Stem cell-based therapy for corn ealepithelial reconstruction: Present and future

Canadian Journal of Ophthalmology

Volumn 48, Issue 1, 2013, Pages 13-21

  Menzel Severing, Johannes ^a   Kruse, Friedrich E ^a   Schlotzer Schrehardt, Ursula ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COLLAGEN FIBRIL; FIBRIN; TISSUE SCAFFOLD;

CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL EFFECTIVENESS; CONFERENCE PAPER; CORNEA SURGERY; CORNEAL EPITHELIAL RECONSTRUCTION; CULTURED LIMBAL EPITHELIAL TRANSPLANTATION; EXTRACELLULAR MATRIX; HAIR FOLLICLE; HUMAN; LIMBAL STEM CELL TRANSPLANTATION; MICROENVIRONMENT; NONHUMAN; PATIENT SAFETY; PHENOTYPE; STEM CELL; TEMPERATURE;

EID: 84875154966     PISSN: 00084182     EISSN: 17153360     Source Type: Journal    
DOI: 10.1016/j.jcjo.2012.11.009     Document Type: Conference Paper

References (82)

1. Cotsarelis G, Cheng SZ, Dong G, Sun TT, Lavker RM. Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell. 1989;57:201-9.
2. Li W, Hayashida Y, Chen YT, Tseng SC. Niche regulation of corneal epithelial stem cells at the limbus. Cell Res. 2007;17:26-36.
3. Pellegrini G, Rama P, Mavilio F, De Luca M. Epithelial stem cells in corneal regeneration and epidermal gene therapy. J Pathol. 2009;217:217-28.
4. Burman S, Sangwan V. Cultivated limbal stem cell transplantation for ocular surface reconstruction. Clin Ophthalmol. 2008;2:489-502.
5. Kenyon KR, Tseng SC. Limbal autograft transplantation for ocular surface disorders. Ophthalmology. 1989;96:709-22.
6. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell. 1975;6:331-43.
7. Pellegrini G, Traverso CE, Franzi AT, Zingirian M, Cancedda R, De Luca M. Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. Lancet. 1997;349:990-3.
8. Meyer-Blazejewska EA, Kruse FE, Bitterer K, et al. Preservation of the limbal stem cell phenotype by appropriate culture techniques. Invest Ophthalmol Vis Sci. 2010;51:765-74.
9. Shortt AJ, Secker GA, Notara MD, et al. Transplantation of ex vivo cultured limbal epithelial stem cells: a review of techniques and clinical results. Surv Ophthalmol. 2007;52:483-502.
10. Pellegrini G, Rama P, De Luca M. Vision from the right stem. Trends Mol Med. 2010;17:2177-90.
11. Ahmad S, Osei-Bempong C, Dana R, Jurkunas U. The culture and transplantation of human limbal stem cells. J Cell Physiol. 2010;225:15-9.
12. Sangwan VS, Matalia HP, Vemuganti GK, et al. Clinical outcome of autologous cultivated limbal epithelium transplantation. Indian J Ophthalmol. 2006;54:29-34.
13. Rama P, Matuska S, Paganoni G, Spinelli A, De Luca M, Pellegrini G. Limbal stem-cell therapy and long-term corneal regeneration. N Engl J Med. 2010;363:147-55.
14. Baylis O, Figueiredo F, Henein C, Lako M, Ahmad S. 13 years of cultured limbal epithelial cell therapy: a review of the outcomes. JCell Biochem. 2011;112:993-1002.
15. Schwab IR, Johnson NT, Harkin DG. Inherent risks associated with manufacture of bioengineered ocular surface tissue. Arch Ophthalmol. 2006;124:1734-40.
16. Dua HS, Rahman I, Miri A, Said DG. Variations in amniotic membrane: relevance for clinical applications. Br J Ophthalmol. 2010;94:963-4.
17. Chen YT, Li W, Hayashida Y, et al. Human amniotic epithelial cells as novel feeder layers for promoting ex vivo expansion of limbal epithelial progenitor cells. Stem Cells. 2007;25:1995-2005.
18. Notara M, Haddow DB, MacNeil S, Daniels JT. A xenobiotic-free culture system for human limbal epithelial stem cells. Regen Med. 2007;2:919-27.
19. Omoto M, Miyashita H, Shimmura S, et al. The use of human mesenchymal stem cell-derived feeder cells for the cultivation of transplantable epithelial sheets. Invest Ophthalmol Vis Sci. 2009;50:2109-15.
20. Lu R, Bian F, Lin J, et al. Identification of human fibroblast cell lines as a feeder layer for human corneal epithelial regeneration. PLoS One. 2012;7:e38825.
