Sex-, diet-, and cancer-dependent epistatic effects on complex traits in mice

Frontiers in Genetics

Volumn 2, Issue OCT, 2011, Pages

  Leamy, Larry J ^a   Gordon, Ryan R ^b   Pomp, Daniel ^b,c,d  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

^b IL   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Context dependency; Diet; Epistasis; Mice; PyMT; Sex; Weight and obesity traits

Indexed keywords

MUS;

EID: 84875207192     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2011.00071     Document Type: Article

References (39)

1. Allan, M. F., Eisen, E. J., and Pomp, D. (2004). The M16 mouse: an outbred animal model of early onset polygenic obesity and diabesity. Obes. Res. 12, 1397-1407.
2. Allan, M. F., Eisen, E. J., and Pomp, D. (2005). Genomic mapping of direct and correlated responses to long-term selection for rapid growth rate in mice. Genetics 170, 1863-1877.
3. Allison, D. B., Pietrobelli, A., Faith, M. S., Fontaine, K. R., Gropp, E., and Fernandez, J. R. (2003). "Genetic influences on obesity," in Obesity: Mechanisms and Clinical Management, ed. R. Eckel (New York: Elsevier), 31-74.
4. Bell, C. G., Walley, A. J., and Froguel, P. (2005). The genetics of human obesity. Nat. Rev. Genet. 6, 221-234.
5. Bing, C., Russell, S., Becket, E., Pope, M., Tisdale, M. J., Trayhurn, P., and Jenkins, J. R. (2006). Adipose atrophy in cancer cachexia: morphologic and molecular analysis of adipose tissue in tumour-bearing mice. Br. J. Cancer 95, 1028-1037.
6. Brockmann, G. A., Kratzsch, J., Haley, C. S., Renne, L., Schwerin, M., and Karle, S. (2000). Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F2 variance of growth and obesity in DU5i × DBA/2 mice. Genome Res. 10, 1941-1957.
7. Cheverud, J. (2000). "Detecting epistasis among quantitative trait loci," in Epistasis and the Evolutionary Process, eds J. Wolf, E. III Brodie, and M. Wade (New York: Oxford University Press), 58-81.
8. Cheverud, J. M., Ehrich, T. H., Hrbek, T., Kenney, J. P., Pletscher, L. S., and Semenkovich, C. F. (2004). Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LG X SM recombinant inbred mouse strains. Diabetes 53, 3328-3336.
9. Cheverud, J. M., Lawson, H. A., Fawcett, G. I., Wang, B., Pletscher, S., Fox, A. R., Maxwell, T. J., Ehrich, T. H., Kenney-Hunt, J. P., Wolf, J. B., and Semenkovich, C. F. (2011). Diet-dependent genetic and genomic imprinting effects on obesity in mice. Obesity (Silver Spring) 10, 160-170.
10. Cheverud, J. M., Routman, E., Duarte, F. M., van Swinderen, B., Cothran, K., and Perel, C. (1996). Quantitative trait loci for murine growth. Genetics 142, 1305-1319.
11. Cheverud, J. M., Routman, E. J., and Irschick, D. K. (1997). Pleiotropic effects of individual gene loci on mandibular morphology. Evolution 51, 2004-2014.
12. Cheverud, J. M., Vaughn, T. T., Pletscher, L. S., Peripato, A. C., Adams, E. S., Erikson, C. F., and King-Ellison, K. J. (2001). Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice. Mamm. Genome 12, 3-12.
13. Darvasi, A., Weinreb, A., Minke, V., Weller, J. I., and Soller, M. (1993). Detecting marker-QTL linkage and estimating QTL gene effect and map location using a saturated genetic map. Genetics 134, 943-951.
14. Dong, C., Wang, S., Wei-Dong, L., Li, D., Zhao, H., and Price, R. A. (2003). Interacting genetic loci on chromosomes 20 and 10 influence extreme human obesity. Am. J. Hum. Genet. 72, 115-124.
15. Ehrich, T. H., Hrbek, T., Kenney-Hunt, J. P., Pletscher, L. S., Wang, B., Semenkovich, C. F., and Cheverud, J. M. (2005). Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J X SM/J murine model of obesity. Diabetes 54, 1863-1872.
16. Gordon, R. R., Hunter, K. W., Sorensen, P., and Pomp, D. (2008a). Genotype × diet interactions in mice predisposed to mammary cancer. I. Body weight and fat. Mamm. Genome 19, 163-178.
17. Gordon, R., Hunter, K., La Merrill, M., Sørensen, P., Threadgill, D., and Pomp, D. (2008b). Genotype × diet interactions in mice predisposed to mammary cancer: II. Tumors and metastases. Mamm. Genome 19, 179-189.
