. M., and Smart, T. G. (2002) J. Neurosci. 22, 5328-5333
36. Liu, D. T., Tibbs, G. R., and Siegelbaum, S. A. (1996) Neuron 16, 983-990
37. Rayes, D., De Rosa, M. J., Sine, S. M., and Bouzat, C. (2009) J. Neurosci. 29, 6022-6032
38. Groot-Kormelink, P. J., Boorman, J. P., and Sivilotti, L. G. (2001) Br. J. Pharmacol. 134, 789-796
39. Dellisanti, C. D., Yao, Y., Stroud, J. C., Wang, Z. Z., and Chen, L. (2007) Nat. Neurosci. 10, 953-962
40. Cooper, E., Couturier, S., and Ballivet, M. (1991) Nature 350, 235-238
41. Béhé, P., Stern, P., Wyllie, D. J. A., Nassar, M., Schoepfer, R., and Colquhoun, D. (1995) Proc. Roy. Soc. Lond. B 262, 205-213
42. Premkumar, L. S., and Auerbach, A. (1997) J. Gen. Physiol. 110, 485-502