A novel mouse model that closely mimics human uterine leiomyomas

Fertility and Sterility

Volumn 99, Issue 3, 2013, Pages

  Drosch, Michael ^a,b   Bullerdiek, Jörn ^a   Zollner, Thomas M ^b   Prinz, Florian ^b   Koch, Markus ^b   Schmidt, Nicole ^b  

^a UNIVERSITY OF BREMEN   (Germany)

^b BAYER PHARMA AG   (Germany)

Author keywords

benign tumor; Fibroid; FISH; primary culture; xenografts

Indexed keywords

LENTIVIRUS VECTOR;

ARTICLE; CARCINOGENICITY; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DISEASE MODEL; DNA MODIFICATION; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MEDICAL RESEARCH; MOUSE; MYOMETRIUM; NONHUMAN; PATHOGENESIS; PRIMARY CELL CULTURE; PRIORITY JOURNAL; SCID MOUSE; SIMIAN VIRUS 40; UTERUS MYOMA; WESTERN BLOTTING; XENOGRAFT;

EID: 84875217833     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2012.11.032     Document Type: Article

References (54)

1. D. Day Baird, D.B. Dunson, M.C. Hill, D. Cousins, and J.M. Schectman High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence Am J Obstet Gynecol 188 2003 100 107
2. D.L. Olive Analysis of clinical fertility trials: a methodologic review Fertil Steril 45 1986 157 171
3. C.J. Dembek, E.M. Pelletier, K.B. Isaacson, and J.B. Spies Payer costs in patients undergoing uterine artery embolization, hysterectomy, or myomectomy for treatment of uterine fibroids J Vasc Interv Radiol 18 2007 1207 1213
4. P. Evans, and S. Brunsell Uterine fibroid tumors: diagnosis and treatment Am Fam Physician 75 2007 1503 1508
5. D. Linder, and S.M. Gartler Glucose-6-phosphate dehydrogenase mosaicism: utilization as a cell marker in the study of leiomyomas Science 150 1965 67 69
6. D.E. Townsend, R.S. Sparkes, M.C. Baluda, and G. McClelland Unicellular histogenesis of uterine leiomyomas as determined by electrophoresis by glucose-6-phosphate dehydrogenase Am J Obstet Gynecol 107 1970 1168 1173
7. A.A. Sandberg Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyoma Cancer Genet Cytogenet 158 2005 1 26
8. M.K. Lobel, P. Somasundaram, and C.C. Morton The genetic heterogeneity of uterine leiomyomata Obstet Gynecol Clin North Am 33 2006 13 39
9. M. Klemke, A. Meyer, M.H. Nezhad, S. Bartnitzke, N. Drieschner, and C. Frantzen Overexpression of HMGA2 in uterine leiomyomas points to its general role for the pathogenesis of the disease Genes Chromosomes Cancer 48 2009 171 178
10. E.F. Schoenmakers, S. Wanschura, R. Mols, J. Bullerdiek, H. van den Berghe, and W.J. van de Ven Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours Nat Genet 10 1995 436 444
11. N. Makinen, M. Mehine, J. Tolvanen, E. Kaasinen, Y. Li, and H.J. Lehtonen MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas Science 334 2011 252 255
12. D.N. Markowski, S. Bartnitzke, T. Loning, N. Drieschner, B.M. Helmke, and J. Bullerdiek MED12 mutations in uterine fibroids - their relationship to cytogenetic subgroups Int J Cancer 2012
13. J.I. Everitt, D.C. Wolf, S.R. Howe, T.L. Goldsworthy, and C. Walker Rodent model of reproductive tract leiomyomata. Clinical and pathological features Am J Pathol 146 1995 1556 1567
14. S.R. Howe, M.M. Gottardis, J.I. Everitt, T.L. Goldsworthy, D.C. Wolf, and C. Walker Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines Am J Pathol 146 1995 1568 1579
15. C.L. Walker, D. Hunter, and J.I. Everitt Uterine leiomyoma in the Eker rat: a unique model for important diseases of women Genes Chromosomes Cancer 38 2003 349 356
16. R.S. Yeung, G.H. Xiao, F. Jin, W.C. Lee, J.R. Testa, and A.G. Knudson Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (Tsc2) gene Proc Natl Acad Sci U S A 91 1994 11413 11416
