Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation

Genes to Cells

Volumn 15, Issue 9, 2010, Pages 1003-1013

  Kim, Sol ^a   Yamamoto, Junichi ^a   Chen, Yexi ^a   Aida, Masatoshi ^a,c   Wada, Tadashi ^b   Handa, Hiroshi ^a   Yamaguchi, Yuki ^a  

^a Tokyo Institute of Technology ^*  (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IM PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DOWN REGULATION; HUMAN; HUMAN CELL; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; REGULATORY MECHANISM;

ALTERNATIVE SPLICING; ANIMALS; BINDING SITES; CELL LINE; GENE EXPRESSION; HELA CELLS; HUMANS; IMMUNOBLOTTING; MOLECULAR WEIGHT; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; POLY A; POLYADENYLATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SPODOPTERA;

EID: 77955948497     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2010.01436.x     Document Type: Article

References (25)

1. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K. Current protocols in molecular biology 1987, New York, John Wiley & Sons
2. Brown KM, Gilmartin GM. A mechanism for the regulation of pre-mRNA 3′ processing by human cleavage factor Im. Mol. Cell 2003, 12:1467-1476.
3. Buratowski S. Progression through the RNA polymerase II CTD cycle. Mol. Cell 2009, 36:541-546.
4. Chen Y, Yamaguchi Y, Tsugeno Y, Yamamoto J, Yamada T, Nakamura M, Hisatake K, Handa H. DSIF, the Paf1 complex, and Tat-SF1 have non-redundant, cooperative roles in RNA polymerase II elongation. Genes Dev. 2009, 23:2765-2777.
5. Coseno M, Martin G, Berger C, Gilmartin G, Keller W, Doublie S. Crystal structure of the 25 kDa subunit of human cleavage factor Im. Nucleic Acids Res. 2008, 36:3474-3483.
6. Dantonel J-C, Murthy KGK, Manley JL, Tora L. Transcription factor TFIID recruits factor CPSF for formation of 3′ end of mRNA. Nature 1997, 389:399-402.
7. Dettwiler S, Aringhieri C, Cardinale S, Keller W, Barabino SML. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. J. Biol. Chem. 2004, 279:35788-35797.
8. Hirose Y, Manley JL. RNA polymerase II is an essential mRNA polyadenylation factor. Nature 1998, 395:93-96.
9. Horton RM, Ho SN, Pullen JK, Hunt HD, Cai Z, Pease LR. Gene splicing by overlap extension. Methods Enzymol. 1993, 217:270-279.
10. Kubo T, Wada T, Yamaguchi Y, Shimizu A, Handa H. Knock-down of 25-kDa subunit of cleavage factor Im in HeLa cells alters alternative polyadenylation within 3′ UTRs. Nucleic Acid Res. 2006, 34:6264-6271.
11. Licatalosi DD, Geiger G, Minet M, Schroeder S, Cilli K, McNeil JB, Bentley DL. Functional interaction of yeast pre-mRNA 3′ end processing factors with RNA polymerase II. Mol. Cell 2002, 9:1101-1111.
12. Mandel CR, Bai Y, Tong L. Protein factors in pre-mRNA 3′-end processing. Cell. Mol. Life Sci. 2008, 65:1099-1122.
13. Mandel CR, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley JL, Tong L. Polyadenylation factor CPSF-73 is the pre-mRNA 3-prime-end-processing endonuclease. Nature 2006, 444:953-956.
14. Mayr C, Bartel DP. Widespread shortening of 3′UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell 2009, 138:673-684.
15. Muro EM, Herrington R, Janmohamed S, Frelin C, Andrade-Navarro MA, Iscove NN. Identification of gene 3′ ends by automated EST cluster analysis. Proc. Natl Acad. Sci. USA 2008, 105:20286-20290.
16. Proudfoot NJ, Furger A, Dye MJ. Integrating mRNA processing with transcription. Cell 2002, 108:501-512.
17. Richard P, Manley JL. Transcription termination by nuclear RNA polymerases. Genes Dev. 2009, 23:1247-1269.
18. Ruegsegger U, Beyer K, Keller W. Purification and characterization of human cleavage factor Im involved in the 3′ end processing of messenger RNA precursors. J. Biol. Chem. 1996, 271:6107-6113.
19. Ruegsegger U, Blank D, Keller W. Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits. Mol. Cell 1998, 1:243-253.
20. Sandberg R, Neilson JR, Sarma A, Sharp PA, Burge CB. Proliferating cells express mRNAs with shortened 3′ untranslated regions and fewer microRNA target sites. Science 2008, 320:1643-1647.
21. Takagaki Y, Manley JL. Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation. Mol. Cell 1998, 2:761-771.
22. Takagaki Y, Seipelt RL, Peterson ML, Manley JL. The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. Cell 1996, 87:941-952.
23. Tian B, Hu J, Zhang H, Lutz CS. A large-scale analysis of mRNA polyadenylation of human and mouse genes. Nucleic Acids Res. 2005, 33:201-212.
24. Venkataraman K, Brown KM, Gilmartin GM. Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition. Genes Dev. 2005, 19:1315-1327.
25. Yamada T, Yamaguchi Y, Inukai N, Okamoto S, Mura T, Handa H. P-TEFb-mediated phosphorylation of the hSpt5 C-terminal repeats is critical for processive transcription elongation. Mol. Cell 2006, 21:227-237.