The anorexia of ageing: Physiopathology, prevalence, associated comorbidity and mortality. A systematic review

Maturitas

Volumn 74, Issue 4, 2013, Pages 293-302

  Malafarina, Vincenzo ^a   Uriz Otano, Francisco ^a   Gil Guerrero, Lucía ^a   Iniesta, Raquel ^b  

^a Hospital San Juan di Dios   (Spain)

^b Servicio de Soportes Estadístico   (Spain)

Author keywords

Anorexia of ageing; Appetite regulation; Elderly; Loss of appetite; Nutritional intervention

Indexed keywords

CHOLECYSTOKININ; DEXLOXIGLUMIDE; GLUCOSE; INSULIN; LEPTIN; LOXIGLUMIDE; MEGESTROL ACETATE;

AGING; ANOREXIA; ANOREXIA OF AGING; APPETITE; BRAIN DEPTH STIMULATION; CALORIC INTAKE; COMORBIDITY; ELDERLY CARE; FOOD INTAKE; GLUCOSE METABOLISM; HORMONE RELEASE; HUMAN; HYPOTHALAMUS; INGESTION; MORTALITY; NUTRITIONAL ASSESSMENT; PATHOPHYSIOLOGY; POLYPHARMACY; PREVALENCE; REVIEW; SATIETY; SYSTEMATIC REVIEW;

AGED; AGING; ANOREXIA; APPETITE; COMORBIDITY; FEMALE; HUMANS; MALE;

EID: 84875212707     PISSN: 03785122     EISSN: 18734111     Source Type: Journal    
DOI: 10.1016/j.maturitas.2013.01.016     Document Type: Review

References (46)