17. M.H. Hassan, E. Eyzaguirre, H.M.M. Arafa, F.M.A. Hamada, S.A. Salama, and A. Al-Hendy Memy I: a novel murine model for uterine leiomyoma using adenovirus-enhanced human fibroid explants in severe combined immune deficiency mice Am J Obstet Gynecol 199 2008 156.e1 156.e8
18. K. Cesen-Cummings, K.D. Houston, J.A. Copland, V.J. Moorman, C.L. Walker, and B.J. Davis Uterine leiomyomas express myometrial contractile-associated proteins involved in pregnancy-related hormone signaling J Soc Gynecol Investig 10 2003 11 20
19. D. Dixon, H. He, and J.K. Haseman Immunohistochemical localization of growth factors and their receptors in uterine leiomyomas and matched myometrium Environ Health Perspect 108 Suppl 5 2000 795 802
20. C. Stern, B. Kazmierczak, B. Thode, B. Rommel, S. Bartnitzke, and P. Dal Cin Leiomyoma cells with 12q15 aberrations can be transformed in vitro and show a relatively stable karyotype during precrisis period Cancer Genet Cytogenet 54 1991 223 228
21. F. Suzuki, K. Suzuki, and O. Nikaido An improved soft agar method for determining neoplastic transformation in vitro Methods Cell Sci 8 1983 109 113
22. H. Ishikawa, K. Ishi, V.A. Serna, R. Kakazu, S.E. Bulun, and T. Kurita Progesterone is essential for maintenance and growth of uterine leiomyoma Endocrinology 151 2010 2433 2442
23. W. Chen, and W.C. Hahn SV40 early region oncoproteins and human cell transformation Histol Histopathol 18 2003 541 550
24. Y.W. Choi, I.C. Lee, and S.R. Ross Requirement for the simian virus 40 small tumor antigen in tumorigenesis in transgenic mice Mol Cell Biol 8 1988 3382 3390
25. S.A. Hahn, A.B. Seymour, A.T. Hoque, M. Schutte, L.T. da Costa, and M.S. Redston Allelotype of pancreatic adenocarcinoma using xenograft enrichment Cancer Res 55 1995 4670 4675
26. G. Suo, A. Sadarangani, B. Lamarca, B. Cowan, and J.Y. Wang Murine xenograft model for human uterine fibroids: an in vivo imaging approach Reprod Sci 16 2009 827 842
27. W.C. Hahn, S.K. Dessain, M.W. Brooks, J.E. King, B. Elenbaas, and D.M. Sabatini Enumeration of the simian virus 40 early region elements necessary for human cell transformation Mol Cell Biol 22 2002 2111 2123
28. S. Drayton, and G. Peters Immortalisation and transformation revisited Curr Opin Genet Dev 12 2002 98 104
29. A. Rangarajan, S.J. Hong, A. Gifford, and R.A. Weinberg Species- and cell type-specific requirements for cellular transformation Cancer Cell 6 2004 171 183
30. K. Politi, M. Szabolcs, P. Fisher, A. Kljuic, T. Ludwig, and A. Efstratiadis A mouse model of uterine leiomyosarcoma Am J Pathol 164 2004 325 336
31. M.G. Dodson, J. Slota, C. Lange, and E. Major Distinction of the Phenotypes of in vitro anchorage-independent soft-agar growth and in vivo tumorigenicity in the nude mouse Cancer Res 41 1981 1441 1446
32. S.J. Robboy, R.C. Bentley, K. Butnor, and M.C. Anderson Pathology and pathophysiology of uterine smooth-muscle tumors Environ Health Perspect 108 Suppl 5 2000 779 784
33. T. Hong, Y. Shimada, S. Uchida, A. Itami, Z. Li, and Y. Ding Expression of angiogenic factors and apoptotic factors in leiomyosarcoma and leiomyoma Int J Mol Med 8 2001 141 148
34. B. Moller, C. Rasmussen, B. Lindblom, and M. Olovsson Expression of the angiogenic growth factors VEGF, FGF-2, EGF and their receptors in normal human endometrium during the menstrual cycle Mol Hum Reprod 7 2001 65 72
35. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
36. S. Raptis, and B. Bapat Genetic instability in human tumors EXS 96 2006 303 320