18. Guy, C. T., Cardiff, R. D., and Muller, W. J. (1992). Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol. Cell Biol. 22, 3794-3802.
19. Haley, C. S., and Knott, S. A. (1992). A simple regression technique for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69, 315-324.
20. Ivakine, E. A., Mortin-Toth, S. M., Gulban, O. M., Valova, A., Canty, A., Scott, C., and Danska, J. (2006). The Idd4 locus displays sex-specific epistatic effects on type 1 diabetes susceptibility in nonobese diabetic mice. Diabetes 55, 3611-3619.
21. Leamy, L. J., Pomp, D., and Lightfoot, J. T. (2009). Genetic variation for body weight change in mice in response to physical exercise. BMC Genet. 10, 58. doi:10.1186/1471-2156-10-58
22. Leamy, L. J., Pomp, D., and Lightfoot, J. T. (2010). A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice. BMC Genet. 11, 83. doi:10.1186/1471-2156-11-83
23. Leamy, L. J., Routman, E., and Cheverud, J. (1999). Quantitative trait loci for early and late developing skull characters in mice: a test of the genetic independence model of morphological integration. Am. Nat. 153, 201-214.
24. Li, J., and Ji, L. (2005). Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity 95, 221-227.
25. Loos, R. J. F., Ruchat, S., Rankinen, T., Tremblay, A., Pérusse, L., and Bouchard, C. (2007). Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Québec Family Study. Am. J. Clin. Nutr. 85, 26-34.
26. Manly, K. F., Cudmore, R. H. Jr., and Meer, J. M. (2001). Map Manager QTX, cross-platform software for genetic mapping. Mamm. Genome 12, 930-932.
27. Musani, S. K., Erickson, S., and Allison, D. B. (2008). Obesity - still highly heritable after all these years. Am. J. Clin. Nutr. 87, 275-276.
28. Nehrenberg, D. L., Wang, S., Hannon, R. M., Garland, T. Jr., and Pomp, D. (2010). QTL underlying voluntary exerercise in mice: interactions with the "mini-muscle" locus and sex. J. Hered. 101, 42-53.
29. O'Rahilly, S., Farooqi, I. S., Yeo, G. S. H., and Challis, B. (2003). Minireview: Human obesity - lessons from monogenic disorders. Endocrinology 144, 3757-3764.
30. Penrod, N. M., Poku, K. A., Vaughn, D. E., Asselberg, F. W., Brown, N. J., Moors, J. H., and William, S. M. (2011). Epistatic interactions in genetic regulation of t-PA and PAI-1 levels in a Ghanaian population. PLoS ONE 6, e16639. doi:10.1371/journal.pone.0016639
31. Pomp, D., Nehrenberg, D., and Estrada-Smith, E. (2008). Complex genetics of obesity in mouse models. Annu. Rev. Nutr. 28, 331-345.
32. Rankinen, T., Zubert, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Perusse, L., and Bouchard, C. (2006). The human obesity gene map: the 2005 update. Obesity (Silver Spring) 14, 529-644.
33. Stone, S., Abkevich, V., Russell, D. L., Riley, R., Timms, K., Tran, T., Trem, D., Frank, D., Jammulapati, S., Neff, C. D., Iliev, D., Gress, R., Gongping, H., Frech, G. C., Adams, T. D., Skolnick, M. H., Lanchbury, J. S., Gutin, A., Hunt, S. C., and Shattuck, D. (2006). TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition. Hum. Mol. Genet. 15, 2709-2720.
34. Stylianou, I. M., Korstanje, R., Li, R., Sheehan, S., Paigen, B., and Churchill, G. A. (2006). Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm. Genome 17, 22-36.
35. Taylor, B. A., and Phillips, S. J. (1997). Obesity QTLs on mouse chromosomes 2 and 17. Genomics 43, 249-257.
36. Wolf, J. B., Leamy, L. J., Routman, E. J., and Cheverud, J. M. (2005). Epistatic pleiotropy and the genetic architecture of covariation within early and late-developing skull trait complexes in mice. Genetics 171, 683-694.
37. Wolf, J. B., Pomp, D., Eisen, E. J., Cheverud, J. M., and Leamy, L. J. (2006). The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice. Evol. Dev. 8, 468-476.
38. Yi, N., Diament, A., Chiu, S., Kim, K., Allison, D. B., Fisler, J. S., and Warden, C. H. (2004). Characterization of epistasis influencing complex spontaneous obesity in the BSB model. Genetics 167, 399-409.
39. Yi, N., Zinniel, D. K., Kyoungmi, K., Eisen, E. J., Bartolucci, A., Allison, D. B., and Pomp, D. (2006). Bayesian analyses of multiple epistatic QTL models for body weight and body composition in mice. Genet. Res. 87, 45-60.