Epitope-guided engineering of monobody binders for in vivo inhibition of Erk-2 signaling

ACS Chemical Biology

Volumn 8, Issue 3, 2013, Pages 608-616

  Mann, Jasdeep K ^a   Wood, Jordan F ^b   Stephan, Anne Fleur ^a   Tzanakakis, Emmanuel S ^a,b,c   Ferkey, Denise M ^b   Park, Sheldon ^a  

^a State University of New York   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c University at Buffalo SUNY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; EPITOPE; MITOGEN ACTIVATED PROTEIN KINASE 1; MONOBODY BINDER; UNCLASSIFIED DRUG; FIBRONECTIN; MAPK1 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR;

ARTICLE; BIOENGINEERING; CAENORHABDITIS ELEGANS; CELL STRAIN HEK293; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MAMMAL CELL; MOLECULAR INTERACTION; NEMATODE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; YEAST; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; METABOLISM; PROTEIN ENGINEERING; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CAENORHABDITIS ELEGANS; EPITOPES; FIBRONECTINS; HEK293 CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MODELS, MOLECULAR; PROTEIN ENGINEERING; PROTEIN KINASE INHIBITORS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875200773     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb300579e     Document Type: Article

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