21. Sharma SM, Fuchsluger T, Ahmad S, et al. Comparative analysis of human-derived feeder layers with 3T3 fibroblasts for the ex vivo expansion of human limbal and oral epithelium. Stem Cell Rev. 2012;8:696-705.
22. Nakamura T, Ang LP, Rigby H, et al. The use of autologous serum in the development of corneal and oral epithelial equivalents in patients with Stevens-Johnson syndrome. Invest Ophthalmol Vis Sci. 2006;47:909-16.
23. Basu S, Fernandez MM, Das S, Gaddipati S, Vemuganti GK, Sangwan VS. Clinical outcomes of xeno-free allogeneic cultivated limbal epithelial transplantation for bilateral limbal stem cell deficiency. Br J Ophthalmol. 2012;96:1504-9.
24. Shahdadfar A, Haug K, Pathak M, et al. Ex vivo expanded autologous limbal epithelial cells on amniotic membrane using a culture medium with human serum as single supplement. Exp Eye Res. 2012;97:1-9.
25. Albert R, Vereb Z, Csomos K, et al. Cultivation and characterization of cornea limbal epithelial stem cells on lens capsule in animal material-free medium. PLoS One. 2012;7:e47187.
26. Shortt AJ, Secker GA, Rajan MS, et al. Ex vivo expansion and transplantation of limbal epithelial stem cells. Ophthalmology. 2008;115:1989-97.
27. Daniels JT, Secker GA, Shortt AJ, Tuft SJ, Seetharaman S. Stem cell therapy delivery: treading the regulatory tightrope. Regen Med.. 2006;1:715-9.
28. Levis H, Daniels JT. New technologies in limbal epithelial stem cell transplantation. Curr Opin Biotechnol. 2009;20:593-7.
29. Shortt AJ, Secker GA, Lomas RJ, et al. The effect of amniotic membrane preparation method on its ability to serve as a substrate for the ex-vivo expansion of limbal epithelial cells. Biomaterials. 2009;30:1056-65.
30. Dietrich-Ntoukas T, Hofmann-Rummelt C, Kruse FE, Schlotzer- Schrehardt U. Comparative analysis of the basement membrane composition of the human limbus epithelium and amniotic membrane epithelium. Cornea. 2012;31:564-9.
31. Rama P, Bonini S, Lambiase A, et al. Autologous fibrin-cultured limbal stem cells permanently restore the corneal surface of patients with total limbal stem cell deficiency. Transplantation. 2001;72:1478-85.
32. Han B, Schwab IR, Madsen TK, Isseroff RR. A fibrin-based bioengineered ocular surface with human corneal epithelial stem cells. Cornea. 2002;21:505-10.
33. Talbot M, Carrier P, Giasson CJ, et al. Autologous transplantation of rabbit limbal epithelia cultured on fibrin gels for ocular surface reconstruction. Mol Vis. 2006;12:65-75.
34. Forni MF, Loureiro RR, Cristovam PC, Bonatti JA, Sogayar MC, Gomes JA. Comparison between different biomaterial scaffolds for limbal-derived stem cells growth and enrichment. Curr Eye Res. 2012 Oct 10. [Epub ahead of print].
35. McIntosh Ambrose W, Salahuddin A, So S, et al. Collagen Vitrigel membranes for the in vitro reconstruction of separate corneal epithelial, stromal, and endothelial cell layers. JBiomed Mater Res B Appl Biomater. 2009;90:818-31.
36. Brown RA, Wiseman M, Chuo C-B, Cheema U, Nazhat SN. Ultrarapid engineering of biomimetic materials and tissues: fabrication of nano- and microstructures by plastic compression. Adv Funct Mater. 2005;15:1762-70.
37. Dravida S, Gaddipati S, Griffith M, et al. A biomimetic scaffold for culturing limbal stem cells: a promising alternative for clinical transplantation. J Tissue Eng Regen Med. 2008;2:263-71.
38. Takezawa T, Ozaki K, Nitani A, Takabayashi C, Shimo-Oka T. Collagen vitrigel: a novel scaffold that can facilitate a three- dimensional culture for reconstructing organoids. Cell Transplant. 2004;13:463-73.
39. Reichl S, Borrelli M, Geerling G. Keratin films for ocular surface reconstruction. Biomaterials. 2011;32:3375-86.
40. Bray LJ, George KA, Ainscough SL, Hutmacher DW, Chirila TV, Harkin DG. Human corneal epithelial equivalents constructed on Bombyx mori silk fibroin membranes. Biomaterials. 2011;32:5086-91.
41. Grolik M, Szczubialka K, Wowra B, et al. Hydrogel membranes based on genipin-cross-linked chitosan blends for corneal epithelium tissue engineering. JMater Sci Mater Med. 2012;23:1991-2000.