1. J.E. Morley, and A.J. Silver Anorexia in the elderly Neurobiology of Aging 9 1 1988 9 16
2. C. Franceschi, M. Capri, and D. Monti Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans Mechanisms of Ageing and Development 128 1 2007 92 105
3. N. Hays, and S. Roberts The anorexia of aging in humans Physiology Behavior 88 3 2006 257 266
4. J.E. Morley Anorexia of aging: physiologic and pathologic American Journal of Clinical Nutrition 66 4 1997 760 773
5. V. Malafarina, F. Uriz Otano, R. Iniesta, and L. Gil-Guerrero Sarcopenia in the elderly: diagnosis, physiopathology and treatment Maturitas 71 2 2012 109 114
6. H. Degens, and M. Korhonen Factors contributing to the variability in muscle ageing Maturitas 73 3 2012 197 201
7. D. Moher, A. Liberati, J. Tetzlaff, and D. Altman Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement Annals of Internal Medicine 151 4 2009 W64 264,9
8. A. Liberati, D. Altman, and J. Tetzlaff The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration Annals of Internal Medicine 151 4 2009 W65 W94
9. Agency for Healthcare Research and Quality. Methods reference guide for effectiveness and comparative effectiveness reviews, version 1.0 [draft posted October 2007]. Rockville, MD. Available from: http://effectivehealthcare.ahrq. gov/repFiles/2007-10DraftMethodsGuide.pdf.
10. A. de Boer, G. Ter Horst, and M. Lorist Physiological and psychosocial age-related changes associated with reduced food intake in older persons Ageing Research Reviews 12 1 2012 316 328
11. K. Sturm, C. MacIntosh, B. Parker, J. Wishart, M. Horowitz, and I. Chapman Appetite, food intake, and plasma concentrations of cholecystokinin, ghrelin, and other gastrointestinal hormones in undernourished older women and well-nourished young and older women Journal of Clinical Endocrinology and Metabolism 88 8 2003 3747 3755
12. C.G. MacIntosh, J.E. Morley, and J. Wishart Effect of exogenous cholecystokinin (CCK)-8 on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: evidence for increased CCK activity as a cause of the anorexia of aging Journal of Clinical Endocrinology and Metabolism 86 12 2001 5830 5837
13. C.G. MacIntosh, J.M. Andrews, and K.L. Jones Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility American Journal of Clinical Nutrition 69 5 1999 999 1006
14. V. Di Francesco, M. Zamboni, and A. Dioli Delayed postprandial gastric emptying and impaired gallbladder contraction together with elevated cholecystokinin and peptide YY serum levels sustain satiety and inhibit hunger in healthy elderly persons Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60 December (12) 2005 1581 1585
15. M. Serra Prat, E. Palomera, P. Clave, and M. Puig Domingo Effect of age and frailty on ghrelin and cholecystokinin responses to a meal test American Journal of Clinical Nutrition 89 5 2009 1410 1417
16. M. Martinez, A. Hernanz, J. Gómez Cerezo, J.M. Peña, J.J. Vazquez, and F. Arnalich Alterations in plasma and cerebrospinal fluid levels of neuropeptides in idiopathic senile anorexia Regulatory Peptides 49 2 1993 109 117
17. J. Morley Pathophysiology of the anorexia of aging Current Opinion in Clinical Nutrition Metabolic Care 16 1 2013 27 32
18. J.M. Bauer, A. Haack, and K. Winning Impaired postprandial response of active ghrelin and prolonged suppression of hunger sensation fin the elderly The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 65 3 2010 307 311
19. S. Schneider, R. Al Jaouni, and C. Caruba Effects of age, malnutrition and refeeding on the expression and secretion of ghrelin Clinical Nutrition 27 5 2008 724 731
20. V. Di Francesco, M. Zamboni, and E. Zoico Unbalanced serum leptin and ghrelin dynamics prolong postprandial satiety and inhibit hunger in healthy elderly: another reason for the "anorexia of aging" American Journal of Clinical Nutrition 83 5 2006 1149 1152
21. V. Di Francesco, R. Barazzoni, and L. Bissoli The quantity of meal fat influences the profile of postprandial hormones as well as hunger sensation in healthy elderly people Journal of the American Medical Directors Association 11 3 2010 188 193
22. A.E. Rigamonti, A.I. Pincelli, and B. Corrà Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients Journal of Endocrinology 175 1 2002 R1 R5
23. V. Di Francesco, F. Fantin, and L. Residori Effect of age on the dynamics of acylated ghrelin in fasting conditions and in response to a meal Journal of the American Geriatrics Society 56 7 2008 1369 1370
24. R. Visvanathan, and I. Chapman Undernutrition and anorexia in the older person Gastroenterology Clinics of North America 38 3 2009 393 409
25. C.G. MacIntosh, M. Horowitz, and M.A. Verhagen Effect of small intestinal nutrient infusion on appetite, gastrointestinal hormone release, and gastric myoelectrical activity in young and older men American Journal of Gastroenterology 96 4 2001 997 1007
26. C. Moss, W.S. Dhillo, G. Frost, and M. Hickson Gastrointestinal hormones: the regulation of appetite and the anorexia of ageing Journal of Human Nutrition and Dietetics 25 1 2012 3 15
27. C.G. Cook, J.M. Andrews, and K.L. Jones Effects of small intestinal nutrient infusion on appetite and pyloric motility are modified by age American Journal of Physiology 273 2 1997 R755 R761
28. W.K. Clarkston, M.M. Pantano, J.E. Morley, M. Horowitz, J.M. Littlefield, and F.R. Burton Evidence for the anorexia of aging: gastrointestinal transit and hunger in healthy elderly vs. young adults American Journal of Physiology 272 1 1997 R243 R248
29. E.H. Zandstra, M.F. Mathey, C. Graaf, and W.A. van Staveren Short-term regulation of food intake in children, young adults and the elderly European Journal of Clinical Nutrition 54 3 2000 239 246
30. B.J. Rolls, K.A. Dimeo, and D.J. Shide Age-related impairments in the regulation of food intake American Journal of Clinical Nutrition 62 5 1995 923 931
31. S.B. Roberts, P. Fuss, and M.B. Heyman Control of food intake in older men Journal of the American Medical Association (Chicago, IL) 272 20 1994 1601 1606
32. M. Yukawa, D. Cummings, and C. Matthys Effect of aging on the response of ghrelin to acute weight loss Journal of the American Geriatrics Society 54 4 2006 648 653
33. C.G. MacIntosh, J. Sheehan, N. Davani, J.E. Morley, M. Horowitz, and I.M. Chapman Effects of aging on the opioid modulation of feeding in humans Journal of the American Geriatrics Society 49 11 2001 1518 1524
34. F. Landi, R. Liperoti, and F. Lattanzio Effects of anorexia on mortality among older adults receiving home care: an observation study The Journal of Nutrition, Health Aging 16 1 2012 79 83
35. L.M. Donini, L.J. Dominguez, and M. Barbagallo Senile anorexia in different geriatric settings in Italy The Journal of Nutrition, Health Aging 15 9 2011 775 781
36. F. Landi, A. Russo, and R. Liperoti Anorexia, physical function, and incident disability among the frail elderly population: results from the ilSIRENTE study Journal of the American Medical Directors Association 11 4 2010 268 274
37. O. Vázquez-Valdez, S. Aguilar Navarro, and J. Avila-Funes Association between anorexia of aging and disability in older community-dwelling Mexicans Journal of the American Geriatrics Society 58 10 2010 2044 2046
38. C. Cornali, S. Franzoni, G. Frisoni, and M. Trabucchi Anorexia as an independent predictor of mortality Journal of the American Geriatrics Society 53 2 2005 354 355
39. M. Serra Prat, E. Palomera, M. Roca, and M. Puig Domingo Long-term effect of ghrelin on nutritional status and functional capacity in the elderly: a population-based cohort study Clinical Endocrinology 73 1 2010 41 47
40. D. Reuben, S. Hirsch, K. Zhou, and G. Greendale The effects of megestrol acetate suspension for elderly patients with reduced appetite after hospitalization: a phase II randomized clinical trial Journal of the American Geriatrics Society 53 6 2005 970 975
41. F. Landi, A. Laviano, and A. Cruz Jentoft The anorexia of aging: is it a geriatric syndrome? Journal of the American Medical Directors Association 11 3 2010 153 156
42. V. Malafarina, F. Uriz Otano, R. Iniesta, and L. Gil-Guerrero Effectiveness of nutritional supplementation on muscle mass in treatment of sarcopenia in old age: a systematic review Journal of the American Medical Directors Association 14 1 2013 10 17
43. M. Dermott, J. McDaniel, E. Weiss, T. Tomazic, and M. Mattfeldt Beman Is physical activity associated with appetite? A survey of long-term care residents Journal of Nutrition for the Elderly 28 1 2009 72 80
44. T. Valenzuela Efficacy of progressive resistance training interventions in older adults in nursing homes: a systematic review Journal of the American Medical Directors Association 13 5 2012 418 422
45. C.K.B. Ferrari Functional foods and physical activities in health promotion of aging people Maturitas 58 4 2007 327 339
46. R. Yu, F. Yau, S. Ho, and J. Woo Cardiorespiratory fitness and its association with body composition and physical activity in Hong Kong Chinese women aged from 55 to 94 years Maturitas 69 4 2011 348 353