37. M. Zaitseva, B.J. Vollenhoven, and P.A.W. Rogers In vitro culture significantly alters gene expression profiles and reduces differences between myometrial and fibroid smooth muscle cells Mol Hum Reprod 12 2006 187 207
38. J.H. Schiller, and G. Bittner Loss of the tumorigenic phenotype with in vitro, but not in vivo, passaging of a novel series of human bronchial epithelial cell lines: possible role of an α5/β1-integrin-fibronectin interaction Cancer Res 55 1995 6215 6221
39. J.E. Visvader Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis Genes Dev 23 2009 2563 2577
40. A. Raouf, Y. Zhao, K. To, J. Stingl, A. Delaney, and M. Barbara Transcriptome analysis of the normal human mammary cell commitment and differentiation process Cell Stem Cell 3 2008 109 118
41. M. Al-Hajj, M.S. Wicha, A. Benito-Hernandez, S.J. Morrison, and M.F. Clarke Prospective identification of tumorigenic breast cancer cells Proc Natl Acad Sci U S A 100 2003 3983 3988
42. A. Moore, L. Yu, C. Swartz, X. Zheng, L. Wang, and L. Castro Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture J Cell Commun Signal 8 2010 10
43. C.E. Gargett, K. Bucak, and P.A. Rogers Isolation, characterization and long-term culture of human myometrial microvascular endothelial cells Hum Reprod 15 2000 293 301
44. R. Casey, P.A. Rogers, and B.J. Vollenhoven An immunohistochemical analysis of fibroid vasculature Hum Reprod 15 2000 1469 1475
45. C.E. Gargett, K. Bucak, M. Zaitseva, S. Chu, N. Taylor, and P.J. Fuller Estrogen receptor-alpha and -beta expression in microvascular endothelial cells and smooth muscle cells of myometrium and leiomyoma Mol Hum Reprod 8 2002 770 775
46. M. Nisolle, S. Gillerot, F. Casanas-Roux, J. Squifflet, M. Berliere, and J. Donnez Immunohistochemical study of the proliferation index, oestrogen receptors and progesterone receptors A and B in leiomyomata and normal myometrium during the menstrual cycle and under gonadotrophin-releasing hormone agonist therapy Hum Reprod 14 1999 2844 2850
47. K. Kawaguchi, S. Fujii, I. Konishi, T. Iwai, Y. Nanbu, and H. Nonogaki Immunohistochemical analysis of oestrogen receptors, progesterone receptors and Ki-67 in leiomyoma and myometrium during the menstrual cycle and pregnancy Virchows Arch 419 1991 309 315
48. K. Mittal, and R.I. Demopoulos MIB-1 (Ki-67), p53, estrogen receptor, and progesterone receptor expression in uterine smooth muscle tumors Hum Pathol 32 2001 984 987
49. D.D. Baird, T.A. Garrett, S.K. Laughlin, B. Davis, R.C. Semelka, and S.D. Peddada Short-term change in growth of uterine leiomyoma: tumor growth spurts Fertil Steril 95 2011 242 246
50. M. Karbowniczek, D. Zitserman, D. Khabibullin, T. Hartman, J. Yu, and T. Morrison The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development J Clin Invest 120 2010 93 102
51. J.J. Yu, V.A. Robb, T.A. Morrison, E.A. Ariazi, M. Karbowniczek, and A. Astrinidis Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells Proc Natl Acad Sci U S A 106 2009 2635 2640
52. R.L. Kempson, and M.R. Hendrickson Smooth muscle, endometrial stromal, and mixed mullerian tumors of the uterus Mod Pathol 13 2000 328 342
53. G.P. Flake, J. Andersen, and D. Dixon Etiology and pathogenesis of uterine leiomyomas: a review Environ Health Perspect 111 2003 1037 1054
54. V. Bourlev, S. Pavlovitch, D. Stygar, N. Volkov, B. Lindblom, and M. Olovsson Different proliferative and apoptotic activity in peripheral versus central parts of human uterine leiomyomas Gynecol Obstet Invest 55 2003 199 204