42. Sharma S, Mohanty S, Gupta D, Jassal M, Agrawal AK, Tandon R. Cellular response of limbal epithelial cells on electrospun poly-S- caprolactone nanofibrous scaffolds for ocular surface bioengineer- ing: a preliminary in vitro study. Mol Vis. 2011;17:2898-910.
43. Nishida K, Yamato M, Hayashida Y, et al. Functional bioengi- neered corneal epithelial sheet grafts from corneal stem cells expanded ex vivo on a temperature-responsive cell culture surface. Transplantation. 2004;77:379-85.
44. Hayashida Y, Nishida K, Yamato M, et al. Transplantation of tissue-engineered epithelial cell sheets after excimer laser photoablation reduces postoperative corneal haze. Invest Ophthalmol Vis Sci. 2006;47:552-7.
45. Yang J, Yamato M, Nishida K, et al. Cell delivery in regenerative medicine: the cell sheet engineering approach. J Control Release. 2006;116:193-203.
46. Hirayama M, Satake Y, Higa K, Yamaguchi T, Shimazaki J. Transplantation of cultivated oral mucosal epithelium prepared in fibrin-coated culture dishes. Invest Ophthalmol Vis Sci. 2012;53:1602-9.
47. Burillon C, Huot L, Justin V, et al. Cultured autologous oral mucosal epithelial cell sheet (CAOMECS) transplantation for the treatment of corneal limbal epithelial stem cell deficiency. Invest Ophthalmol Vis Sci. 2012;53:1325-31.
48. Barbaro V, Ferrari S, Fasolo A, Ponzin D, Di Iorio E. Reconstruction of a human hemicornea through natural scaffolds compatible with the growth of corneal epithelial stem cells and stromal keratocytes. Mol Vis. 2009;15:2084-93.
49. Shafiq MA, Gemeinhart RA, Yue BY, Djalilian AR. Decellularized human cornea for reconstructing the corneal epithelium and anterior stroma. Tissue Eng Part C Methods. 2012;18:340-8.
50. Schlotzer-Schrehardt U, Dietrich T, Saito K, et al. Characterization of extracellular matrix components in the limbal epithelial stem cell compartment. Exp Eye Res. 2007;85:845-60.
51. Ordonez P, Di Girolamo N. Limbal epithelial stem cells: role of the niche microenvironment. Stem Cells. 2012;30:100-7.
52. Blazejewska EA, Schlotzer-Schrehardt U, Zenkel M, et al. Corneal limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial-like cells. Stem Cells. 2009;27:642-52.
53. Chen SY, Hayashida Y, Chen MY, Xie HT, Tseng SC. A new isolation method of human limbal progenitor cells by maintaining close association with their niche cells. Tissue Eng Part C Methods. 2011;17:537-48.
54. Levis HJ, Brown RA, Daniels JT. Plastic compressed collagen as a biomimetic substrate for human limbal epithelial cell culture. Biomaterials. 2010;31:7726-37.
55. Levis HJ, Menzel-Severing J, Drake RA, Daniels JT. Plastic compressed collagen constructs for ocular cell culture and transplantation: a new and improved technique of confined fluid loss. Curr Eye Res. 2012 Sep 27. [Epub ahead of print].
56. Bray LJ, George KA, Hutmacher DW, Chirila TV, Harkin DG. A dual-layer silk fibroin scaffold for reconstructing the human corneal limbus. Biomaterials. 2012;33:3529-38.
57. Zajicova A, Pokorna K, Lencova A, et al. Treatment of ocular surface injuries by limbal and mesenchymal stem cells growing on nanofiber scaffolds. Cell Transplant. 2010;19:1281-90.
58. Dellatore SM, Garcia AS, Miller WM. Mimicking stem cell niches to increase stem cell expansion. Curr Opin Biotechnol. 2008;19:534-40.
59. Yan J, Qiang L, Gao Y, et al. Effect of fiber alignment in electrospun scaffolds on keratocytes and corneal epithelial cells behavior. J Biomed Mater Res A. 2011 Dec 2. [Epub ahead of print].
60. Lawrence BD, Pan Z, Liu A, Kaplan DL, Rosenblatt MI. Human corneal limbal epithelial cell response to varying silk film geometric topography in vitro. Acta Biomater. 2012;8:3732-43.
61. Zieris A, Chwalek K, Prokoph S, et al. Dual independent delivery of pro-angiogenic growth factors from starPEG-heparin hydrogels. JControl Release. 2011;156:28-36.
62. Tanioka H, Kawasaki S, Yamasaki K, et al. Establishment of a cultivated human conjunctival epithelium as an alternative tissue source for autologous corneal epithelial transplantation. Invest Ophthalmol Vis Sci. 2006;47:3820-7.
63. Ono K, Yokoo S, Mimura T, et al. Autologous transplantation of conjunctival epithelial cells cultured on amniotic membrane in a rabbit model. Mol Vis. 2007;13:1138-43.
64. Ang LP, Tanioka H, Kawasaki S, et al. Cultivated human conjunctival epithelial transplantation for total limbal stem cell deficiency. Invest Ophthalmol Vis Sci. 2010;51:758-64.
65. Nakamura T, Takeda K, Inatomi T, Sotozono C, Kinoshita S. Long-term results of autologous cultivated oral mucosal epithelial transplantation in the scar phase of severe ocular surface disorders. Br JOphthalmol. 2011;95:942-6.
66. Inatomi T, Nakamura T, Koizumi N, Sotozono C, Yokoi N, Kinoshita S. Midterm results on ocular surface reconstruction using cultivated autologous oral mucosal epithelial transplantation. Am J Ophthalmol. 2006;141:267-75.
67. Nishida K, Yamato M, Hayashida Y, et al. Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium. N Engl JMed. 2004;351:1187-96.
68. Yang X, Moldovan NI, Zhao Q, et al. Reconstruction of damaged cornea by autologous transplantation of epidermal adult stem cells. Mol Vis. 2008;14:1064-70.
69. Meyer-Blazejewska EA, Call MK, Yamanaka O, et al. From hair to cornea: toward the therapeutic use of hair follicle-derived stem cells in the treatment of limbal stem cell deficiency. Stem Cells. 2011;29:57-66.
70. Ricardo JR, Cristovam PC, Filho PA, et al. Transplantation of conjunctival epithelial cells cultivated ex vivo in patients with total limbal stem cell deficiency. Cornea. 2012 May 10. [Epub ahead of print].
71. Ma Y, Xu Y, Xiao Z, et al. Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells. Stem Cells. 2006;24:315-21.
72. Jiang TS, Cai L, Ji WY, et al. Reconstruction of the corneal epithelium with induced marrow mesenchymal stem cells in rats. Mol Vis. 2010;16:1304-16.
73. Ye J, Yao K, Kim JC. Mesenchymal stem cell transplantation in a rabbit corneal alkali burn model: engraftment and involvement in wound healing. Eye (Lond). 2006;20:482-90.
74. Ho JH, Ma WH, Tseng TC, Chen YF, Chen MH, Lee OK. Isolation and characterization of multi-potent stem cells from human orbital fat tissues. Tissue Eng Part A. 2011;17:255-66.
75. Gomes JA, Geraldes Monteiro B, Melo GB, et al. Corneal reconstruction with tissue-engineered cell sheets composed of human immature dental pulp stem cells. Invest Ophthalmol Vis Sci. 2010;51:1408-14.
76. Reza HM, Ng BY, Gimeno FL, Phan TT, Ang LP. Umbilical cord lining stem cells as a novel and promising source for ocular surface regeneration. Stem Cell Rev. 2011;7:935-47.
77. Homma R, Yoshikawa H, Takeno M, et al. Induction of epithelial progenitors in vitro from mouse embryonic stem cells and application for reconstruction of damaged cornea in mice. Invest Ophthal- mol Vis Sci. 2004;45:4320-6.
78. Ahmad S, Stewart R, Yung S, et al. Differentiation of human embryonic stem cells into corneal epithelial-like cells by in vitro replication of the corneal epithelial stem cell niche. Stem Cells. 2007;25:1145-55.
79. Kumagai Y, Kurokawa MS, Ueno H, et al. Induction of corneal epithelium-like cells from cynomolgus monkey embryonic stem cells and their experimental transplantation to damaged cornea. Cornea. 2010;29:432-8.
80. Notara M, Hernandez D, Mason C, Daniels JT. Characterization of the phenotype and functionality of corneal epithelial cells derived from mouse embryonic stem cells. Regen Med. 2012;7:167-78.
81. Hayashi R, Ishikawa Y, Ito M, et al. Generation of corneal epithelial cells from induced pluripotent stem cells derived from human dermal fibroblast and corneal limbal epithelium. PLoS One. 2012;7:e45435.
82. Ortega-Zilic N, Hunziker T, Lauchli S, et al. EpiDex(R) Swiss field trial 2004-2008. Dermatology. 2010;221:365-72.